{"id":19365,"date":"2022-11-11T02:02:19","date_gmt":"2022-11-11T02:02:19","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19365"},"modified":"2023-04-08T03:26:29","modified_gmt":"2023-04-08T03:26:29","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e7%a0%94%e7%a9%b6%e5%8f%91%e7%8e%b0-nmn-%e4%bf%9d%e6%8a%a4%e8%82%a0%e5%a3%81%e5%85%8d%e5%8f%97%e7%99%8c%e7%97%87%e6%94%be%e5%b0%84%e6%b2%bb","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19365","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u7814\u7a76\u53d1\u73b0 NMN \u4fdd\u62a4\u80a0\u58c1\u514d\u53d7\u764c\u75c7\u653e\u5c04\u6cbb\u7597\u635f\u4f24"},"content":{"rendered":"<p>\u4e2d\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0cNMN \u53ef\u4ee5\u9632\u6b62\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u2014\u2014\u901a\u5e38\u7528\u4e8e\u6cbb\u7597\u8001\u5e74\u764c\u75c7\u60a3\u8005\u3002<\/p>\n<div class=\"s-blog-header\">\n<div class=\"s-blog-header-bottom\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-info s-font-body\"><span class=\"s-blog-date\">2022\u5e7411\u67089\u65e5<\/span><span class=\"dot\">\u00a0\u00b7\u00a0<\/span><span class=\"s-blog-tags\"><span class=\"s-blog-tag \">NMN\u7684\u79d1\u7814\u8fdb\u5c55\uff0c<\/span><span class=\"s-blog-tag last\">\u764c\u75c7<\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-blog-body s-blog-padding\">\n<div class=\"s-repeatable s-block s-component s-mh \">\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19366\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/386525_433344.webp\" alt=\"\" width=\"735\" height=\"447\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/386525_433344.webp 735w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/386525_433344-300x182.webp 300w\" sizes=\"auto, (max-width: 735px) 100vw, 735px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">By\u00a0Victor Ciardha<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published:\u00a012:54 p.m. PST Nov 7, 2022\u00a0| Updated:\u00a04:24 p.m. PST Nov 8, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>NMN \u53ef\u51cf\u5c11\u66b4\u9732\u4e8e\u8f90\u5c04\u7684\u80a0\u7ec6\u80de\u4e2d\u7684 DNA \u635f\u4f24\u548c\u6d3b\u6027\u6c27 \uff08ROS\uff09\u3002<\/li>\n<li>\u5728\u5c0f\u9f20\u4e2d\uff0c\u7528 NMN \u4ecb\u5165\u6709\u52a9\u4e8e\u9632\u6b62\u8f90\u5c04\u66b4\u9732\u540e\u5bf9\u80a0\u58c1\u9020\u6210\u7684\u7ed3\u6784\u635f\u4f24\u3002<\/li>\n<li>\u957f\u5bff\u57fa\u56e0sirtuins\u53ef\u4ee5\u4ecb\u5bfc NMN\u7684\u76ca\u5904\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u653e\u5c04\u7597\u6cd5\u901a\u5e38\u7528\u4e8e\u6cbb\u7597\u592a\u865a\u5f31\u800c\u65e0\u6cd5\u63a5\u53d7\u624b\u672f\u6216\u63a5\u53d7\u5316\u5b66\u7597\u6cd5\u7684\u8001\u5e74\u764c\u75c7\u60a3\u8005\u3002 \u7136\u800c\uff0c\u63a5\u53d7\u8179\u90e8\u548c\u76c6\u8154\u80bf\u7624\u653e\u7597\u7684\u60a3\u8005\u4e2d\u670960%\u81f380%\u60a3\u6709\u80a0\u9053\u635f\u4f24\u3002 \u6b64\u5916\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u53ef\u7528\u4e8e\u633d\u6551\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u7684\u65b9\u6cd5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u73b0\u5728\uff0c\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u548c\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5728\u5b66\u672f\u671f\u520a\u300a\u81ea\u7531\u57fa\u751f\u7269\u5b66\u4e0e\u533b\u5b66\u300b\uff08<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584922008978?casa_token=hqQ2_zyuKmYAAAAA:Tviq2N92VltLv7O6uVXTsoN2r9wO7x0e0atz4N5t7aFDDA_QWyBEG1o86C0m0tBxltl-ZAxf\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Free Radical Biology and Medicine<\/em><\/a>\uff09\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u8868\u660e NMN \u53ef\u4ee5\u6539\u5584\u5c0f\u9f20\u7684\u8f90\u5c04\u635f\u4f24\u3002 \u5728\u7f3a\u4e4f\u4e00\u79cd\u540d\u4e3a NRF2 \u7684\u86cb\u767d\u8d28\u7684\u5c0f\u9f20\u80a0\u9053\u7ec6\u80de\u4e2d\uff0cZhao \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cNMN \u53ef\u51cf\u5c11 DNA \u635f\u4f24\u5e76\u51cf\u5c11\u8f90\u5c04\u5f15\u8d77\u7684 \u6d3b\u6027\u6c27 \uff08ROS\uff09 \u3002\u00a0\u7528 NMN \u4ecb\u5165\u540e\u8fd8\u53ef\u4ee5\u4fdd\u62a4\u7f3a\u4e4f NRF2 \u7684\u5c0f\u9f20\u514d\u53d7\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u3002\u00a0NMN \u6709\u5e0c\u671b\u7684\u6548\u679c\u662f\u7531\u957f\u5bff\u57fa\u56e0 \uff08Sirtuins\uff09 \u7684\u589e\u52a0\u800c\u4ecb\u5bfc\u7684\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u4fdd\u62a4\u80a0\u58c1\u514d\u53d7\u8f90\u5c04<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u8f90\u5c04\u901a\u8fc7\u4ea7\u751f\u6d3b\u6027\u6c27 \uff08ROS\uff09 \u548c\u8bf1\u5bfc DNA \u635f\u4f24\u6765\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u4f46\u5b83\u4e5f\u53ef\u80fd\u5bf9\u5468\u56f4\u7684\u7ec6\u80de\u9020\u6210\u635f\u4f24\u3002 NRF2 \u86cb\u767d\u5728\u51cf\u5c11 ROS \u548c DNA \u635f\u4f24\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u51cf\u5c11\u3002 \u56e0\u6b64\uff0cNRF2 \u7f3a\u4e4f\u4f7f\u8001\u5e74\u4eba\u66f4\u5bb9\u6613\u53d7\u5230\u8f90\u5c04\u5f15\u8d77\u7684\u635f\u4f24\u3002 \u51fa\u4e8e\u8fd9\u4e2a\u539f\u56e0\uff0cZhao \u53ca\u5176\u540c\u4e8b\u5bf9NRF2\u7f3a\u9677\u7ec6\u80de\u8fdb\u884c\u4e86\u5b9e\u9a8c\uff0c\u4ee5\u6a21\u62df\u8870\u8001\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u60c5\u51b5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u66b4\u9732\u4e8e\u8f90\u5c04\u4e0b\u7684 NRF2 \u7f3a\u9677\u578b\u80a0\u9053\u7ec6\u80de\u4e0d\u4ec5\u8868\u73b0\u51fa\u66f4\u9ad8\u6c34\u5e73\u7684 ROS\u3001DNA \u635f\u4f24\u548c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u800c\u4e14\u5b83\u4eec\u8fd8\u6709\u66f4\u591a\u7684\u8870\u8001\u7ec6\u80de\u2014\u2014\u5728\u672a\u88ab\u6d88\u9664\u65f6\u4f1a\u52a0\u901f\u8870\u8001\u8fc7\u7a0b\u7684\u7ec6\u80de\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u8f90\u5c04\u53ef\u80fd\u4f1a\u5f15\u53d1\u764c\u75c7\u60a3\u8005\u7684\u8870\u8001\u3002 \u7136\u800c\uff0cNMN \u7684\u4ecb\u5165\u51cf\u5c11\u4e86 ROS\u3001DNA \u635f\u4f24\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNMN\u53ef\u4ee5\u5e2e\u52a9\u5f25\u8865\u53d7\u5230\u8f90\u5c04\u6311\u6218\u7684\u80a0\u7ec6\u80de\u4e2dNRF2\u7684\u7f3a\u4e4f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/489415_301558.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u00a0(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584922008978?casa_token=hqQ2_zyuKmYAAAAA:Tviq2N92VltLv7O6uVXTsoN2r9wO7x0e0atz4N5t7aFDDA_QWyBEG1o86C0m0tBxltl-ZAxf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">Zhao et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584922008978?casa_token=hqQ2_zyuKmYAAAAA:Tviq2N92VltLv7O6uVXTsoN2r9wO7x0e0atz4N5t7aFDDA_QWyBEG1o86C0m0tBxltl-ZAxf\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Radic. Biol. Med.<\/em><\/a>\u00a0\uff09\u00a0<strong>NMN \u51cf\u5c11\u6d3b\u6027\u6c27 \uff08ROS\uff09<\/strong>\u3002 \u5f53 NRF2 \u86cb\u767d\u4ece\u5c0f\u9f20\u80a0\u9053\u7ec6\u80de \uff08NRF2KO\uff09 \u4e2d\u901a\u8fc7\u9057\u4f20\u5b66\u65b9\u6cd5\u53bb\u9664\u65f6\uff0cROS \u6c34\u5e73\u4f1a\u589e\u52a0\u3002 \u7136\u800c\uff0c\u7528NMN\uff08NRF2KO+NMN\uff09\u4ecb\u5165\u8fd9\u4e9b\u7ec6\u80de\u5219\u4f1a\u964d\u4f4eRAS\u6c34\u5e73\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Sirtuins \u662f\u5229\u7528 NAD+ \u4fc3\u8fdb\u7ec6\u80de\u5b58\u6d3b\u6d3b\u52a8\u7684\u9176\u3002 Zhao \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cNMN \u589e\u52a0\u4e86 sirtuin \u6c34\u5e73\uff0c\u8fd9\u8868\u660e NMN \u7684\u4f5c\u7528\u662f\u7531 sirtuin \u4ecb\u5bfc\u7684\u3002 \u7136\u540e\uff0c\u4ed6\u4eec\u901a\u8fc7\u7ed9NRF2\u7f3a\u9677\u5c0f\u9f20\u5582\u98df300 mg\/kg\/\u5929\u7684NMN\u6765\u6d4b\u8bd5NMN\u548csirtuins\u662f\u5426\u53ef\u4ee5\u9632\u6b62\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u3002 \u7136\u540e\u5c06\u5c0f\u9f20\u66b4\u9732\u4e8e\u8179\u90e8\u8f90\u5c04\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u901a\u8fc7\u8bc4\u4f30\u80a0\u58c1\u7684\u51e0\u4e2a\u7279\u5f81\uff08\u5305\u62ec\u7ed2\u6bdb\u957f\u5ea6\uff09\u6765\u6d4b\u91cf\u80a0\u635f\u4f24\u3002 \u7ed2\u6bdb\u662f\u80a0\u58c1\u7684\u4ea7\u7269\uff0c\u6709\u52a9\u4e8e\u589e\u52a0\u80a0\u7684\u8868\u9762\u79ef\u4ee5\u5438\u6536\u8425\u517b\u3002 \u867d\u7136\u8f90\u5c04\u66b4\u9732\u5bfc\u81f4\u672a\u7ecfNMN\u4ecb\u5165\u7684NRF2\u7f3a\u9677\u5c0f\u9f20\u7684\u7ed2\u6bdb\u957f\u5ea6\u51cf\u5c11\uff0c\u4f46\u5f53\u8fd9\u4e9b\u5c0f\u9f20\u7528NMN\u4ecb\u5165\u540e\uff0c\u7ed2\u6bdb\u957f\u5ea6\u6062\u590d\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u5728NRF2\u4f4e\u7684\u60c5\u51b5\u4e0b\uff0cNMN\u53ef\u4ee5\u9632\u6b62\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div>\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img decoding=\"async\" class=\"crop-default\" title=\"\" src=\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/171584_747386.png\" alt=\"\" data-description=\"\" data-image-link=\"javascript:void(0);\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u00a0(<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584922008978?casa_token=hqQ2_zyuKmYAAAAA:Tviq2N92VltLv7O6uVXTsoN2r9wO7x0e0atz4N5t7aFDDA_QWyBEG1o86C0m0tBxltl-ZAxf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">Zhao et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584922008978?casa_token=hqQ2_zyuKmYAAAAA:Tviq2N92VltLv7O6uVXTsoN2r9wO7x0e0atz4N5t7aFDDA_QWyBEG1o86C0m0tBxltl-ZAxf\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Radic. Biol. Med.<\/em><\/a>\u00a0\uff09\u00a0<strong>NMN \u53ef\u9632\u6b62\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24<\/strong>\u3002 \u4e0e\u672a\u7ecfNMN\u4ecb\u5165\u7684 NRF2 \u7f3a\u9677\u5c0f\u9f20 \uff08CTRL\uff09 \u76f8\u6bd4\uff0c\u66b4\u9732\u4e8e\u7535\u79bb\u8f90\u5c04 \uff08NRF2KO-IR\uff09 \u7684 NRF2 \u7f3a\u9677\u5c0f\u9f20\u7684\u7ed2\u6bdb\u8f83\u77ed\u3002 \u7136\u800c\uff0c\u7528 NMN \uff08NRF2KO-NMN + IR\uff09 \u4ecb\u5165\u540e\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u53ef\u4ee5\u6062\u590d\u7ed2\u6bdb\u957f\u5ea6\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cNMN \u4fc3\u8fdb\u4e86 sirtuin 1 \uff08SIRT1\uff09 \u7684\u529f\u80fd\u3002 \u7136\u800c\uff0c\u5b58\u5728\u4e00\u4e2a\u7531\u4e03\u4e2asirtuin\u7ec4\u6210\u7684\u5bb6\u65cf\uff0c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cNMN\u589e\u52a0\u4e86sirtuin 6 \uff08SIRT6\uff09\u548csirtuin 7 \uff08SIRT7\uff09\u3002 \u8fd9\u4e9bsirtuins\u4f3c\u4e4e\u5177\u6709\u6297\u6c27\u5316\u7279\u6027\uff0c\u56e0\u4e3a\u5b83\u4eec\u4ecb\u5bfc\u6d3b\u6027\u6c27\uff08ROS\uff09\u7684\u51cf\u5c11\u2014\u2014\u53ef\u80fd\u5bf9\u7ec6\u80de\u9020\u6210\u635f\u5bb3\u7684\u6c27\u5316\u5242\u3002 Sirtuins \u8fd8\u4ecb\u5bfc DNA \u4fee\u590d\u8fc7\u7a0b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-quote-content\">\n<div class=\"quote-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u201c\u6211\u4eec\u7684\u7ed3\u679c\u63ed\u793a\u4e86 SIRT6 \u548c SIRT7 \u72ec\u7acb\u4e8e NRF2 \u7684\u529f\u80fd\uff0c\u5e76\u6697\u793a sirtuin \u5bb6\u65cf \u6210\u5458\u7684\u590d\u6742\u7f51\u7edc\u662f\u4e0d\u540c\u751f\u7406\u6216\u75c5\u7406\u72b6\u6001\u7684\u8c03\u8282\u5242\uff0c\u201d\u4f5c\u8005\u8bf4\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u51cf\u5c11\u764c\u75c7\u6cbb\u7597\u7684\u526f\u4f5c\u7528\u5e76\u63d0\u9ad8\u7597\u6548<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u764c\u75c7\u6cbb\u7597\u8fdc\u975e\u5b8c\u7f8e\uff0c\u5e76\u4f34\u968f\u7740\u957f\u671f\u7684\u526f\u4f5c\u7528\u3002 \u4f46\u662f\uff0cNMN \u53ef\u4ee5\u9632\u6b62\u5176\u4e2d\u4e00\u4e9b\u526f\u4f5c\u7528\u3002 \u4f8b\u5982\uff0cNMN \u4e0e\u66f2\u514b\u82a6\u4e01\u8054\u5408\u663e\u793a\u53ef\u5145\u5206<a href=\"https:\/\/www.nmn.com\/news\/nmn-buckwheat-heart-chemotherapy\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u4fdd\u62a4\u5fc3\u810f\u514d\u53d7\u5316\u7597\u836f\u7269\u591a\u67d4\u6bd4\u661f\u9020\u6210\u7684\u635f\u5bb3<\/a>\u3002 \u73b0\u5728\uff0cZhao \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0cNMN \u53ef\u4ee5\u51cf\u8f7b\u653e\u5c04\u6cbb\u7597\u7684\u957f\u671f\u526f\u4f5c\u7528\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-quote-content\">\n<div class=\"quote-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u201cNMN \u53ef\u80fd\u662f\u51cf\u8f7b\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u7684\u4e00\u79cd\u6709\u5e0c\u671b\u7684\u8865\u5145\u5242\uff0c\u201d\u4f5c\u8005\u8bf4\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u8fd8\u589e\u5f3a\u4e86\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\uff0c\u8fd9\u662f\u5229\u7528\u514d\u75ab\u7ec6\u80de\u6291\u5236\u80bf\u7624\u8fdb\u5c55\u7684\u764c\u75c7\u7597\u6cd5\u7684\u6700\u65b0\u521b\u65b0\u3002 \u4f8b\u5982\uff0cNMN \u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u5f3a\u9488\u5bf9\u76ae\u80a4\u764c\u548c\u809d\u764c\u7684<a href=\"https:\/\/www.ihealthtaiwan.com\/blog\/study-shows-nmn-enhances-immune-cell-tumor-suppression-while-increasing-lifespan\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u81ea\u7136\u6740\u624b\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/a>\uff0c\u5e76<a href=\"https:\/\/www.nmn.com\/news\/nmn-increases-cancer-fighting-immune-cells\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u589e\u5f3a\u9488\u5bf9\u8840\u764c\u7684 CAR-T \u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/a>\u3002 \u6b64\u5916\uff0cNAD+ \u524d\u4f53\u00a0<a href=\"https:\/\/nad.com\/news\/dysfunction-mitochondria-drives-tumor-suppressing-lymphocytes-cellular-exhaustion\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">NR \u4e5f\u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u7597\u6cd5<\/a>\uff0c\u5e76\u4e14\u00a0<a href=\"https:\/\/nad.com\/news\/nad-boosting-agent-prevent-brain-tumor-growth\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">NRH \u53ef\u4ee5\u9632\u6b62\u8111\u764c\u624b\u672f\u540e\u7684\u80bf\u7624\u518d\u751f<\/a>\u3002 \u56e0\u6b64\uff0c\u5c06 NAD+ \u53ca\u5176\u524d\u4f53\u4e0e\u4f20\u7edf\u7684\u764c\u75c7\u6cbb\u7597\u7ed3\u5408\u8d77\u6765\u5f88\u6709\u5e0c\u671b\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Zhao X, Zhang M, Wang J, Ji K, Wang Y, Sun X, Xu C, Wang Q, He N, Song H, Du L, Wang F, Huang H, Liu Y, Liu Q. NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7. Free Radic Biol Med. 2022 Oct 14:S0891-5849(22)00897-8. doi: 10.1016\/j.freeradbiomed.2022.10.267. Epub ahead of print. PMID: 36252808.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/study-finds-nmn-protects-intestinal-wall-from-cancer-treatment-injury<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19365\" class=\"pvc_stats all  \" data-element-id=\"19365\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0cNMN \u53ef\u4ee5\u9632\u6b62\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u2014\u2014\u901a\u5e38\u7528\u4e8e\u6cbb\u7597\u8001\u5e74\u764c\u75c7\u60a3\u8005\u3002 2022\u5e7411\u67089\u65e5\u00a0\u00b7\u00a0NMN\u7684\u79d1\u7814\u8fdb\u5c55\uff0c\u764c\u75c7 By\u00a0Victor Ciardha Published:\u00a012:54 p.m. PST Nov 7, 2022\u00a0| Updated:\u00a04:24 p.m. PST Nov 8, 2022 \u91cd\u5927\u4eae\u70b9 NMN \u53ef\u51cf\u5c11\u66b4\u9732\u4e8e\u8f90\u5c04\u7684\u80a0\u7ec6\u80de\u4e2d\u7684 DNA \u635f\u4f24\u548c\u6d3b\u6027\u6c27 \uff08ROS\uff09\u3002 \u5728\u5c0f\u9f20\u4e2d\uff0c\u7528 NMN \u4ecb\u5165\u6709\u52a9\u4e8e\u9632\u6b62\u8f90\u5c04\u66b4\u9732\u540e\u5bf9\u80a0\u58c1\u9020\u6210\u7684\u7ed3\u6784\u635f\u4f24\u3002 \u957f\u5bff\u57fa\u56e0sirtuins\u53ef\u4ee5\u4ecb\u5bfc NMN\u7684\u76ca\u5904\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19365\" class=\"pvc_stats all  \" data-element-id=\"19365\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19366,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[629,535,536,12,54],"class_list":["post-19365","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn-","tag-535","tag-536","tag-12","tag-54"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19365"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19365\/revisions"}],"predecessor-version":[{"id":19367,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19365\/revisions\/19367"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19366"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19365"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}