![\"\"](\"https:\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto\/3160820\/665173_451321.png\" "\\"\\"")
<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\nPublished:\u00a02:36 p.m. PST Sep 29, 2022\u00a0| Updated:\u00a010:14 am PST Oct 27, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u591a\u56ca\u5375\u5de2\u7efc\u5408\u5f81\uff08PCOS\uff09- \u4e00\u79cd\u5bfc\u81f4\u4e0d\u5b55\u548c\u4ee3\u8c22\u529f\u80fd\u969c\u788d\u7684\u6fc0\u7d20\u7d0a\u4e71 – \u5f71\u54cd6%\u81f312%\u7684\u5973\u6027<\/a>\u5728\u5176\u751f\u80b2\u671f\u3002 \u5e38\u89c1\u7684 PCOS \u76f8\u5173\u75c7\u72b6\u5305\u62ec\u80a5\u80d6\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4 2 \u578b\u7cd6\u5c3f\u75c5\u548c\u5fc3\u8840\u7ba1\u5e76\u53d1\u75c7\u3002 \u4e34\u5e8a\u533b\u751f\u63a8\u8350\u996e\u98df\u548c\u8fd0\u52a8\u548c\/\u6216\u4e8c\u7532\u53cc\u80cd\u7b49\u836f\u7269\u6765\u63a7\u5236PCOS\uff0c\u4f46\u7ea646%\u7684\u5973\u6027\u53d1\u73b0\u996e\u98df\u548c\u8fd0\u52a8\u96be\u4ee5\u7ef4\u6301\uff0c\u4e8c\u7532\u53cc\u80cd\u6709\u6076\u5fc3\u7b49\u526f\u4f5c\u7528\u3002<\/p>\n \u73b0\u5728\uff0c\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a \u300aMolecular Metabolism\u300b \u4e0a\u7684\u79d1\u5b66\u8bba\u6587\u4e2d\uff0c\u6fb3\u5927\u5229\u4e9a\u65b0\u5357\u5a01\u5c14\u58eb\u5927\u5b66\u7684 Walters \u53ca\u5176\u540c\u4e8b\u8868\u660e\uff0c<\/span>\u7528 2 g\/L NMN \u4ecb\u5165 PCOS \u5c0f\u9f20\u6a21\u578b\u53ef\u4ee5\u6539\u5584\u80a5\u80d6\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u7b49\u4ee3\u8c22\u75c7\u72b6\uff0c\u5e76\u6062\u590d\u808c\u8089 NAD+ \u6c34\u5e73<\/a>\u3002 \u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u4ee5\u51e0\u4e4e\u6ca1\u6709\u8d1f\u9762\u526f\u4f5c\u7528\u800c\u95fb\u540d\u7684NMN\u53ef\u80fd\u4f1a\u9006\u8f6c\u4e0ePCOS\u76f8\u5173\u7684\u4ee3\u8c22\u5f02\u5e38\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n NMN \u6539\u5584\u65b0\u9648\u4ee3\u8c22\u5e76\u589e\u52a0 NAD+<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n \u4e3a\u4e86\u8bc4\u4f30\u00a0NMN\u00a0<\/a>\u5982\u4f55\u5f71\u54cd PCOS \u7684\u4ee3\u8c22\u529f\u80fd\u969c\u788d\uff0cWalters \u53ca\u5176\u540c\u4e8b\u901a\u8fc7\u5c06\u96cc\u6027\u5c0f\u9f20\u66b4\u9732\u4e8e\u6027\u6fc0\u7d20\u4e8c\u6c22\u777e\u916e\u4e2d\u5efa\u7acb\u4e86 PCOS \u5c0f\u9f20\u6a21\u578b\u3002 \u5728\u7528 NMN \u4ecb\u5165\u8fd9\u4e9b\u5c0f\u9f20\u7684\u996e\u7528\u6c34\u540e\uff0c\u6fb3\u5927\u5229\u4e9a\u7814\u7a76\u5c0f\u7ec4\u6d4b\u91cf\u4e86\u80f0\u5c9b\u7d20\u62b5\u6297\uff0c\u8fd9\u662f\u4e00\u79cd\u4ee3\u8c22\u969c\u788d\u7684\u8ff9\u8c61\uff0c\u901a\u8fc7\u4ee3\u8c22\u8461\u8404\u7cd6\u6240\u9700\u7684\u80f0\u5c9b\u7d20\u91cf\u6765\u8861\u91cf\u3002 \u4e0e\u5065\u5eb7\u5c0f\u9f20\u76f8\u6bd4\uff0cPCOS\u5c0f\u9f20\u4ee3\u8c22\u8461\u8404\u7cd6\u6240\u9700\u7684\u80f0\u5c9b\u7d20\u91cf\u662f\u5065\u5eb7\u5c0f\u9f20\u7684\u4e24\u500d\u591a\uff0c\u800c NMN \u53ef\u4ee5\u51cf\u8f7b\u8fd9\u79cd\u60c5\u51b5\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e NMN \u53ef\u4ee5\u6062\u590d PCOS \u5c0f\u9f20\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n (Aflatounian et al., 2022 |<\/a>\u00a0Molecular Metabolism<\/em><\/a>)<\/a>\u00a0NMN \u53ef\u9006\u8f6c PCOS \u76f8\u5173\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\u3002 \u4e0e\u5065\u5eb7\u5c0f\u9f20\uff08Control\uff09\u76f8\u6bd4\uff0c\u901a\u8fc7\u80f0\u5c9b\u7d20\u62b5\u6297\uff08HOMA\uff09\u7684\u7a33\u6001\u6a21\u578b\u8bc4\u4f30\u6d4b\u91cf\u7684\u80f0\u5c9b\u7d20\u62b5\u6297\uff08IR\uff09\u968f\u7740PCOS\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u4f46 NMN \u9006\u8f6c\u4e86\u8fd9\u79cd\u6548\u5e94\uff08PCOS+NMN\uff09\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u4e3a\u4e86\u786e\u5b9a NMN \u63d0\u9ad8\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u662f\u5426\u4f1a\u6539\u5584\u4e0e PCOS \u76f8\u5173\u7684\u80a5\u80d6\uff0cWalters \u53ca\u5176\u540c\u4e8b\u79f0\u91cd\u4e86\u4f4d\u4e8e\u5168\u8eab\u591a\u4e2a\u4f4d\u7f6e\u7684\u79f0\u4e3a\u201c\u8102\u80aa\u57ab\u201d\u7684\u8102\u80aa\u50a8\u5b58\u5668\u3002 \u7814\u7a76\u4eba\u5458\u6d4b\u91cf\u4e86\u5176\u4e2d\u4e94\u4e2a\u8102\u80aa\u57ab\u7684\u91cd\u91cf\uff0c\u53d1\u73b0\u5b83\u4eec\u5728 PCOS \u5c0f\u9f20\u4e2d\u7684\u91cd\u91cf\u90fd\u66f4\u5927\u3002 \u7136\u800c\uff0cNMN \u7684\u4ecb\u5165\u964d\u4f4e\u4e86\u6240\u6709\u4e94\u4e2a\u8102\u80aa\u57ab\u7684\u91cd\u91cf\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNMN\u53ef\u4ee5\u5bf9PCOS\u4e2d\u7684\u80a5\u80d6\u75c7\u4ea7\u751f\u5e2e\u52a9\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n (Aflatounian et al., 2022 |<\/a>\u00a0Molecular Metabolism<\/em><\/a>)<\/a>\u00a0NMN \u53ef\u9006\u8f49 PCOS \u76f8\u95dc\u7684\u80a5\u80d6\u3002 PCOS \u5c0f\u9f20\u7684\u8102\u80aa\u588a\uff08\u4f86\u81ea\u8eab\u9ad4\u7684\u4e94\u500b\u90e8\u4f4d\uff09\u6bd4\u5065\u5eb7\u5c0f\u9f20 (ctrl) \u91cd\uff0c\u4f46 NMN (PCOS+NMN) \u7684\u91cd\u91cf\u6bd4\u5065\u5eb7\u5c0f\u9f20\u7684\u9ad4\u91cd\u8981\u5c0f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u7531\u65bc\u7814\u7a76\u8868\u660e\u88dc\u5145 NMN \u6703\u589e\u52a0\u9577\u58fd\u5206\u5b50 NAD+ \u7684\u7d30\u80de\u6fc3\u5ea6\uff0c\u56e0\u6b64\u7814\u7a76\u5c0f\u7d44\u6aa2\u67e5\u4e86\u808c\u8089 NAD+ \u6c34\u5e73\u3002 \u96d6\u7136 PCOS \u5c0f\u9f20\u7684\u808c\u8089\u00a0NAD+\u00a0<\/a>\u6fc3\u5ea6\u7d04\u70ba\u5065\u5eb7\u5c0f\u9f20\u7684\u4e00\u534a\uff0c\u4f46 NMN \u50be\u5411\u65bc\u6062\u5fa9\u9019\u4e9b\u6c34\u5e73\uff0c\u5118\u7ba1\u6062\u5fa9\u7684 NAD+ \u6c34\u5e73\u6c92\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u3002 \u9019\u4e9b\u767c\u73fe\u8868\u660e\uff0c\u7528 NMN \u589e\u52a0 NAD+ \u53ef\u4ee5\u6e1b\u8f15 PCOS \u5c0f\u9f20\u7684\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\u3002 NAD+ \u53ef\u80fd\u6539\u5584\u4ee3\u8b1d\u529f\u80fd\u7684\u78ba\u5207\u6a5f\u5236\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u00a0(Aflatounian et al., 2022 |<\/a>\u00a0Molecular Metabolism<\/em><\/a>)<\/a>\u00a0NMN \u50be\u5411\u65bc\u6062\u5fa9\u8207 PCOS \u76f8\u95dc\u7684\u808c\u8089 NAD+ \u6d88\u8017\u3002 \u60a3\u6709 PCOS \u7684\u96cc\u6027\u5c0f\u9f20\u7684\u808c\u8089 NAD+ \u6c34\u5e73\u662f\u5065\u5eb7\u5c0f\u9f20\uff08\u5c0d\u7167\uff09\u7684\u4e00\u534a\uff0c\u7136\u800c\uff0cNMN \u6062\u5fa9\u4e86\u9019\u4e9b NAD+ \u6c34\u5e73\uff08PCOS+NMN\uff09\uff0c\u5118\u7ba1 NAD+ \u6062\u5fa9\u6c92\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u201c\u5728\u9019\u88e1\uff0c\u6211\u5011\u767c\u73fe\uff0c\u5728 PCOS \u7684\u9ad8\u96c4\u6027\u6fc0\u7d20\u5316\u56d3\u9f52\u52d5\u7269\u6a21\u578b\u4e2d\uff0c\u808c\u8089\u4e2d\u7684 NAD \u6c34\u5e73\u986f\u8457\u964d\u4f4e\uff0c\u800c\u7528 NAD \u524d\u9ad4 NMN \u7684\u4ecb\u5165\u53ef\u4ee5\u7cfe\u6b63\u9019\u7a2e\u7f3a\u9677\uff0c\u201dWalters \u53ca\u5176\u540c\u4e8b\u8aaa\u3002 \u201c\u9019\u7a2e\u808c\u8089\u4e2d NAD \u6c34\u5e73\u7684\u6062\u5fa9\u4f34\u96a8\u8457\u96d9\u6c2b\u777e\u916e<\/strong>[dihydrotestosterone] \u7684\u4ecb\u5165\u6240\u8a98\u5c0e\u7684\u4e00\u7cfb\u5217\u4ee3\u8b1d\u53c3\u6578\u7684\u6539\u5584\u3002\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u7528NMN\u89e3\u51b3\u4ee3\u8c22\u529f\u80fd\u969c\u788d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u5c3d\u7ba1\u8be5\u7814\u7a76\u5e76\u672a\u8bc1\u660eNMN\u53ef\u4ee5\u6062\u590dPCOS\u5973\u6027\u7684\u4e0d\u5b55\u75c7\uff0c\u4f46\u5b83\u63d0\u4f9b\u4e86\u5e0c\u671b\uff0c\u5373\u9664\u4e86\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u4e4b\u5916\uff0cNMN\u8fd8\u53ef\u4ee5\u9006\u8f6c\u4ee3\u8c22\u969c\u788d\u3002 \u6b64\u5916\uff0c\u901a\u8fc7\u63d0\u9ad8\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u548c\u51cf\u5c11\u80a5\u80d6\uff0cNMN\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u9632\u4e0ePCOS\u76f8\u5173\u7684\u5e74\u9f84\u76f8\u5173\u75be\u75c5\uff0c\u59822\u578b\u7cd6\u5c3f\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002 \u968f\u7740\u5927\u91cfNMN\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8fdb\u884c\uff0c\u8fd9\u9879\u7814\u7a76\u589e\u52a0\u4e86NMN\u53ef\u80fd\u63d0\u4f9b\u66f4\u591a\u5e2e\u52a9\u7684\u75be\u75c5\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Declining muscle NAD+\u00a0in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation. Mol Metab. 2022 Sep 9; 65:101583. doi: 10.1016\/j.molmet.2022.101583. Epub ahead of print. PMID: 36096453; PMCID: PMC9490589.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n https:\/\/www.nmn.com\/news\/study-shows-nmn-corrects-female-hormonal-disorder-related-metabolic-dysfunction<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
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