{"id":18864,"date":"2022-08-29T00:42:43","date_gmt":"2022-08-29T00:42:43","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18864"},"modified":"2022-08-29T01:10:43","modified_gmt":"2022-08-29T01:10:43","slug":"nmn%e5%8f%af%e4%bb%a5%e4%bf%ae%e5%a4%8d%e5%8f%97%e6%8d%9f%e5%8f%8a%e9%80%80%e5%8c%96%e7%9a%84dna%e8%ae%a9%e8%ba%ab%e4%bd%93%e5%b9%b4%e8%bd%bb20%e5%b9%b4","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18864","title":{"rendered":"NMN\u53ef\u4ee5\u4fee\u590d\u53d7\u635f\u53ca\u9000\u5316\u7684DNA\u8ba9\u8eab\u4f53\u5e74\u8f7b20\u5e74"},"content":{"rendered":"

\u4eba\u7c7b\u4e3a\u4ec0\u4e48\u4f1a\u8870\u8001\uff1f \u8870\u8001\u6700\u4e3b\u8981\u539f\u56e0\u53ef\u5f52\u7c7b\u4e8e\u4ee5\u4e0b\u4e24\u70b9\uff1a<\/span><\/p>\n

    \n
  1. \n

    NAD+ \u4ea7\u91cf\u4e0b\u964d<\/p>\n<\/li>\n

  2. \n

    \u7ec6\u80de\u529f\u80fd\u8870\u9000<\/p>\n<\/li>\n<\/ol>\n

    \u5fb7\u56fd\u751f\u7406\u5b66\u5bb6Otto Warburg\u4e8e 1930\u5e74\u53d1\u73b0NAD+ \uff08\u8bfa\u52a0\u56e0\u5b50\uff09\u5bf9\u4eba\u4f53\u5bff\u547d\u5177\u6709\u5173\u5065\u4f5c\u7528\uff0cOtto Warburg\u6307\u51fa\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u4eba\u4f53\u5185 NAD+ \u6c34\u5e73\u5448\u73b0\u65ad\u5d16\u5f0f\u4e0b\u964d\uff0c\u8fdb\u800c\u5bfc\u81f4\u751f\u7269\u4f53\u7ec6\u80de\u80fd\u91cf\u7684\u53d1\u7535\u673a – \u7c92\u7ebf\u4f53\u529f\u80fd\u8870\u9000<\/strong><\/u>\uff0c\u968f\u4e4b\u8111\u90e8\u7ec6\u80de\u6d3b\u529b\u4e0b\u964d\uff0c\u8870\u7aed\u8001\u5316\uff0c\u4fc3\u4f7f\u4eba\u4f53Sirtuins\u957f\u5bff\u57fa\u56e0\u5931\u53bb\u6d3b\u6027 \uff0c\u89e6\u53d1\u8870\u8001\uff0c\u5bfc\u81f4\u8eab\u4f53\u5404\u79cd\u673a\u80fd\u7684\u8870\u9000\u3002<\/span><\/p>\n

    \"\"<\/p>\n

    \u957f\u5bff\u51bb\u9f84\u79d8\u8bc0\uff1a \u8ba9\u7ec6\u80de\u5e74\u8f7b\u5316<\/strong><\/span><\/h3>\n

    \u8ba9\u7ec6\u80de\u5e74\u8f7b\u5316\u8981\u505a\u5bf9\u4ee5\u4e0b\u4e09\u4ef6\u4e8b\uff1a<\/span><\/p>\n

      \n
    1. \n
        \n
      1. \n

        \u4f7f\u7c92\u7ebf\u4f53\uff08\u7ec6\u80de\u53d1\u7535\u673a\uff09 \u5065\u5eb7\u8fd0\u4f5c<\/p>\n<\/li>\n

      2. \n

        \u63d0\u9ad8Sirtuins\uff08\u957f\u5bff\u57fa\u56e0\u548c\u6297\u538b\u56e0\u5b50\uff09\u6d3b\u6027<\/p>\n<\/li>\n

      3. \n

        \u63d0\u9ad8AMPK\uff08\u4ee3\u8c22\u63a2\u6d4b\u5668\uff09\u6d3b\u6027<\/p>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

        \u7c92\u7ebf\u4f53\uff1a \u4e3b\u8981\u4e3a\u7ec6\u80de\u6d3b\u52a8\u63d0\u4f9b\u80fd\u91cf\uff0c\u6240\u4ee5\u6709\u300c\u7ec6\u80de\u53d1\u7535\u673a\u300d\u4e4b\u79f0\u3002<\/span><\/p>\n

        \u4ec0\u4e48\u662f\u7c92\u7ebf\u4f53\uff1f<\/strong><\/span><\/h3>\n
        \"\"<\/div>\n
        \n
        \n
        \n
        <\/div>\n
        \u4eba\u4f53\u6bcf\u4e2a\u5668\u5b98\u90fd\u6709\u7ec6\u80de\uff0c\u6bcf\u4e2a\u7ec6\u80de\u90fd\u6709\u7c92\u7ebf\u4f53\uff0c\u8d1f\u8d23\u4ea7\u751f\u4eba\u4f5390%\u7684\u80fd\u91cf\u3002 \u7c92\u7ebf\u4f53\u529f\u80fd\u5982\u4e0b\uff1a<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
        <\/div>\n
          \n
        • \n
            \n
          • \n

            \u5c06\u98df\u7269\u4e2d\u53d6\u5f97\u7684\u8425\u517b\u8f6c\u6362\u6210\u80fd\u91cf\u4f9b\u7ec6\u80de\u8fd0\u4f5c<\/p>\n<\/li>\n

          • \n

            \u6392\u51fa\u9020\u6210\u8001\u5316\u7684\u6d3b\u6027\u6c27\uff08\u81ea\u7531\u57fa\uff09<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

            \u4eba\u4f53\u81ea30\u300140\u5c81\u8d77\u7c92\u7ebf\u4f53\u6d3b\u6027\u5c31\u4f1a\u5f00\u59cb\u8870\u9000\uff0c\u8fdb\u800c\u5bfc\u81f4\u5927\u91cf\u6d3b\u6027\u6c27\u56e4\u79ef\u4e8e\u4f53\u5185\u653b\u51fb\u81ea\u5df1\u7684\u7ec6\u80de\uff0c\u9020\u6210\u7ec6\u80de\u635f\u4f24\u3002 \u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u8eab\u4f53\u7c92\u7ebf\u4f53\u80fd\u91cf\u4e0d\u8db3\u3001DNA\u7834\u574f\u53d7\u635f\uff0c\u4e3a\u4e86\u751f\u5b58\u9700\u6c42\uff0c\u8eab\u4f53\u4f18\u5148\u5c06\u80fd\u91cf\u4f9b\u4f5c\u547c\u5438\u548c\u4f53\u6e29\u8c03\u8282\u4f7f\u7528\uff0c\u7ed3\u679c\u4f7f\u5f97Sirtuins\u957f\u5bff\u57fa\u56e0\u4fee\u590d\u5de5\u4f5c\u65e0\u6cd5\u8fdb\u884c\uff0c\u8fdb\u800c\u5bfc\u81f4\u8870\u5f31\u3001\u8001\u5316\u4ee5\u53ca\u75c5\u75c7\/\u764c\u75c7<\/strong><\/u>\u3002 <\/strong> \u56e0\u6b64\uff0c\u7c92\u7ebf\u4f53\u7684\u6d3b\u8dc3\u7a0b\u5ea6\u4e0e\u957f\u5bff\u6709\u6781\u5927\u7684\u5173\u8fde\uff0c\u7c92\u7ebf\u4f53\u8981\u5065\u5eb7\u5c31\u8981\u63d0\u4f9b\u8db3\u591f\u71c3\u6599\u7ed9\u5b83\u8fd0\u4f5c\uff0c\u800c\u7c92\u7ebf\u4f53\u7684\u71c3\u6599\u5c31\u662fNAD+ \uff08co-enzyme \u8f85\u9176\uff09\u3002 \u53ea\u8981\u6709\u8db3\u591f\u71c3\u6599\uff0c\u5de5\u5382\uff08\u53d1\u7535\u673a\uff09\u5c31\u4f1a\u7ee7\u7eed\u8fd0\u4f5c\uff0c\u7c92\u7ebf\u4f53\u5c31\u4e0d\u4f1a\u8870\u8001\/\u574f\u6b7b\u3002<\/span><\/p>\n

            \"\"<\/h3>\n

            NMN \u4e3a\u7ebf\u7c92\u4f53\uff08\u7ec6\u80de\u53d1\u7535\u673a\uff09\u63d0\u4f9b\u71c3\u6599\uff08NAD+\uff09\uff0c\u4f7f\u7c92\u7ebf\u4f53\u5065\u5eb7\u5730\u8fd0\u4f5c\uff0c\u4fdd\u6301\u7ec6\u80de\u7684\u6d3b\u529b\u4e0e\u9752\u6625<\/em><\/p>\n

            \u6709\u5173\u6297\u8870\u8001\uff0c\u4f60\u5fc5\u987b\u8981\u77e5\u9053\u7684\u7269\u8d28NAD+<\/strong><\/span><\/h3>\n

            NAD+ \uff08Nicothamide Adenine Dinucleotide \u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09 \u662f\u4e0e\u4eba\u4f53\u8870\u8001\u6709\u7740\u5bc6\u5207\u5173\u7cfb\u7684\u4e00\u79cd\u91cd\u8981\u7269\u8d28\u3002 NAD+\u6fc0\u6d3b\u957f\u5bff\u86cb\u767dsirtuins\u8425\u517b\u7ec6\u80de\u7684\u5173\u952e\u300c\u8f85\u9176\u300dCo-enzyme\uff0c\u4e3a\u4eba\u4f53\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u63d0\u4f9b\u80fd\u91cf \uff08\u80fd\u91cf\u5236\u9020\u56e0\u5b50 \/\u300c\u53d1\u7535\u673a\u300d\u7684\u71c3\u6599\uff09<\/strong><\/u>\uff0c\u53ef\u589e\u5f3a\u4eba\u4f53\u7ec6\u80de\u6d3b\u6027\uff0c\u5ef6\u957f\u7ec6\u80de\u8870\u8001\u5468\u671f\uff0c \u63a8\u8fdf\u8870\u8001\uff0c\u5ef6\u957f\u5bff\u547d\uff0c\u4fc3\u8fdb\u4eba\u4f53\u5065\u5eb7\u514d\u75ab\u3002 \u800c\u5f53NAD+\u4ea7\u91cf\u4e0b\u964d\u65f6\uff0c\u8eab\u4f53\u4e0d\u591f\u71c3\u6599\uff0c\u4fbf\u4f1a\u51fa\u73b0\u4ee5\u4e0b\u673a\u80fd\u8870\u8001\u73b0\u8c61\uff1a<\/span><\/p>\n

            <\/div>\n
              \n
            • \n

              \u5927\u8111\u53ca\u795e\u7ecf\u7cfb\u7edf\uff1a \u8bb0\u5fc6\u529b\u8870\u9000\uff0c\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d<\/p>\n<\/li>\n

            • \n

              \u5668\u5b98\u529f\u80fd\u8870\u9000 \u2013 \u8111\u3001\u795e\u7ecf\u3001\u5fc3\u810f\u3001\u809d\u3001\u80ba\u3001\u80be\u3001\u80a0\u9053\u3001\u773c\u3001\u76ae\u80a4\u3001\u808c\u8089\u3001\u8840\u6db2\u5faa\u73af<\/p>\n<\/li>\n

            • \n

              \u4f53\u529b\u4e0d\u8db3\u3001\u514d\u75ab\u529b\u4f4e<\/p>\n<\/li>\n

            • \n

              \u7761\u7720\u8d28\u7d20\u4e0d\u4f73<\/p>\n<\/li>\n

            • \n

              \u808c\u80a4\u677e\u5f1b\u3001\u80a4\u8272\u6697\u54d1\u3001\u76b1\u7eb9\u6d6e\u73b0<\/p>\n<\/li>\n

            • \n

              \u51fa\u73b0\u767d\u53d1\u95ee\u9898<\/p>\n<\/li>\n

            • \n

              \u8d1f\u8377\/\u538b\u529b\u5927\u3001\u7cbe\u795e\u6b20\u4f73<\/p>\n<\/li>\n<\/ul>\n

              <\/div>\n
              \n

              \u300c\u957f\u5bff+\u6297\u8870\u8001\u300d\u76f4\u63a5\u8865\u5145NAD+ \u5c31\u53ef\u4ee5\u4e86\u5417\uff1f<\/strong><\/span><\/h3>\n

              \u7814\u7a76\u53d1\u73b0\uff0cNAD+\u5206\u5b50\u8f83\u5927\uff0c\u5f88\u96be\u900f\u8fc7\u7ec6\u80de\u819c\u8fdb\u5165\u7ec6\u80de\u5185<\/strong>\uff0c\u56e0\u6b64\u65e0\u6cd5\u4ece\u98df\u7269\u6216\u5916\u754c\u76f4\u63a5\u8865\u5145\u3002 \u770b\u5230\u8fd9\u91cc\u4e5f\u4e0d\u7528\u5931\u671b\uff0c\u56e0\u4e3a\u7ecf\u8fc7\u591a\u5e74\u7684\u8bc1\u5b9e\uff0c\u4e0d\u5c11NAD+\u76f8\u5173\u79d1\u5b66\u7814\u7a76\u5e26\u6765\u4e86\u66d9\u5149\uff1a<\/span><\/p>\n

              <\/div>\n
                \n
              • \n

                2013\u5e74\uff0c David Sinclai\u6559\u6388\u7814\u7a76\u53d1\u73b0\u8865\u5145NMN\u80fd\u63d0\u5347\u4f53\u5185NAD+\u6c34\u5e73\uff0c\u6fc0\u6d3b\u957f\u5bff\u56e0\u5b50\uff0c\u5ef6\u7f13\u8870\u8001<\/span>\u3002 <\/strong><\/p>\n<\/li>\n

              • \n

                2016\u5e74\uff0c\u54c8\u4f5b\u5927\u5b66\u3001\u534e\u76db\u987f\u5927\u5b66\u3001\u65e5\u672c\u5e86\u5e94\u5927\u5b66\u7b49\u90fd\u76f8\u7ee7\u53d1\u5e03NMN\u6297\u8870\u8001\u7814\u7a76\u62a5\u544a\uff0c\u6307NMN\u53ef\u6062\u590d\u7ec6\u80de\u5e74\u8f7b\uff0c\u5ef6\u957f\u4eba\u4f53\u751f\u547d\u3002 \u670d\u7528NMN\u540e\uff0c\u53ef\u6709\u6548\u8fc5\u901f\u8fdb\u5165\u8840\u6db2\u5e76\u4f5c\u7528\u4e8e\u5176\u4ed6\u8eab\u4f53\u7ec4\u7ec7\uff0c\u63d0\u5347 NAD+ \u6c34\u5e73\uff0c\u9006\u8f6c\u7ec6\u80de\u8870\u8001\u4f5c\u7528\u3002 <\/strong><\/span><\/p>\n<\/li>\n

              • \n

                2019\u5e74\u521d\uff0c\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u7684\u533b\u5b66\u535a\u58eb\u4eca\u4e95\u4f38\u4e00\u90ce\u5728NATURE\u4e0a\u53d1\u8868\u7684\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0cNMN\u53ef\u4ee5\u901a\u8fc7\u7ec6\u80de\u4e0a\u7684\u8f6c\u8fd0\u86cb\u767d\u8fdb\u5165\u7ec6\u80de\u3002 \u79d1\u5b66\u5bb6\u5df2\u7ecf\u786e\u8ba4\u4eba\u4f53\u8865\u5145NMN \u540e\uff0c\u53ef\u4ee5\u901a\u8fc7\u4e00\u7cfb\u5217\u7b80\u5355\u7684\u5316\u5b66\u53cd\u5e94\u76f4\u63a5\u8f6c\u5316\u6210\u4e3a\uff08NAD+\uff09<\/span>\u3002 <\/strong><\/p>\n<\/li>\n

              • \n

                2019\u5e742\u6708\uff0c\u65e5\u672cShinkowa\uff08\u65b0\u5174\u548c\uff09\u5236\u836f\u6709\u9650\u516c\u53f8\u53d1\u5e03\u300a\u957f\u671f\uff0824\u5468\uff09\u53e3\u670dNMN \u5bf9\u4eba\u4f53\u7684\u76ca\u5904\u300b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u671f\u62a5\u544a\uff0c \u8bc1\u5b9e\u4eba\u4f53\u53e3\u670dNMN\u540e\uff0c\u5bf9sirtuins\u957f\u5bff\u86cb\u767d\u53ca\u591a\u79cd\u7c7b\u578b\u6fc0\u7d20\u8868\u8fbe\u90fd\u6709\u6240\u589e\u52a0\uff0c \u56e0\u4e3a\u7ebf\u7c92\u4f53\u6ee1\u5e03\u5168\u8eab\u6240\u6709\u5668\u5b98\u91cc\u7684\u7ec6\u80de\uff0c\u53ea\u8981\u7ebf\u7c92\u4f53\u5065\u5eb7\u5c31\u4f1a\u5bf9\u8eab\u4f53\u4ea7\u751f\u5f88\u591a\u597d\u5904\uff1a\u6539\u5584\u8eab\u4f53\u8840\u6db2\u5faa\u73af\uff0c\u7ef4\u6301\u80a0\u9053\u5065\u5eb7\uff0c\u8c03\u6574\u80a0\u9053\u7cfb\u7edf\uff0c\u7ef4\u6301\u514d\u75ab\u548c\u795e\u7ecf\u7cfb\u7edf\u5065\u5eb7 \uff0c\u5f3a\u5316\u808c\u8089\uff0c\u7ef4\u6301\u80ba\u90e8\u5065\u5eb7\uff0c\u4fc3\u8fdb\u8111\u90e8\u3001\u5fc3\u810f\u548c\u809d\u810f\u529f\u80fd\uff0c\u6297\u808c\u80a4\u8870\u8001\uff0c\u4fdd\u62a4\u773c\u775b\u7b49<\/span>\u7b49\u22ef\u22ef <\/strong><\/p>\n<\/li>\n<\/ul>\n

                <\/div>\n<\/div>\n
                \n

                \u957f\u5bff\u57fa\u56e0 Sirtuins Activities \u6d3b\u6027 & AMPK Activities \u4ee3\u8c22\u63a2\u6d4b\u5668\u6d3b\u6027<\/strong><\/span><\/h3>\n

                \u957f\u5bff\u57fa\u56e0\uff08\u6297\u538b\u56e0\u5b50\u7684\u6d3b\u6027\uff09\u4e3b\u8981\u7528\u5904\uff1a<\/strong><\/u><\/span><\/p>\n

                  \n
                • \n
                    \n
                  • \n

                    \u5bf9\u6297\u538b\u529b\u5f15\u53d1\u7684\u81ea\u7531\u57fa\u5bf9\u7ec6\u80de\u7684\u635f\u5bb3<\/p>\n<\/li>\n

                  • \n

                    \u51cf\u4f4eDNA\u7a81\u53d8\u673a\u4f1a<\/p>\n<\/li>\n

                  • \n

                    \u63a7\u5236\u8eab\u4f53\u5404\u4e2a\u53d1\u708e\u90e8\u4f4d<\/p>\n<\/li>\n

                  • \n

                    \u9700\u8981NAD+\u6765\u8fd0\u4f5c<\/strong><\/u><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                    AMPK\uff08\u4ee3\u8c22\u63a2\u6d4b\u5668\u7684\u6d3b\u6027\uff09\u7684\u4f5c\u7528\uff1a<\/strong><\/u><\/span><\/p>\n

                      \n
                    • \n
                        \n
                      • \n

                        \u4e3a\u7ec6\u80de\u5f00\u6e90\u8282\u6d41\uff08\u80fd\u91cf\u4e0a\uff09\uff1a\u63a2\u6d4b\u7ec6\u80de\u662f\u5426\u9700\u8981\u80fd\u91cf\uff0c\u5982\u9700\u8981\u4fbf\u4f1a\u63d0\u4f9b; \u63a2\u6d4b\u9700\u8981\u4ee3\u8c22\u7684\u574f\u7ec6\u80de\/\u7c92\u7ebf\u4f53\/DNA\uff0c\u4fbf\u4f1a\u6e05\u7406\/\u51c0\u5316<\/p>\n<\/li>\n

                      • \n

                        \u51cf\u5c11\u7cd6\u5f15\u53d1\u7684\u53d1\u708e\u548c\u7ef4\u6301\u5065\u5eb7\u8840\u7cd6\u6c34\u5e73<\/p>\n<\/li>\n

                      • \n

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                      • \n

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                      • \n

                        \u51cf\u4f4eDNA\u548c\u7ec6\u80de\u7684\u635f\u4f24<\/p>\n<\/li>\n

                      • \n

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                        <\/path><\/svg><\/i> \"Loading\"<\/p>\n

                        <\/div>\n","protected":false},"excerpt":{"rendered":"

                        \u4eba\u7c7b\u4e3a\u4ec0\u4e48\u4f1a\u8870\u8001\uff1f \u8870\u8001\u6700\u4e3b\u8981\u539f\u56e0\u53ef\u5f52\u7c7b\u4e8e\u4ee5\u4e0b\u4e24\u70b9\uff1a NAD+ \u4ea7\u91cf\u4e0b\u964d \u7ec6\u80de\u529f\u80fd\u8870\u9000 \u5fb7\u56fd\u751f\u7406\u5b66\u5bb6Otto Warburg\u4e8e 1930\u5e74\u53d1\u73b0NAD+ \uff08\u8bfa\u52a0\u56e0\u5b50\uff09\u5bf9\u4eba\u4f53\u5bff\u547d\u5177\u6709\u5173\u5065\u4f5c\u7528\uff0cOtto Warburg\u6307\u51fa\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u4eba\u4f53\u5185 NAD+ \u6c34\u5e73\u5448\u73b0\u65ad\u5d16\u5f0f\u4e0b\u964d\uff0c\u8fdb\u800c\u5bfc\u81f4\u751f\u7269\u4f53\u7ec6\u80de\u80fd\u91cf\u7684\u53d1\u7535\u673a – \u7c92\u7ebf\u4f53\u529f\u80fd\u8870\u9000\uff0c\u968f\u4e4b\u8111\u90e8\u7ec6\u80de\u6d3b\u529b\u4e0b\u964d\uff0c\u8870\u7aed\u8001\u5316\uff0c\u4fc3\u4f7f\u4eba\u4f53Sirtuins\u957f\u5bff\u57fa\u56e0\u5931\u53bb\u6d3b\u6027 \uff0c\u89e6\u53d1\u8870\u8001\uff0c\u5bfc\u81f4\u8eab\u4f53\u5404\u79cd\u673a\u80fd\u7684\u8870\u9000\u3002<\/p>\n

                        <\/div>\n

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