{"id":19327,"date":"2022-11-04T02:06:08","date_gmt":"2022-11-04T02:06:08","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19327"},"modified":"2022-11-04T02:06:08","modified_gmt":"2022-11-04T02:06:08","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn-%e5%87%8f%e5%b0%91%e5%b0%8f%e9%bc%a0%e7%bb%93%e8%82%a0%e7%82%8e","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19327","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN \u51cf\u5c11\u5c0f\u9f20\u7ed3\u80a0\u708e"},"content":{"rendered":"<p>\u7ed9\u4e88 NMN \u53ef\u9632\u6b62\u7ed3\u80a0\u708e\u6a21\u578b\u5c0f\u9f20\u51fa\u73b0\u7834\u574f\u6027\u708e\u75c7<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19330\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/406861_279872.webp\" alt=\"\" width=\"736\" height=\"454\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/406861_279872.webp 736w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/406861_279872-300x185.webp 300w\" sizes=\"auto, (max-width: 736px) 100vw, 736px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"author\">By\u00a0Jonathan D. Grinstein, Ph.D.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published:\u00a02:32 p.m. PST Jan 27, 2022\u00a0| Updated:\u00a03:09 p.m. PST Sep 26, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>Highlights<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>\u5728\u5de8\u566c\u7ec6\u80de\u4e2d NAD+ \u5408\u6210\u4e0d\u8db3\u4f1a\u4fc3\u8fdb\u5c0f\u9f20\u5bf9\u7ed3\u80a0\u708e\u7684\u6613\u611f\u6027\u3002<\/li>\n<li>\u541e\u566c\u6b7b\u7ec6\u80de\u548c\u4fee\u590d\u7ec4\u7ec7\u7684\u5de8\u566c\u7ec6\u80de\u6e05\u7406\u6d3b\u52a8\u4f9d\u8d56\u4e8e NAD+ \u5408\u6210\u3002<\/li>\n<li>NMN \u4ecb\u5165\u53ef\u51cf\u8f7b\u7ed3\u80a0\u708e\u7684\u4e25\u91cd\u7a0b\u5ea6\u5e76\u63d0\u9ad8\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><strong><span style=\"color: #ff6600;\">\u708e\u75c7\u662f\u5bf9\u5165\u4fb5\u8005\u7684\u91cd\u8981\u514d\u75ab\u53cd\u5e94\u7684\u6839\u6e90<\/span><\/strong>\u3002 \u9996\u5148\uff0c\u708e\u75c7\u6fc0\u6d3b\u65f6\uff0c\u4f1a\u62db\u52df\u5927\u91cf\u514d\u75ab\u7ec6\u80de\u6765\u6d88\u706d\u6709\u5bb3\u7ec6\u83cc\u6216\u75c5\u6bd2\uff08\u75c5\u539f\u4f53\uff09\u3002 \u7136\u800c\uff0c\u708e\u75c7\u6700\u7ec8\u5fc5\u987b\u5931\u6d3b\uff0c\u56e0\u4e3a\u6301\u7eed\u548c\u8fc7\u5ea6\u7684\u708e\u75c7\u4f1a\u5bfc\u81f4\u75be\u75c5\uff0c\u4f8b\u5982\u54ee\u5598\u548c\u708e\u75c7\u6027\u80a0\u75c5 \uff08IBD\uff09\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">\u97e9\u56fd\u4e9a\u6d32\u5927\u5b66\u5927\u5b66\uff08Ajou University\uff09\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5e2e\u52a9\u9610\u660e\u4e86\u708e\u75c7\u548c\u7ed3\u80a0\u708e\u7684\u6f5c\u5728\u673a\u5236\uff0c\u53d1\u73b0 NAD+\uff08\u4e00\u79cd\u5bf9\u7ec6\u80de\u80fd\u91cf\u81f3\u5173\u91cd\u8981\u7684\u5316\u5408\u7269\uff09\u7684\u6c34\u5e73\u4e0e\u5c0f\u9f20\u7ed3\u80a0\u708e\u7684\u4e25\u91cd\u7a0b\u5ea6\u6709\u5173\u3002 NAMPT\u8fd9\u79cd\u9176\u4f1a\u4ea7\u751f\u4e00\u79cd\u79f0\u4e3a NMN \u7684 NAD+ \u524d\u4f53\uff0c\u00a0<\/span><a style=\"background-color: #ffffff; font-size: 1rem;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u5728 Redox Biology \u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u8bba\u6587\u4e2d<\/a><span style=\"font-size: 1rem;\">\uff0c\u53d1\u73b0\u5728\u79f0\u4e3a\u5de8\u566c\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u7f3a\u4e4f NAMPT \u7684\u5c0f\u9f20\uff0c\u663e\u793a\u51fa\u7ed3\u80a0\u708e\u4e25\u91cd\u7a0b\u5ea6\u589e\u52a0\u4ee5\u5e94\u5bf9\u708e\u75c7\u4ee5\u53ca\u5b58\u6d3b\u7387\u964d\u4f4e\u00a0\u3002 \u7814\u7a76\u4eba\u5458\u53d1\u73b0\u75be\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\u548c\u5b58\u6d3b\u7387\uff0c\u90fd\u53ef\u4ee5\u901a\u8fc7\u5728\u4e00\u5468\u5185\u7ed9\u5c0f\u9f20\u6ce8\u5c04 3 \u6b21 NMN \uff08500 mg\/kg\uff09 \u6765\u633d\u6551\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNAMPT \u4f9d\u8d56\u7684 NAD+ \u751f\u7269\u5408\u6210\u9014\u5f84\u6fc0\u6d3b\u53ef\u4ee5\u6cbb\u7597\u708e\u75c7\u6027\u75be\u75c5\uff0c\u5982\u708e\u75c7\u6027\u80a0\u75c5 \uff08IBD\uff09\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #ff6600;\">\u5bfb\u627e\u708e\u75c7\u5e73\u8861<\/span><\/strong><\/p>\n<p><span style=\"font-size: 1rem;\">\u6211\u4eec\u7684\u80a0\u9053\u662f\u65b0\u9648\u4ee3\u8c22\u7684\u5927\u90fd\u5e02\uff0c\u5145\u6ee1\u4e86\u5e9e\u5927\u7684\u5fae\u751f\u7269\u548c\u7ec6\u80de\u7fa4\u3002 \u5de8\u566c\u7ec6\u80de\uff0c\u5728\u5fae\u8c03\u80a0\u7c98\u819c\u514d\u75ab\u7cfb\u7edf\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002 \u8fd9\u4e9b\u80a0\u9053\u5de8\u566c\u7ec6\u80de\u7684\u529f\u80fd\u662f\u6e05\u9664\u75c5\u539f\u4f53\u3001\u7ec6\u83cc\u58c1\u6210\u5206\u548c\u5782\u6b7b\u7684\u7ec6\u80de\u3002<\/span><\/p>\n<p><span style=\"font-size: 1rem;\">\u7136\u800c\uff0c\u5728\u708e\u75c7\u6d88\u9000\u9636\u6bb5\u672a\u80fd\u5bf9\u75c5\u539f\u4f53\u4ea7\u751f\u5f3a\u6709\u529b\u7684\u4fdd\u62a4\u53cd\u5e94\u53ef\u80fd\u5bfc\u81f4\u6301\u7eed\u6027\u548c\u8fc7\u5ea6\u708e\u75c7\uff0c\u8fd9\u5728\u708e\u75c7\u6027\u80a0\u75c5 \uff08IBD\uff09 \u4e2d\u7ecf\u5e38\u89c2\u5bdf\u5230\u3002 \u6b64\u5916\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u5f3a\u5236\u708e\u75c7\u6d88\u9000\u53ef\u80fd\u4ee3\u8868\u4e00\u79cd\u63a7\u5236\u80a0\u9053\u708e\u75c7\u548c\u6062\u590d\u7ec4\u7ec7\u529f\u80fd\u7684\u65b0\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/p>\n<p><strong><span style=\"font-size: 1rem; color: #ff6600;\">NAD+\u5408\u6210\u8c03\u8282\u80a0\u9053\u708e\u75c7<\/span><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u70df\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u57fa\u8f6c\u79fb\u9176 \uff08NAMPT\uff09 \u5728\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u7684\u5faa\u73af\u751f\u7269\u5408\u6210\u9014\u5f84\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5bf9\u7ef4\u6301\u7ec6\u80de\u80fd\u91cf\u81f3\u5173\u91cd\u8981\u3002 NAMPT \u50ac\u5316 NMN\uff0c\u5b83\u662f NAD+ \u7684\u76f4\u63a5\u524d\u4f53\uff0c\u5728\u751f\u7269\u5b66\u4e0a\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\uff0c\u5e76\u4e14\u4e0e\u5404\u79cd\u708e\u75c7\u6027\u75be\u75c5\u6709\u5173\uff0c\u5305\u62ec\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u7cd6\u5c3f\u75c5\u548c\u8d25\u8840\u75c7\u3002 \u7136\u800c\uff0cNAMPT \u5728\u708e\u6027\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u5c1a\u672a\u5b8c\u5168\u9610\u660e\uff0c\u7279\u522b\u662f\u5728\u00a0\u708e\u75c7\u6027\u80a0\u75c5 \uff08IBD\uff09\u00a0\u7684\u60c5\u51b5\u4e0b\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">\u4e3a\u4e86\u7814\u7a76 NAMPT \u5728 IBD \u4e2d\u7684\u4f5c\u7528\uff0cHong \u53ca\u5176\u540c\u4e8b\u5728\u5de8\u566c\u7ec6\u80de\u7f3a\u4e4f\u529f\u80fd\u6027 NAMPT \u57fa\u56e0\u7684\u5c0f\u9f20\u4e2d\u8bf1\u5bfc\u4e86\u7ed3\u80a0\u708e\u3002 \u8fd9\u79cd\u57fa\u56e0\u6539\u53d8\u5bfc\u81f4\u5c0f\u9f20\u906d\u53d7\u957f\u671f\u3001\u4e25\u91cd\u7684\u708e\u75c7\uff0c\u5c3d\u7ba1\u6700\u521d\u7684\u708e\u75c7\u53cd\u5e94\u88ab\u4fdd\u7559\u4e0b\u6765\uff0c\u5c3d\u7ba1\u7f3a\u4e4f NAMPT \u6d3b\u6027\u3002 \u8fd9\u4e9b\u5177\u6709NAMPT\u7f3a\u9677\u578b\u5de8\u566c\u7ec6\u80de\u7684\u5c0f\u9f20\u4e5f\u8868\u73b0\u51fa\u4f53\u91cd\u663e\u8457\u964d\u4f4e\u548c\u5b58\u6d3b\u7387\u964d\u4f4e\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-19328\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/795985_528374-1024x388.webp\" alt=\"\" width=\"900\" height=\"341\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/795985_528374-1024x388.webp 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/795985_528374-300x114.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/795985_528374-768x291.webp 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/795985_528374.webp 1113w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><strong>(Hong et al., 2022 |<\/strong><\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em><strong>Redox Biology<\/strong><\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><strong>)<\/strong><\/a> \u5de8\u566c\u7ec6\u80de\u4e2dNAMPT\u7684\u7f3a\u5931\u589e\u5f3a\u4e86DSS\u8bf1\u5bfc\u7684\u7ed3\u80a0\u708e\u3002 \uff08\u5de6\uff09\u7528 2.5% \u786b\u9178\u8461\u805a\u91a3\u94a0 \uff08DSS\uff09 \u8bf1\u5bfc\u7684\u7ed3\u80a0\u708e\u5c0f\u9f20\u7684\u5b58\u6d3b\u66f2\u7ebf\u3002 \uff08E\uff09 \u75be\u75c5\u6d3b\u52a8\u6307\u6570\uff08\u53f3\uff09\u75be\u75c5\u6d3b\u52a8\u6307\u6570 \uff08DAI\uff09 \u6839\u636e\u5927\u4fbf\u7a20\u5ea6\u3001\u5927\u4fbf\u51fa\u8840\u548c\u4f53\u91cd\u51cf\u8f7b\u8fdb\u884c\u8bc4\u5206\u3002 \u5404\u4e2a\u53c2\u6570\u4ece0\u7f29\u653e\u52304\uff08\u603b\u51710-12\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u867d\u7136 NAMPT \u7f3a\u5931\u4e0d\u5f71\u54cd\u5de8\u566c\u7ec6\u80de\u7684\u52df\u96c6\u6216\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u4f46 NAMPT \u7f3a\u5931\u635f\u5bb3\u4e86\u5de8\u566c\u7ec6\u80de\u7684\u201c\u6e05\u7406\u201d\u8fc7\u7a0b\uff08\u541e\u566c\u4f5c\u7528\uff09\uff0c\u8fd9\u5bf9\u4e8e\u708e\u75c7\u7684\u6d88\u9000\u548c\u7ec4\u7ec7\u5e73\u8861\u7684\u6062\u590d\u5f88\u91cd\u8981\u3002 \u541e\u566c\u4f5c\u7528\u7684\u964d\u4f4e\u963b\u788d\u4e86\u6e05\u9664\u56e0 NAD+ \u6c34\u5e73\u4e0d\u8db3\u800c\u4ea7\u751f\u7684\u7ec4\u7ec7\u788e\u7247\u548c\u6b7b\u7ec6\u80de\u3002 \u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5de8\u566c\u7ec6\u80de\u4e2d\u7684NAMPT\u7f3a\u5931\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u6a21\u578b\u4e2d\u957f\u671f\u4e25\u91cd\u7684\u7ed3\u80a0\u708e\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN\u63d0\u9ad8\u7d50\u8178\u708e\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u5728\u9019\u4e9b\u76f8\u540c\u7684\u5c0f\u9f20\u4e2d\uff0cHong \u548c\u4ed6\u7684\u540c\u4e8b\u6bcf\u9031\u6ce8\u5c04 3 \u6b21 500 mg\/kg NMN \u6216\u751f\u7406\u9e7d\u6c34\u3002 NMN \u6cbb\u7642\u6e1b\u8f15\u4e86\u9ad4\u91cd\u6e1b\u8f15\u548c\u7d50\u8178\u708e\u7684\u56b4\u91cd\u7a0b\u5ea6\uff0c\u5f9e\u800c\u63d0\u9ad8\u4e86\u5b58\u6d3b\u7387\u3002 \u8a73\u7d30\u5730\u8aaa\uff0c\u9e7d\u6c34\u6ce8\u5c04\u6709 33% \u7684\u5b58\u6d3b\u7387\uff084\/12 \u96bb\u5c0f\u9f20\uff09\uff0c\u800c NMN \u4ecb\u5165\u5247\u6709 67% \u7684\u5b58\u6d3b\u7387\uff088\/12 \u96bb\u5c0f\u9f20\uff09\u3002 \u4e00\u81f4\u5730\uff0cNMN \u4ecb\u5165\u589e\u52a0\u4e86\u8655\u65bc\u8907\u88fd\u72c0\u614b\u7684\u7d30\u80de\u6578\u91cf\uff0c\u540c\u6642\u6e1b\u5c11\u4e86\u7d30\u80de\u6b7b\u4ea1\u6a19\u8a8c\u7269\u4e26\u6e1b\u5c11\u4e86\u5de8\u566c\u7d30\u80de\u6d78\u6f64\u3002 \u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0cNMN \u901a\u904e\u589e\u5f37\u708e\u75c7\u7684\u6d88\u9000\u4f86\u4fdd\u8b77\u5c0f\u9f20\u514d\u53d7\u7d50\u8178\u708e\u7684\u4fb5\u5bb3\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19329\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/54442_420555.webp\" alt=\"\" width=\"929\" height=\"336\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/54442_420555.webp 929w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/54442_420555-300x109.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/11\/54442_420555-768x278.webp 768w\" sizes=\"auto, (max-width: 929px) 100vw, 929px\" \/><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><strong>(Hong et al., 2022 |<\/strong><\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em><strong>Redox Biology<\/strong><\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35063804\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><strong>)<\/strong><\/a>\u00a0NMN \u6e1b\u8f15\u4e86\u7f3a\u4e4f NAMPT \u7684\u5c0f\u9f20\u7d50\u8178\u708e\u7684\u56b4\u91cd\u7a0b\u5ea6\u3002 \uff08\u5de6\uff09\u75be\u75c5\u6d3b\u52d5\u6307\u6578 (DAI) \u6839\u64da\u5927\u4fbf\u7a20\u5ea6\u3001\u5927\u4fbf\u51fa\u8840\u548c\u9ad4\u91cd\u6e1b\u8f15\u9032\u884c\u8a55\u5206\u3002 \u5404\u500b\u53c3\u6578\u5f9e 0 \u7e2e\u653e\u5230 4\uff08\u7e3d\u5171 0-12\uff09\u3002 \uff08\u6b63\u78ba\u7684\uff09<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u63a5\u4e0b\u4f86\uff0cHong \u548c\u4ed6\u7684\u540c\u4e8b\u6aa2\u67e5\u4e86 NMN \u6ce8\u5c04\u4f34\u96a8\u7684\u4efb\u4f55\u6bd2\u526f\u4f5c\u7528\u662f\u5426\u53ef\u80fd\u51fa\u73fe\u5728\u5c0f\u9f20\u8eab\u4e0a\u3002 \u7d50\u8178\u3001\u809d\u81df\u6216\u813e\u81df\u672a\u898b\u8089\u773c\u548c\u93e1\u4e0b\u7570\u5e38\uff0cNMN\u6cbb\u7642\u5f8c\u8840\u6e05\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u548c\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u6c34\u5e73\u672a\u5347\u9ad8\uff0c\u8868\u660e\u6ce8\u5c04NMN\u53ef\u6e1b\u8f15\u7d50\u8178\u708e\u800c\u7121\u660e\u986f\u809d\u6bd2\u6027 .<\/p>\n<p><span style=\"font-size: 1rem;\">\u201c\u7e3d\u7684\u4f86\u8aaa\uff0c\u6211\u5011\u7684\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u901a\u904e NMN \u4ecb\u5165 \u6fc0\u6d3b NAMPT \u4f9d\u8cf4\u7684 NAD+ \u751f\u7269\u5408\u6210\u9014\u5f91\u662f\u6cbb\u7642\u708e\u75c7\u6027\u75be\u75c5\u7684\u6f5b\u5728\u6cbb\u7642\u7b56\u7565\uff0c\u201dHong \u53ca\u5176\u540c\u4e8b\u7e3d\u7d50\u9053\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>NMN\u53ef\u4ee5\u6cbb\u7642\u708e\u75c7\u6027\u8178\u75c5 (IBD)\u55ce\uff1f<\/p>\n<p><span style=\"font-size: 1rem;\">\u5118\u7ba1\u6709\u9019\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4f46\u9019\u9805\u7814\u7a76\u7684\u81e8\u5e8a\u8f49\u5316\u76f8\u95dc\u6027\u4f3c\u4e4e\u662f\u6709\u9650\u7684\u3002 \u9019\u662f\u56e0\u70ba\u8207\u201c\u5de8\u566c\u7d30\u80de\u7279\u7570\u6027 NAMPT \u8017\u7aed\u201d\u76f8\u95dc\u7684\u60c5\u6cc1\u9810\u8a08\u5728\u81e8\u5e8a\u74b0\u5883\u4e2d\u4e0d\u6703\u8f15\u6613\u9047\u5230\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u5118\u7ba1\u5982\u6b64\uff0cHong \u53ca\u5176\u540c\u4e8b\u5f37\u8abf\uff0cNAD+ \u5728\u6e05\u9664\u5de8\u566c\u7d30\u80de\u7684\u6d3b\u6027\u548c\u96a8\u5f8c\u7684\u708e\u75c7\u6d88\u9000\u4e2d\u81f3\u95dc\u91cd\u8981\u3002 \u5728\u5305\u62ec\u5de8\u566c\u7d30\u80de\u5728\u5167\u7684\u7d30\u80de\u4e2d\uff0cNAD+ \u4e3b\u8981\u7531\u7159\u9170\u80fa\uff08\u7dad\u751f\u7d20 B3 \u7684\u4e00\u7a2e\u5f62\u5f0f\uff0c\u4e5f\u7a31\u70ba\u83f8\u9178\uff09\u4ee5\u53ca\u9b5a\u3001\u8089\u548c\u8611\u83c7\u7b49\u5404\u7a2e\u81b3\u98df\u4f86\u6e90\u88fd\u6210\u3002 \u5982\u679c\u6c92\u6709\u9069\u7576\u7684\u88dc\u5145\uff0c\u4eba\u5011\u53ef\u80fd\u6703\u60a3\u4e0a\u5b83\u7684\u7f3a\u4e4f\u75c7\uff0c\u9019\u7a2e\u60c5\u6cc1\u88ab\u7a31\u70ba\u7cd9\u76ae\u75c5\u3002<\/p>\n<p><span style=\"font-size: 1rem;\">\u540c\u65f6\uff0cIBD\u60a3\u8005\u901a\u5e38\u96be\u4ee5\u8fdb\u98df\u6216\u53e3\u670d\u4efb\u4f55\u4e1c\u897f\uff0c\u56e0\u4e3a\u4ed6\u4eec\u7ecf\u5e38\u51fa\u73b0\u8179\u75db\u3001\u8179\u6cfb\u6216\u98df\u6b32\u4e0b\u964d\u3002 \u5438\u6536\u4e0d\u826f\u662f IBD \u60a3\u8005\u7684\u53e6\u4e00\u4e2a\u5e38\u89c1\u95ee\u9898\u3002 \u56e0\u6b64\uff0c\u8fd9\u4e9b\u6311\u6218\u5f80\u5f80\u4f1a\u5bfc\u81f4\u8425\u517b\u5931\u8861\u6216\u7f3a\u4e4f\u3002 \u636e\u62a5\u9053\uff0cIBD\u60a3\u8005\u8425\u517b\u4e0d\u826f\u7684\u60a3\u75c5\u7387\u572820%\u81f385%\u4e4b\u95f4\u3002 \u6b64\u5916\uff0c\u8425\u517b\u4e0d\u826f\u662f\u4e0e IBD \u60a3\u8005\u4e0d\u826f\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u7684\u6700\u5173\u952e\u56e0\u7d20\u4e4b\u4e00\u3002 \u56e0\u6b64\uff0c\u8fd9\u4e00\u96c6\u4f53\u4fe1\u606f\u610f\u5473\u7740 NAD+ \u7f3a\u4e4f\u53ef\u80fd\u53d1\u751f\u5728\u514d\u75ab\u7ec6\u80de\u4e2d\u2014\u2014\u8fd9\u76f8\u5f53\u4e8e\u6211\u4eec\u7814\u7a76\u4e2d\u5de8\u566c\u7ec6\u80de\u4e2d NAMPT \u7684\u6d88\u8017\u2014\u2014\u8425\u517b\u4e0d\u826f\u7684\u6162\u6027 IBD \u60a3\u8005\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u6b64\u5916\uff0c\u8870\u8001\u4f34\u968f\u7740\u5305\u62ec\u4eba\u7c7b\u5728\u5185\u7684\u591a\u79cd\u751f\u7269\u4f53\u7684\u7ec4\u7ec7\u548c\u7ec6\u80de NAD+ \u6c34\u5e73\u9010\u6e10\u4e0b\u964d\u3002 NAD+ \u6c34\u5e73\u7684\u4e0b\u964d\u4e0e\u8bb8\u591a\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u6709\u5173\uff0c\u4f8b\u5982\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u3001\u764c\u75c7\u548c\u4ee3\u8c22\u75be\u75c5\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u636e\u62a5\u9053\uff0c\u5728\u673a\u4f53\u8870\u8001\u8fc7\u7a0b\u4e2d\uff0c\u8bb8\u591a\u7ec4\u7ec7\u4e2d\u7684NAMPT\u6c34\u5e73\u4e5f\u4f1a\u964d\u4f4e\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u56e0\u6b64\uff0cNAD+ \u7684\u964d\u4f4e\u4f3c\u4e4e\u81f3\u5c11\u90e8\u5206\u5f52\u56e0\u4e8e\u8870\u8001\u7ec6\u80de\u4e2dNAMPT\u6c34\u5e73\u7684\u964d\u4f4e\u3002 \u7efc\u4e0a\u6240\u8ff0\uff0c\u8865\u5145 NMN\uff08\u6216\u70df\u9170\u80fa\uff09\u4f3c\u4e4e\u662f\u4e00\u79cd\u6709\u6548\u7684\u6539\u5584\u7b56\u7565\uff0c\u6709\u52a9\u4e8e\u964d\u4f4e IBD \u60a3\u8005\u708e\u75c7\u7684\u4e25\u91cd\u7a0b\u5ea6\u548c\u6301\u7eed\u65f6\u95f4\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5e74\u8001\u6216\u8425\u517b\u4e0d\u826f\u7684\u60a3\u8005\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Hong SM, Lee AY, Hwang SM, Ha YJ, Kim MJ, Min S, Hwang W, Yoon G, Kwon SM, Woo HG, Kim HH, Jeong WI, Shen HM, Im SH, Lee D, Kim YS. NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages. Redox Biol. 2022 Jan 15; 50:102237. doi: 10.1016\/j.redox.2022.102237. Epub ahead of print. PMID: 35063804.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>https:\/\/www.nmn.com\/news\/nmn-reduces-colitis-in-mice<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19327\" class=\"pvc_stats all  \" data-element-id=\"19327\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed9\u4e88 NMN \u53ef\u9632\u6b62\u7ed3\u80a0\u708e\u6a21\u578b\u5c0f\u9f20\u51fa\u73b0\u7834\u574f\u6027\u708e\u75c7 By\u00a0Jonathan D. Grinstein, Ph.D. Published:\u00a02:32 p.m. PST Jan 27, 2022\u00a0| Updated:\u00a03:09 p.m. PST Sep 26, 2022 Highlights \u5728\u5de8\u566c\u7ec6\u80de\u4e2d NAD+ \u5408\u6210\u4e0d\u8db3\u4f1a\u4fc3\u8fdb\u5c0f\u9f20\u5bf9\u7ed3\u80a0\u708e\u7684\u6613\u611f\u6027\u3002 \u541e\u566c\u6b7b\u7ec6\u80de\u548c\u4fee\u590d\u7ec4\u7ec7\u7684\u5de8\u566c\u7ec6\u80de\u6e05\u7406\u6d3b\u52a8\u4f9d\u8d56\u4e8e NAD+ \u5408\u6210\u3002 NMN \u4ecb\u5165\u53ef\u51cf\u8f7b\u7ed3\u80a0\u708e\u7684\u4e25\u91cd\u7a0b\u5ea6\u5e76\u63d0\u9ad8\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19327\" class=\"pvc_stats all  \" data-element-id=\"19327\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":19330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[409,172,272],"tags":[622,472],"class_list":["post-19327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nad","category-nmn-","category-272","tag-nmn-","tag-472"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19327"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19327\/revisions"}],"predecessor-version":[{"id":19332,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19327\/revisions\/19332"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/19330"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19327"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}