{"id":18160,"date":"2022-06-12T14:02:19","date_gmt":"2022-06-12T14:02:19","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18160"},"modified":"2022-06-12T14:36:17","modified_gmt":"2022-06-12T14:36:17","slug":"nad-%e7%bb%93%e5%90%88%e5%b9%b6%e6%8a%91%e5%88%b6%e4%bf%83%e8%bf%9b%e7%a5%9e%e7%bb%8f%e5%85%83%e9%80%80%e5%8c%96%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b4%a8","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18160","title":{"rendered":"NAD+ \u7ed3\u5408\u5e76\u6291\u5236\u4fc3\u8fdb\u795e\u7ecf\u5143\u9000\u5316\u7684\u86cb\u767d\u8d28"},"content":{"rendered":"

\u7814\u7a76\u4eba\u5458\u63d0\u51fa\uff0c\u65b0\u53d1\u73b0\u7684 Sarm1 \u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7ed3\u5408\u4f4d\u70b9\u53ef\u80fd\u662f\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684\u836f\u7269\u9776\u70b9\u3002<\/p>\n

\u5c06\u4fe1\u53f7\u4ece\u4e00\u4e2a\u795e\u7ecf\u5143\u4f20\u9012\u5230\u53e6\u4e00\u4e2a\u795e\u7ecf\u5143\u7684\u8f74\u7a81\u9000\u5316\u53d1\u751f\u5728\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u3002\u4e00\u79cd\u540d\u4e3a\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u5206\u5b50\u901a\u8fc7\u5bf9\u4e00\u79cd\u540d\u4e3a Sarm1 \u7684\u86cb\u767d\u8d28\u7684\u4e0d\u6e05\u695a\u7684\u4f5c\u7528\u5728\u7ef4\u6301\u8f74\u7a81\u4e2d\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5728\u88ab\u6fc0\u6d3b\u65f6\u4f1a\u5bfc\u81f4\u795e\u7ecf\u5143\u9000\u5316\u3001\u795e\u7ecf\u5143\u8fdb\u884c\u6027\u840e\u7f29\u548c\u529f\u80fd\u4e27\u5931\u3002<\/p>\n

\u6700\u8fd1\uff0c\u6765\u81ea\u4e2d\u56fd\u5317\u4eac\u7684\u5317\u4eac\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728 Nature \u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\uff0c\u4ed6\u4eec\u53d1\u73b0 NAD+ \u4e0e\u4eba\u7c7b Sarm1 \u4e0a\u6291\u5236\u5176\u4fc3\u795e\u7ecf\u9000\u884c\u6027\u6d3b\u52a8\u7684\u533a\u57df\u7ed3\u5408\u3002\u6b64\u5916\uff0cSarm1 \u4e0e NAD+ \u7ed3\u5408\u533a\u57df\u7684\u7834\u574f\u6fc0\u6d3b\u4e86\u8be5\u86cb\u767d\u8d28\u5e76\u5bfc\u81f4\u5c0f\u9f20\u795e\u7ecf\u5143\u7684\u8f74\u7a81\u9000\u5316\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u4e86\u4e00\u79cd\u673a\u5236\uff0c\u5373 NAD+ \u4ecb\u5bfc Sarm1 \u6291\u5236\u4fc3\u8fdb\u795e\u7ecf\u5143\u9000\u5316\u3002<\/p>\n

NAD+ \u662f\u5236\u9020\u80fd\u91cf\u548c\u7ef4\u6301\u7ec6\u80de\u5065\u5eb7\u7684\u91cd\u8981\u5206\u5b50\u3002\u7ec6\u80de\u4e2d\u7684 NAD+ \u6c34\u5e73\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u964d\u4f4e\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u8fd9\u4e0e\u67d0\u4e9b\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u5173\uff0c\u4f8b\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002\u7814\u7a76\u4eba\u5458\u5c1a\u672a\u5b8c\u5168\u786e\u5b9a\u7ec6\u80de\u4e2d\u7684 NAD+ \u6c34\u5e73\u5982\u4f55\u6f5c\u5728\u5730\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u9000\u5316\u3002<\/p>\n

\"\"<\/p>\n

Sarm1\u86cb\u767d\u7684\u6fc0\u6d3b\u4fc3\u8fdbNAD+\u7684\u5206\u5b50\u5206\u89e3\uff0c\u5176\u6fc0\u6d3b\u8bf1\u5bfc\u795e\u7ecf\u5143\u9000\u5316\u3002\u5b83\u5177\u6709\u4e09\u4e2a\u86cb\u767d\u8d28\u533a\u57df\uff0c\u4e5f\u79f0\u4e3a\u7ed3\u6784\u57df\uff0c\u5206\u522b\u79f0\u4e3a ARM\u3001TIR \u548c SAM\uff0c\u8fd9\u4e9b\u7ed3\u6784\u57df\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd Sarm1 \u7684\u795e\u7ecf\u9000\u884c\u6027\u6fc0\u6d3b\u3002<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e00\u79cd\u79f0\u4e3a\u7535\u5b50\u663e\u5fae\u955c\u7684\u6280\u672f\u6765\u83b7\u53d6\u751f\u7269\u6837\u672c\u7684\u9ad8\u5206\u8fa8\u7387\u56fe\u50cf\uff0c\u4ee5\u89c2\u5bdf Sarm1 \u7684\u7cbe\u7ec6\u5206\u5b50\u7ec6\u8282\u3002\u4ed6\u4eec\u53d1\u73b0 ARM \u7ed3\u6784\u57df\u4e0e TIR \u7ed3\u6784\u57df\u76f8\u4e92\u4f5c\u7528\uff0cNAD+ \u4e0e ARM \u7ed3\u6784\u57df\u7684\u7ed3\u5408\u6291\u5236\u4e86 TIR \u7ed3\u6784\u57df\u7684\u6d3b\u6027\u4ee5\u53ca Sarm1 \u4fc3\u8fdb\u795e\u7ecf\u5143\u9000\u5316\u7684\u6d3b\u6027\u3002<\/p>\n

\u6291\u5236 ARM \u7ed3\u6784\u57df\u548c TIR \u7ed3\u6784\u57df\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u7a81\u53d8\u5bfc\u81f4\u5e7f\u6cdb\u7684\u8f74\u7a81\u53d8\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cARM \u7ed3\u6784\u57df\u4e0e Sarm1 \u7684 TIR \u7ed3\u6784\u57df\u76f8\u4e92\u4f5c\u7528\uff0c\u6291\u5236\u4e86 Sarm1 \u7684\u795e\u7ecf\u9000\u884c\u6027\u6d3b\u52a8\u3002<\/p>\n

\u6b64\u5916\uff0cSarm1 \u901a\u8fc7\u7834\u574f\u5176 NAD+ \u7ed3\u5408\u4f4d\u70b9\u4ee5\u53ca ARM \u548c TIR \u7ed3\u6784\u57df\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u88ab\u6fc0\u6d3b\uff0c\u4ece\u800c\u5bfc\u81f4\u8f74\u7a81\u53d8\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e NAD+ \u4ecb\u5bfc\u7684 Sarm1 \u81ea\u6211\u6291\u5236\u5bfc\u81f4\u795e\u7ecf\u5143\u9000\u5316\u3002<\/p>\n

\n

\u201c\u7279\u522b\u6709\u8da3\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0 NAD+ \u4f5c\u4e3a Sarm1 ARM \u7684\u65b0\u578b\u914d\u4f53\uff0c\u201d\u7814\u7a76\u4eba\u5458\u5728\u4ed6\u4eec\u7684\u7814\u7a76\u4e2d\u8bf4\u3002 \u201cNAD+\u7ed3\u5408\u53ef\u4ee5\u4fc3\u8fdb\u86cb\u767d\u8d28\u7684\u81ea\u6211\u6291\u5236\uff0c\u56e0\u4e3a\u635f\u5bb3NAD+\u7ed3\u5408\u7684\u7a81\u53d8\u4ea7\u751f\u4e86\u7ec4\u6210\u578b\u6d3b\u6027Sarm1\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u79cd NAD+ \u4ecb\u5bfc\u7684\u81ea\u6211\u6291\u5236\u673a\u5236\u5f97\u5230\u4e86\u53e6\u4e00\u9879\u7814\u7a76\u7684\u652f\u6301\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u53d1\u73b0\u4e5f\u53ef\u80fd\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n

\u201c\u65b0\u53d1\u73b0\u7684 NAD+ \u7ed3\u5408\u4f4d\u70b9\u53ef\u80fd\u6210\u4e3a\u4e00\u4e2a\u6709\u524d\u9014\u7684\u836f\u7269\u9776\u70b9\uff0c\u201d\u7814\u7a76\u4eba\u5458\u5efa\u8bae\u9053\u3002 \u201cNAD+ \u7684\u5c0f\u5206\u5b50\u7c7b\u4f3c\u7269\u4f1a\u963b\u65ad Sarm1 \u7684\u6fc0\u6d3b\u2026\u2026\u6b64\u7c7b\u5316\u5408\u7269\u53ef\u80fd\u5bf9\u6cbb\u7597\u4e0d\u540c\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u5177\u6709\u5e7f\u6cdb\u7684\u610f\u4e49\u3002\u201d<\/p>\n<\/div>\n

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\u5168\u6587\u6765\u6e90<\/strong><\/p>\n

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\u7814\u7a76\u4eba\u5458\u63d0\u51fa\uff0c\u65b0\u53d1\u73b0\u7684 Sarm1 \u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7ed3\u5408\u4f4d\u70b9\u53ef\u80fd\u662f\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684\u836f\u7269\u9776\u70b9\u3002 \u5c06\u4fe1\u53f7\u4ece\u4e00\u4e2a\u795e\u7ecf\u5143\u4f20\u9012\u5230\u53e6\u4e00\u4e2a\u795e\u7ecf\u5143\u7684\u8f74\u7a81\u9000\u5316\u53d1\u751f\u5728\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u3002\u4e00\u79cd\u540d\u4e3a\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u5206\u5b50\u901a\u8fc7\u5bf9\u4e00\u79cd\u540d\u4e3a Sarm1 \u7684\u86cb\u767d\u8d28\u7684\u4e0d\u6e05\u695a\u7684\u4f5c\u7528\u5728\u7ef4\u6301\u8f74\u7a81\u4e2d\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5728\u88ab\u6fc0\u6d3b\u65f6\u4f1a\u5bfc\u81f4\u795e\u7ecf\u5143\u9000\u5316\u3001\u795e\u7ecf\u5143\u8fdb\u884c\u6027\u840e\u7f29\u548c\u529f\u80fd\u4e27\u5931\u3002 \u6700\u8fd1\uff0c\u6765\u81ea\u4e2d\u56fd\u5317\u4eac\u7684\u5317\u4eac\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5728 Nature \u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\uff0c\u4ed6\u4eec\u53d1\u73b0 NAD+ \u4e0e\u4eba\u7c7b Sarm1 \u4e0a\u6291\u5236\u5176\u4fc3\u795e\u7ecf\u9000\u884c\u6027\u6d3b\u52a8\u7684\u533a\u57df\u7ed3\u5408\u3002\u6b64\u5916\uff0cSarm1 \u4e0e NAD+ \u7ed3\u5408\u533a\u57df\u7684\u7834\u574f\u6fc0\u6d3b\u4e86\u8be5\u86cb\u767d\u8d28\u5e76\u5bfc\u81f4\u5c0f\u9f20\u795e\u7ecf\u5143\u7684\u8f74\u7a81\u9000\u5316\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u4e86\u4e00\u79cd\u673a\u5236\uff0c\u5373 NAD+ \u4ecb\u5bfc Sarm1 \u6291\u5236\u4fc3\u8fdb\u795e\u7ecf\u5143\u9000\u5316\u3002<\/p>\n

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