{"id":19231,"date":"2022-10-19T02:43:37","date_gmt":"2022-10-19T02:43:37","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19231"},"modified":"2022-10-19T02:57:16","modified_gmt":"2022-10-19T02:57:16","slug":"%e5%93%88%e4%bd%9b%e5%8c%bb%e5%ad%a6%e9%99%a2%e7%a0%94%e7%a9%b6%e8%a1%a8%e6%98%8e%ef%bc%9a%e6%8f%90%e9%ab%98%e9%95%bf%e5%af%bf%e8%9b%8b%e7%99%bd%e6%b4%bb%e6%80%a7%e5%8f%af%e6%94%b9","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19231","title":{"rendered":"\u54c8\u4f5b\u533b\u5b66\u9662\u7814\u7a76\u8868\u660e\uff1a\u63d0\u9ad8\u201c\u957f\u5bff\u86cb\u767d\u201d\u6d3b\u6027\u53ef\u6539\u5584\u809d\u635f\u4f24"},"content":{"rendered":"<p>\u7f8e\u56fd\u8d1d\u52d2\u533b\u5b66\u9662\u3001\u54c8\u4f5b\u533b\u5b66\u9662\u3001\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7b49\u591a\u4e2a\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c<strong><span style=\"color: #ff6600;\">\u8865\u5145NMN\u53ef\u4ee5\u63d0\u5347NAD+\u6c34\u5e73\uff0c\u4ece\u800c\u63d0\u9ad8\u201c\u957f\u5bff\u86cb\u767d\u201d\u6d3b\u6027\u3001\u5ef6\u957f\u7aef\u7c92\u957f\u5ea6\uff0c\u6539\u5584\u809d\u7ea4\u7ef4\u5316\u3002<\/span><\/strong><\/p>\n<div class=\"content-def\">\n<p>\u7aef\u7c92\u662f\u67d3\u8272\u4f53\u672b\u7aef\u7684\u4e00\u5c0f\u6bb5DNA\uff0c\u4fdd\u62a4\u7740\u67d3\u8272\u4f53\u7684\u5b8c\u6574\u6027\u3002\u7aef\u7c92\u7684\u957f\u5ea6\u968f\u5e74\u9f84\u7684\u589e\u957f\u800c\u7f29\u77ed\uff0c\u540c\u65f6\u4f1a\u5f15\u8d77\u8870\u8001\u76f8\u5173\u9000\u884c\u6027\u75be\u75c5\uff0c\u5c24\u5176\u662f\u5bf9\u809d\u810f\u548c\u80ba\u635f\u5bb3\u6700\u4e25\u91cd\u3002\u56fd\u9645\u9876\u520a\u300a\u81ea\u7136\u8bc4\u8bba\u9057\u4f20\u5b66\u300b\uff08<em>Nature Reviews Genetics<\/em>\uff09\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5f53\u7aef\u7c92\u53d7\u635f\u65f6\uff0c\u5927\u7ea620%\u548c7%\u7684\u4eba\u7fa4\u4f1a\u51fa\u73b0\u80ba\u548c\u809d\u7ea4\u7ef4\u5316\u3002<\/p>\n<p>\u6b64\u524d\u7684\u76f8\u5173\u5b9e\u9a8c\u5df2\u8bc1\u5b9e\uff0c\u957f\u5bff\u86cb\u767dSirt1\u5728\u809d\u810f\u7684\u591a\u79cd\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5e76\u4e0e\u809d\u75c5\u7684\u53d1\u5c55\u6709\u5173\u3002\u5982\u56fd\u9645\u9876\u520a\u300a\u81ea\u7136\u8bc4\u8bba\u5206\u5b50\u7ec6\u80de\u751f\u7269\u5b66\u300b\uff08<em>Nature Reviews Molecular Cell Biology<\/em>\uff09\u7684\u4e00\u9879\u7814\u7a76\u663e\u793a\uff0c\u809d\u810f\u4e2d\u7f3a\u4e4f\u957f\u5bff\u86cb\u767d\u65f6\uff0c\u4f1a\u52a0\u901f\u809d\u810f\u8102\u80aa\u53d8\u6027\u548c\u80f0\u5c9b\u7d20\u62b5\u6297\u3002<!--more--><\/p>\n<p>\u867d\u7136\u7aef\u7c92\u548c\u957f\u5bff\u86cb\u767d\u90fd\u4e0e\u8870\u8001\u53ca\u76f8\u5173\u75be\u75c5\u6709\u5173\uff0c\u4f46\u5b83\u4eec\u4e4b\u95f4\u7684\u5173\u7cfb\u5e76\u4e0d\u660e\u786e\u3002\u8fd1\u671f\uff0c\u7f8e\u56fd\u8d1d\u52d2\u533b\u5b66\u9662\u3001\u54c8\u4f5b\u533b\u5b66\u9662\u3001\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7b49\u591a\u4e2a\u673a\u6784\u7684\u7814\u7a76\u4eba\u5458\u5728\u300a\u7ec6\u80de\u4ee3\u8c22\u300b\uff08<em>Cell Metabolism<\/em>\uff09\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u8865\u5145NMN\u53ef\u4ee5\u63d0\u9ad8\u957f\u5bff\u86cb\u767d\u6d3b\u6027\u6765\u589e\u52a0\u7aef\u7c92\u957f\u5ea6\uff0c\u4ece\u800c\u6539\u5584\u809d\u7ea4\u7ef4\u5316\u3002<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5287\" src=\"https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/09\/20220921151617.png\" sizes=\"auto, (max-width: 679px) 100vw, 679px\" srcset=\"https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/09\/20220921151617.png 679w, https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/09\/20220921151617-300x164.png 300w\" alt=\"\u56fe1 \u67d3\u8272\u4f53\u3001\u7aef\u7c92\u793a\u610f\u56fe\" width=\"679\" height=\"371\" \/><figcaption>\u56fe1 \u67d3\u8272\u4f53\u3001\u7aef\u7c92\u793a\u610f\u56fe<\/figcaption><\/figure>\n<\/div>\n<p>\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9996\u5148\u8bbe\u8ba1\u4e86\u4e00\u79cd\u7aef\u7c92\u529f\u80fd\u969c\u788d\u7684\u6a21\u578b\u9f20\u3002\u968f\u7740\u7aef\u7c92\u9010\u6e10\u7f29\u77ed\uff0c\u6a21\u578b\u9f20\u4f1a\u51fa\u73b0\u4e0e\u7aef\u7c92\u529f\u80fd\u969c\u788d\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5982\u65e9\u8870\u53ca\u809d\u7ec6\u80de\u53d7\u635f\u7b49\u3002<\/p>\n<p>\u63a5\u7740\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86\u6a21\u578b\u9f20\u4e0e\u6b63\u5e38\u9f20\u7684\u809d\u810f\u7ec4\u7ec7\u4e2d\u201c\u957f\u5bff\u86cb\u767d\u201d\u542b\u91cf\uff0c\u53d1\u73b0\u6a21\u578b\u9f20\u809d\u810f\u4e2d\u7684\u201c\u957f\u5bff\u86cb\u767d\u201d\u663e\u8457\u964d\u4f4e\uff0c\u8bf4\u660e\u7aef\u7c92\u7f29\u77ed\u53ef\u6291\u5236\u201c\u957f\u5bff\u86cb\u767d\u201d\u7684\u6d3b\u6027\u3002<\/p>\n<p>\u7531\u4e8e\u201c\u957f\u5bff\u86cb\u767d\u201d\u662f\u4e00\u7c7bNAD+\u4f9d\u8d56\u9176\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u8bbe\u60f3\u901a\u8fc7\u8865\u5145NMN\u63d0\u9ad8NAD+\u6c34\u5e73\uff0c\u4ece\u800c\u63d0\u9ad8\u201c\u957f\u5bff\u86cb\u767d\u201d\u6d3b\u6027\uff0c\u6539\u5584\u7aef\u7c92\u529f\u80fd\u969c\u788d\u5f15\u8d77\u7684\u809d\u75c5\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e0e\u5065\u5eb7\u5c0f\u9f20\u76f8\u6bd4\uff0c\u6a21\u578b\u9f20\u7684NAD+\u6c34\u5e73\u663e\u8457\u964d\u4f4e\u3002\u4f46\u8865\u5145NMN\u540e\uff0c\u6a21\u578b\u9f20\u7684NAD+\u6c34\u5e73\u6062\u590d\u6b63\u5e38\uff0c\u540c\u65f6\u6a21\u578b\u9f20\u809d\u810f\u7ec6\u80de\u6bd2\u6027\u3001\u7ea4\u7ef4\u5316\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u6c34\u5e73\u663e\u8457\u964d\u4f4e\u3002\u8fd9\u8868\u660e\uff0c\u5373\u4f7f\u5728\u7aef\u7c92\u7f29\u77ed\u7684\u60c5\u51b5\u4e0b\uff0cNMN\u4ecd\u53ef\u663e\u8457\u6539\u5584\u809d\u635f\u4f24\u548c\u7ea4\u7ef4\u5316\u3002<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-4405\" src=\"https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/08\/678kilo.png\" sizes=\"auto, (max-width: 588px) 100vw, 588px\" srcset=\"https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/08\/678kilo.png 588w, https:\/\/cms.nmn.cn\/wp-content\/uploads\/2022\/08\/678kilo-300x244.png 300w\" alt=\"\u56fe2 \u6a21\u578b\u9f20\u548c\u6b63\u5e38\u5c0f\u9f20\u7684\u809d\u7ea4\u7ef4\u5316\u5bf9\u6bd4\u7ea2\u8272\u4fe1\u53f7\u4ee3\u8868\u809d\u7ea4\u7ef4\u5316\u60c5\u51b5\uff1b\u76f8\u6bd4\u672a\u5904\u7406\uff0cNMN\u53ef\u4f7f\u7ea2\u8272\u4fe1\u53f7\u51cf\u5f31\" width=\"588\" height=\"478\" \/><figcaption>\u56fe2 \u6a21\u578b\u9f20\u548c\u6b63\u5e38\u5c0f\u9f20\u7684\u809d\u7ea4\u7ef4\u5316\u5bf9\u6bd4<br \/>\n\u7ea2\u8272\u4fe1\u53f7\u4ee3\u8868\u809d\u7ea4\u7ef4\u5316\u60c5\u51b5\uff1b\u76f8\u6bd4\u672a\u5904\u7406\uff0cNMN\u53ef\u4f7f\u7ea2\u8272\u4fe1\u53f7\u51cf\u5f31<\/figcaption><\/figure>\n<\/div>\n<p>\u4e3a\u4e86\u66f4\u6df1\u5165\u5730\u4e86\u89e3NMN\u5982\u4f55\u4f7f\u7aef\u7c92\u529f\u80fd\u969c\u788d\u7684\u809d\u7ec6\u80de\u514d\u53d7\u635f\u4f24\uff0c\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86NMN\u4e0e\u7aef\u7c92\u53ca\u957f\u5bff\u86cb\u767d\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n<p>\u7ed3\u679c\u53d1\u73b0\uff0c\u8865\u5145NMN\u540e\uff0c\u4e0e\u957f\u5bff\u86cb\u767d\u6b63\u5e38\u8868\u8fbe\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u7f3a\u4e4f\u957f\u5bff\u86cb\u767d\u7684\u5c0f\u9f20\u7aef\u7c92\u66f4\u77ed\u3002\u8fd9\u8bf4\u660e\uff0c\u901a\u8fc7\u8865\u5145NMN\u7ef4\u6301\u7aef\u7c92\u957f\u5ea6\u7684\u4f5c\u7528\u9700\u8981\u957f\u5bff\u86cb\u767d\u7684\u53c2\u4e0e\u3002<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u8865\u5145NMN\u63d0\u9ad8NAD+\u7684\u6c34\u5e73\uff0c\u53ef\u4ee5\u6709\u6548\u9632\u6b62\u56e0\u957f\u5bff\u86cb\u767d\u7f3a\u4e4f\u5f15\u8d77\u7684\u7aef\u7c92\u53d8\u77ed\uff0c\u8fdb\u800c\u6539\u5584\u809d\u7ea4\u7ef4\u5316\u3002\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u201c\u867d\u7136\u8be5\u7814\u7a76\u5c1a\u5904\u4e8e\u52a8\u7269\u5b9e\u9a8c\u6c34\u5e73\uff0c\u4f46\u8fd9\u4e3a\u8bc1\u5b9eNMN\u6539\u5584\u4eba\u7c7b\u809d\u7ea4\u7ef4\u5316\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6253\u4e0b\u4e86\u57fa\u7840\uff0c\u4e5f\u4e3a\u6539\u5584\u5176\u4ed6\u4e0e\u7aef\u7c92\u529f\u80fd\u969c\u788d\u7684\u76f8\u5173\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002\u201d<\/p>\n<\/div>\n<div class=\"footer-content\">\n<div class=\"footer-block\">\n<div class=\"header\">\u53c2\u8003\u6587\u732e<\/div>\n<div class=\"content\">\n<p>[1] Amano H , Chaudhury A , Rodriguez-Aguayo C , et al. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease[J]. Cell Metabolism, 2019, 29(6).<\/p>\n<p>[2] DE\u00a0 Gottschling,\u00a0 Aparicio O M ,\u00a0 Billington B L , et al. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.[J]. Cell, 1990, 63(4):751-762.<\/p>\n<p>[3] Sahin Erg\u00fcn,Colla Simona,Liesa Marc et al. Telomere dysfunction induces metabolic and mitochondrial compromise.[J] .Nature, 2011, 470: 359-65.<\/p>\n<p>\u6587\u7ae0\u6765\u6e90\uff1a<a href=\"https:\/\/www.nmn.cn\/news\/yu08n\">\u54c8\u4f5b\u533b\u5b66\u9662\u7814\u7a76\u8868\u660e\uff1a\u63d0\u9ad8\u201c\u957f\u5bff\u86cb\u767d\u201d\u6d3b\u6027\u53ef\u6539\u5584\u809d\u635f\u4f24\uff5cNMN\u4e2d\u56fd<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_19231\" class=\"pvc_stats all  \" data-element-id=\"19231\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 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