{"id":18716,"date":"2022-08-10T04:02:05","date_gmt":"2022-08-10T04:02:05","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18716"},"modified":"2022-08-11T02:34:03","modified_gmt":"2022-08-11T02:34:03","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e7%be%8e%e5%9c%8b25%e4%ba%banmn%e8%87%a8%e5%ba%8a%e8%a9%a6%e9%a9%97%e7%99%bb%e4%b8%8a%e9%a0%82%e7%b4%9a%e6%9c%9f%e5%88%8a%ef%bc%8cnmn%e5%8f%af","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18716","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u7f8e\u570b25\u4ebaNMN\u81e8\u5e8a\u8a66\u9a57\u767b\u4e0a\u9802\u7d1a\u671f\u520a\uff0cNMN\u53ef\u4ee5\u6e1b\u7de9\u4e26\u6539\u5584\u8207\u5e74\u9f61\u6709\u95dc\u7684\u8870\u8001"},"content":{"rendered":"<p id=\"viewer-34ftb\" class=\"mm8Nw _1j-51 roLFQS _1FoOD _3M0Fe Z63qyL roLFQS public-DraftStyleDefault-block-depth0 fixed-tab-size public-DraftStyleDefault-text-ltr\"><span class=\"_2PHJq public-DraftStyleDefault-ltr\">2021\u5e744\u670823\u65e5\uff0c\u54c8\u4f5b\u91ab\u5b78\u9662\u907a\u50b3\u5b78\u6559\u6388\u5927\u885b\u00b7\u8f9b\u514b\u840a\u723e\u63a8\u7279\u66f4\u65b0\u4e86\u4e00\u5247\u8207NMN\u76f8\u95dc\u7684\u8cc7\u8a0a\uff1a\u300aScience\u300b\u671f\u520a\u6700\u65b0\u7814\u7a76\u986f\u793a\uff0c\u6301\u7e8c10\u5468\u670d\u7528250mg\u7684NAD+\u88dc\u5145\u5291NMN\u53ef\u6709\u6548\u6539\u5584\u5973\u6027\u65b0\u9673\u4ee3\u8b1d\u3002<\/span><\/p>\n<div data-hook=\"rcv-block4\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18719\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021.webp\" alt=\"\" width=\"360\" height=\"347\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021.webp 360w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021-300x289.webp 300w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><\/div>\n<p><!--more--><\/p>\n<div id=\"viewer-57eun\" class=\"_2vd5k b6lcWf\">\n<div class=\"_3CWa- sxFoib sxFoib _3vo3y zOjvSU zOjvSU\">\n<div class=\"_2kEVY\" tabindex=\"0\" role=\"button\" data-hook=\"imageViewer\">\n<div class=\"\"><span style=\"color: #82868b; font-size: 1rem;\">\u5927\u536b\u535a\u58eb\u63d0\u5230\u7684\u662f\u4e00\u9879\u6765\u81ea\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u4eba\u7c7b\u8425\u517b\u4e2d\u5fc3\u7684NMN\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u62db\u52df25\u4f4d\u8d85\u91cd\u6216\u80a5\u80d6\u7684\u4e2d\u8001\u5e74\u5973\u6027\uff0855-75\u5c81\uff09\u4f5c\u4e3a\u6d4b\u8bd5\u5bf9\u8c61\uff0c\u8fdb\u884c\u4e3a\u671f10\u5468\uff0c\u5e76\u4ee5\u5b89\u6170\u5242\u4e3a\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c (Clinical Trial.gov NCT 03151239)\u3002\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728\u300aScience\u300b\u4e0a\uff0c\u9898\u4e3a\u300cNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women\u300d\u7684\u7814\u7a76\u6587\u7ae0[1].\u7814\u7a76\u8868\u660e:\u00a0\u00a0NMN\u63d0\u9ad8\u4e86\u80f0\u5c9b\u7d20\u589e\u52a0\u9aa8\u9abc\u808c\u8461\u8404\u7cd6\u6444\u53d6\u7684\u80fd\u529b\uff0c\u6539\u5584\u4e86\u4e0e\u808c\u8089\u7ed3\u6784\u548c\u91cd\u5851\u6709\u5173\u7684\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"viewer-fah38\" class=\"_2vd5k b6lcWf\">\n<div class=\"_3CWa- sxFoib sxFoib _3mymk\">\n<div class=\"_2kEVY\" tabindex=\"0\" role=\"button\" data-hook=\"imageViewer\">\n<div><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18718\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/science.webp\" alt=\"\" width=\"740\" height=\"363\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/science.webp 740w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/science-300x147.webp 300w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/div>\n<div class=\"\"><span style=\"color: #82868b; font-size: 1rem;\">Science\u671f\u520a\u622a\u56fe<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>\u5728\u63a5\u53d7\u7814\u7a76\u7684\u5973\u6027\u4e2d\uff0c\u670913\u4f4d\u5973\u6027\u572810\u5468\u5185\u6bcf\u5929\u53e3\u670d250\u6beb\u514bNMN\uff0c\u5728\u540c\u4e00\u65f6\u671f\u5185\u6bcf\u5929\u670912\u4f4d\u5973\u6027\u670d\u7528\u5b89\u6170\u5242\uff0c\u540c\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u5229\u7528\u7ecf\u76ae\u6d3b\u68c0\u8003\u5bdf\u4e86\u53d7\u8bd5\u8005\u808c\u8089\u7ec4\u7ec7\u7684\u8461\u8404\u7cd6\u5438\u6536\u80fd\u529b\u4ee5\u53ca\u80f0\u5c9b\u7d20\u4fe1\u53f7\u3002<\/p>\n<p id=\"viewer-5ie5a\" class=\"mm8Nw _1j-51 roLFQS _1FoOD _3M0Fe Z63qyL roLFQS public-DraftStyleDefault-block-depth0 fixed-tab-size public-DraftStyleDefault-text-ltr\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18717\" style=\"color: #838383; font-size: 1rem;\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021-2.webp\" alt=\"\" width=\"740\" height=\"752\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021-2.webp 740w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/08\/aging2021-2-295x300.webp 295w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/p>\n<div id=\"viewer-fvnf3\" class=\"_2vd5k b6lcWf\">\n<div class=\"_3CWa- sxFoib sxFoib _3mymk\">\n<div class=\"_2kEVY\" tabindex=\"0\" role=\"button\" data-hook=\"imageViewer\">\n<div class=\"\"><\/div>\n<div class=\"\"><span style=\"color: #82868b; font-size: 1rem;\">\u5b9e\u9a8c\u6570\u636e\u663e\u793a\uff0c\u8fde\u7eed\u53e3\u670dNMN\u80f6\u56ca10\u5468\u5f8c\uff08\u6bcf\u65e5250mg\uff0c\u968f\u65e9\u9910\u670d\u7528\uff09\uff0c\u53d7\u8bd5\u8005\u7684AKT\u82cf\u6c28\u9178308\u548c\u4e1d\u6c28\u9178473\u78f7\u9178\u5316\u6c34\u5e73\u51fa\u73b0\u4e86\u5927\u5e45\u63d0\u5347\uff0c\u6697\u793aNMN\u663e\u7740\u63d0\u5347\u4e86\u9aa8\u9abc\u808c\u7684\u518d\u751f\u548c\u6062\u590d\u80fd\u529b\u3002\u53d7\u8bd5\u8005\u9aa8\u9abc\u808c\u4e2d\u9ad8\u8fbe31%\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u63d0\u5347\uff0c\u5219\u8bf4\u660eNMN\u5bf9\u4eba\u4f53\u8870\u8001\u7684\u4ee3\u8c22\u673a\u80fd\u505a\u51fa\u4e86\u957f\u8db3\u7684\u9006\u8f6c\u3002<\/span><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>\u8be5\u7814\u7a76\u7684\u4e00\u4f4d\u4f5c\u8005Samuel Klein\u6559\u6388\u8868\u793a\uff0c\u867d\u7136\u4ed6\u4eec\u7684\u8bd5\u9a8c\u7ed3\u679c\u63d0\u793aNMN\u5bf9\u9aa8\u9abc\u808c\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u65b9\u9762\u5b58\u5728\u76ca\u5904\uff0c\u4f46\u8fd8\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u786e\u5b9aNMN\u5bf9\u9884\u9632\u6216\u63a7\u5236\u7cd6\u5c3f\u75c5\u524d\u671f\u6216\u7cd6\u5c3f\u75c5\u662f\u5426\u5177\u6709\u4e34\u5e8a\u6548\u679c\uff0c\u76ee\u524d\u4ed6\u4eec\u8fd8\u5728\u8fdb\u884c\u53e6\u4e00\u9879\uff0c\u4e5f\u5305\u542b\u4e86\u7537\u6027\u53c2\u4e0e\u8005\u7684\u8bc4\u4f30NMN\u7684\u8bd5\u9a8c\u3002<\/p>\n<p id=\"viewer-ehl11\" class=\"mm8Nw _1j-51 roLFQS _1FoOD _3M0Fe Z63qyL roLFQS public-DraftStyleDefault-block-depth0 fixed-tab-size public-DraftStyleDefault-text-ltr\"><span class=\"_2PHJq public-DraftStyleDefault-ltr\">\u53c3\u8003\u8cc7\u6599\uff1a<\/span><\/p>\n<p id=\"viewer-f7cp\" class=\"mm8Nw _1j-51 roLFQS _1FoOD _3M0Fe Z63qyL roLFQS public-DraftStyleDefault-block-depth0 fixed-tab-size public-DraftStyleDefault-text-ltr\"><span class=\"_2PHJq public-DraftStyleDefault-ltr\">[1]https:\/\/science.sciencemag.org\/lookup\/doi\/10.1126\/science.abe9985.DOI: 10.1126\/science.abe9985 (2021)\u200b\u200b\u200b\u200b<\/span><\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18716\" class=\"pvc_stats all  \" data-element-id=\"18716\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 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