{"id":1933,"date":"2017-01-10T00:12:58","date_gmt":"2017-01-10T05:12:58","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=1933"},"modified":"2022-05-23T14:16:49","modified_gmt":"2022-05-23T14:16:49","slug":"%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e5%bb%b6%e9%95%bf%e5%af%bf%e5%91%bd%e7%b3%bb%e5%88%97-4-%e8%b0%83%e6%8e%a7%e7%bb%86%e8%83%9e%e5%91%a8%e6%9c%9f%e4%b8%8e%e9%98%b2%e7%99%8c%e6%95%88%e6%9e%9c","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=1933","title":{"rendered":"\u767d\u85dc\u82a6\u9187\u5ef6\u957f\u5bff\u547d\u7cfb\u5217 4 &#8211; \u8c03\u63a7\u7ec6\u80de\u5468\u671f\u4e0e\u9632\u764c\u6548\u679c"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>\u7ec6\u80de\u5468\u671f\uff1a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16908\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/awb.jpg\" alt=\"\" width=\"400\" height=\"363\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/awb.jpg 400w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/awb-300x272.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<ul>\n<li>1.\u5f53\u7ec6\u80de\u5904\u65bc\u4e00\u822c\u7684\u751f\u957f\u72b6 \u6001\u65f6\uff0c\u7ec6\u80de\u4f1a\u4e0d\u65ad\u5438\u53d6\u517b\u5206\u800c\u957f\u5927\uff0c\u6211\u4eec\u79f0\u6b64\u4e00\u65f6\u671f\u4e3aG1\u671fDNA \u5408\u6210\u51c6\u5907\u671f\u3002<\/li>\n<li>2.\u5f53\u7ec6\u80de\u751f\u957f\u5230\u67d0\u4e00\u7279\u5b9a\u5927\u5c0f\u7684\u65f6\u5019\uff0c\u4f1a\u63a5\u53d7\u5230\u7ec6\u80de\u5185\u90e8\u7684\u6307\u793a\uff0c\u8fdb\u5165\u5230\u4e0b\u4e00\u4e2a\u9636\u6bb5 S \u671f\uff08Synthesis\uff09\uff0cDNA \u5408 \u6210\u671f\uff1b\u5728\u8fd9\u4e2a\u9636\u6bb5\u4e2d\uff0c\u67d3\u8272\u4f53\u7684\u590d\u5236\u4e3a\u6700\u91cd\u8981\u7684\u73b0\u8c61\u3002<\/li>\n<li>3.\u7d27\u63a5\u7740\u7ec6\u80de\u4f1a \u8fdb\u5165\u4e00\u4e2a\u77ed\u6682\u7684\u5206\u88c2\u51c6\u5907\u671f G2\u671f\uff0c\u4e3a\u968f\u5f8c\u7684\u7ec6\u80de\u5206\u88c2\u4f5c\u51c6\u5907\uff0c\u68c0\u67e5\u6240\u6709\u76f8\u5173\u5206\u5b50\u6216\u673a\u5236\u662f\u5426\u5df2\u7ecf\u51c6\u5907\u5c31\u7eea\u3002<\/li>\n<li>4. \u6700\u5f8c\u8fdb\u5165 M \u671f\u6709\u4e1d\u5206\u88c2\u671f\uff0c\u5c06\u590d\u5236\u7684\u67d3\u8272\u4f53\u5e73\u5747\u5206\u914d\u5230\u4e24\u4e2a\u5373\u5c06\u5f62\u6210\u7684\u5b50\u7ec6\u80de\u5185\u3002\u5206\u88c2\u5b8c\u7684\u7ec6\u80de\uff0c\u4f1a\u91cd\u65b0\u56de\u5230G1\u671f\uff0c\u8fdb\u5165\u4e0b\u4e00\u4e2a\u7ec6\u80de\u5468\u671f\u3002<\/li>\n<\/ul>\n<p>G1\u671f\u7684\u7ec6\u80de\u4e5f\u53ef\u80fd\u8131\u79bb\u751f\u957f\u5468\u671f\uff0c\u8fdb\u5165\u4e0d\u751f\u957f\u7684\u4f11\u7720\u72b6\u6001\uff08G0\u671f\uff09\uff1b\u53ea\u8981\u6709\u9002\u5f53\u7684\u8baf\u606f\uff0c\u7761\u68a6\u4e2d\u7684\u7ec6\u80de\u5c31\u4f1a\u9192\u6765\uff0c\u91cd\u65b0\u6295\u5165\u751f\u957f\u5468\u671f\u3002\u5728\u6bcf\u4e00\u4e2a\u7ec6\u80de\u5468\u671f\u7684\u9636\u6bb5\uff0c\u90fd\u6709\u4e00\u4e2a\u68c0\u67e5\u70b9 (checkpoint)\u786e\u8ba4\u6bcf\u4e00\u4e2a\u6b65\u9aa4\u662f\u5426\u5b8c\u6210\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16909 alignright\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/c00504_ph05\u7d30\u80de.jpg\" alt=\"\" width=\"320\" height=\"213\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/c00504_ph05\u7d30\u80de.jpg 320w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/c00504_ph05\u7d30\u80de-300x200.jpg 300w\" sizes=\"auto, (max-width: 320px) 100vw, 320px\" \/><\/p>\n<p>p53\u662f\u5b58\u5728\u4eba\u4f53\u7ec6\u80de\u5185\u7684 \u4e00\u79cd\u6297\u764c\u86cb\u767d\u8d28\uff0c\u5b83\u6709\u6291\u5236\u7ec6\u80de\u751f\u957f\u53ca\u7ef4\u6301\u9057\u4f20\u7269\u8d28\u5b8c\u6574\u6027\u7684\u529f\u80fd\uff0c\u7136\u800c\u5f53\u7ec6\u80de\u53d7\u5230\u6e38\u79bb\u8f90\u5c04\uff0c\u6216\u5f53\u7ec6\u80de \u7f3a\u6c27\u4e36\u7f3a\u517b\u65f6\uff0c p53 \u88ab\u6fc0\u5316\uff0c\u9020\u6210\u7ec6\u80de\u5185\u7684 p53 \u5927\u91cf\u589e\u52a0\u3002\u9664\u4e86 \u4e0a\u8ff0\u523a\u6fc0\u5916\uff0c\u5316\u5b66\u6cbb\u7597\u4e0a\u5e38\u7528\u7684\u836f\u7269\u4e5f\u4f1a\u5f15\u53d1\u7c7b\u4f3c\u7684\u53cd\u5e94\u3002p53 \u7684\u6d3b\u5316\u4e0e\u589e\u52a0\uff0c\u5e38\u5bfc\u81f4\u4e24\u79cd\u53ef\u80fd\u7684\u7ed3\u679c\uff1a\u4e00\u662f\u7ec6\u80de\u5468\u671f\u505c\u6b62\u5728G1 \u6216G2\u671f\uff0c\u7ec6\u80de\u7531\u6b64\u5f97\u4ee5\u4fee\u8865\u635f\u574f\uff0c\u53e6\u4e00\u662f \u8fc7\u5ea6\u53d7\u635f\u7684\u7ec6\u80de\u91c7\u81ea\u6740\u884c\u4e3a(apoptosis)\u800c\u6b7b\u4ea1\u3002\u8fd9\u79cd\u4f9d\u8d56p53\u7684\u7ec6\u80de\u201c\u81ea\u6108\u80fd\u529b\u201d\uff0c\u6709\u7ef4\u6301\u57fa\u56e0 \u4f53\u7a33\u5b9a\u7684\u529f\u80fd\uff0c\u900f\u8fc7\u5b83\u4eec\u5bf9\u7ec6\u80de\u5468\u671f\u68c0\u67e5\u70b9\u7684\u8c03\u63a7\u6765\u6709\u6548\u907f\u514dDNA\u7a81\u53d8\u7684\u7d2f\u79ef\u3002\u5982\u679c\u56e0 p53 \u7684\u7a81\u53d8\u800c\u5931\u53bb\u529f\u80fd\uff0c\u4f7f\u5f97\u8fd9\u4e9b\u6709\u201c\u7f3a\u9677\u201d \u7684\u7ec6\u80de\u7ee7\u7eed\u4e0d\u53d7\u63a7\u5236\u7684\u751f\u957f\u5206\u88c2\uff0c\u4fbf\u5bfc\u81f4\u7a81 \u53d8\u7684\u7d2f\u79ef\u548c\u764c\u75c7\u7684\u751f\u6210<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16910 alignleft\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/250px-Cancer_requires_multiple_mutations_from_NIH.png\" alt=\"\" width=\"194\" height=\"400\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/250px-Cancer_requires_multiple_mutations_from_NIH.png 194w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2017\/01\/250px-Cancer_requires_multiple_mutations_from_NIH-146x300.png 146w\" sizes=\"auto, (max-width: 194px) 100vw, 194px\" \/><\/p>\n<h2>\u80bf\u7624\u4e4b\u53d1\u751f<\/h2>\n<p>\u662f\u56e0\u4e3a\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u5f8c\uff0c\u6291\u5236 p53 \u80bf\u7624\u6291\u5236\u57fa\u56e0\uff0c\u4f7f\u5f97p21 \u86cb\u767d\u8d28\u65e0\u6cd5\u6d3b\u5316\uff0c\u9020\u6210\u7ec6\u80de\u5468\u671f\u67d0\u79cdCDK \u6216Cyclin \u7684\u529f\u80fd\u53d1\u751f\u4e25\u91cd\u7f3a\u9677\uff0c\u963b\u6b62\u4e86\u51cb\u4ea1\u7a0b\u5f0f\uff0c\u5bfc\u81f4\u67d3\u8272\u4f53\u7684\u9519\u8bef\u590d\u5236\u4e0d\u65ad\u589e\u751f\uff0c \u800c\u6709\u673a\u4f1a\u4f20\u5165\u5b50\u7ec6\u80de\u5185\uff0c\u800c\u957f\u4e45\u7684\u7a81\u53d8\u7d2f\u79ef\u81f4\u4f7f\u7ec6\u80de\u5b8c\u5168\u8131\u79bb\u7ec6\u80de\u5468\u671f\u7684\u63a7\u5236\u3002\u6700\u5f8c\u5f62\u6210\u5931\u63a7\u7684\u7ec6\u80de\u5206\u88c2\u72b6\u51b5\uff0c\u6210\u4e3a\u6211\u4eec\u6240\u719f\u77e5\u7684\u80bf\u7624\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16899 alignright\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2016\/10\/photo-68.jpg\" alt=\"\" width=\"400\" height=\"190\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2016\/10\/photo-68.jpg 400w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2016\/10\/photo-68-300x143.jpg 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p>Resveratrol\u767d\u85dc\u82a6\u9187\uff0c\u5177\u6709\u4fc3\u8fdb\u6b63\u5e38\u7ec6\u80de\u7684\u5065\u5eb7\u53d1\u80b2\u548c\u52a0\u901f\u4e0d\u5065\u5eb7\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u8d77\u5230\u5f88\u597d\u7684\u8f85\u52a9\u6cbb\u7597\u6548\u679c\u3002\u81ea\u4eceJangetal. \u65bc1997\u5e74\u7cfb\u7edf\u5730\u62a5\u5bfc\u4e86\u767d\u85dc\u82a6\u9187\u7684\u6297\u80bf\u7624\u4f5c\u7528\u5f8c\uff0c\u8fc4\u4eca\u53d1\u73b0\u5b83\u80fd\u6291\u5236\u591a\u79cd\u764c\u7ec6\u80de\u7684\u751f\u957f\uff0c\u5305\u62ec\u80c3\u764c\u4e36\u80a0\u764c\u4e36\u4e73\u817a\u764c\u4e36\u767d\u8840\u75c5\u7b49\u3002<\/p>\n<p>\u7531\u767d\u85dc\u82a6\u9187\u8c03\u63a7\u7ec6\u80de\u5468\u671f\uff0c\u63a2\u8ba8\u591a\u915a\u7269\u8d28\u7684\u9632\u764c\u6548\u679c:<\/p>\n<p>\u76ee\u524d\u5df2\u77e5\u5728\u80bf\u7624\u5f62\u6210\u7684\u8fc7\u7a0b\u4e2d\uff0c\u767d\u85dc\u82a6\u9187\u5728\u4e0d\u540c\u7ec6\u80de\u682a\u4e2d\uff0c\u7686\u663e\u793a\u8bb8\u591a\u6297\u764c\u6f5c\u529b\u6d3b\u6027<\/p>\n<ul>\n<li><span style=\"color: #ff0000;\">\uff08A\uff09\u6291\u5236\u589e\u751f\u4e0e\u5206\u5316\u3002<\/span><\/li>\n<li><span style=\"color: #ff0000;\">\uff08B\uff09\u4f7f\u7ec6\u80de\u5468\u671f\u505c\u7559\u65bcS\u671f\u3002<\/span><\/li>\n<li><span style=\"color: #ff0000;\">\uff08C\uff09\u6291\u5236CDK7\u548cp34Cdc2\u6fc0\u9176\u4f7f\u7ec6\u80de\u505c\u6ede\u65bcS\u4e0eG2\/M\u671f\u3002<\/span><\/li>\n<li><span style=\"color: #ff0000;\">\uff08D\uff09\u5c11\u90e8\u5206\u7684\u764c\u7ec6\u80de\u4f1a\u505c\u7559\u65bcS\/G2\u671f\u3002<\/span><\/li>\n<li><span style=\"color: #ff0000;\">\uff08E\uff09\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/li>\n<li><span style=\"color: #ff0000;\">\uff08F\uff09\u6297\u8840\u7ba1\u65b0\u751f\u4e36\u6297\u764c\u8f6c\u79fb\u4e0e\u764c\u7ec6\u80de\u5165\u4fb5\u7684\u80fd\u529b\u3002<\/span><\/li>\n<\/ul>\n<p>\u7f8e\u56fd\u6700\u65b0\u7814\u7a76\u53d1\u73b0\uff0c<strong><span style=\"color: #ff0000;\">\u300c\u767d\u85dc\u82a6\u9187\u300d\u53ef\u4ee5\u5e2e\u52a9\u63d0\u5347\u653e\u5c04\u6cbb\u7597\u7597\u6548\uff0c\u764c\u7ec6\u80de\u4e00\u65e6\u63a5\u89e6\u767d\u85dc\u82a6\u9187\uff0c\u5bf9\u653e\u7597\u5c31\u4f1a\u53d8\u5f97\u7279\u522b\u654f\u611f\uff0c\u7597\u7a0b\u8fc7\u7a0b\u4e2d\u764c\u7ec6\u80de\u6b7b\u4ea1\u6570\u76ee\u5c31\u4f1a\u5927\u5927\u589e\u52a0<\/span><\/strong>\u3002<\/p>\n<p>\u7f8e\u56fd\u5bc6\u82cf\u91cc\u5927\u5b66\u7814\u7a76\u56e2\u961f\u8fc7\u53bb\u7814\u7a76\u53d1\u73b0\uff0c<strong><span style=\"color: #ff0000;\">\u767d\u85dc\u82a6\u9187\u53ef\u589e\u52a0\u6444\u62a4\u817a\u764c\u764c\u7ec6\u80de\u5bf9\u653e\u7597\u7684\u654f\u611f\u6027\u5bf9\u9ed1\u8272\u7d20\u7624\u4e5f\u6709\u6548\u679c<\/span><\/strong>\u3002<\/p>\n<p>\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u82e5\u5355\u5355\u53ea\u7528\u767d\u85dc\u82a6\u9187\u505a\u6cbb\u7597\uff0c\u53ef\u6740\u6b7b\u767e\u5206\u4e4b<strong><span style=\"color: #0000ff;\">\u56db\u5341\u56db\u80bf\u7624\u7ec6\u80de<\/span><\/strong>\uff0c\u4f46\u5982\u679c\u7ed3\u5408\u767d\u85dc\u82a6\u9187\u4e0e\u653e\u5c04\u6cbb\u7597\uff0c\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u6bd4\u7387\u53ef\u4e0a\u5347\u5230<strong><span style=\"color: #0000ff;\">\u767e\u5206\u4e4b\u516d\u5341\u516d<\/span><\/strong>\u3002<\/p>\n<p><iframe loading=\"lazy\" src=\"http:\/\/v.qq.com\/iframe\/player.html?vid=t0130vuf7ke&amp;tiny=0&amp;auto=0\" width=\"90%\" height=\"360\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"> <\/iframe><\/p>\n<p>Dr William Li 2010\u5e74\u5728TED\u4e0a\u7684\u6f14\u8bb2 \uff1a \u674e\u5a01\u5ec9\u62a5\u544a\u4e00\u9879\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u601d\u7ef4\uff1a\u63a7\u5236\u9935\u517b\u80bf\u7624\u7684\u5fae\u8840\u7ba1\u751f\u6210\u3002<\/p>\n<p>\u771f\u5b9e\u6848\u4f8b\u73b0\u5728\u6709\u5f88\u591a\uff0c\u53d7\u9650\u4e8e\u7ba1\u7406\u6761\u4f8b\u6211\u4eec\u5c31\u4e0d\u5728\u8fd9\u4f8b\u4e3e &#8211;\u00a0\u6709\u9700\u8981\u7684\u670b\u53cb\u53ef\u4ee5\u8054\u7edc\u6211\u4eec\u3002<\/p>\n<p>\u656c\u8bf7\u5173\u6ce8 &#8211; <a href=\"http:\/\/johnhealth.blog\/ch\/?p=1943\">\u7cfb\u52175<\/a><\/p>\n<hr \/>\n<p>\u8425\u517b\u8865\u5145\u5e94\u7528\u4e8e\u764c\u75c7\u51b6\u7597\uff0c\u8fd8\u6709\u5404\u79cd\u5404\u6837\u7684\u963b\u6270,\u8bb0\u5f97\u542c\u8fc7\u80c3\u764c\u60a3\u8005 \u83f2\u83f2\u5979\u7684\u5206\u4eab\uff1a \u4e0d\u8981\u5149\u95ee\u533b\u751f\u4f60\u8981\u4e0d\u8981\u7528 &#8211; \u56e0\u4e3a\u5f88\u591a\u533b\u751f\u53d7\u4e13\u4e1a\u7684\u5f71\u54cd\uff0c\u5e76\u4e0d\u77e5\u9053\u8fd9\u4e9b\u4e1c\u897f\u90fd\u4eba\u4f53\u7684\u5e2e\u52a9\uff0c\u76f8\u53cd\u4ed6\u4eec\u5f80\u5f80\u662f\u4f1a\u963b\u5236\u4f60\u7528\u3002\u5982\u679c\u5f00\u660e\u70b9\u7684\u533b\u751f\u4e5f\u8bb8\u4f1a\u9f13\u52b1\u4f60\u7528\u3002\u91cd\u8981\u7684\u662f\u4f60\u8981\u5206\u6790\u90a3\u4e9b\u66f4\u591a\u7684\u764c\u75c7\u60a3\u8005\u662f\u600e\u6837\u5b58\u6d3b\u4e0b\u6765\u7684\u3002<span style=\"color: #ff0000;\">\u4ed6\/\u5979\u4eec\u7528\u8fc7\u4ec0\u4e48\uff0c\u8fd9\u624d\u662f\u4f60\u8981\u91cd\u70b9\u5173\u6ce8\u7684\u3002<\/span><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_1933\" class=\"pvc_stats all  \" data-element-id=\"1933\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 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class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u7ec6\u80de\u5468\u671f\uff1a 1.\u5f53\u7ec6\u80de\u5904\u65bc\u4e00\u822c\u7684\u751f\u957f\u72b6 \u6001\u65f6\uff0c\u7ec6\u80de\u4f1a\u4e0d\u65ad\u5438\u53d6\u517b\u5206\u800c\u957f\u5927\uff0c\u6211\u4eec\u79f0\u6b64\u4e00\u65f6\u671f\u4e3aG1\u671fDNA \u5408\u6210\u51c6\u5907\u671f\u3002 2.\u5f53\u7ec6\u80de\u751f\u957f\u5230\u67d0\u4e00\u7279\u5b9a\u5927\u5c0f\u7684\u65f6\u5019\uff0c\u4f1a\u63a5\u53d7\u5230\u7ec6\u80de\u5185\u90e8\u7684\u6307\u793a\uff0c\u8fdb\u5165\u5230\u4e0b\u4e00\u4e2a\u9636\u6bb5 S \u671f\uff08Synthesis\uff09\uff0cDNA \u5408 \u6210\u671f\uff1b\u5728\u8fd9\u4e2a\u9636\u6bb5\u4e2d\uff0c\u67d3\u8272\u4f53\u7684\u590d\u5236\u4e3a\u6700\u91cd\u8981\u7684\u73b0\u8c61\u3002 3.\u7d27\u63a5\u7740\u7ec6\u80de\u4f1a \u8fdb\u5165\u4e00\u4e2a\u77ed\u6682\u7684\u5206\u88c2\u51c6\u5907\u671f 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