{"id":18350,"date":"2022-07-01T15:28:10","date_gmt":"2022-07-01T15:28:10","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18350"},"modified":"2022-07-01T15:47:09","modified_gmt":"2022-07-01T15:47:09","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91%e8%84%91%e6%8d%9f%e4%bc%a4%e5%be%8c-nad-%e6%b0%b4%e5%b9%b3%e4%b8%8b%e9%99%8d%e7%9a%84%e6%b2%bb%e7%96%97%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18350","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011\u8111\u635f\u4f24\u5f8c NAD+ \u6c34\u5e73\u4e0b\u964d\u7684\u6cbb\u7597\u65b9\u6cd5"},"content":{"rendered":"

\u79d1\u5b66\u5bb6\u4eec\u8be6\u7ec6\u9610\u8ff0\u4e86 NAD+ \u6d88\u8017\u5982\u4f55\u635f\u5bb3\u7c92\u7ebf\u4f53\u62b5\u6297\u81ea\u7531\u57fa\u548c\u6d3b\u6027\u6c27\u7269\u8d28\u79ef\u7d2f\u7684\u80fd\u529b\u3002<\/p>\n

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\u5728\u8111\u635f\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u7684\u4e3b\u8981\u80fd\u91cf\u5236\u9020\u5de5\u5382-\u7c92\u7ebf\u4f53\u4f1a\u91ca\u653e\u79f0\u4e3a\u81ea\u7531\u57fa\u7684\u53cd\u5e94\u6027\u5206\u5b50\uff0c\u4ece\u800c\u5bfc\u81f4\u8fdb\u4e00\u6b65\u7684\u7ec6\u80de\u635f\u4f24\u3002 \u6700\u8fd1\uff0c\u9a6c\u91cc\u5170\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728\u5b66\u672f\u671f\u520a\u300a\u8111\u79d1\u5b66\u300b(Brain Sciences\u00a0)\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u7efc\u8ff0\u8bba\u6587\uff0c\u4ed6\u4eec\u8be6\u7ec6\u9610\u8ff0\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u5206\u5b50\u673a\u5236\uff0c\u5373\u7c92\u7ebf\u4f53\u62b5\u6d88\u8111\u635f\u4f24\u5f8c\u81ea\u7531\u57fa\u7684\u79ef\u7d2f<\/a>\uff0c\u5e76\u786e\u5b9a\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6cd5\u3002
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\u5728\u4ed6\u4eec\u7684\u8bba\u6587\u4e2d\uff0c\u4ed6\u4eec\u5047\u8bbe\uff0c\u4e00\u79cd\u53eb\u505a\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+)\u00a0\u7684\u57fa\u672c\u5206\u5b50\u5728\u8111\u635f\u4f24\u5f8c\u7684\u5206\u89e3\u4ee3\u8c22\u964d\u4f4e\u4e86\u7c92\u7ebf\u4f53\u4fee\u590d\u7ec6\u80de\u4e2d\u81ea\u7531\u57fa\u79ef\u7d2f\u4e36\u53cd\u5e94\u6027\u5206\u5b50\u79ef\u7d2f\u9020\u6210\u7684\u635f\u4f24\u7684\u80fd\u529b\u3002 \u7814\u7a76\u4eba\u5458\u5efa\u8bae\uff0c\u7528\u4e00\u79cd\u53eb\u505a\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN)\u00a0\u7684\u5206\u5b50\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u80fd\u4f1a\u51cf\u5c11\u8111\u635f\u4f24\u9020\u6210\u7684\u7ec6\u80de\u635f\u4f24\u3002<\/p>\n

NAD+ \u5bf9\u7ec6\u80de\u4e2d\u7684\u80fd\u91cf\u4ea7\u751f\u81f3\u5173\u91cd\u8981\uff0c\u5e76\u4e14\u5728\u4ee3\u8c22\u53cd\u5e94\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002 NAD+ \u8fd8\u901a\u8fc7\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u548c\u7ea0\u6b63\u5bf9\u6211\u4eec\u57fa\u56e0\u7ec4\u7684 DNA \u5206\u5b50\u7f16\u7801\u7684\u635f\u4f24\u6765\u6fc0\u6d3b\u5728\u8870\u8001\u548c\u75be\u75c5\u4e2d\u8d77\u9884\u9632\u4f5c\u7528\u7684\u9176\u3002 \u7136\u800c\uff0c\u7814\u7a76\u8868\u660e\uff0c\u52a8\u7269\u548c\u4eba\u7c7b\u7684 NAD+ \u6c34\u5e73\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u4e0b\u964d\uff0c\u5e76\u4e14\u5728\u53d7\u635f\u8111\u7ec4\u7ec7\u7684\u7c92\u7ebf\u4f53\u4e2d\u4e5f\u4f1a\u964d\u4f4e\u3002<\/p>\n

\u6d3b\u6027\u6c27\uff08\u542b\u6c27\u7684\u4e0d\u7a33\u5b9a\u5206\u5b50\uff09\u7684\u4ea7\u751f\u4e0e\u7ec6\u80de\u89e3\u6bd2\u8fc7\u7a0b\u7684\u6548\u7387\u4e4b\u95f4\u7684\u5e73\u8861\u51b3\u5b9a\u4e86\u6709\u5bb3\u6d3b\u6027\u6c27\u7684\u6c34\u5e73\u3002 \u6d3b\u6027\u6c27\u7684\u4ea7\u751f\u548c\u79f0\u4e3a\u81ea\u7531\u57fa\u89e3\u6bd2\u7684\u7ec6\u80de\u8fc7\u7a0b\uff08\u9176\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u81ea\u7531\u57fa\u635f\u4f24\uff09\u53d6\u51b3\u65bc NAD+ \u6c34\u5e73\u7684\u9ad8\u4f4e\u3002\u00a0\u7c92\u7ebf\u4f53\u4e2d NAD+ \u6c34\u5e73\u7684\u964d\u4f4e\u4f1a\u589e\u52a0\u6d3b\u6027\u6c27\u7269\u8d28\uff08\u5982\u8d85\u6c27\u5316\u7269\uff09\u7684\u4ea7\u751f\u5e76\u6291\u5236\u81ea\u7531\u57fa\u89e3\u6bd2\uff0c\u4f8b\u5982\u8d85\u6c27\u5316\u7269\u89e3\u6bd2\u3002<\/p>\n

NAD+ \u6c34\u5e73\u7684\u964d\u4f4e\u901a\u8fc7\u964d\u4f4e\u67d0\u4e9b\u9176\u7684\u6709\u6548\u6027\u6765\u6291\u5236\u81ea\u7531\u57fa\u89e3\u6bd2\u3002 \u4e00\u79cd\u4f9d\u8d56 NAD+ \u53d1\u6325\u529f\u80fd\u7684\u9176\u79f0\u4e3a sirtuin 3 (SIRT3)\uff0c\u5b83\u901a\u8fc7\u79f0\u4e3a\u8131\u4e59\u9170\u5316\u7684\u8fc7\u7a0b\u53bb\u9664\u6291\u5236\u86cb\u767d\u8d28\u529f\u80fd\u7684\u5206\u5b50\u6807\u7b7e\u3002 \u5f53\u8db3\u591f\u7684 NAD+ \u6c34\u5e73\u4fc3\u8fdb SIRT3 \u7684\u529f\u80fd\u65f6\uff0c\u5b83\u4f1a\u53bb\u4e59\u9170\u5316\u5e76\u56e0\u6b64\u6fc0\u6d3b\u4e00\u79cd\u79f0\u4e3a\u7c92\u7ebf\u4f53\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176 (MnSOD) \u7684\u9176\uff0c\u8fd9\u662f\u4e00\u79cd\u5fc5\u9700\u7684\u7c92\u7ebf\u4f53\u6297\u6c27\u5316\u9176\uff0c\u53ef\u4ee5\u89e3\u6bd2\u6d3b\u6027\u6c27\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(Klimova et al., 2020 |<\/a>\u00a0Brain Sciences<\/em><\/a>)\u00a0<\/a>\u8111\u635f\u4f24\u5f8c NAD+ \u6c34\u5e73\u964d\u4f4e\u4f1a\u6291\u5236 NAD+ \u4f9d\u8d56\u6027\u9176 SIRT3 \u7684\u6d3b\u6027\u3002 MnSOD \u4e59\u9170\u5316\u5728\u6ca1\u6709 SIRT3 \u7684\u60c5\u51b5\u4e0b\u79ef\u7d2f\u4ee5\u6d88\u9664\u4e59\u9170\u5316\uff08\u5373\u53bb\u4e59\u9170\u5316\uff09\u3002 \u7531\u65bc MnSOD \u6d3b\u6027\u53d7\u5230\u6291\u5236\uff0c\u6d3b\u6027\u6c27\u8d85\u6c27\u5316\u7269 (O2\uff0d) \u4f1a\u79ef\u805a\uff0c\u4ece\u800c\u5bfc\u81f4\u7c92\u7ebf\u4f53\u75c5\u53d8\u3002<\/p>\n

\u5f53 NAD+ \u6c34\u5e73\u5728\u8111\u635f\u4f24\u7b49\u60c5\u51b5\u4e0b\u964d\u4f4e\u65f6\uff0c\u5728\u6d3b\u6027\u6c27\u89e3\u6bd2\u4e2d\u5177\u6709\u91cd\u8981\u529f\u80fd\u4f5c\u7528\u7684\u9176\uff08\u5982 MnSOD\uff09\u4f1a\u53d7\u5230\u6291\u5236\uff0c\u4ece\u800c\u5bfc\u81f4\u81ea\u7531\u57fa\u548c\u6d3b\u6027\u6c27\u7684\u79ef\u7d2f\u3002 \u201c\u6211\u4eec\u516c\u5e03\u7684\u6570\u636e\u8868\u660e\uff0c\u6025\u6027\u8111\u635f\u4f24\u5f8c\uff0c\u8111\u7ec4\u7ec7 ROS \u6c34\u5e73\u7684\u5ef6\u8fdf\u589e\u52a0\u662f\u7531\u65bc\u6291\u5236\u4e86\u7c92\u7ebf\u4f53 NAD+ \u5206\u89e3\u4ee3\u8c22\u5f15\u53d1\u7684\u7c92\u7ebf\u4f53\u6297\u6c27\u5316\u673a\u5236\uff0c\u4ee5\u53ca\u968f\u4e4b\u800c\u6765\u7684\u9176\u7684\u8fc7\u5ea6\u4e59\u9170\u5316\uff0c\u8fd9\u4e9b\u9176\u7684\u6d3b\u6027\u5bf9\u65bc\u8d85\u6c27\u5316\u7269\u89e3\u6bd2\u81f3\u5173\u91cd\u8981\u3002\u201d \u8bba\u6587\u4e2d\u7684\u7814\u7a76\u4eba\u5458\u5982\u6b64\u4e3b\u5f20\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u4f7f\u7528NMN\u6765\u63d0\u9ad8 NAD+ \u6c34\u5e73\uff0c\u4ee5\u62b5\u6d88\u7ec6\u80de NAD+ \u6c34\u5e73\u968f\u5e74\u9f84\u589e\u957f\u800c\u964d\u4f4e\u7684\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u4e0b\u964d\u3002 \u8fd9\u7bc7\u7efc\u8ff0\u8bba\u6587\u7684\u4f5c\u8005\u8ba4\u4e3a\uff0c\u8865\u5145 NMN \u53ef\u80fd\u6784\u6210\u4e00\u79cd\u4ecb\u5165\u65b9\u6cd5\uff0c\u901a\u8fc7\u9632\u6b62\u7c92\u7ebf\u4f53\u4e2d NAD+ \u6c34\u5e73\u7684\u6d88\u8017\u6765\u51cf\u8f7b\u8111\u635f\u4f24\u5bfc\u81f4\u7684 NAD+ \u6c34\u5e73\u964d\u4f4e\u7684\u5f71\u54cd\u3002 \u7531\u65bc\u7c92\u7ebf\u4f53\u4e2d\u6d3b\u6027\u6c27\u6d53\u5ea6\u7684\u589e\u52a0\u4f1a\u5bf9\u7ec6\u80de\u9020\u6210\u635f\u5bb3\uff0c\u56e0\u6b64\u4f7f\u7528 NMN \u53ef\u4ee5\u6539\u5584\u56e0\u53d7\u4f24\u800c\u6d41\u5411\u5927\u8111\u7684\u8840\u6d41\u91cf\u51cf\u5c11\u5f8c\u7684\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n

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Klimova N, Fearnow A, Kristian T. Role of NAD+-Modulated Mitochondrial Free Radical Generation in Mechanisms of Acute Brain Injury. Brain Sci. 2020 Jul 14;10(7):449. doi: 10.3390\/brainsci10070449. PMID: 32674501; PMCID: PMC7408119.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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https:\/\/www.nmn.com\/news\/a-therapeutic-approach-to-falling-nad-levels-after-brain-injury<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u79d1\u5b66\u5bb6\u4eec\u8be6\u7ec6\u9610\u8ff0\u4e86 NAD+ \u6d88\u8017\u5982\u4f55\u635f\u5bb3\u7c92\u7ebf\u4f53\u62b5\u6297\u81ea\u7531\u57fa\u548c\u6d3b\u6027\u6c27\u7269\u8d28\u79ef\u7d2f\u7684\u80fd\u529b\u3002 \u5728\u8111\u635f\u4f24\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u7684\u4e3b\u8981\u80fd\u91cf\u5236\u9020\u5de5\u5382-\u7c92\u7ebf\u4f53\u4f1a\u91ca\u653e\u79f0\u4e3a\u81ea\u7531\u57fa\u7684\u53cd\u5e94\u6027\u5206\u5b50\uff0c\u4ece\u800c\u5bfc\u81f4\u8fdb\u4e00\u6b65\u7684\u7ec6\u80de\u635f\u4f24\u3002 \u6700\u8fd1\uff0c\u9a6c\u91cc\u5170\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728\u5b66\u672f\u671f\u520a\u300a\u8111\u79d1\u5b66\u300b(Brain Sciences\u00a0)\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u7efc\u8ff0\u8bba\u6587\uff0c\u4ed6\u4eec\u8be6\u7ec6\u9610\u8ff0\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u5206\u5b50\u673a\u5236\uff0c\u5373\u7c92\u7ebf\u4f53\u62b5\u6d88\u8111\u635f\u4f24\u5f8c\u81ea\u7531\u57fa\u7684\u79ef\u7d2f\uff0c\u5e76\u786e\u5b9a\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

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