{"id":18280,"date":"2022-06-25T15:55:03","date_gmt":"2022-06-25T15:55:03","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18280"},"modified":"2022-06-26T12:47:29","modified_gmt":"2022-06-26T12:47:29","slug":"nad-%e5%89%8d%e4%bd%93-nmn-%e5%92%8c-nr-%e5%8f%af%e4%bb%a5%e6%8a%91%e5%88%b6%e8%bf%87%e6%95%8f%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18280","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NAD+ \u524d\u4f53 NMN \u548c NR \u53ef\u4ee5\u6291\u5236\u8fc7\u654f\u53cd\u5e94"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18283\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/682107_944702.webp\" alt=\"\" width=\"674\" height=\"411\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/682107_944702.webp 674w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/682107_944702-300x183.webp 300w\" sizes=\"auto, (max-width: 674px) 100vw, 674px\" \/><\/p>\n<p>NMN \u548c NR \u53ef\u4f5c\u4e3a\u6709\u6548\u7684\u4fdd\u5065\u54c1\uff0c\u5bf9\u6297\u7531\u5c0f\u9f20\u708e\u75c7\u56e0\u5b50\u7684\u767d\u7ec6\u80de\u5206\u6ccc\u7269\u4ecb\u5bfc\u7684\u5f3a\u70c8\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p class=\"date main-color-g\">Published:\u00a01:07 p.m. PST Jun 7, 2022\u00a0| Updated:\u00a01:50 p.m. PST Jun 8, 2022<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><em><strong>\u91cd\u5927\u4eae\u70b9<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<ul>\n<li>NMN\u548cNR\u53ef\u51cf\u8f7b\u88ab\u79f0\u4e3a\u8fc7\u654f\u6027\u4f11\u514b\u7684\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\uff0c\u8fd9\u53ef\u901a\u8fc7\u5c0f\u9f20\u4f53\u6e29\u4e0b\u964d\u548c\u8033\u6735\u80bf\u80c0\u51cf\u5c11\u6765\u8861\u91cf\u3002<\/li>\n<li>\u4e24\u79cd NAD+ \u524d\u4f53\u90fd\u6291\u5236\u4e86\u79f0\u4e3a\u80a5\u5927\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u91ca\u653e\u4fc3\u708e\u86cb\u767d\u3002<\/li>\n<li>\u901a\u8fc7\u57fa\u56e0\u5220\u9664\u86cb\u767d\u8d28Sirt6\u53ef\u4ee5\u51cf\u8f7bNMN\u548cNR\u5bf9\u8fc7\u654f\u6027\u4f11\u514b\u7684\u597d\u5904\uff0c\u8868\u660eSirt6\u662f\u6291\u5236\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u6240\u5fc5\u9700\u7684\u3002<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--more--><\/p>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u60f3\u8c61\u4e00\u4e0b\uff0c\u7531\u4e8e\u53ef\u80fd\u4f1a\u5f15\u53d1\u60a8\u8fc7\u654f\u7684\u98df\u7269\u3001\u836f\u7269\u6216\u5316\u5b66\u6bd2\u7d20\u5f15\u53d1\u7a81\u7136\u7684\u3001\u5371\u53ca\u751f\u547d\u7684\u8fc7\u654f\u6027\u4f11\u514b\u3002 \u7814\u7a76\u8868\u660e\uff0c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5589409\/#:~:text=Table%20I%20%20%20%20Region%20%20,0.24%202012%3A%200.24%20%201%20more%20rows%20\" target=\"_blank\" rel=\"noopener\" data-type=\"web\">1.6%\u5230 5.1% \u7684\u7f8e\u56fd\u516c\u6c11\u7ecf\u5386\u8fc7\u8fd9\u79cd\u7c7b\u578b\u7684\u8fc7\u654f\u53cd\u5e94<\/a>\uff0c\u79f0\u4e3a\u8fc7\u654f\u6027\u4f11\u514b\u3002 \u5927\u7ea6 1% \u7684\u8fc7\u654f\u6027\u4f11\u514b\u4f1a\u5bfc\u81f4\u6b7b\u4ea1\uff0c\u800c\u4e14\u9664\u4e86\u6ce8\u5c04\u80be\u4e0a\u817a\u7d20\u5916\uff0c\u6ca1\u6709\u5df2\u77e5\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u66f4\u6709\u8da3\u7684\u662f\uff0c\u52a8\u7269\u7814\u7a76\u8868\u660e\uff0c\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 \uff08NAD+\uff09 \u524d\u4f53\u70df\u9170\u80fa\uff08nicotinamide\uff09\u00a0\u53ef\u6291\u5236\u79f0\u4e3a\u7ec4\u7ec7\u80fa\u7684\u4fc3\u708e\u86cb\u767d\u4ece\u79f0\u4e3a\u80a5\u5927\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u4e2d\u91ca\u653e\u3002 \u7531\u4e8e\u80a5\u5927\u7ec6\u80de\u7ec4\u7ec7\u80fa\u91ca\u653e\u662f\u8fc7\u654f\u53cd\u5e94\u7684\u6807\u5fd7\uff0c\u8fd9\u4e00\u53d1\u73b0\u4e3a\u4fc3\u8fdb NAD+ \u4ee5\u62b5\u5fa1\u8fd9\u4e9b\u8fc7\u654f\u53cd\u5e94\u63d0\u4f9b\u4e86\u4e00\u7ebf\u5e0c\u671b\u3002 \u7136\u800c\uff0c\u5c1a\u672a\u5b8c\u6210\u6d4b\u8bd5NAD+\u524d\u4f53\u51cf\u8f7b\u8fc7\u654f\u53cd\u5e94\u7684\u529f\u6548\u3002 \u4e3a\u4ec0\u4e48\u4e0d\u4ece\u6d4b\u8bd5\u8fc4\u4eca\u4e3a\u6b62\u5df2\u77e5\u7684\u6700\u6709\u6548\u7684 NAD+ \u589e\u5f3a\u5242\u2014\u2014\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 \uff08NMN\uff09 \u548c\u70df\u9170\u80fa\u6838\u82f7 \uff08NR\uff09 \u5f00\u59cb\uff1f<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u97e9\u56fd\u5168\u5317\u56fd\u7acb\u5927\u5b66\u533b\u5b66\u9662\u7684 Park \u548c\u540c\u4e8b\u53d1\u8868\u5728 \u5b66\u672f\u671f\u520a\u300aTheranostics\u300b \u4e0a\u8868\u660e\uff0c\u7ed9\u5c0f\u9f20\u6ce8\u5c04 100 mg\/kg NMN \u6216 150 mg\/kg NR \u53ef\u4ee5\u4fdd\u6301\u5c0f\u9f20\u7684\u4f53\u6e29\uff0c\u9632\u6b62\u4e0e\u8fc7\u654f\u53cd\u5e94\u76f8\u5173\u7684\u4f53\u6e29\u4e0b\u964d\u3002 \u97e9\u56fd\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u7528 NMN \u6216 NR \u4ecb\u5165\u5c0f\u9f20\u53ef\u663e\u8457\u6291\u5236\u80a5\u5927\u7ec6\u80de\u5728\u66b4\u9732\u4e8e\u79f0\u4e3a\u6297\u539f\u7684\u8fc7\u654f\u8bf1\u5bfc\u5206\u5b50\u540e\u91ca\u653e\u4fc3\u708e\u86cb\u767d\u3002 \u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0c\u5220\u9664\u5bf9\u80a5\u5927\u7ec6\u80de\u6fc0\u6d3b\u81f3\u5173\u91cd\u8981\u7684Sirt6\u4f1a\u964d\u4f4eNR\u7684\u4fdd\u62a4\u4f5c\u7528\u3002 \u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u8865\u5145 NMN \u6216 NR \u53ef\u80fd\u901a\u8fc7\u6291\u5236\u4fc3\u708e\u86cb\u767d\u7684\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u6765\u5e2e\u52a9\u5e73\u606f\u4e25\u91cd\u7684\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<h3><strong><span style=\"color: #ff0000;\">NMN \u548c NR \u8865\u5145\u5242\u53ef\u6291\u5236\u5c0f\u9f20\u7684\u8fc7\u654f\u53cd\u5e94<\/span><\/strong><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u4e3a\u4e86\u786e\u5b9a NMN \u662f\u5426\u53ef\u4ee5\u9632\u6b62\u8fc7\u654f\u53cd\u5e94\uff0cPark \u53ca\u5176\u540c\u4e8b\u7ed9\u5c0f\u9f20\u6ce8\u5c04\u4e86 100 mg\/kg \u7684 NMN\u3002 24 \u5c0f\u65f6\u540e\uff0c\u5c0f\u9f20\u88ab\u6ce8\u5c04\u8fc7\u654f\u53cd\u5e94\u8bf1\u5bfc\u6297\u539f\u3002 \u7814\u7a76\u5c0f\u7ec4\u968f\u540e\u6d4b\u91cf\u4e86\u8fc7\u654f\u53cd\u5e94\u7684\u4e00\u4e2a\u5173\u952e\u6307\u6807\u2014\u2014\u4f53\u6e29\u2014\u2014\u56e0\u4e3a\u5728\u8fc7\u654f\u6027\u4f11\u514b\u671f\u95f4\u4f53\u6e29\u4f1a\u5927\u5e45\u4e0b\u964d\u3002 \u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u672a\u63a5\u53d7 NMN \u4ecb\u5165\u7684\u5c0f\u9f20\u4f53\u6e29\u4e0b\u964d\u4e86 4\u00b0C\uff0c\u4f46\u63a5\u53d7 NMN \u6cbb\u7597\u7684\u5c0f\u9f20\u4ec5\u4e0b\u964d\u4e86\u7ea6 2\u00b0C\u3002 \u6b64\u5916\uff0cPark \u53ca\u5176\u540c\u4e8b\u53d1\u73b0 NMN \u6cbb\u7597\u53ef\u4ee5\u6291\u5236\u8033\u6735\u80bf\u80c0\uff0c\u8fd9\u662f\u8fc7\u654f\u53cd\u5e94\u7684\u53e6\u4e00\u4e2a\u6807\u5fd7\u3002 \u8fd9\u4e9b\u7ed3\u679c\u901a\u8fc7 NR \u6ce8\u5c04 150 mg\/kg \u91cd\u73b0\uff0c\u8bf4\u660e\u8865\u5145 NAD+ \u524d\u4f53\u53ef\u4ee5\u663e\u8457\u51cf\u8f7b\u5c0f\u9f20\u7684\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18281\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/636526_875951.webp\" alt=\"\" width=\"580\" height=\"277\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/636526_875951.webp 580w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/636526_875951-300x143.webp 300w\" sizes=\"auto, (max-width: 580px) 100vw, 580px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff08Kim et al.\uff0c 2022 |<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Theranostics<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff09<\/a>\u00a0<strong>NMN \u6216 NR \u6cbb\u7597\u53ef\u6291\u5236\u5c0f\u9f20\u7684\u8fc7\u654f\u53cd\u5e94<\/strong>\u3002 \u7ed9\u5c0f\u9f20\u6ce8\u5c04 NMN \u53ef\u4ee5\u51cf\u5c11\u5b83\u4eec\u7684\u4f53\u6e29\u964d\u4f4e\uff08\u56fe C\uff09\u5e76\u51cf\u5c11\u8033\u6735\u80bf\u80c0\uff08\u56fe F\uff09\uff0c\u8fd9\u662f\u8fc7\u654f\u53cd\u5e94\u7684\u4e24\u4e2a\u6807\u5fd7\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>NMN \u548c NR \u6291\u5236\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u4fc3\u708e\u86cb\u767d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u7531\u4e8e\u80a5\u5927\u7ec6\u80de\u5728\u8fc7\u654f\u53cd\u5e94\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0cPark \u53ca\u5176\u540c\u4e8b\u6d4b\u91cf\u4e86 NMN \u548c NR \u7684\u4ecb\u5165\u662f\u5982\u4f55\u5f71\u54cd\u5176\u708e\u75c7\u56e0\u5b50\u7684\u91ca\u653e\u3002 \u4ed6\u4eec\u4ece\u5065\u5eb7\u5c0f\u9f20\u7684\u9aa8\u9ad3\u4e2d\u5206\u79bb\u51fa\u80a5\u5927\u7ec6\u80de\uff0c\u5e76\u5728 NMN \u6216 NR \u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u7528\u5f15\u8d77\u8fc7\u654f\u7684\u6297\u539f\u5bf9\u5176\u8fdb\u884c\u7814\u7a76\u3002 \u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cNMN \u6216 NR \u7684\u4ecb\u5165\u4f7f\u80a5\u5927\u7ec6\u80de\u4e2d\u4fc3\u708e\u7ec4\u86cb\u767d\u548c\u767d\u7ec6\u80de\u4ecb\u7d20 6 \uff08IL-6\uff09 \u7684\u91ca\u653e\u51cf\u5c11\u4e86\u8fd1\u4e00\u534a\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNMN\u548cNR\u53ef\u51cf\u8f7b\u80a5\u5927\u7ec6\u80de\u4fc3\u708e\u53cd\u5e94\uff0c\u4ece\u800c\u4f20\u64ad\u751f\u7406\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-image\">\n<div class=\"s-component-content\">\n<div class=\"s-img-wrapper\">\u00a0<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-18282\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/888482_441707.webp\" alt=\"\" width=\"451\" height=\"303\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/888482_441707.webp 451w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/06\/888482_441707-300x202.webp 300w\" sizes=\"auto, (max-width: 451px) 100vw, 451px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff08Kim et al.\uff0c 2022 |<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\"><em>Theranostics<\/em><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35547746\/\" target=\"_blank\" rel=\"noopener\" data-type=\"\">\uff09<\/a>\u00a0<strong>NMN \u548c NR \u7684\u4ecb\u5165\u663e\u8457\u6291\u5236\u4e86\u80a5\u5927\u7ec6\u80de\u4e2d\u4fc3\u708e\u7ec4\u7ec7\u80fa\u548c IL-6 \u86cb\u767d\u7684\u91ca\u653e<\/strong> \u3002 NMN \u548c NR \u5bf9\u57f9\u517b\u7684\u80a5\u5927\u7ec6\u80de\u7684\u4ecb\u5165\u663e\u8457\u51cf\u5c11\u4e86\u5b83\u4eec\u5728\u66b4\u9732\u4e8e\u8fc7\u654f\u539f\uff08\u6297\u539f\uff09\u540e\u91ca\u653e\u7684\u7ec4\u7ec7\u80fa\uff08\u5de6\u56fe\uff09\u548c IL-6\uff08\u53f3\u56fe\uff09\u708e\u75c7\u56e0\u5b50\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cNAD+ \u524d\u4f53\u901a\u8fc7\u6291\u5236\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u708e\u75c7\u56e0\u5b50\uff08\u4e00\u79cd\u79f0\u4e3a\u8131\u7c92\u7684\u7ec6\u80de\u8fc7\u7a0b\uff09\u6765\u5e73\u606f\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<h3><strong><span style=\"font-size: 1rem; color: #ff0000;\">\u9700\u8981 Sirt6 \u86cb\u767d\u6765\u51cf\u8f7b NAD+ \u524d\u4f53\u7684\u8fc7\u654f\u53cd\u5e94<\/span><\/strong><\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><span style=\"font-size: 1rem;\">\u7531\u4e8e\u5df2\u77e5Sirt6\u5728\u8c03\u8282\u80a5\u5927\u7ec6\u80de\u5bf9\u8fc7\u654f\u539f\u7684\u53cd\u5e94\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0cPark\u548c\u4ed6\u7684\u540c\u4e8b\u6d4b\u8bd5\u4e86\u57fa\u56e0\u5220\u9664\u662f\u5426\u4f1a\u6539\u53d8 NMN \u548c NR \u5bf9\u8fc7\u654f\u53cd\u5e94\u7684\u6709\u76ca\u4f5c\u7528\u3002 \u4ed6\u4eec\u53d1\u73b0\uff0c\u5728\u4ece\u5c0f\u9f20\u4f53\u5185\u5220\u9664 Sirt6 \u540e\uff0cNMN \u548c NR \u5bf9\u5bf9\u6297\u8fc7\u654f\u53cd\u5e94\u5f15\u8d77\u7684\u4f53\u6e29\u4e0b\u964d\u6216\u8033\u6735\u80bf\u80c0\u6ca1\u6709\u5f71\u54cd\u3002 \u6b64\u5916\uff0cNMN \u6216 NR \u90fd\u4e0d\u80fd\u6291\u5236\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u4fc3\u708e\u86cb\u767d\u3001\u7ec4\u7ec7\u80fa\u6216 IL-6 \u7684\u589e\u52a0\u3002 \u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cSirt6 \u529f\u80fd\u5bf9\u4e8e\u5e73\u606f\u8fc7\u654f\u53cd\u5e94\u662f\u5fc5\u8981\u7684\uff0c\u6fc0\u6d3b Sirt6 \u53ef\u80fd\u63d0\u4f9b\u53e6\u4e00\u79cd\u5bf9\u6297\u8fc7\u654f\u53cd\u5e94\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u4e2d\u63d0\u4f9b\u7684\u6570\u636e\u4f3c\u4e4e\u4ee4\u4eba\u4fe1\u670d\uff0c\u56e0\u4e3a NAD+ \u524d\u4f53\u8865\u5145\u5242\u51e0\u4e4e\u53ef\u4ee5\u51cf\u5c11\u4e00\u534a\u7684\u4f53\u6e29\u4e0b\u964d\uff0c\u5e76\u663e\u8457\u51cf\u5c11\u8fc7\u654f\u53cd\u5e94\u671f\u95f4\u7684\u8033\u6735\u80bf\u80c0\u3002 \u6b64\u5916\uff0cNMN\u548cNR\u8fd8\u663e\u8457\u964d\u4f4e\u4e86\u57f9\u517b\u7269\u4e2d\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u7684\u7ec4\u7ec7\u80fa\u548c IL-6 \u4fc3\u708e\u86cb\u767d\u7684\u6570\u91cf\u3002 \u5269\u4e0b\u7684\u6700\u5927\u95ee\u9898\u662f\u670d\u7528 NMN \u6216 NR \u7684\u4eba\u7c7b\u662f\u5426\u53ef\u4ee5\u51cf\u8f7b\u6025\u6027\u8fc7\u654f\u6027\u4f11\u514b\u7684\u5f71\u54cd\u3002 \u7531\u4e8e\u5c1a\u672a\u5728\u8fc7\u654f\u6027\u7684\u4eba\u7c7b\u4e2d\u8fdb\u884c\u5b9e\u9a8c\uff0c\u56e0\u6b64\u8fd9\u4e2a\u95ee\u9898\u4ecd\u7136\u96be\u4ee5\u56de\u7b54\u3002 \u5f88\u96be\u60f3\u8c61\u670d\u7528\u9ad8\u5242\u91cf\u7684 NMN \u6216 NR \u53ef\u4ee5\u963b\u6b62\u4eba\u7684\u8fc7\u654f\u53cd\u5e94\uff0c\u4f46\u8865\u5145\u5176\u4e2d\u4e00\u79cd NAD+ \u524d\u4f53\u4e5f\u8bb8\u53ef\u4ee5\u4f1a\u964d\u4f4e\u8fc7\u654f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>NAD+\u524d\u4f53\u8865\u5145\u5242\u80fd\u5426\u6539\u5584\u5e38\u89c1\u7684\u8fc7\u654f\u75c7\u72b6\uff1f<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c<strong><span style=\"color: #ff0000;\">NMN\u6216NR\u7684\u4ecb\u5165\u80fd\u51cf\u5c11\u80a5\u5927\u7ec6\u80de\u91ca\u653e\u7684\u4fc3\u708e\u75c7\u86cb\u767d\u3001\u7ec4\u7ec7\u80fa\u548cIL-6\uff0c\u8fd9\u5c31\u63d0\u51fa\u4e86NAD+\u524d\u4f53\u662f\u5426\u80fd\u5e2e\u52a9\u6cbb\u7597\u666e\u901a\u8fc7\u654f\u7684\u95ee\u9898<\/span><\/strong>\u3002 \u8fc7\u654f\u6027\u4f11\u514b\u662f\u8fc7\u654f\u53cd\u5e94\u8c31\u7cfb\u4e2d\u6700\u4e25\u91cd\u7684\u4e00\u7aef\uff0c\u800c\u53d1\u751f\u5728\u8fc7\u654f\u6027\u4f11\u514b\u4e2d\u7684\u8bb8\u591a\u76f8\u540c\u7684\u7ec6\u80de\u8fc7\u7a0b\u4e5f\u53d1\u751f\u5728\u666e\u901a\u8fc7\u654f\u4e2d\u3002 \u4e5f\u5c31\u662f\u8bf4\uff0c\u7ec4\u7ec7\u80fa\u548cIL-6\u7684\u91ca\u653e\u5728\u666e\u901a\u8fc7\u654f\u4e2d\u7ecf\u5e38\u53d1\u751f\uff0c\u800c\u4e14\u7a0b\u5ea6\u4e0d\u4e00\u3002 \u672a\u6765\u7684\u4eba\u4f53\u8bd5\u9a8c\u53ef\u4ee5\u7814\u7a76NMN\u6216NR\u8865\u5145\u5242\u5bf9\u8840\u6db2\u708e\u75c7\u56e0\u5b50\u6c34\u5e73\u7684\u5f71\u54cd\uff0c\u6216\u68c0\u67e5\u5bf9\u82b1\u7c89\u7b49\u666e\u901a\u8fc7\u654f\u8005\u7684\u75c7\u72b6\u4e25\u91cd\u7a0b\u5ea6\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-separator\">\n<div class=\"s-separator-content\">\n<div class=\"separator\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>Kim HW, Ryoo GH, Jang HY, Rah SY, Lee DH, Kim DK, Bae EJ, Park BH. NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice. Theranostics. 2022 Apr 11; 12(7):3316-3328. doi: 10.7150\/thno.69684. PMID: 35547746; PMCID: PMC9065190.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p>\u6587\u7ae0\u6765\u6e90<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section\">\n<div class=\"container\">\n<div class=\"sixteen columns\">\n<div class=\"s-blog-section-inner\">\n<div class=\"s-component s-text\">\n<div class=\"\">\n<div class=\"s-component-content s-font-body\">\n<p><a href=\"https:\/\/www.nmn.com\/news\/nad-precursors-nmn-and-nr-suppress-hyper-allergic-reactions\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nmn.com\/news\/nad-precursors-nmn-and-nr-suppress-hyper-allergic-reactions<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18280\" class=\"pvc_stats all  \" data-element-id=\"18280\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>NMN \u548c NR \u53ef\u4f5c\u4e3a\u6709\u6548\u7684\u4fdd\u5065\u54c1\uff0c\u5bf9\u6297\u7531\u5c0f\u9f20\u708e\u75c7\u56e0\u5b50\u7684\u767d\u7ec6\u80de\u5206\u6ccc\u7269\u4ecb\u5bfc\u7684\u5f3a\u70c8\u8fc7\u654f\u53cd\u5e94\u3002 Published:\u00a01:07 p.m. PST Jun 7, 2022\u00a0| Updated:\u00a01:50 p.m. PST Jun 8, 2022 \u91cd\u5927\u4eae\u70b9 NMN\u548cNR\u53ef\u51cf\u8f7b\u88ab\u79f0\u4e3a\u8fc7\u654f\u6027\u4f11\u514b\u7684\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\uff0c\u8fd9\u53ef\u901a\u8fc7\u5c0f\u9f20\u4f53\u6e29\u4e0b\u964d\u548c\u8033\u6735\u80bf\u80c0\u51cf\u5c11\u6765\u8861\u91cf\u3002 \u4e24\u79cd NAD+ \u524d\u4f53\u90fd\u6291\u5236\u4e86\u79f0\u4e3a\u80a5\u5927\u7ec6\u80de\u7684\u767d\u7ec6\u80de\u91ca\u653e\u4fc3\u708e\u86cb\u767d\u3002 \u901a\u8fc7\u57fa\u56e0\u5220\u9664\u86cb\u767d\u8d28Sirt6\u53ef\u4ee5\u51cf\u8f7bNMN\u548cNR\u5bf9\u8fc7\u654f\u6027\u4f11\u514b\u7684\u597d\u5904\uff0c\u8868\u660eSirt6\u662f\u6291\u5236\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u6240\u5fc5\u9700\u7684\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18280\" class=\"pvc_stats all  \" data-element-id=\"18280\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" 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