{"id":19226,"date":"2022-10-19T02:36:49","date_gmt":"2022-10-19T02:36:49","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=19226"},"modified":"2022-10-19T02:37:22","modified_gmt":"2022-10-19T02:37:22","slug":"%e3%80%8a%e5%9b%bd%e9%99%85%e5%88%86%e5%ad%90%e7%a7%91%e5%ad%a6%e6%9d%82%e5%bf%97%e3%80%8b%e7%a0%94%e7%a9%b6%e5%8f%91%e7%8e%b0%ef%bc%9a%ce%b2%e7%83%9f%e9%85%b0%e8%83%ba%e5%8d%95%e6%a0%b8%e8%8b%b7","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=19226","title":{"rendered":"\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\u7814\u7a76\u53d1\u73b0\uff1a\u03b2\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u53ef\u4ee5\u4fdd\u62a4\u5927\u9f20\u795e\u7ecf\u5143\uff0c\u4fdd\u7559\u8ba4\u77e5\u529f\u80fd"},"content":{"rendered":"

\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\u6587\u7ae0\u8bc1\u5b9e\uff1a\u8865\u5145NMN\uff08\u03b2\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u53ef\u4fee\u590d\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u4fdd\u62a4\u5927\u8111\u6d77\u9a6c\u533a\u7684\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u63d0\u9ad8\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u5e76\u4fc3\u8fdb\u518d\u751f\uff0c\u4ece\u800c\u9632\u6b62\u5927\u8111\u6d77\u9a6c\u533a\u840e\u7f29\uff0c\u4fdd\u7559\u8ba4\u77e5\u529f\u80fd\u548c\u8bb0\u5fc6\u529b\u3002<\/p>\n

\n

\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53d1\u751f\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u7684\u98ce\u9669\u8fdc\u9ad8\u4e8e\u5065\u5eb7\u4eba\u7fa4\u3002\u4e0e\u5065\u5eb7\u4eba\u7fa4\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f53\u5185\u7684NAD+\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09\u5206\u5b50\u6c34\u5e73\u964d\u4f4e\uff0c\u800cNAD+\u7f3a\u4e4f\u4f1a\u5bfc\u81f4\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\uff0c\u8fdb\u800c\u9020\u6210\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u5927\u8111\u840e\u7f29\uff0c\u53d1\u751f\u8ba4\u77e5\u969c\u788d\u7b49\u98ce\u9669\u3002<\/p>\n

2020\u5e745\u6708\uff0c\u9a6c\u91cc\u5170\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5728\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\uff08International Journal of Molecular Sciences\uff09\u4e0a\u53d1\u8868\u4e00\u9879\u7814\u7a76\uff0c\u7814\u7a76\u8bc1\u5b9e\u8865\u5145NMN\uff08\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u53ef\u4fdd\u62a4\u5927\u8111\u6d77\u9a6c\u533a\u7684\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u63d0\u9ad8\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u5e76\u4fc3\u8fdb\u518d\u751f\uff0c\u4ece\u800c\u9632\u6b62\u5927\u8111\u6d77\u9a6c\u533a\u840e\u7f29\uff0c\u4fdd\u7559\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u8ba4\u77e5\u4e0e\u8bb0\u5fc6\u529b\u3002<\/p>\n

\u4f5c\u4e3aNAD+\u7684\u76f4\u63a5\u524d\u4f53\uff0cNMN\u5df2\u88ab\u8bc1\u660e\u53ef\u6709\u6548\u63d0\u5347\u4f53\u5185NAD+\u7684\u6c34\u5e73\u3002\u57fa\u4e8e\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u63a2\u7a76\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u8865\u5145NMN\u6765\u6709\u6548\u963b\u6b62\u7cd6\u5c3f\u75c5\u5927\u9f20\u4f53\u5185NAD+\u6c34\u5e73\u7684\u964d\u4f4e\u3002\u7814\u7a76\u53d1\u73b0\u7ed9\u7cd6\u5c3f\u75c5\u5927\u9f20\u8179\u8154\u6ce8\u5c04NMN\u540e\uff0c\u5927\u9f20\u8111\u4e2d\u7684NAD+\u6c34\u5e73\u5f97\u5230\u4e86\u663e\u8457\u63d0\u5347\u3002<\/p>\n

\u540c\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\u7cd6\u5c3f\u75c5\u5927\u9f20\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u53d7\u635f\uff0c\u8017\u6c27\u91cf\u663e\u8457\u964d\u4f4e\uff0c\u800c\u8865\u5145NMN\u540e\uff0c\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ebf\u7c92\u4f53\u7684\u8017\u6c27\u91cf\u663e\u8457\u63d0\u9ad8\uff0c\u7ebf\u7c92\u4f53\u529f\u80fd\u6062\u590d\u5230\u4e0e\u5065\u5eb7\u5927\u9f20\u76f8\u540c\u7684\u6c34\u5e73\u3002 \u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e0e\u5065\u5eb7\u5927\u9f20\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u5927\u9f20\u53c2\u4e0e\u5b66\u4e60\u548c\u8bb0\u5fc6\u7684\u6d77\u9a6c\u533a\u795e\u7ecf\u5143\u7684\u6570\u91cf\u53ca\u4f53\u79ef\u5747\u663e\u8457\u4e0b\u964d\uff0c\u8fd9\u8bf4\u660e\uff0c\u7cd6\u5c3f\u75c5\u4f7f\u5927\u8111\u6d77\u9a6c\u533a\u53d1\u751f\u4e86\u840e\u7f29\u3002\u800c\u8865\u5145NMN\u540e\uff0c\u4e0a\u8ff0\u75c7\u72b6\u4e0d\u4ec5\u5f97\u5230\u4e86\u6291\u5236\uff0c\u800c\u4e14\u635f\u4f24\u7684\u795e\u7ecf\u5143\u8fd8\u5f97\u5230\u4fee\u590d\u3002<\/p>\n

\n
\"\u56fe1
\u56fe1 A\uff1a\u6d77\u9a6c\u8111\u533a\u4f53\u79ef\u5c55\u793a\uff0cB\uff1a\u6d77\u9a6c\u8111\u533a\u795e\u7ecf\u5143\u6570\u91cf\u5c55\u793a<\/figcaption><\/figure>\n<\/div>\n

\u7531\u4e8e\u5927\u8111\u6d77\u9a6c\u533a\u4e0e\u8ba4\u77e5\u80fd\u529b\u5bc6\u5207\u76f8\u5173\uff0c\u7279\u522b\u662f\u7a7a\u95f4\u5b66\u4e60\u548c\u8bb0\u5fc6\u80fd\u529b\u3002\u7814\u7a76\u4eba\u5458\u5bf9\u5927\u9f20\u8fdb\u884c\u4e86\u4e00\u9879\u201cY\u8ff7\u5bab\u201d\u5b9e\u9a8c\uff0c\u4ee5\u63a2\u7a76\u8865\u5145NMN\u662f\u5426\u53ef\u4ee5\u6291\u5236\u7cd6\u5c3f\u75c5\u9020\u6210\u7684\u5927\u9f20\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u3002 \u201cY\u8ff7\u5bab\u201d\u75313\u4e2a\u201c\u624b\u81c2\u201d\u7ec4\u6210\uff0c\u53ef\u8861\u91cf\u5b9e\u9a8c\u52a8\u7269\u63a2\u7d22\u65b0\u73af\u5883\u7684\u610f\u613f\uff0c\u6b63\u5e38\u7684\u5927\u9f20\u90fd\u559c\u6b22\u63a2\u7d22\u65b0\u624b\u81c2\uff0c\u800c\u4e0d\u518d\u8fd4\u56de\u5df2\u7ecf\u63a2\u7d22\u8fc7\u7684\u624b\u81c2\u3002\u8bb0\u5fc6\u53d7\u635f\u7684\u5927\u9f20\u4f1a\u56e0\u4e3a\u5fd8\u8bb0\u8ff7\u5bab\u7684\u4e0d\u540c\u624b\u81c2\uff0c\u4ece\u800c\u51cf\u5c11\u5bf9\u65b0\u624b\u81c2\u7684\u63a2\u7d22\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u7cd6\u5c3f\u75c5\u5927\u9f20\u5728\u8ff7\u5bab\u65b0\u624b\u81c2\u4e0a\u7684\u63a2\u7d22\u65f6\u95f4\u4ec5\u4e3a\u5065\u5eb7\u5927\u9f20\u7684\u4e00\u534a\uff0c\u800c\u8865\u5145NMN\u540e\uff0c\u5176\u63a2\u7d22\u65f6\u95f4\u6062\u590d\u5230\u4e0e\u5065\u5eb7\u5927\u9f20\u4e00\u81f4\u7684\u6c34\u5e73\u3002<\/p>\n

\n
\"\u56fe2
\u56fe2 Y\u8ff7\u5bab<\/figcaption><\/figure>\n<\/div>\n

\u672c\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0c\u8865\u5145NMN\u53ef\u4ee5\u6291\u5236\u7cd6\u5c3f\u75c5\u5bfc\u81f4\u7684NAD+\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u4ece\u800c\u4fdd\u62a4\u795e\u7ecf\u5143\uff0c\u9632\u6b62\u5927\u8111\u6d77\u9a6c\u533a\u53d1\u751f\u840e\u7f29\uff0c\u4fdd\u7559\u8ba4\u77e5\u4e0e\u8bb0\u5fc6\u80fd\u529b\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u5173\u4e8eNMN\u7684\u7814\u7a76\u5df2\u7ecf\u9010\u6e10\u6df1\u5165\uff0c\u9664\u4e86\u5728\u795e\u7ecf\u548c\u8111\u840e\u7f29\u65b9\u9762\uff0c\u8fd8\u6709\u9aa8\u9abc\u3001\u808c\u80a4\u3001\u5668\u5b98\u4fee\u590d\u7b49\u65b9\u9762\uff0c\u6bd4\u5982\u65e5\u672c\u91d1\u6cfd\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8865\u5145NAD+\u524d\u4f53\u53ef\u4ee5\u63d0\u9ad8\u5c0f\u9f20\u9762\u90e8\u795e\u7ecf\u635f\u4f24\u540e\u4fee\u590d\u80fd\u529b\uff1b\u745e\u58eb\u4e00\u9879\u7814\u7a76\u8bc1\u5b9e\u8865\u5145NMN\u53ef\u663e\u8457\u63d0\u9ad8\u808c\u8089\u5e72\u7ec6\u80de\u7684\u6570\u91cf\u7b49\u7b49\u3002\u603b\u7684\u6765\u8bf4\uff0cNMN\u5df2\u7ecf\u5728\u591a\u4e2a\u9886\u57df\u53d1\u5149\u53d1\u70ed\uff0c\u6216\u8bb8\u6211\u4eec\u53ef\u4ee5\u671f\u5f85\u5b83\u88ab\u771f\u6b63\u6295\u5165\u5230\u5b9e\u9645\u5e94\u7528\u4e2d\u7684\u6548\u679c\u3002<\/p>\n<\/div>\n

\n
\n
\u53c2\u8003\u6587\u732e<\/div>\n
\n
\n
\n

[1] Lee, H. J. et al. Diabetes and Alzheimer\u2019s Disease. Mechanisms and Nutritional Aspects. Clinical nutrition research 7, 229\u2013240; 10.7762\/cnr.2018.7.4.229 (2018).<\/span><\/p>\n

[2] Chandrasekaran, K. et al. Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons. International journal of molecular sciences 21; 10.3390\/ijms21113756 (2020).<\/span><\/p>\n

\u6587\u7ae0\u6765\u6e90\uff1a\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\u7814\u7a76\u53d1\u73b0\uff1a\u03b2\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u53ef\u4ee5\u4fdd\u62a4\u5927\u9f20\u795e\u7ecf\u5143\uff0c\u4fdd\u7559\u8ba4\u77e5\u529f\u80fd\uff5cNMN\u4e2d\u56fd<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/div>\n

<\/path><\/svg><\/i> \"Loading\"<\/p>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\u6587\u7ae0\u8bc1\u5b9e\uff1a\u8865\u5145NMN\uff08\u03b2\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u53ef\u4fee\u590d\u7cd6\u5c3f\u75c5\u5927\u9f20\u7ebf\u7c92\u4f53\u635f\u4f24\uff0c\u4fdd\u62a4\u5927\u8111\u6d77\u9a6c\u533a\u7684\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u63d0\u9ad8\u795e\u7ecf\u5143\u5b58\u6d3b\u7387\u5e76\u4fc3\u8fdb\u518d\u751f\uff0c\u4ece\u800c\u9632\u6b62\u5927\u8111\u6d77\u9a6c\u533a\u840e\u7f29\uff0c\u4fdd\u7559\u8ba4\u77e5\u529f\u80fd\u548c\u8bb0\u5fc6\u529b\u3002 \u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53d1\u751f\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u7684\u98ce\u9669\u8fdc\u9ad8\u4e8e\u5065\u5eb7\u4eba\u7fa4\u3002\u4e0e\u5065\u5eb7\u4eba\u7fa4\u76f8\u6bd4\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f53\u5185\u7684NAD+\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09\u5206\u5b50\u6c34\u5e73\u964d\u4f4e\uff0c\u800cNAD+\u7f3a\u4e4f\u4f1a\u5bfc\u81f4\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\uff0c\u8fdb\u800c\u9020\u6210\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u5927\u8111\u840e\u7f29\uff0c\u53d1\u751f\u8ba4\u77e5\u969c\u788d\u7b49\u98ce\u9669\u3002<\/p>\n

<\/div>\n

<\/path><\/svg><\/i> \"Loading\"<\/p>\n

<\/div>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,581,304,431],"class_list":["post-19226","post","type-post","status-publish","format-standard","hentry","category-nmn-","category-272","tag-nmn","tag-581","tag-304","tag-431"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19226"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19226\/revisions"}],"predecessor-version":[{"id":19228,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/19226\/revisions\/19228"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19226"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}