{"id":185,"date":"2022-02-25T15:17:56","date_gmt":"2022-02-25T15:17:56","guid":{"rendered":"http:\/\/choosebiz.me\/?p=185"},"modified":"2022-08-16T14:13:59","modified_gmt":"2022-08-16T14:13:59","slug":"nmn-%e4%bd%bf%e9%aa%a8%e7%bb%84%e7%bb%87%e5%b9%b2%e7%bb%86%e8%83%9e%e6%81%a2%e5%a4%8d%e6%b4%bb%e5%8a%9b","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=185","title":{"rendered":"\u3010NMN\u79d1\u6280\u8fdb\u5c55\u3011NMN \u4f7f\u9aa8\u7ec4\u7ec7\u5e72\u7ec6\u80de\u6062\u590d\u6d3b\u529b"},"content":{"rendered":"<p>\u8bd5\u5242\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u4e0e\u6838\u5c0f\u4f53\u7ec4\u88c5\u86cb\u767d 1 like-2 (NAP1L2) \u5bf9\u63a5\uff0c\u4ee5\u91cd\u632f\u9aa8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u201c\u5e72\u7ec6\u80de\u7279\u6027\u201d\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17498\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/bone.jpg\" alt=\"\" width=\"677\" height=\"414\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/bone.jpg 677w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/bone-300x183.jpg 300w\" sizes=\"auto, (max-width: 677px) 100vw, 677px\" \/><\/p>\n<p class=\"date main-color-g\">Published:\u00a02:52 p.m. PST Feb 8, 2022\u00a0| Updated:\u00a06:18 p.m. PST Feb 8, 2022<\/p>\n<p>\u91cd\u5927\u4eae\u70b9<\/p>\n<ul>\n<li>\u00b7\u8be5\u7814\u7a76\u8868\u660e\uff0cNMN\u4e0eSIRT1\u86cb\u767d\u7ed3\u5408\uff0c\u6fc0\u6d3b\u9aa8\u9abc\u518d\u751f\uff08\u6210\u9aa8\uff09\u7684\u57fa\u56e0\u3002<\/li>\n<li>\u00b7\u901a\u8fc7\u523a\u6fc0\u6210\u9aa8\u4f5c\u7528\uff0cNMN\u53ef\u9632\u6b62\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u53d1\u5c55\u3002<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>\u968f\u7740\u4eba\u4eec\u5e74\u9f84\u7684\u589e\u957f\uff0c\u65b0\u9aa8\u7ec6\u80de\u7684\u5206\u89e3\u548c\u751f\u6210\uff08\u6210\u9aa8\uff09\u4e5f\u5728\u4e0b\u964d\u3002\u9aa8\u9abc\u518d\u751f\u7684\u6df7\u4e71\u6e90\u65bc\u5e72\u7ec6\u80de\u5728\u5176\u539f\u59cb\u7684\u4e36\u5e74\u8f7b\u7684\u72b6\u6001\uff08\u5e72\u7ec6\u80de\u7279\u6027\uff09\u4e2d\u88ab\u8017\u5c3d\u3002\u9aa8\u5e72\u7ec6\u80de\u7684\u5e72\u7ec6\u80de\u7279\u6027\u4e0b\u964d\u662f\u7531\u65bc\u5e72\u7ec6\u80de\u5728\u901a\u8fc7\u7ec6\u80de\u5468\u671f\u8fdb\u5c55\u5230\u6210\u719f\u4e3a\u6210\u9aa8\u7ec6\u80de\u65f6\u7684\u7a81\u53d8\u79ef\u7d2f\u3002<\/p>\n<p>\u6362\u53e5\u8bdd\u8bf4\uff0c\u5f53\u5e72\u7ec6\u80de\u53d8\u6210\u6210\u9aa8\u7ec6\u80de\u65f6\uff0c\u9aa8\u9abc\u4f1a\u53d8\u786c\uff0c\u53ef\u80fd\u5bb9\u6613\u9aa8\u6298\uff0c\u5e76\u51fa\u73b0\u5b54\u9699\uff08\u9aa8\u8d28\u758f\u677e\u75c7\uff09\uff0c\u5bfc\u81f4\u865a\u5f31\u3002\u4e34\u5e8a\u533b\u751f\u53ef\u4ee5\u7528\u865a\u5f31\u6307\u6570\u6765\u8861\u91cf\u865a\u5f31\u7a0b\u5ea6\uff0c\u8fd9\u4e2a\u6570\u5b57\u4ee3\u8868\u4e86\u8001\u5e74\u4eba\u7684\u6574\u4f53\u4f53\u80fd\u548c\u5065\u5eb7\u72b6\u51b5\u3002\u7531\u65bc\u8fd9\u4e9b\u539f\u56e0\uff0c\u7814\u7a76\u7684\u65b9\u5411\u662f\u5bfb\u627e\u7ef4\u6301\u9aa8\u95f4\u8d28\u5e72\u7ec6\u80de\uff08BMSCs\uff09\u7684\u5e72\u7ec6\u80de\u7279\u6027\u7684\u65b9\u6cd5\uff0c\u9aa8\u95f4\u8d28\u5e72\u7ec6\u80de\u662f\u4ea7\u751f\u6210\u9aa8\u7ec6\u80de\u7684\u5e72\u7ec6\u80de\uff0c\u540c\u65f6\u4e5f\u662f\u9aa8\u7ec4\u7ec7\u7684\u5e72\u7ec6\u80de\u3002<\/p>\n<h3><strong>NMN \u5728\u57fa\u56e0\u4e0a\u7ffb\u65b0\u8001\u5e74\u4eba\u7684\u9aa8\u5e72\u7ec6\u80de<\/strong><\/h3>\n<p>\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u76f4\u63a5\u524d\u4f53\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u53ef\u4ee5\u6062\u590d\u8001\u9f20\u548c\u5927\u9f20\u7b49\u556e\u9f7f\u52a8\u7269\u7684\u9aa8\u7ec4\u7ec7\u5065\u5eb7\u3002 \u8bdd\u867d\u5982\u6b64\uff0c\u5929\u6d25\u533b\u79d1\u5927\u5b66\u7684Liu\u548c\u540c\u4e8b\u5229\u7528\u5e74\u8f7b\u548c\u8001\u5e74\u60a3\u8005\u7684\u9aa8\u9ad3\u95f4\u5145\u8d28\u4e7e\u7ec6\u80de\u6765\u6d4b\u8bd5\u65bd\u7528 NMN \u662f\u5426\u80fd\u6062\u590d\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u7684\u8868\u89c2\u9057\u4f20\u5bc6\u7801\uff0c\u5373\u57fa\u56e0\u8868\u8fbe\u7684\u5e74\u8f7b\u6a21\u5f0f\u3002 \u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u4f4d\u65bc\u5929\u6d25\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u63a5\u53d7\u5316\u7597\u548c\u6c27\u5316\u5e94\u6fc0\u7684 BMSC \u5728\u63a5\u53d7 NMN \u6cbb\u7597\u5f8c\u8868\u73b0\u51fa\u589e\u5f3a\u7684\u5e72\u7ec6\u80de\u7279\u6027\u3002 \u6709\u8da3\u7684\u662f\uff0c\u4e2d\u56fd\u56e2\u961f\u62a5\u544a\u4e86\u8fdb\u4e00\u6b65\u7684\u6570\u636e\uff0c\u663e\u793a NMN \u4e0e DNA \u7ed3\u5408\uff0c\u53ef\u80fd\u4f7f\u57fa\u56e0\u8868\u8fbe\u8c31\u6062\u590d\u6d3b\u529b\u3002<\/p>\n<p>\u86cb\u767d\u8d28\u6838\u5c0f\u4f53\u7ec4\u88c5\u86cb\u767d 1-like 2 (NAP1L2) \u7684\u8868\u8fbe\u589e\u52a0\u4e0e\u8870\u8001\u76f8\u5173\u3002 Liu \u53ca\u5176\u540c\u4e8b\u5047\u8bbe\uff0c\u968f\u7740 NAP1L2 \u6c34\u5e73\u7684\u589e\u52a0\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\uff08\u4e00\u79cd\u6838\u5c0f\u4f53\u4f34\u4fa3\uff09\u4f1a\u4ece DNA \u5305\u88f9\u7684\u86cb\u767d\u8d28\uff08\u6838\u5c0f\u4f53\uff09\u4e2d\u53bb\u9664\u79f0\u4e3a\u4e59\u9170\u57fa\u7684\u5206\u5b50\u6807\u7b7e\u3002 NAP1L2 \u8fd8\u62db\u52df\u53bb\u4e59\u9170\u5316\u9176\u86cb\u767d Sirtuin1 (SIRT1)\uff0c\u8be5\u86cb\u767d\u4ece\u9a71\u52a8\u6210\u9aa8\u7684\u57fa\u56e0\u7684\u542f\u52a8\u5b50\u533a\u57df\u53bb\u9664\u4e59\u9170\u57fa\u56e2\u3002<\/p>\n<p>NAP1L2 \u86cb\u767d\u8d28\u6c34\u5e73\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u589e\u52a0\uff0c\u4e0e\u8eab\u4f53\u865a\u5f31\u76f8\u5173<\/p>\n<p>\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u60f3\u6cd5\uff0c\u4f4d\u65bc\u5929\u6d25\u7684\u7814\u7a76\u5c0f\u7ec4\u8bd5\u56fe\u5c06NAP1L2\u86cb\u767d\u8868\u8fbe\u7684\u589e\u52a0\u4e0e\u8001\u5e74\u4eba\u7684BMSCs\u4e2d\u7684\u8870\u8001\u8054\u7cfb\u8d77\u6765\u3002\u4e3a\u4e86\u6d4b\u91cf\u8870\u8001\uff0c\u7814\u7a76\u4eba\u5458\u7528\u5206\u5b50\u6807\u8bb0\u7269\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u6d4b\u91cf\u8870\u8001\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\u4e86\u67d3\u8272\u4f53\u672b\u7aef\uff08\u7aef\u7c92\uff09\u7684\u529f\u80fd\u969c\u788d\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u5bf9\u8001\u5e74BMSC\u86cb\u767d\u6c34\u5e73\u7684\u5206\u6790\u53d1\u73b0\uff0c\u5728\u7528\u8fc7\u6c27\u5316\u6c22\uff08H2O2\uff09\u5bf9BMSCs\u65bd\u52a0\u538b\u529b\u5f8c\uff0c\u8870\u8001\u76f8\u5173\u7684\u5206\u6ccc\u8868\u578b\uff08SASP\uff09\u6807\u5fd7\u7269\u4e0eNAP1L2\u6c34\u5e73\u7684\u589e\u52a0\u540c\u6b65\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cBMSC\u7684\u8870\u8001\u548c\u5e72\u7ec6\u80de\u7279\u6027\u4e27\u5931\u4e0eNAP1L2\u6c34\u5e73\u7684\u5347\u9ad8\u540c\u6b65\u53d1\u751f\u3002<\/p>\n<h3>NMN \u4e0e NAP1L2 \u7ed3\u5408\u4ee5\u523a\u6fc0\u7ec6\u80de\u518d\u751f SIRT1 \u86cb\u767d<\/h3>\n<p>\u4e3a\u4e86\u4e86\u89e3 NMN \u662f\u5982\u4f55\u5f71\u54cd\u8001\u5e74\u4eba BMSCs \u4e2d\u7684 NAP1L2 \u6c34\u5e73\u7684\uff0cLiu \u53ca\u5176\u540c\u4e8b\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u4e2d\u7528 1 mM NMN \u6d53\u5ea6\u4ecb\u5165\u4e86 BMSCs\u3002 \u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u6709\u8da3\u7684\u662f\uff0cNMN \u4e0e NAP1L2 \u86cb\u767d\u5bf9\u63a5\uff0c\u5e76\u4e14\u8fd8\u51cf\u8f7b\u4e86\u4e0e\u8870\u8001\u76f8\u5173\u7684 \u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\u7684\u79ef\u7d2f\u3002 \u4e0d\u4ec5\u5982\u6b64\uff0cNMN \u6cbb\u7597\u8fd8\u51cf\u8f7b\u4e86\u8870\u8001 BMSCs \u4e2d\u7aef\u7c92 DNA \u635f\u4f24\u7684\u79ef\u7d2f\u3002 \u6b64\u5916\uff0c\u7528 NMN \u4ecb\u5165\u7ec6\u80de\u8fd8\u6291\u5236\u4e86 SASP \u56e0\u5b50\u57fa\u56e0\u7684\u8868\u8fbe\u3002 \u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u81f3\u5c11\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u4e2d\uff0cNMN \u53ef\u4ee5\u4f7f BMSCs \u6062\u590d\u6d3b\u529b\u3002 \u5982\u679c\u8fd9\u4e9b\u53d1\u73b0\u5728\u6d3b\u4eba\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u5219\u53ef\u80fd\u610f\u5473\u7740\u4f7f\u7528 NMN \u53ef\u4ee5\u6062\u590d BMSC \u7684\u201c\u5e72\u7ec6\u80de\u7279\u6027\u201d\uff0c\u53ef\u80fd\u4f1a\u6062\u590d\u6210\u9aa8\u529f\u80fd\uff0c\u7f13\u89e3\u4eba\u7c7b\u8870\u8001\u5f8c\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17499\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/814909_988505.webp\" alt=\"\" width=\"895\" height=\"419\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/814909_988505.webp 895w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/814909_988505-300x140.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/02\/814909_988505-768x360.webp 768w\" sizes=\"auto, (max-width: 895px) 100vw, 895px\" \/><\/p>\n<p>(Liu et al. 2022 |\u00a0Aging Cell)\u00a0NMN \u53ef\u9632\u6b62\u9aa8\u7ec6\u80de\u8870\u8001\u7684\u79ef\u7d2f\u3002\u00a0\u7ed3\u5408 NAP1L2 \u7684\u5316\u5408\u7269\u7684\u8ba1\u7b97\u673a\u5efa\u6a21\u53ef\u8bc6\u522b NMN\uff08\u5de6\uff09\u3002 \u7ed9\u4e88\u5316\u7597\u5242\u4f9d\u6258\u6cca\u82f7\uff08Eto\uff0948\u5c0f\u65f6\u4ee5\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001\u3002 \u4e8b\u5b9e\u4e0a\uff0c\u5927\u7ea6 80% \u7684\u9aa8\u9ad3\u5e72\u7ec6\u80de (BMSCs) \u53d8\u5f97\u8870\u8001\u3002 \u5728\u8fd9 48 \u5c0f\u65f6\u5185\u7528 NMN \u5904\u7406\u76f8\u540c\u7684\u7ec6\u80de\u53ef\u4f7f\u8870\u8001\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u964d\u4f4e\u7ea6 50%\uff08\u53f3\u56fe\uff09\u3002<\/p>\n<p>\u8bc1\u5b9e\u8fd9\u4e00\u6982\u5ff5\u7684\u8fdb\u4e00\u6b65\u8bc1\u636e\u6765\u81ea\u4e00\u9879\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8868\u660e NAP1L2 \u6c34\u5e73\u5347\u9ad8\u4e0e\u8001\u5e74\u4eba\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u76f8\u5173\u3002 \u4f8b\u5982\uff0c\u53d1\u73b0 NAP1L2 \u8868\u8fbe\u4e0e\u9aa8\u5bc6\u5ea6\u4e4b\u95f4\u5b58\u5728\u8d1f\u76f8\u5173\uff0c\u8fd9\u610f\u5473\u7740\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u548c NAP1L2 \u6c34\u5e73\u7684\u589e\u52a0\uff0c\u9aa8\u9abc\u53d8\u5f97\u66f4\u52a0\u591a\u5b54\u3002 \u5c3d\u7ba1\u9700\u8981\u8fdb\u4e00\u6b65\u6d4b\u8bd5\uff0c\u4f46\u8865\u5145 NMN \u53ef\u4ee5\u589e\u52a0\u4eba\u4f53\u9aa8\u5bc6\u5ea6\u4ee5\u4f7f\u9aa8\u9abc\u66f4\u5f3a\u58ee\u7684\u53ef\u80fd\u6027\u4ecd\u7136\u5b58\u5728\u3002 NMN \u8bd5\u5242\u7684\u524d\u666f\u610f\u5473\u7740\u4eba\u7c7b\u53ef\u4ee5\u4ece\u8865\u5145\u8be5\u5316\u5408\u7269\u4e2d\u53d7\u76ca\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u53ef\u80fd\u4f1a\u9006\u8f6c\u865a\u5f31\u6307\u6570\u5f97\u5206\u3002 \u8fd9\u6837\u505a\uff0c\u6211\u4eec\u53ef\u4ee5\u8fc7\u4e0a\u66f4\u5065\u5eb7\u7684\u751f\u6d3b\uff0c\u5e76\u6709\u671b\u51cf\u8f7b\u8001\u5e74\u4eba\u7684\u60b2\u4f24\u548c\u7edd\u671b\u3002 \u4e5f\u8bb8\u901a\u8fc7\u6539\u5584\u6574\u4f53\u5e78\u798f\u611f\uff0c\u670d\u7528 NMN \u7684\u8001\u5e74\u4eba\u53ef\u4ee5\u6709\u66f4\u597d\u7684\u4eba\u751f\u89c2\uff0c\u63d0\u4f9b\u6f5c\u5728\u7684\u4e50\u89c2\u6765\u6e90\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b:<\/p>\n<p>Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, Wang J, Jiang H, Guo J, Li X, Wang J, Sui L, Li C, Liu D, Liu Z. NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation. Aging Cell. 2022 Jan 15:e13551. doi: 10.1111\/acel.13551. Epub ahead of print. PMID: 35032339.<\/p>\n<p>\u6587\u7ae0\u4f86\u6e90:<\/p>\n<p>https:\/\/www.nmn.com\/news\/nmn-restores-stem-cells-bone-tissue-activating-nap1l2-protein<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_185\" class=\"pvc_stats all  \" data-element-id=\"185\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8bd5\u5242\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN) \u4e0e\u6838\u5c0f\u4f53\u7ec4\u88c5\u86cb\u767d 1 like-2 (NAP1L2) \u5bf9\u63a5\uff0c\u4ee5\u91cd\u632f\u9aa8\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u201c\u5e72\u7ec6\u80de\u7279\u6027\u201d\u3002 Published:\u00a02:52 p.m. PST Feb 8, 2022\u00a0| Updated:\u00a06:18 p.m. PST Feb 8, 2022 \u91cd\u5927\u4eae\u70b9 \u00b7\u8be5\u7814\u7a76\u8868\u660e\uff0cNMN\u4e0eSIRT1\u86cb\u767d\u7ed3\u5408\uff0c\u6fc0\u6d3b\u9aa8\u9abc\u518d\u751f\uff08\u6210\u9aa8\uff09\u7684\u57fa\u56e0\u3002 \u00b7\u901a\u8fc7\u523a\u6fc0\u6210\u9aa8\u4f5c\u7528\uff0cNMN\u53ef\u9632\u6b62\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u53d1\u5c55\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_185\" class=\"pvc_stats all  \" data-element-id=\"185\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17498,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172,272],"tags":[171,277,243,510],"class_list":["post-185","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","category-272","tag-nmn","tag-277","tag-243","tag-510"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=185"}],"version-history":[{"count":3,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/185\/revisions"}],"predecessor-version":[{"id":17501,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/185\/revisions\/17501"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17498"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=185"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}