{"id":190,"date":"2022-02-26T14:33:17","date_gmt":"2022-02-26T14:33:17","guid":{"rendered":"http:\/\/choosebiz.me\/?p=190"},"modified":"2022-05-27T03:10:23","modified_gmt":"2022-05-27T03:10:23","slug":"nmn%e7%9a%84%e4%ba%ba%e4%bd%93%e8%af%95%e9%aa%8c","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=190","title":{"rendered":"NMN\u7684\u4eba\u4f53\u8bd5\u9a8c"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17495\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/111.jpg\" alt=\"\" width=\"1200\" height=\"677\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/111.jpg 1200w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/111-300x169.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/111-1024x578.jpg 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/111-768x433.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>\u8981\u4f7f NMN \u88ab FDA \u6279\u51c6\u4e3a\u6cbb\u7597\u5236\u5242\uff0c\u5fc5\u987b\u8bc1\u660e\u8fd9\u79cd NAD+ \u524d\u4f53\u5728\u6cbb\u7597\u4eba\u7c7b\u75be\u75c5\u65b9\u9762\u65e2\u5b89\u5168\u53c8\u6709\u6548\u3002 \u8fd9\u4e9b\u7814\u7a76\u901a\u5e38\u7531\u4e34\u5e8a\u524d\u7814\u7a76\u63d0\u4f9b\u4fe1\u606f\u548c\u6307\u5bfc\u2500\u2500\u8fd9\u662f\u4e00\u4e2a\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u524d\u5f00\u59cb\u7684\u7814\u7a76\u9636\u6bb5\uff0c\u5728\u6b64\u671f\u95f4\u6536\u96c6\u91cd\u8981\u7684\u53ef\u884c\u6027\u4e36\u8fed\u4ee3\u6d4b\u8bd5\u548c\u836f\u7269\u5b89\u5168\u6570\u636e\uff0c\u901a\u5e38\u662f\u5728\u5b9e\u9a8c\u5ba4\u52a8\u7269\u6216\u57f9\u517b\u7684\u4eba\u4f53\u7ec6\u80de\u4e2d\u6765\u8fdb\u884c\u3002<\/p>\n<p>\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0cNMN \u53ef\u4ee5\u5f25\u8865\u556e\u9f7f\u52a8\u7269 NAD+ \u4e0e\u5e74\u9f84\u548c\u75be\u75c5\u76f8\u5173\u7684\u7f3a\u9677\u3002 \u8fd9\u4e9b\u4e34\u5e8a\u524d\u7814\u7a76\u662f\u5728\u4eba\u7c7b\u7814\u7a76\u4e4b\u524d\u5efa\u7acb\u4e34\u5e8a\u4ef7\u503c\u57fa\u7840\u6240\u5fc5\u9700\u7684\uff0c\u8868\u660e NMN \u53ef\u4ee5\u63d0\u9ad8 NAD+ \u6c34\u5e73\u5e76\u5f71\u54cd\u556e\u9f7f\u52a8\u7269\u7684\u5065\u5eb7\u548c\u5bff\u547d\u3002<!--more--><\/p>\n<p>\u8fd9\u4e9b\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u7ed3\u679c\u4e3a\u6d4b\u8bd5 NMN \u7684\u76ca\u5904\u662f\u5426\u8f6c\u5316\u4e3a\u4eba\u7c7b\u94fa\u5e73\u4e86\u9053\u8def\u3002 \u5df2\u7ecf\u542f\u52a8\u4e86\u51e0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6765\u7814\u7a76 NMN \u5bf9\u4eba\u4f53\u751f\u7406\u548c\u5065\u5eb7\u7684\u5b89\u5168\u6027\u548c\u76ca\u5904\u3002 \u8fc4\u4eca\u4e3a\u6b62\uff0c\u5df2\u7ecf\u5b8c\u6210\u4e86\u4e24\u9879\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u663e\u793a\u4e86 NMN \u5728\u4eba\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u76ca\u5904\u3002<\/p>\n<p>\u51e0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u6216\u6b63\u5728\u7814\u7a76\u673a\u6784\u6216\u5927\u5b66\u4ee5\u53ca\u751f\u7269\u6280\u672f\u516c\u53f8\u8fdb\u884c\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u6b63\u5728\u8fdb\u884c\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff1a<\/p>\n<p>2021\u5e746\u670830\u65e5\uff0c\u5b8c\u6210\u4e86\u9898\u4e3a\u201c<strong><span style=\"color: #ff0000;\">\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\u201d\uff08NMN\uff09\u5bf9\u5fc3\u810f\u4ee3\u8c22\u529f\u80fd\u7684\u5f71\u54cd\u7684\u4e34\u5e8a\u8bd5\u9a8c(\u7f16\u53f7:NCT03151239<\/span><\/strong>)\u3002 \u8fd9\u9879\u7814\u7a76\u7740\u773c\u65bc\u6444\u53d6 500 mg NMN \u81f3\u5c11\u516b\u5468\u5bf9\u57fa\u672c\u5fc3\u8840\u7ba1\u548c\u4ee3\u8c22\u529f\u80fd\u7684\u5b89\u5168\u6027\u548c\u5f71\u54cd\uff0c\u7279\u522b\u662f\u7cd6\u5c3f\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u91cd\u8981\u5371\u9669\u56e0\u7d20\u3002 \u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86 NMN \u5bf9\u6fc0\u7d20\u80f0\u5c9b\u7d20\u63a7\u5236\u8840\u7cd6\u7684\u6548\u679c\u7684\u5f71\u54cd\u3002 \u7814\u7a76\u4eba\u5458\u8fd8\u5c06\u7814\u7a76 NMN \u5bf9\u8840\u8102\u4e36\u8eab\u4f53\u548c\u809d\u810f\u8102\u80aa\u4ee5\u53ca\u5fc3\u8840\u7ba1\uff08\u5fc3\u810f\uff09\u548c\u4ee3\u8c22\u5065\u5eb7\u7684\u5176\u4ed6\u8840\u6db2\u4e36\u8102\u80aa\u7ec4\u7ec7\u548c\u808c\u8089\u7ec4\u7ec7\u6807\u5fd7\u7269\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u4e5f\u5728\u8fdb\u884c\u53e6\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c(\u7f16\u53f7: NCT04571008)\uff0c\u9898\u4e3a NMN \u8865\u5145\u5bf9\u5668\u5b98\u7cfb\u7edf\u751f\u7269\u5b66 (VAN) \u7684\u5f71\u54cd\uff0c\u8be5\u8bd5\u9a8c\u65bc 2020 \u5e74 10 \u6708\u5f00\u59cb\uff0c\u76ee\u6807\u5b8c\u6210\u65e5\u671f\u4e3a 2025 \u5e74 9 \u6708\u3002 \u8fd9\u9879\u7814\u7a76\u662f\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8865\u5145\u8bd5\u9a8c (\u7f16\u53f7:NCT03151239)\uff0c\u91c7\u7528\u7c7b\u4f3c\u7684\u808c\u8089\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u6d4b\u91cf\u3002 \u4e3b\u8981\u533a\u522b\u5728\u65bc\uff0c\u8be5\u8bd5\u9a8c\u5728\u66f4\u957f\u7684\u65f6\u95f4\u5185\uff0816 \u5468\uff09\u8bc4\u4f30\u4e86\u8f83\u4f4e\u5242\u91cf\u7684 NMN\uff08300 mg\uff09\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u745e\u58eb\u751f\u7269\u6280\u672f\u516c\u53f8 Seneque SA \u6b63\u5728\u5bf9 NMN \u8fdb\u884c\u5404\u79cd\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u4e00\u9879\u5df2\u5b8c\u6210\uff0c\u4e24\u9879\u6b63\u5728\u8fdb\u884c\u4e2d\uff1a<\/p>\n<p>\u5df2\u5b8c\u6210\u7684\u4e34\u5e8a\u8bd5\u9a8c(\u7f16\u53f7: NCT04685096)\uff0c\u9898\u4e3a\u542b\u6709 N<strong><span style=\"color: #ff0000;\">MN (2%) \u4e0e\u5b89\u6170\u5242\u7684\u5316\u5986\u54c1\u914d\u65b9\u7684\u6297\u8870\u8001\u529f\u6548<\/span><\/strong>\uff0c\u65bc 2021 \u5e74 4 \u6708 16 \u65e5\u5b8c\u6210\u3002\u8be5\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\u63a5\u53d7\u542b\u6709 NMN (2%) \u7684\u5316\u5986\u54c1\u914d\u65b9\u7684\u4e9a\u6d32\u548c\u975e\u88d4\u7f8e\u56fd\u5065\u5eb7\u5fd7\u613f\u8005\u961f\u5217\u7684\u76ae\u80a4\u76b1\u7eb9\u4e36\u6d6e\u80bf\u548c\u75b2\u52b3\u9ed1\u773c\u5708\u5916\u89c2\u3002 \u4e0e\u53c2\u8003\u5316\u5986\u54c1\u914d\u65b9\u76f8\u6bd4\uff0c\u5728\u6bcf\u5929\u4e24\u6b21\u4f7f\u7528 28 \u5929\u548c 56 \u5929\u5f8c\uff0c\u4f7f\u7528\u76ae\u80a4\u75c5\u5b66\u63a7\u5236\u4e0b\u7684\u4e34\u5e8a\u8bc4\u5206\u5bf9\u4ea7\u54c1\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p>\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c (\u7f16\u53f7:NCT04862338)\uff0c\u9898\u4e3a\u201c<strong><span style=\"color: #ff0000;\">\u5065\u5eb7\u6210\u4eba\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff0c400 mg\/\u5929\uff09\u7684\u836f\u6548\u5b66\u548c\u8010\u53d7\u6027<\/span><\/strong>\u201d\uff0c\u76ee\u6807\u5b8c\u6210\u65e5\u671f\u4e3a 2021 \u5e74 10 \u6708 1 \u65e5\u3002\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0cSenesque SA \u6b63\u5728\u8bc4\u4f30\u5176\u751f\u7406\u548c\u751f\u7269\u5b66\u4f5c\u7528\u901a\u8fc7\u7814\u7a76\u8be5\u4ea7\u54c1\u7684\u8010\u53d7\u6027\u548c\u836f\u6548\u5b66\uff0c\u5728 28 \u5929\u5185\u63a5\u53d7\u91cd\u590d\u5242\u91cf\u7684\u5065\u5eb7\u6210\u4eba\u7684\u4e13\u6709 NMN \u8865\u5145\u5242 (NMN-C)\u3002 \u4e34\u5e8a\u8bd5\u9a8c\u5c06\u6d4b\u91cf\u670d\u7528 NMN \u5f8c\u7b2c 14 \u5929\u548c\u7b2c 28 \u5929\u8840\u6db2 NAD+ \u6c34\u5e73\u7684\u53d8\u5316\uff0c\u5e76\u8bc4\u4f30\u7814\u7a76\u53c2\u4e0e\u8005\u7684\u4e0d\u826f\u751f\u7406\u4e8b\u4ef6\uff0c\u4f8b\u5982\u9ad8\u8840\u538b\u6216\u5fc3\u7387\u6ce2\u52a8\u3002 \u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5b8c\u6210\u62db\u52df\uff0c\u6b63\u5728\u79ef\u6781\u5f00\u5c55\u4e2d\u3002<\/p>\n<p>Senesque SA \u6b63\u5728\u8fdb\u884c\u7684\u7b2c\u4e8c\u9879\u4e34\u5e8a\u8bd5\u9a8c (\u7f16\u53f7:NCT04664361)\uff0c\u9898\u4e3a <strong><span style=\"color: #ff0000;\">NMN \u5bf9\u4e2d\u7b49\u4f53\u529b\u6d3b\u52a8\u7684\u5065\u5eb7\u5fd7\u613f\u8005\u7684\u808c\u8089\u6062\u590d\u548c\u4f53\u80fd\u7684\u5f71\u54cd<\/span><\/strong>\uff0c\u81ea 2021 \u5e74 3 \u6708 9 \u65e5\u8d77\u4e00\u76f4\u5728\u62db\u52df\u53c2\u4e0e\u8005\u3002\u672c\u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4f30 NMN \u8865\u5145\u5242\u7684\u6548\u679c \uff08250 \u548c 500 mg\/\u5929\uff0c\u8d85\u8fc7 38 \u5929\uff09\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5728\u808c\u8089\u6062\u590d\u4e36\u4f53\u80fd\u4e36\u5fc3\u80ba\u6062\u590d\u548c\u5bf9\u52aa\u529b\u7684\u8270\u5de8\u6027\u7684\u611f\u77e5\u65b9\u9762\u8fdb\u884c\u9002\u5ea6\u4f53\u80b2\u953b\u70bc\u3002 \u8be5\u7814\u7a76\u8fd8\u5c06\u7814\u7a76\u4f53\u80b2\u953b\u70bc\u524d\u5f8c\u7684\u8840\u4e73\u9178\u6c34\u5e73\u4e36\u5bf9\u8fd0\u52a8\u5f8c\u808c\u8089\u75bc\u75db\uff08\u75c9\u631b\uff09\u5f3a\u5ea6\u7684\u611f\u77e5\u4e36\u8eab\u4f53\u6210\u5206\u548c\u8840\u6db2\u4e2d\u7684 NAD+ \u6c34\u5e73\u3002<\/p>\n<p>NMN\u7684\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u5982\u706b\u5982\u837c\u7684\u8fdb\u884c\u5f53\u4e2d\uff0c\u76f8\u4fe1\u5728\u4e0d\u4e45\u7684\u5c06\u6765\uff0c\u6211\u4eec\u5c06\u4f1a\u770b\u5230\u66f4\u591a\u79d1\u5b66\u5b9e\u8bc1\u7684\u8bc1\u636e\u6765\u8868\u660eNMN\u5728\u4eba\u4f53\u4e0a\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p>\u6587\u7ae0\u6765\u6e90: https:\/\/www.nmn.com\/clinical-trials<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_190\" class=\"pvc_stats all  \" data-element-id=\"190\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 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