{"id":18424,"date":"2022-07-17T21:31:00","date_gmt":"2022-07-17T21:31:00","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18424"},"modified":"2022-07-18T12:01:59","modified_gmt":"2022-07-18T12:01:59","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e6%8a%97%e9%aa%a8%e8%b4%a8%e7%96%8f%e6%9d%be%e7%9a%84%e7%a0%94%e7%a9%b6%e6%9c%ba%e5%88%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18424","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u767d\u85dc\u82a6\u9187\u6297\u9aa8\u8d28\u758f\u677e\u7684\u7814\u7a76\u673a\u5236\u8fdb\u5c55"},"content":{"rendered":"<p>\uff3b\u6458\u8981\uff3d \u9aa8\u8d28\u758f\u677e\u662f\u4e00\u79cd\u968f\u7740\u5e74\u9f84\u589e\u957f\u6216\u75c5\u6001\u800c\u9aa8\u8d28\u4e0d\u65ad\u6d41\u5931\u3001\u9aa8\u5fae\u7ed3\u6784\u4e0d\u65ad\u6076\u5316\u4e14\u6613\u81f4\u9aa8\u6298\u7684\u5168\u8eab\u4ee3\u8c22\u6027\u75be<br \/>\n\u75c5\u3002\u968f\u7740\u4eba\u53e3\u7684\u8001\u9f84\u5316\uff0c\u5168\u4e16\u754c\u7684\u53d1\u75c5\u7387\u90fd\u5728\u6301\u7eed\u4e0a\u5347\uff0c\u8fd9\u4e25\u91cd\u7684\u5f71\u54cd\u4e86\u8001\u5e74\u4eba\u7fa4\u7684\u5065\u5eb7\u548c\u751f\u6d3b\u8d28\u91cf\u3002\u767d\u85dc\u82a6\u9187\u5177\u6709<br \/>\n\u96cc\u6fc0\u7d20\u6837\u4f5c\u7528\u4e14\u5728\u9aa8\u9abc\u4e2d\u5177\u6709\u591a\u5411\u9776\u70b9\uff0c\u80fd\u4fc3\u8fdb\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6210\u9aa8\u5206\u5316\u3001\u589e\u52a0\u6210\u9aa8\u7ec6\u80de\u589e\u6b96\u751f\u957f\u53ca\u6291\u5236\u7834\u9aa8\u7ec6\u80de\uff0c<br \/>\n\u767d\u85dc\u82a6\u9187\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7684\u7814\u7a76\u65e5\u76ca\u589e\u591a\u5e76\u6709\u4e00\u5b9a\u7684\u8fdb\u5c55\u3002\u672c\u6587\u5c06\u5bf9\u8fd1\u5e74\u6765\u767d\u85dc\u82a6\u9187\u9632\u6cbb\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u7814\u7a76\u8fdb\u5c55\u4f5c\u4e00<br \/>\n\u7efc\u8ff0\u3002<!--more--><\/p>\n<p>\uff3b\u5173\u952e\u8bcd\uff3d \u767d\u85dc\u82a6\u9187\uff1b\u9aa8\u8d28\u758f\u677e\uff1b\u96cc\u6fc0\u7d20\uff1b\u7814\u7a76<br \/>\n\u00b7\u7efc\u8ff0\u548c\u8bb2\u5ea7\u00b7<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u6297\u9aa8\u8d28\u758f\u677e\u7684\u7814\u7a76\u673a\u5236\u8fdb\u5c55<br \/>\n\u9648\u6960\uff0c\u9976\u5609\uff0c\u674e\u6210\u6c5f<br \/>\n\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5185\u5206\u6ccc\u79d1\uff0c\u6d59\u6c5f \u676d\u5dde 310003<\/p>\n<p>Advances in researches on mechanism of resveratrol anti \u2043 osteoporosis<br \/>\nCHEN Nan , RAO Jia, LI Cheng\u2043jiang. Department of Endocrine, First Affiliated Hospital of Medical College, Zhejiang Univer\u2043<br \/>\nsity , Hangzhou 310003, China<br \/>\n\uff3bAbstract\uff3d Osteoporosis is a systemic metabolic disease characterized by continuous loss of bone, deterioration of<br \/>\nbone microstructure and the risk of fracture with age or illness. With the aging of the population, the incidence of the disease<br \/>\naround the world continues to rise, which seriously affects the health and quality of life of the elderly. Resveratrol has estro\u2043<br \/>\ngen\u2043like effect and multiple targets on bone. It can promote osteogenic differentiation of bone marrow mesenchymal stem<br \/>\ncells, increase the proliferation and growth of osteoblasts and inhibit osteoclasts. At the cellular, animal and clinical level,<br \/>\nresearch on resveratrol in the treatment of osteoporosis is increasing and there has been some progress. This article reviews<br \/>\nthe recent progress of researches on resveratrol in the prevention and treatment of osteoporosis.<br \/>\n\uff3bKey words\uff3d resveratrol; osteoporosis; estrogen; research<\/p>\n<p>&nbsp;<\/p>\n<p>\u9aa8\u9abc\u662f\u65b0\u9648\u4ee3\u8c22\u5f88\u6d3b\u8dc3\u7684\u5668\u5b98\uff0c\u4e0d\u65ad\u5730\u901a\u8fc7\u6210\u9aa8\u7ec6\u80de\u5408\u6210\u65b0\u9aa8\u66ff\u6362\u7834\u9aa8\u7ec6\u80de\u5438\u6536\u964d\u89e3\u7684\u53d7\u635f\u9aa8\u6216<br \/>\n\u65e7\u9aa8\uff0c\u4f7f\u4eba\u4f53\u7684\u9aa8\u9abc\u7cfb\u7edf\u7ef4\u6301\u6b63\u5e38\u7684\u529f\u80fd\u3002\u4f46\u662f\uff0c\u9aa8\u9abc\u5408\u6210\u4e0e\u9aa8\u9abc\u5206\u89e3\u5438\u6536\u4e4b\u95f4\u7684\u5fae\u5999\u5e73\u8861\u4f1a\u968f\u7740\u8001\u5316<br \/>\n\u6216\u75c5\u6001\u7684\u7834\u574f\u800c\u6d88\u5931\uff0c\u5bfc\u81f4\u9aa8\u8d28\u6d41\u5931\u548c\u9aa8\u8d28\u758f\u677e\u3002\u9aa8\u8d28\u758f\u677e\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6162\u6027\u5168\u8eab\u6027\u9aa8\u4ee3\u8c22\u6027\u75be\u75c5\uff0c<br \/>\n\u5177\u6709\u9aa8\u91cf\u51cf\u5c11\u3001\u9aa8\u5bc6\u5ea6\u964d\u4f4e\u3001\u9aa8\u9abc\u5b54\u9699\u5ea6\u589e\u52a0\u3001\u9aa8\u67b6\u5fae\u7ed3\u6784\u6076\u5316\u53ca\u6613\u81f4\u9aa8\u6298\u7684\u7279\u70b9\u3002\u9aa8\u8d28\u758f\u677e\u75c7\u662f\u4e00\u4e2a<br \/>\n\u91cd\u8981\u7684\u5065\u5eb7\u95ee\u9898\uff0c\u968f\u7740\u4eba\u53e3\u7684\u8001\u9f84\u5316\uff0c\u5176\u53d1\u75c5\u7387\u6301\u7eed\u4e0a\u5347\uff0c\u6839\u636e 2016 \u5e74\u7684\u6c47\u603b\u6570\u636e\u663e\u793a\uff0c\u4e2d\u56fd\u5927\u9646 50 \u5c81<br \/>\n\u53ca \u4ee5 \u4e0a \u4eba \u7fa4 \u9aa8 \u8d28 \u758f \u677e \u60a3 \u75c5 \u7387 \u4ece 2008 \u5e74 \u4e4b \u524d \u768414.94%\u589e\u52a0\u52302012\u20142015\u5e74\u768427.96%\uff0c\u636e\u7edf\u8ba1\u5168\u7403<br \/>\n\u8d85\u8fc72\u4ebf\u4eba\u60a3\u6709\u8fd9\u79cd\u75be\u75c5\uff0c\u4f30\u8ba1\u6bcf\u5e74\u6709900\u4e07\u65b0\u53d1\u9aa8\u8d28\u758f\u677e\u6027\u9aa8\u6298\uff3b1-2\uff3d<\/p>\n<p>\u3002\u76ee\u524d\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7684\u5927\u591a\u6570\u836f\u7269<br \/>\n\u4f5c\u7528\u673a\u5236\u662f\u901a\u8fc7\u6291\u5236\u9aa8\u5438\u6536\u548c\u4fc3\u8fdb\u9aa8\u5f62\u6210\uff0c\u524d\u8005\u5305\u62ec\u964d\u9499\u7d20\u3001\u53cc\u81a6\u9178\u76d0\u3001\u96cc\u6fc0\u7d20\u7b49\uff0c\u540e\u8005\u5305\u62ec\u7532\u72b6\u65c1\u817a<br \/>\n\u6fc0\u7d20\u53ca\u5176\u7c7b\u4f3c\u7269\uff0c\u4f46\u5176\u957f\u671f\u5e94\u7528\u4e5f\u5e26\u6765\u5f88\u591a\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u5982\u53cc\u81a6\u9178\u76d0\u6613\u5f15\u8d77\u4e25\u91cd\u808c\u8089\u9aa8\u9abc\u75db\u3001\u80be\u529f\u80fd\u8870<\/p>\n<p>\u7aed\uff0c\u96cc\u6fc0\u7d20\u589e\u52a0\u5fc3\u529b\u8870\u7aed\u3001\u4e2d\u98ce\u3001\u4e73\u817a\u764c\u53ca\u5b50\u5bab\u764c\u7684\u98ce\u9669\uff0c\u7532\u72b6\u65c1\u817a\u6fc0\u7d20\u8d39\u7528\u6602\u8d35\u4e14\u589e\u52a0\u9aa8\u8089\u7624\u98ce\u9669\u3002<br \/>\n\u4eba\u4eec\u5bf9\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u8d77\u5230\u66f4\u5b89\u5168\u53ef\u9760\u7597\u6548\u7684\u836f\u7269\u9700\u6c42\u65e5\u76ca\u660e\u663e\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187\uff08Resveratrol\uff0cRes\uff09\u4e5f\u79f03\uff0c4\u2019\uff0c5-\u4e09\u7f9f\u57fa\u4e8c\u82ef\u4e59\u70ef\uff0c\u662f\u4e00\u79cd\u7ecf\u5178\u7684\u5929\u7136\u591a\u915a\u690d\u7269\u6297\u6bd2\u7d20\uff0c\u5e7f\u6cdb<br \/>\n\u5b58\u5728\u4e8e\u8bb8\u591a\u690d\u7269\u548c\u4e2d\u836f\u4e2d(\u5982\u864e\u6756\u3001\u8461\u8404\u76ae\u3001\u767d\u86c7\u85e4\u3001\u5927\u9ec4\u3001\u6d46\u679c\u3001\u82b1\u751f\u7b49)\uff0c\u5177\u6709\u589e\u5f3a\u81ea\u8eab\u514d\u75ab\u529b\u3001\u6297\u708e\u3001\u6297<br \/>\n\u83cc\u3001\u6297\u6c27\u5316\u3001\u4fdd\u62a4\u5fc3\u8840\u7ba1\u3001\u6297\u80bf\u7624\u7b49\u4f5c\u7528\uff3b3-4\uff3d\uff0c\u5176\u4ea6\u662f\u591a\u915a\u6027\u690d\u7269\u96cc\u6fc0\u7d20\uff0c\u53ef\u4ee5\u4e0e\u96cc\u6fc0\u7d20\u53d7\u4f53\u7ed3\u5408\uff0c\u53d1\u6325\u96cc\u6fc0<br \/>\n\u7d20\u6837\u4f5c\u7528\u3002\u8fd1\u5e74\u6765\u7531\u4e8e\u767d\u85dc\u82a6\u9187\u5177\u6709\u591a\u9776\u70b9\u3001\u5373\u65f6\u53ef\u7528\u3001\u4f4e\u6210\u672c\u3001\u4f4e\u6bd2\u7b49\u7279\u6027\uff0c\u5176\u5728\u9aa8\u8d28\u758f\u677e\u7684\u6cbb\u7597\u4f5c<br \/>\n\u7528\u8d8a\u6765\u8d8a\u53d7\u5173\u6ce8\u3002\u6545\u672c\u6587\u5c31\u767d\u85dc\u82a6\u9187\u5bf9\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u75c7\u7684\u7814\u7a76\u73b0\u72b6\u8fdb\u884c\u7efc\u8ff0\u3002<\/p>\n<p>1 \u767d\u85dc\u82a6\u9187\u5bf9\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u5f71\u54cd<\/p>\n<p>2 \u767d\u85dc\u82a6\u9187\u5bf9\u6210\u9aa8\u7ec6\u80de\u7684\u5f71\u54cd<\/p>\n<p>3 \u767d\u85dc\u82a6\u9187\u5bf9\u7834\u9aa8\u7ec6\u80de\u7684\u5f71\u54cd<\/p>\n<p>4 \u767d\u85dc\u82a6\u9187\u5bf9ROS\u4e0e\u94c1\u7684\u5f71\u54cd<\/p>\n<p>5 \u767d\u85dc\u82a6\u9187\u7684\u96cc\u6fc0\u7d20\u6837\u4f5c\u7528<\/p>\n<p>6 \u767d\u85dc\u82a6\u9187\u5728\u52a8\u7269\u53ca\u4e34\u5e8a\u4e2d\u7684\u7814\u7a76<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-18419\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/07\/Screenshot-1310-1024x576.png\" alt=\"\" width=\"900\" height=\"506\" 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href=\"https:\/\/www.google.ca\/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=&amp;ved=2ahUKEwiept2L5ID5AhXPg4kEHXvyDygQFnoECAMQAQ&amp;url=https%3A%2F%2Fwww.zgxyzz.org.cn%2FCN%2Farticle%2FdownloadArticleFile.do%3FattachType%3DPDF%26id%3D18867&amp;usg=AOvVaw0MZp4-ubLiJbHCiHuGdxOT\">https:\/\/www.google.ca\/url?sa=t&amp;rct=j&amp;q=&amp;esrc=s&amp;source=web&amp;cd=&amp;ved=2ahUKEwiept2L5ID5AhXPg4kEHXvyDygQFnoECAMQAQ&amp;url=https%3A%2F%2Fwww.zgxyzz.org.cn%2FCN%2Farticle%2FdownloadArticleFile.do%3FattachType%3DPDF%26id%3D18867&amp;usg=AOvVaw0MZp4-ubLiJbHCiHuGdxOT<\/a><\/p>\n<p>&nbsp;<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18424\" class=\"pvc_stats all  \" data-element-id=\"18424\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 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