{"id":18286,"date":"2022-06-25T18:30:42","date_gmt":"2022-06-25T18:30:42","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18286"},"modified":"2022-06-26T12:49:12","modified_gmt":"2022-06-26T12:49:12","slug":"nmn-%e9%80%9a%e8%bf%87%e6%bf%80%e6%b4%bb-ampk-%e6%98%be%e8%91%97%e5%a2%9e%e5%8a%a0%e7%bb%86%e8%83%9e%e8%83%bd%e9%87%8f%e4%bb%a3%e8%b0%a2","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18286","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN \u901a\u8fc7\u6fc0\u6d3b AMPK \u663e\u8457\u589e\u52a0\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18289\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/126597_732327.webp\" alt=\"\" width=\"677\" height=\"418\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/126597_732327.webp 677w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/126597_732327-300x185.webp 300w\" sizes=\"auto, (max-width: 677px) 100vw, 677px\" \/><\/p>\n<p><span style=\"font-size: 1rem;\">\u7528NMN\u4ecb\u5165\u4eba\u4f53\u7ec6\u80de\u4f1a\u4f7fNAD+\u6c34\u5e73\u589e\u52a0\u4e09\u500d\uff0c\u5e76\u589e\u52a0 AMPK \u7684\u6d3b\u6027\u2014\u2014\u4e00\u79cd\u5728\u4f4e\u80fd\u91cf\u65f6\u5f00\u542f\u7cd6\u548c\u8102\u80aa\u4ee3\u8c22\u7684\u9176\u3002<\/span><\/p>\n<p><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<ul>\n<li>\u7528NMN\u4ecb\u5165\u4eba\u7c7b\u4e73\u817a\u764c\u7ec6\u80de\u53ef\u5c06 AMPK \u7684\u6d3b\u6027\u63d0\u9ad8 1\uff0c200%\uff0cAMPK \u662f\u4e00\u79cd\u4ee3\u8c22\u4e3b\u5f00\u5173\uff0c\u53ef\u589e\u5f3a\u7ec6\u80de\u80fd\u91cf\u4ea7\u751f\u3002<\/li>\n<li>NMN \u4f7f\u7ec6\u80de\u5185 NAD+ \u7684\u6d53\u5ea6\u589e\u52a0\u4e09\u500d\uff0c\u8fd9\u662f\u4e00\u79cd\u5df2\u77e5\u7684\u7ec6\u80de\u80fd\u91cf\u5408\u6210\u7684\u91cd\u8981\u5206\u5b50\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u51cf\u5c11\u3002<\/li>\n<li>\u8fd9\u4e9b\u7ed3\u679c\u652f\u6301 NMN \u901a\u8fc7\u589e\u52a0\u7ec6\u80de NAD+ \u6c34\u5e73\u548c\u523a\u6fc0 AMPK \u6d3b\u6027\u6765\u63d0\u4f9b\u6297\u8870\u8001\u76ca\u5904\u3002<\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>\u7531\u4e8e\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09\u00a0\u5728\u7ec6\u80de\u5065\u5eb7\u4e2d\u7684\u57fa\u672c\u4f5c\u7528\uff0c\u63d0\u9ad8\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u6c34\u5e73\u5177\u6709\u5f88\u597d\u7684\u6297\u8870\u8001\u80fd\u529b\u3002 \u540c\u6837\uff0cAMPK \u901a\u5e38\u5728\u4f4e\u80fd\u91cf\u6c34\u5e73\uff08\u5305\u62ec\u70ed\u91cf\u9650\u5236\uff09\u65f6\u88ab\u6fc0\u6d3b\uff0c\u5b83\u662f\u4e00\u79cd\u4fc3\u8fdb\u4e0e\u957f\u5bff\u76f8\u5173\u7684\u8fc7\u7a0b\u7684\u57fa\u672c\u5206\u5b50\u3002 \u7814\u7a76\u8868\u660e\uff0c<strong><span style=\"color: #0000ff;\">\u670d\u7528\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09<\/span><\/strong>\u00a0\u8865\u5145\u5242<strong><span style=\"color: #0000ff;\">\u53ef\u4f7f\u4eba\u4f53\u7684 NAD+ \u51e0\u4e4e\u7ffb\u500d<\/span><\/strong>\u3002 \u4ee3\u8c22\u53c2\u6570\u7684\u6539\u5584\uff0c\u5982<strong><span style=\"color: #0000ff;\">\u7cd6\u5c3f\u75c5\u524d\u671f\u5973\u6027\u7684\u80f0\u5c9b\u7d20\u654f\u611f\u6027<\/span><\/strong>\u548c<strong><span style=\"color: #0000ff;\">\u957f\u8dd1\u8fd0\u52a8\u5458\u7684\u808c\u8089\u6c27\u5229\u7528\u7387<\/span><\/strong>\u4e5f\u4e0eNAD+\u6c34\u5e73\u7684\u589e\u52a0\u6709\u5173\u3002 \u7136\u800c\uff0c\u8fd8\u9700\u8981\u5256\u6790\u4e00\u79cd\u66f4\u7cbe\u786e\u7684\u7ec6\u80de\u673a\u5236\uff0c\u901a\u8fc7\u8fd9\u79cd\u673a\u5236\u4e86\u89e3\u589e\u52a0 NAD+ \u6c34\u5e73\u4f1a\u5e26\u6765\u54ea\u4e9b\u597d\u5904\u3002<\/p>\n<p>\u65e5\u672c Wellness-One Co.\uff0c Ltd \u7684Yamamoto \u53ca\u5176\u540c\u4e8b\u53d1\u8868\u5728\u5b66\u672f\u671f\u520a\u300a\u751f\u7269\u533b\u5b66\u7814\u7a76\u4e0e\u73af\u5883\u79d1\u5b66\u300b\uff08<em>Journal of Biomedical Research and Environmental Sciences\uff09\u00a0<\/em>\u4e0a\u53d1\u8868\u8bba\u6587<a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u8bc1\u660e\uff0c \u5728\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u7528 1 mg\/mL NMN \u4ecb\u5165\u4eba\u7c7b MCF-7 \u4e73\u817a\u764c\u7ec6\u80de\u4f1a\u63d0\u9ad8 AMP \u6d3b\u5316\u86cb\u767d\u6fc0\u9176 \uff08AMPK \uff09 \u6d3b\u52a8\u8d85\u8fc7 1\uff0c200%<\/a>\u3002 \u66f4\u91cd\u8981\u7684\u662f\uff0cNMN \u7684\u4ecb\u5165\u5c06\u7ec6\u80de\u5185 NAD+ \u6c34\u5e73\u63d0\u9ad8\u4e86\u4e09\u500d\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u901a\u8fc7\u589e\u52a0 NAD+ \u6c34\u5e73\uff0cNMN \u53ef\u4ee5\u4fc3\u8fdb\u7531 AMPK \u6fc0\u6d3b\u7684\u957f\u5bff\u76f8\u5173\u8fc7\u7a0b\uff0c\u5305\u62ec\u589e\u5f3a\u7c92\u7ebf\u4f53\u5065\u5eb7\u548c\u7ec6\u80de\u81ea\u566c\u2014\u2014\u7ec6\u80de\u788e\u7247\u5904\u7406\u7cfb\u7edf\u3002 \u8fd9\u9879\u7814\u7a76\u8fd8\u63d0\u4f9b\u4e86\u66f4\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u8865\u5145 NMN \u7b49 NAD+ \u524d\u4f53\u53ef\u4ee5\u63a8\u52a8\u7ec6\u80de\u80fd\u91cf\u4ea7\u751f\uff0c\u4ece\u800c\u7f13\u89e3\u8870\u8001\u8fc7\u7a0b\u4e2d\u4e0d\u7a33\u5b9a\u7684\u80fd\u91cf\u6c34\u5e73\u3002<\/p>\n<p>NMN\u5c06 AMPK \u6d3b\u6027\u63d0\u9ad8 12 \u500d\u5e76\u63d0\u9ad8 NAD+ \u6c34\u5e73<\/p>\n<p>\u4e3a\u4e86\u6d4b\u8bd5\u65bd\u7528 NMN \u5bf9 AMPK \u6d3b\u6027\u7684\u5f71\u54cd\uff0cYamamoto \u53ca\u5176\u540c\u4e8b\u5728\u57f9\u517b\u7269\u4e2d\u7528 1 mg\/kg \u4ecb\u5165 MCF-7 \u4eba\u4e73\u817a\u764c\u7ec6\u80de\u5e76\u6d4b\u91cf\u4e86 AMPK \u6d3b\u6027\u3002 \u572824\u5c0f\u65f6\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e0e\u672a\u7ecf\u4ecb\u5165\u7684\u7ec6\u80de\u76f8\u6bd4\uff0c\u6709NMN\u4ecb\u5165\u7684AMPK\u6d3b\u6027\u5728\u4e00\u5c0f\u65f6\u540e\u589e\u52a0\u4e86\u60ca\u4eba\u76841230.5%\uff0c\u572812\u5c0f\u65f6\u540e\u589e\u52a0\u4e86506.5%\uff0c\u572824\u5c0f\u65f6\u540e\u589e\u52a0\u4e86849.2%\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNMN\u7684\u4ecb\u5165\u5bf9\u653e\u5927 AMPK \u6d3b\u6027\u5177\u6709\u6df1\u8fdc\u7684\u5f71\u54cd\uff0c\u8868\u660e\u4fc3\u8fdb\u7c92\u7ebf\u4f53\u4ea7\u751f\u548c\u7ec6\u80de\u81ea\u566c\u7b49\u8fc7\u7a0b\uff0cNMN \u5728\u8fd9\u4e24\u8005\u90fd\u663e\u793a\u51fa\u6297\u8870\u8001\u4f5c\u7528\u3002<\/p>\n<p><a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">(Kawakami et al., 2022 |<\/a>\u00a0<a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Journal of Biomedical Research &amp; Environmental Sciences<\/em><\/a><a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">)<\/a>\u00a0<strong>NMN \u663e\u8457\u589e\u52a0\u4ee3\u8c22\u5065\u5eb7\u4fc3\u8fdb\u86cb\u767d AMPK \u7684\u6d3b\u6027<\/strong>\u3002 \u7528 1 mg\/mL NMN \u4ecb\u5165 MDF-7 \u4eba\u4e73\u817a\u764c\u7ec6\u80de\u540e\uff0cAMPK \u6d3b\u6027\u5728\u4e00\u5c0f\u65f6\u540e\u589e\u52a0\u8d85\u8fc7 1\uff0c200%\uff0c\u5728 12 \u5c0f\u65f6\u540e\u589e\u52a0\u8d85\u8fc7 500%\uff0c\u5728 24 \u5c0f\u65f6\u540e\u589e\u52a0\u7ea6 850%\u3002 \u8fd9\u4e9b\u7ed3\u679c\u7a81\u51fa\u4e86 NMN \u6cbb\u7597\u5bf9\u589e\u52a0 AMPK \u6d3b\u6027\u7684\u5f71\u54cd\u3002<\/p>\n<p>AMPK \u6700\u8fd1\u5728\u8870\u8001\u7814\u7a76\u4e2d\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002 \u4f8b\u5982\uff0c\u5df2\u53d1\u73b0 AMPK \u53ef\u8c03\u8282\u7ec6\u80de\u80fd\u91cf\u5e73\u8861\u3001\u4fdd\u62a4\u7c92\u7ebf\u4f53\u529f\u80fd\u5e76\u4fc3\u8fdb\u79f0\u4e3a\u81ea\u566c\u7684\u7ec6\u80de\u788e\u7247\u6e05\u6d01\u8fc7\u7a0b\u3002 \u4e5f\u8bb8\u6700\u6709\u8da3\u7684\u662f\uff0c\u901a\u8fc7\u589e\u5f3a\u7c92\u7ebf\u4f53\u529f\u80fd\uff0cAMPK\u5728ATP\u6c34\u5e73\u4e0b\u964d\u65f6\u5145\u5f53\u5206\u5b50\u80fd\u91cf\u5f00\u5173\uff0c\u7528\u4e8e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28974774\/\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u4ea7\u751f\u7ec6\u80de\u80fd\u91cf\u5206\u5b50\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09<\/a>\u3002 \u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0cAMPK \u6d3b\u6027\u4e0b\u964d\u4e0e\u8001\u5e74\u4eba\u7684\u80fd\u91cf\u6c34\u5e73\u964d\u4f4e\u6709\u5173\u3002 \u56e0\u6b64\uff0c\u589e\u52a0 AMPK \u6d3b\u6027\u53ef\u4ee5\u51cf\u8f7b\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u5e76\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n<p>Yamamoto \u53ca\u5176\u540c\u4e8b\u6d4b\u8bd5\u4e86\u7528 NMN \u4ecb\u5165\u764c\u7ec6\u80de\u5bf9\u7ec6\u80de\u5185 NAD+ \u6c34\u5e73\u7684\u5f71\u54cd\u3002 \u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0cNMN\u4f7fMCF-7\u7ec6\u80de\u5185\u7684NAD+\u6c34\u5e73\u589e\u52a0\u4e86\u4e24\u500d\u591a\u3002 \u8fd9\u4e9b\u7ed3\u679c\u6982\u62ec\u4e86\u4e4b\u524d\u7684\u53d1\u73b0\uff0c\u8868\u660e NMN \u6709\u6548\u5730\u63d0\u9ad8\u4e86\u4eba\u4f53\u7ec6\u80de\u4e2d\u7684 NAD+ \u6c34\u5e73\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-18288\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/728724_310559.webp\" alt=\"\" width=\"900\" height=\"409\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/728724_310559.webp 951w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/728724_310559-300x136.webp 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/728724_310559-768x349.webp 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/p>\n<p><a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff08Kawakami et al.\uff0c 2022 |<\/a>\u00a0<a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Journal of Biomedical Research &amp; Environmental Sciences<\/em><\/a><a href=\"https:\/\/www.jelsciences.com\/articles\/jbres1480.pdf\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff09<\/a>\u00a0<strong>NMN \u4f7f\u4eba MCF-7 \u4e73\u817a\u764c\u7ec6\u80de\u4e2d\u7684\u7ec6\u80de\u5185 NAD+ \u6c34\u5e73\u589e\u52a0\u4e09\u500d<\/strong>\u3002 \u4eba\u7c7b MCF-7 \u4e73\u817a\u764c\u7ec6\u80de\u5728\u57f9\u517b\u7269\u4e2d\u7528 1 mg\/mL NMN \u4ecb\u5165\u3002 \u7136\u540e\u6d4b\u91cf\u5438\u5149\u5ea6\u4ee5\u68c0\u6d4b NAD+ \u7684\u5b58\u5728\u3002 \u4e0e\u672a\u6709NMN\u4ecb\u5165\u7684\u7ec6\u80de\u76f8\u6bd4\uff0c\u63a5\u53d7NMN\u4ecb\u5165\u7684\u7ec6\u80de\u5185\u7684NAD+\u6d53\u5ea6\u589e\u52a0\u4e86\u4e09\u500d\u4ee5\u4e0a\u3002 \u8fd9\u4e9b\u7ed3\u679c\u652f\u6301 NMN \u6cbb\u7597\u663e\u8457\u589e\u52a0\u4e86\u4eba\u4f53\u7ec6\u80de\u4e2d\u7684 NAD+ \u6c34\u5e73\u3002<\/p>\n<p>\u6d4b\u8bd5\u764c\u7ec6\u80de\u662f\u5426\u80fd\u6982\u62ec NMN \u5bf9\u5065\u5eb7\u7ec6\u80de\u7684\u5f71\u54cd\uff1f<\/p>\n<p>\u901a\u8fc7\u589e\u5f3a\u7ec6\u80de\u80fd\u91cf\u8c03\u8282 AMPK \u7684\u6d3b\u6027\uff0cNMN \u53ef\u4ee5\u4fc3\u8fdb\u4e73\u817a\u764c\u7ec6\u80de\u8870\u8001\u65f6\u7684\u7ec6\u80de\u518d\u751f\u3002 \u4e0d\u8fc7\uff0c\u8fd9\u9879\u7814\u7a76\u7684\u6700\u5927\u95ee\u9898\u53ef\u80fd\u662fYamamoto\u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u7684MCF-7\u4e73\u817a\u764c\u7ec6\u80de\u8c31\u7cfb\u53ef\u80fd\u5df2\u7ecf\u5177\u6709\u4f4e AMPK \u6d3b\u5316\u548c\u4e0d\u7a33\u5b9a\u7684 NAD+ \u6c34\u5e73\u3002 \u6709\u8bb8\u591a\u66ff\u4ee3\u7ec6\u80de\u7cfb\u5e76\u975e\u6765\u81eaYamamoto\u53ca\u5176\u540c\u4e8b\u53ef\u4ee5\u4f7f\u7528\u7684\u4e73\u817a\u764c\u7b49\u60a3\u75c5\u7ec4\u7ec7\uff0c\u4f8b\u5982\u8840\u7ba1\u7ec6\u80de\uff08\u5185\u76ae\u7ec6\u80de\uff09\u3002 \u4e73\u817a\u764c\u7ec6\u80de\u7684\u4f7f\u7528\u53ef\u80fd\u88ab\u89c6\u4e3a\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u9650\u5236\uff0c\u56e0\u4e3a\u4eba\u4eec\u5bf9\u764c\u75c7\u7b49\u60a3\u75c5\u7ec4\u7ec7\u5982\u4f55\u5f71\u54cd AMPK \u6d3b\u6027\u548c NAD+ \u6c34\u5e73\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n<p>\u5206\u6790 NMN \u5bf9\u4eba\u7c7b\u8840\u6db2 ATP \u6c34\u5e73\u7684\u5f71\u54cd\u68c0\u67e5 NMN \u6297\u8870\u8001\u529f\u6548\u7684\u672a\u6765\u7814\u7a76\u53ef\u4ee5\u89c2\u5bdf<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17185366\/\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">\u8840\u6d46 ATP \u6c34\u5e73<\/a>\u00a0\uff0c\u4ee5\u786e\u5b9a\u670d\u7528 NMN \u662f\u5426\u4f1a\u589e\u52a0\u7ec6\u80de\u80fd\u91cf\u3002 NMN \u7684\u63a8\u8350\u5242\u91cf\u4ecb\u4e8e\u6bcf\u5929 250 mg \u5230 500 mg \u4e4b\u95f4\uff0c\u56e0\u6b64\u5242\u91cf\u4f9d\u8d56\u6027\u5206\u6790\u53ef\u4ee5\u6d4b\u8bd5\u4e0d\u540c\u6bcf\u65e5\u5242\u91cf\u7684 NMN \u7684\u6548\u679c\u3002 \u8be5\u5b9e\u9a8c\u53ef\u80fd\u8de8\u8d8a\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\uff0c\u4ee5\u786e\u5b9aNMN\u662f\u5426\u4e0d\u4ec5\u53ef\u80fd\u63d0\u9ad8 AMPK \u6d3b\u6027\u548c NAD+ \u6c34\u5e73\uff0c\u800c\u4e14\u8fd8\u5e26\u4e0b\u66f4\u9ad8\u7684 ATP \u4ea7\u91cf\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>Kawakami S, Fukuzawa Y, Ichikawa H, Sato T, Ide T, Maeda Y, Yamamoto T. NMN \u201cNicotinamide Mononucleotide\u201d Activates Intracellular Energy and Approaches the Prevention and Improvement of Aging. J Biomed Res Environ Sci. 2022 May 21; 3(5): 560-565. doi: 10.37871\/jbres1480, Article ID: JBRES1480, Available at: https:\/\/www.jelsciences.com\/ articles\/jbres1480.pdf<\/p>\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<p>https:\/\/www.nmn.com\/news\/nmn-dramatically-increases-activation-of-metabolic-regulator-ampk-in-human-cells<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18286\" class=\"pvc_stats all  \" data-element-id=\"18286\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 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