{"id":18628,"date":"2022-08-05T03:08:11","date_gmt":"2022-08-05T03:08:11","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18628"},"modified":"2022-08-05T03:30:14","modified_gmt":"2022-08-05T03:30:14","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn-%e6%8f%90%e9%ab%98%e6%af%8d%e4%bd%93%e5%8d%b5%e5%ad%90%e8%b4%a8%e9%87%8f%e3%80%81%e6%95%b0%e9%87%8f%e5%92%8c%e5%8f%97%e7%b2%be%e8%83%bd","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18628","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN \u63d0\u9ad8\u6bcd\u4f53\u5375\u5b50\u8d28\u91cf\u3001\u6570\u91cf\u548c\u53d7\u7cbe\u80fd\u529b"},"content":{"rendered":"

\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u8865\u5145\u5242\u901a\u8fc7\u6062\u590d\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u6c34\u5e73\u6765\u63d0\u9ad8\u81ea\u7136\u8870\u8001\u5c0f\u9f20\u7684\u5375\u6bcd\u7ec6\u80de\u8d28\u91cf\u3002<\/p>\n

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\u5375\u6bcd\u7ec6\u80de\u662f\u4eba\u7c7b\u751f\u547d\u7684\u5f00\u7aef\u2014\u2014\u7528\u6700\u7b80\u5355\u7684\u672f\u8bed\u6765\u8bf4\uff0c\u5b83\u662f\u4e00\u4e2a\u672a\u6210\u719f\u7684\u5375\u7ec6\u80de\uff0c\u6700\u7ec8\u6210\u719f\u5e76\u6210\u4e3a\u5375\u5b50\u6216\u5375\u5b50\u3002 \u7136\u800c\uff0c\u968f\u7740\u5973\u6027\u5e74\u9f84\u7684\u589e\u957f\uff0c\u5375\u6bcd\u7ec6\u80de\u8d28\u91cf\u4e0b\u964d\uff0c\u63d0\u9ad8\u5375\u6bcd\u7ec6\u80de\u8d28\u91cf\u7684\u6709\u6548\u65b9\u6cd5\u4ecd\u7136\u5f88\u5c11\u3002<\/p>\n

\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a \u300aCell Reports\u300b \u4e0a\u7684\u4e00\u9879\u7814\u7a76\u8bba\u6587\u53d1\u73b0\uff0c\u7ed9\u4e88\u5c0f\u9f20\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u524d\u4f53 NMN \u53ef\u6709\u6548\u63d0\u9ad8\u6bcd\u4f53\u8001\u5316\u5375\u6bcd\u7ec6\u80de\u7684\u8d28\u91cf\u3002 \u8fd9\u9879\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u7b56\u7565\u6765\u6539\u5584\u9ad8\u9f84\u4ea7\u5987\u7684\u751f\u6b96\u7ed3\u679c\u3002 \u7814\u7a76\u4eba\u5458\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\u8868\u793a\uff1a\u201c\u6211\u4eec\u7684\u5de5\u4f5c\u4e3a\u5e94\u7528 NMN \u63d0\u9ad8\u8001\u5e74\u5987\u5973\u7684\u751f\u80b2\u80fd\u529b\u548c\u4eba\u5de5\u751f\u6b96\u6280\u672f\u7684\u6548\u7387\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002 \u201d<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8865\u5145\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u901a\u8fc7\u6062\u590d\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u6c34\u5e73\uff0c\u6709\u6548\u63d0\u9ad8\u81ea\u7136\u8870\u8001\u5c0f\u9f20\u5375\u6bcd\u7ec6\u80de\u7684\u8d28\u91cf<\/strong><\/span>\u3002 \u8865\u5145NMN\u4e0d\u4ec5\u53ef\u4ee5\u589e\u52a0\u8001\u5e74\u5375\u6bcd\u7ec6\u80de\u7684\u6392\u5375\uff0c\u8fd8\u53ef\u4ee5\u589e\u5f3a\u5b83\u4eec\u7684\u53d7\u7cbe\u80fd\u529b\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u8865\u5145NMN\u662f\u4fdd\u62a4\u5375\u6bcd\u7ec6\u80de\u514d\u4e8e\u4e0e\u9ad8\u9f84\u6bcd\u4eb2\u8870\u8001\u76f8\u5173\u7684\u6076\u5316\u7684\u53ef\u884c\u65b9\u6cd5\uff0c\u6709\u52a9\u4e8e\u6539\u5584\u9ad8\u9f84\u5987\u5973\u7684\u751f\u6b96\u7ed3\u679c\u548c\u4eba\u5de5\u751f\u6b96\u6280\u672f\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u9ad8\u8d28\u91cf\u7684\u5375\u6bcd\u7ec6\u80de\u662f\u6210\u529f\u53d7\u7cbe\u548c\u968f\u540e\u80da\u80ce\u53d1\u80b2\u7684\u5148\u51b3\u6761\u4ef6\uff0c\u662f\u751f\u547d\u5f00\u59cb\u7684\u7269\u8d28\u57fa\u7840\u3002 \u5728\u5927\u591a\u6570\u54fa\u4e73\u52a8\u7269\u4e2d\uff0c\u96cc\u6027\u751f\u6b96\u8870\u8001\u7684\u5177\u4f53\u5b9a\u4e49\u662f\u5375\u6bcd\u7ec6\u80de\u548c\u5305\u542b\u5b83\u4eec\u7684\u5145\u6ee1\u6db2\u4f53\u7684\u56ca\uff08\u5373\u5375\u5de2\u5375\u6ce1\uff09\u7684\u6570\u91cf\u548c\u8d28\u91cf\u663e\u8457\u4e0b\u964d\u3002 \u4f4e\u8d28\u91cf\u7684\u5375\u6bcd\u7ec6\u80de\u662f\u9ad8\u9f84\u5987\u5973\u666e\u904d\u5b58\u5728\u4e14\u96be\u4ee5\u514b\u670d\u7684\u95ee\u9898\uff0c\u4e5f\u662f\u5bfc\u81f4\u751f\u80b2\u7ed3\u679c\u6b20\u4f73\u7684\u4e3b\u8981\u539f\u56e0\u3002 \u5c3d\u7ba1\u8fd9\u4e2a\u95ee\u9898\u5f88\u91cd\u8981\uff0c\u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u7ef4\u6301\u5375\u6bcd\u7ec6\u80de\u8d28\u91cf\u7684\u7b56\u7565\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u5f88\u597d\u7684\u63a2\u7d22\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NAD+ \u662f\u65b0\u9648\u4ee3\u8c22\u7684\u5173\u952e\u5143\u7d20\uff0c\u4e5f\u662f\u591a\u79cd\u751f\u7406\u8fc7\u7a0b\u7684\u5173\u952e\u8c03\u8282\u56e0\u5b50\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u548c\u7ec6\u80de\u5b58\u6d3b\u3002 \u6839\u636e\u62a5\u9053\uff0c\u8bb8\u591a\u7ec4\u7ec7\u7684 NAD+ \u6c34\u5e73\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u964d\u4f4e\uff0c\u5e76\u4e0e\u591a\u79cd\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75be\u75c5\u6709\u5173\u3002 \u56e0\u6b64\uff0cNAD+ \u6c34\u5e73\u7684\u6062\u590d\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u6548\u7684\u6297\u8870\u8001\u4ecb\u5165\u63aa\u65bd<\/a>\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u662f NAD+ \u7684\u5173\u952e\u524d\u4f53\uff0c\u65bd\u7528\u5b83\u53ef\u4ee5\u63d0\u9ad8\u7ec6\u80de\u4e2d NAD+ \u7684\u542b\u91cf\u3002 \u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u901a\u8fc7\u5728\u8001\u5e74\u5c0f\u9f20\u4e2d\u7528 NMN \u6cbb\u7597\u6765\u589e\u5f3a NAD+ \u751f\u7269\u5408\u6210\u53ef\u4ee5\u9006\u8f6c\u591a\u4e2a\u5668\u5b98\u4e2d\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u529f\u80fd\u969c\u788d\u3002 \u5c3d\u7ba1\u00a0NMN \u5728\u8870\u8001\u65b9\u9762\u7684\u5e94\u7528<\/a>\u53d6\u5f97\u4e86\u5f88\u5927\u8fdb\u5c55\uff0c\u4f46 NMN \u5bf9\u5973\u6027\u751f\u6b96\u8870\u8001\u7684\u5f71\u54cd\u5c1a\u672a\u5b8c\u5168\u786e\u5b9a\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u4ee5\u524d\u7684\u7814\u7a76\u62a5\u544a\u8868\u660e\uff0c\u6bcd\u4f53\u8001\u5e74\u5c0f\u9f20\u7684\u5375\u6bcd\u7ec6\u80de\u4e2d NAD+ \u6c34\u5e73\u964d\u4f4e\uff0c\u4f46\u53ef\u4ee5\u901a\u8fc7 NMN \u7ba1\u7406\u6062\u590d\u4ee5\u63d0\u9ad8\u8fd9\u4e9b\u5375\u6bcd\u7ec6\u80de\u7684\u8d28\u91cf\u3002 \u8865\u5145 NMN \u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u589e\u52a0\u4e86\u5375\u5de2\u5375\u6ce1\u3001\u6392\u5375\u5375\u6bcd\u7ec6\u80de\u548c\u6210\u719f\u5375\u6bcd\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u4e14\u788e\u7247\u8f83\u5c11\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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NMN \u8865\u5145\u5242\u5bf9\u6bcd\u4f53\u8001\u5316\u5375\u6bcd\u7ec6\u80de NAD+ \u542b\u91cf\u548c\u8d28\u91cf\u7684\u5f71\u54cd<\/strong><\/span>\u3002<\/p>\n

\uff08A\uff09 \u4ece\u5c0f\u9f20\u8eab\u4e0a\u91c7\u96c6\u7684\u6210\u719f\u5375\u6bcd\u7ec6\u80de\u7684\u4ee3\u8868\u6027\u56fe\u50cf\u3002<\/p>\n

\uff08B\uff09 \u5728\u5e74\u8f7b\u3001\u8001\u5e74\u548c\u8865\u5145 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u4e2d\u6392\u5375\u7684\u5375\u6bcd\u7ec6\u80de\u6570\u91cf\u548c\u788e\u88c2\u5375\u6bcd\u7ec6\u80de\u7684\u6bd4\u7387\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\uff0c\u6bcd\u4f53\u8870\u8001\u663e\u8457\u964d\u4f4e\u4e86\u6392\u5375\u5375\u6bcd\u7ec6\u80de\u7684\u6570\u91cf\u548c\u6210\u719f\u5375\u6bcd\u7ec6\u80de\u7684\u6bd4\u7387\uff0c\u4f46\u589e\u52a0\u4e86\u788e\u88c2\u5375\u6bcd\u7ec6\u80de\u7684\u53d1\u751f\u7387\u2014\u6709\u7f3a\u9677\u7684\u672a\u6210\u719f\u5375\u7ec6\u80de\u5206\u88c2\u548c\u5931\u8d25\uff0c\u6700\u7ec8\u5bfc\u81f4\u5b83\u4eec\u6b7b\u4ea1\u3002 \u7136\u800c\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u7528 NMN \u8865\u5145\u8001\u5316\u7684\u5375\u6bcd\u7ec6\u80de\u4ee5\u6062\u590d NAD+ \u6c34\u5e73\u65f6\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u6210\u719f\u7387\u63d0\u9ad8\uff0c\u5e76\u4e14\u8001\u5316\u5375\u6bcd\u7ec6\u80de\u7684\u6570\u91cf\u548c\u788e\u88c2\u7f3a\u9677\u5f97\u5230\u6539\u5584\u3002 \u6b64\u5916\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u6bcd\u4f53\u8870\u8001\u4e25\u91cd\u635f\u5bb3\u5375\u6ce1\u53d1\u80b2\uff0c\u8865\u5145 NMN \u589e\u52a0\u4e86\u5375\u6ce1\u6570\u91cf\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8865\u5145 NMN \u63d0\u9ad8\u4e86\u8870\u8001\u5375\u6bcd\u7ec6\u80de\u7684\u53d7\u7cbe\u80fd\u529b\u3002 \u4ed6\u4eec\u8fd8\u89c2\u5bdf\u5230\u8865\u5145 NMN \u663e\u8457\u4fc3\u8fdb\u4e86\u53d7\u7cbe\u5375\u6bcd\u7ec6\u80de\u968f\u540e\u7684\u80da\u80ce\u53d1\u80b2\u3002 \u6cbf\u7740\u8fd9\u4e9b\u601d\u8def\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u6765\u81ea\u8001\u5e74\u5c0f\u9f20\u7684\u53d7\u7cbe\u5375\u6bcd\u7ec6\u80de\u7684\u80da\u6ce1\uff08\u54fa\u4e73\u52a8\u7269\u65e9\u671f\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684\u7ec6\u80de\u96c6\u5408\uff09\u7684\u5f62\u6210\u7387\u6709\u6240\u63d0\u9ad8\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cNMN\u63d0\u9ad8\u4e86\u8870\u8001\u5375\u6bcd\u7ec6\u80de\u7684\u53d7\u7cbe\u80fd\u529b\uff0c\u5e76\u4fc3\u8fdb\u4e86\u5b83\u4eec\u968f\u540e\u7684\u80da\u80ce\u53d1\u80b2\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u8865\u5145 NMN \u5bf9\u8001\u5e74\u5375\u6bcd\u7ec6\u80de\u53d7\u7cbe\u80fd\u529b\u548c\u80da\u80ce\u53d1\u80b2\u7684\u5f71\u54cd<\/strong>\u3002<\/span><\/p>\n

\uff08D\uff09 \u5e74\u8f7b\u3001\u8001\u5e74\u548c\u8865\u5145 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u65e9\u671f\u53d1\u80b2\u80da\u80ce\u7684\u4ee3\u8868\u6027\u56fe\u50cf\u3002 \u5de6\uff0c2\u7ec6\u80de\u671f\u80da\u80ce; \u53f3\uff0c\u56ca\u80da\u2014\u2014\u4e00\u4e2a\u5feb\u901f\u5206\u88c2\u7684\u7ec6\u80de\u7403\uff0c\u7531\u5c06\u6210\u4e3a\u80da\u80ce\u7684\u5185\u90e8\u7ec6\u80de\u7fa4\u548c\u6ecb\u517b\u548c\u4fdd\u62a4\u80da\u80ce\u7684\u5916\u90e8\u7ec6\u80de\u7fa4\u7ec4\u6210\u3002<\/p>\n

\uff08E\uff09 \u53d7\u7cbe\u7387\u548c<\/p>\n

\uff08F\uff09 \u5728\u65e9\u671f\u54fa\u4e73\u52a8\u7269\u53d1\u80b2\u4e2d\u79f0\u4e3a\u56ca\u80da\u7684\u7ed3\u6784\u5728\u5e74\u8f7b\u3001\u8001\u5e74\u548c\u8865\u5145 NMN \u7684\u8001\u5e74\u5c0f\u9f20\u4e2d\u7684\u5f62\u6210\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Miao Y, Cui Z, Gao Q, Rui R, Xiong B. Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.\u00a0Cell Rep. 2020 Aug 4; 32(5):107987. doi: 10.1016\/j.celrep.2020.107987. PMID: 32755581.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Yamamoto T, Iwata H, Goto H, Shiratuki S, Tanaka H, Monji Y, Kuwayama T. Effect of maternal age on the developmental competence and progression of nuclear maturation in bovine oocytes.\u00a0Mol Reprod Dev. 2010 Jul; 77(7):595-604. doi: 10.1002\/mrd.21188. PMID: 20575084.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.\u00a0Nat Rev Mol Cell Biol. 2016 Nov; 17(11):679-690. doi: 10.1038\/nrm.2016.93. PMID: 27552971.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Croteau DL, Fang EF, Nilsen H, Bohr VA. NAD+ in DNA repair and mitochondrial maintenance.\u00a0Cell Cycle. 2017 Mar 19; 16(6):491-492. doi: 10.1080\/15384101.2017.1285631. Epub 2017 Feb 1. PMID: 28145802.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/nmn-oocyte-quality-and-fertilization-ability<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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