{"id":18501,"date":"2022-07-26T04:14:50","date_gmt":"2022-07-26T04:14:50","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18501"},"modified":"2023-04-08T03:05:46","modified_gmt":"2023-04-08T03:05:46","slug":"%e5%bf%83%e8%84%8f%e5%81%a5%e5%ba%b7%e9%9c%80%e8%a6%81-nmn-%e5%a4%9a%e6%96%b9%e9%9d%a2%e7%9a%84%e4%bf%9d%e6%8a%a4%ef%bc%88%e5%bf%85%e8%af%bb%ef%bc%89","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18501","title":{"rendered":"\u5fc3\u810f\u5065\u5eb7\u9700\u8981 NMN \u591a\u65b9\u9762\u7684\u4fdd\u62a4\uff08\u5fc5\u8bfb\uff09"},"content":{"rendered":"
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01 \u00a0\u8870\u8001\uff0c\u5fc3\u8840\u7ba1\u75c5\u7684\u5143\u51f6\u00a0<\/span><\/span><\/h2>\n

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60\u5c81\u4ee5\u4e0a\u7684\u8001\u5e74\u4eba\u53e3\u8d8a\u6765\u8d8a\u591a\uff0c\u5982\u4f55\u201c\u5065\u5eb7\u5730\u8001\u53bb\u201d\u4e5f\u6210\u4e3a\u5f88\u591a\u4eba\u5173\u5fc3\u7684\u8bdd\u9898\uff0c\u800c\u5934\u53f7\u654c\u4eba\u5c31\u662f\u5fc3\u8840\u7ba1\u75c5\u3002\u6839\u636e\u300a\u4e2d\u56fd\u5fc3\u8840\u7ba1\u5065\u5eb7\u4e0e\u75be\u75c5\u62a5\u544a2019\u300b\uff0c\u5305\u62ec\u51a0\u5fc3\u75c5\u3001\u5fc3\u529b\u8870\u7aed\u3001\u8111\u5352\u4e2d\u3001\u9ad8\u8840\u538b<\/span>\u7b49\u5728\u5185\u7684\u5fc3\u8840\u7ba1\u75c5\u60a3\u75c5\u4eba\u6570\u5df2\u8fbe\u52303.3\u4ebf<\/strong>\u3002<\/p>\n

\u4e0d\u8fc7\u597d\u6d88\u606f\u662f\uff0c\u5c3d\u7ba1\u8870\u8001\u88ab\u8ba4\u4e3a\u662f\u5fc5\u7136\u53d1\u751f\u7684\u8fc7\u7a0b\uff0c\u4f46\u8870\u8001\u7684\u901f\u5ea6\u5728\u4e0d\u540c\u7684\u4e2a\u4f53\u548c\u5668\u5b98\u4e4b\u95f4\u5374\u5b58\u5728\u7740\u663e\u8457\u5dee\u5f02\uff0c\u8fd9\u610f\u5473\u7740\u6211\u4eec\u6709\u53ef\u80fd\u5e72\u9884\u8870\u8001\u7684\u8fdb\u7a0b\uff0c\u8ba9\u8eab\u4f53\u548c\u5668\u5b98\u7684\u201c\u9752\u58ee\u5e74\u65f6\u671f\u201d\u66f4\u4e45<\/span><\/strong>\u3002<\/p>\n

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02 \u00a0\u4e00\u9897\u597d\u5fc3\u810f\uff0c\u8ba9\u4f60\u66f4\u5e74\u8f7b\u00a0<\/span><\/span><\/h2>\n<\/section>\n<\/section>\n

\u5fc3\u810f\u4f5c\u4e3a\u4eba\u4f53\u6700\u91cd\u8981\u7684\u5668\u5b98\uff0c\u5b83\u7684\u5065\u5eb7\u5173\u4e4e\u4eba\u7684\u751f\u6b7b\u5b58\u4ea1\uff0c\u751f\u547d\u4e0d\u606f\uff0c\u8df3\u52a8\u4e0d\u6b62\u3002\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u5fc3\u810f\u7684\u8870\u8001\u6216\u75c5\u53d8\u8868\u73b0\u51fa\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d<\/strong>\u3001\u5fc3\u808c\u7ec6\u80de\u6b7b\u4ea1\u548c\u518d\u751f\u80fd\u529b\u4e0b\u964d<\/strong>\u3001\u7ec6\u80de\u8870\u8001\u548c\u708e\u75c7<\/strong>\u7b49\u3002\u540c\u65f6\uff0c\u4f34\u968f\u7740\u5fc3\u810f\u4e2dNAD+\u6c34\u5e73\u7684\u4e0b\u964d<\/strong>\u3002<\/p>\n

\"\"<\/p>\n

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NAD+\uff08\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff09<\/span><\/strong>\u4f5c\u4e3a\u6211\u4eec\u8eab\u4f53\u91cc\u53c2\u4e0e\u8bb8\u591a\u91cd\u8981\u751f\u5316\u53cd\u5e94\u7684\u8f85\u9176\uff0c\u5bf9\u7ef4\u6301\u7ebf\u7c92\u4f53\u7684\u6b63\u5e38\u5de5\u4f5c\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u800c\u9020\u6210\u5fc3\u810f\u8870\u8001\u53ca\u76f8\u5173\u75be\u75c5\u7684\u4e00\u4e2a\u91cd\u8981\u673a\u5236\u6070\u6070\u662f\u201c\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u201d<\/strong><\/span>\u3002\u7ebf\u7c92\u4f53\u4e0d\u4ec5\u662f\u5fc3\u810f\u80fd\u91cf\uff08ATP\uff09\u7684\u4e3b\u8981\u6765\u6e90\uff0c\u800c\u4e14\u8fd8\u662f\u5fc3\u808c\u7ec6\u80de\u5b58\u6d3b\u7684\u5173\u952e\u8c03\u8282\u5242\u3002\u7531\u4e8e\u5fc3\u810f\u672c\u8eab\u7684ATP\u50a8\u5907\u975e\u5e38\u6709\u9650\uff0c\u56e0\u6b64\u9700\u8981\u7ebf\u7c92\u4f53\u5f3a\u5927\u800c\u4e0d\u95f4\u65ad\u5730\u6765\u63d0\u4f9bATP\uff0c\u4ece\u800c\u7ef4\u6301\u5fc3\u810f\u7684\u529f\u80fd\uff0c\u5426\u5219\u5c31\u53ef\u80fd\u5bfc\u81f4\u5fc3\u529b\u8870\u7aed\u7b49\u75be\u75c5\u72b6\u6001\u3002<\/p>\n

\u6b64\u5916\uff0cNADH\/NAD+\u7684\u6bd4\u7387\u4e5f\u4e0e\u5fc3\u810f\u5065\u5eb7\u606f\u606f\u76f8\u5173<\/strong><\/span>\u3002NADH\u662fNAD+\u7684\u8fd8\u539f\u72b6\u6001\uff0cNADH\/NAD+\u7684\u6bd4\u7387\uff0c\u662f\u7ec6\u80de\u5185\u4fe1\u53f7\u4f20\u5bfc\u7684\u5173\u952e\u56e0\u7d20\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u8870\u7aed\u7684\u4eba\u7c7b\u5fc3\u810f\u4e2d\uff0cNADH\/NAD+\u6bd4\u7387\u660e\u663e\u589e\u52a0\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u63d0\u5347NAD+\u6c34\u5e73\u6709\u52a9\u4e8e\u8fd9\u4e00\u6bd4\u7387\u7684\u964d\u4f4e\u3002<\/p>\n

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03 \u00a0NMN\u00a0\u591a\u65b9\u9762\u4fdd\u62a4\u5fc3\u810f\u5065\u5eb7\u00a0<\/span><\/span><\/h2>\n<\/section>\n<\/section>\n

\u65e2\u7136\u5fc3\u810f\u4e2d\u7684NAD+\u6c34\u5e73\u5982\u6b64\u91cd\u8981\uff0c\u90a3\u4e48\u63d0\u5347NAD+\u6c34\u5e73\u662f\u5426\u6709\u7528\u5462\uff1f\u591a\u9879\u7814\u7a76\u8868\u660e\uff1a\u4f7f\u7528NAD+\u524d\u4f53NMN\uff08\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u53ef\u4ee5\u6539\u5584\u5fc3\u810f\u7684NAD+\u7a33\u6001\uff0c\u7f13\u89e3\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5fc3\u810f\u75c5\u7406\u548c\u751f\u7406\u7684\u53d8\u5316\u3002\u5e76\u4e14\uff0c\u5173\u4e8eNMN\u7684\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\uff0c\u8bc1\u5b9e\u4e86\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n

1 \u4fdd\u62a4\u5fc3\u810f\u514d\u53d7\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24<\/strong><\/p>\n

\u7f3a\u8840\/\u518d\u704c\u6ce8\u635f\u4f24\uff0c\u662f\u6307\u8eab\u4f53\u7ec4\u7ec7\u7f3a\u8840\u4e00\u6bb5\u65f6\u95f4\u540e\uff0c\u5f53\u8840\u6d41\u91cd\u65b0\u6062\u590d\u540e\uff0c\u7ec4\u7ec7\u7684\u635f\u4f24\u975e\u4f46\u6ca1\u597d\u8f6c\uff0c\u53cd\u800c\u8fdb\u4e00\u6b65\u52a0\u91cd\u7684\u7efc\u5408\u5f81\u3002\u5bf9\u5fc3\u810f\u6765\u8bf4\uff0c\u53ef\u80fd\u9020\u6210\u7ebf\u7c92\u4f53\u635f\u4f24\u3001\u808c\u539f\u7ea4\u7ef4\u7ed3\u6784\u7834\u574f\u3001\u5fc3\u7387\u5931\u5e38\u3001\u5fc3\u808c\u987f\u6291\u7b49\u3002<\/p>\n

2 \u4fdd\u6301\u5fc3\u810f\u7ebf\u7c92\u4f53\u7a33\u6001\uff0c\u9884\u9632\u5fc3\u529b\u8870\u7aed<\/strong><\/p>\n

NAD+\u53ca\u5176\u4ecb\u5bfc\u7684Sirtuins\u6d3b\u6027\u7684\u964d\u4f4e\uff0c\u4f1a\u5bf9\u7ebf\u7c92\u4f53\u529f\u80fd\u9020\u6210\u8d1f\u9762\u5f71\u54cd\uff0c\u800c\u5fc3\u810f\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u969c\u788d\u53c8\u662f\u5fc3\u810f\u75be\u75c5\u53d1\u75c5\u673a\u5236\u7684\u5173\u952e\u3002<\/p>\n

2017 \u5e74\uff0c\u51ef\u65af\u897f\u50a8\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u8868\u660e\uff0c\u77ed\u671f\u8179\u8154\u6ce8\u5c04NAD+\u7684\u524d\u4f53NMN\u80fd\u591f\u6210\u529f\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u538b\u529b\u8d85\u8d1f\u8377\u5f15\u8d77\u7684\u5fc3\u529b\u8870\u7aed\u3002\u8fd9\u662f\u56e0\u4e3aNMN\u4fdd\u62a4\u4e86\u7ebf\u7c92\u4f53\u7684\u8d85\u5fae\u7ed3\u6784\uff0c\u964d\u4f4e\u4e86\u6d3b\u6027\u6c27\u6c34\u5e73\uff0c\u5e76\u9632\u6b62\u4e86\u5fc3\u810f\u7ec6\u80de\u6b7b\u4ea1<\/strong>\u3002<\/p>\n

3 \u6539\u5584\u8870\u8001\u5fc3\u810f\u7684\u65b0\u9648\u4ee3\u8c22\u548c\u529f\u80fd<\/strong><\/p>\n

2020\u5e74\uff0c\u7f8e\u56fd\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\uff0c\u6d4b\u8bd5\u4e86\u4e24\u79cd\u4e0d\u540c\u7684\u7ebf\u7c92\u4f53\u9776\u5411\u836f\u7269SS-31\uff08\u4e00\u79cd\u5408\u6210\u56db\u80bd\uff09\u548cNMN\u7684\u4f5c\u7528\uff0c\u7ed3\u679c\u53d1\u73b0SS-31\u90e8\u5206\u9006\u8f6c\u4e86\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u8212\u5f20\u529f\u80fd\u4e0b\u964d\uff0c\u800cNMN\u5219\u5b8c\u5168\u9006\u8f6c\u4e86\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u5fc3\u810f\u6536\u7f29\u529f\u80fd\u7f3a\u9677<\/strong>\u3002\u4e24\u8005\u7684\u534f\u540c\u6548\u5e94\u80fd\u66f4\u597d\u5730\u8ba9\u8001\u5316\u7684\u5fc3\u810f\u6062\u590d\u6d3b\u529b\u3002<\/p>\n

4 \u51cf\u8f7b\u5fc3\u810f\u7ea4\u7ef4\u5316<\/strong><\/p>\n

\u51a0\u72b6\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u5fc3\u810f\u4ee3\u8c22\u5f02\u5e38\u3001\u5fc3\u808c\u7f3a\u8840\u7b49\u591a\u79cd\u56e0\u7d20\u90fd\u53ef\u80fd\u5bfc\u81f4\u5fc3\u810f\u7ea4\u7ef4\u5316\uff0c\u8fdb\u800c\u5bfc\u81f4\u5fc3\u810f\u5f02\u5e38\u50f5\u786c\uff0c\u6700\u7ec8\u5bfc\u81f4\u5fc3\u810f\u8870\u7aed\u7684\u53d1\u751f\u3002<\/p>\n

2021\u5e74\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5bf9\u5fc3\u810f\u7ea4\u7ef4\u5316\u7684\u5c0f\u9f20\u8179\u8154\u6ce8\u5c04NMN\uff0c\u80fd\u591f\u6709\u6548\u63d0\u5347NAD+\u548cSIRT1\uff08\u4e00\u79cdNAD+\u4f9d\u8d56\u6027\u7684\u53bb\u4e59\u9170\u5316\u9176\uff09\uff0c\u4ece\u800c\u51cf\u8f7b\u4f53\u5185\u5fc3\u810f\u7ea4\u7ef4\u5316\u548c\u4f53\u5916\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316<\/strong>\u3002<\/p>\n

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01 \u00a0\u8870\u8001\uff0c\u5fc3\u8840\u7ba1\u75c5\u7684\u5143\u51f6\u00a0 \u7b2c\u4e03\u6b21\u4eba\u53e3\u666e\u67e5\u6570\u636e\u663e\u793a\uff0c\u4e2d\u56fd60\u5c81\u4ee5\u4e0a\u4eba\u53e3\u5360\u6bd418.7%\uff0c\u8fbe\u52302.64\u4ebf\u4eba\u3002\u9884\u8ba12050\u5e74\uff0c\u8fd9\u4e00\u6570\u5b57\u5c06\u8fbe\u52304.87\u4ebf\u3002 60\u5c81\u4ee5\u4e0a\u7684\u8001\u5e74\u4eba\u53e3\u8d8a\u6765\u8d8a\u591a\uff0c\u5982\u4f55\u201c\u5065\u5eb7\u5730\u8001\u53bb\u201d\u4e5f\u6210\u4e3a\u5f88\u591a\u4eba\u5173\u5fc3\u7684\u8bdd\u9898\uff0c\u800c\u5934\u53f7\u654c\u4eba\u5c31\u662f\u5fc3\u8840\u7ba1\u75c5\u3002\u6839\u636e\u300a\u4e2d\u56fd\u5fc3\u8840\u7ba1\u5065\u5eb7\u4e0e\u75be\u75c5\u62a5\u544a2019\u300b\uff0c\u5305\u62ec\u51a0\u5fc3\u75c5\u3001\u5fc3\u529b\u8870\u7aed\u3001\u8111\u5352\u4e2d\u3001\u9ad8\u8840\u538b\u7b49\u5728\u5185\u7684\u5fc3\u8840\u7ba1\u75c5\u60a3\u75c5\u4eba\u6570\u5df2\u8fbe\u52303.3\u4ebf\u3002 \u4e0d\u8fc7\u597d\u6d88\u606f\u662f\uff0c\u5c3d\u7ba1\u8870\u8001\u88ab\u8ba4\u4e3a\u662f\u5fc5\u7136\u53d1\u751f\u7684\u8fc7\u7a0b\uff0c\u4f46\u8870\u8001\u7684\u901f\u5ea6\u5728\u4e0d\u540c\u7684\u4e2a\u4f53\u548c\u5668\u5b98\u4e4b\u95f4\u5374\u5b58\u5728\u7740\u663e\u8457\u5dee\u5f02\uff0c\u8fd9\u610f\u5473\u7740\u6211\u4eec\u6709\u53ef\u80fd\u5e72\u9884\u8870\u8001\u7684\u8fdb\u7a0b\uff0c\u8ba9\u8eab\u4f53\u548c\u5668\u5b98\u7684\u201c\u9752\u58ee\u5e74\u65f6\u671f\u201d\u66f4\u4e45\u3002 \u6211\u4eec\u66fe\u7ecf\u5206\u4eab\u8fc7\u201cNMN\u5982\u4f55\u9006\u8f6c\u8840\u7ba1\u8870\u8001\u201c\uff08\u300a\u8840\u7ba1\u6709\u591a\u8001\uff0c\u4eba\u5c31\u6709\u591a\u8001\uff01\u54c8\u4f5b\u533b\u5b66\u9662\u8bc1\u5b9eNMN\u9006\u8f6c\u8840\u7ba1\u8870\u8001\u300b\uff09\uff0c\u4eca\u5929\u6765\u804a\u804a\u600e\u6837\u8ba9\u5fc3\u810f\u4fdd\u6301\u5e74\u8f7b\u3002<\/p>\n

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