{"id":18155,"date":"2022-06-12T12:35:07","date_gmt":"2022-06-12T12:35:07","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18155"},"modified":"2022-06-12T12:35:58","modified_gmt":"2022-06-12T12:35:58","slug":"%e6%9c%80%e5%a5%bd%e7%9a%84nad%e5%89%8d%e4%bd%93%e6%98%afnmn%ef%bc%8cnr%ef%bc%8cna%e8%bf%98%e6%98%aftrp","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18155","title":{"rendered":"\u6700\u597d\u7684NAD+\u524d\u4f53\u662fNMN\uff0cNR\uff0cNA\u8fd8\u662fTRP?"},"content":{"rendered":"<p>\u4e0d\u53ef\u5426\u8ba4\u7684\u662f\uff0c\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff08NMN\uff09\u548c\u70df\u9170\u80fa\u6838\u7cd6\uff08NR\uff09\u662f\u76ee\u524d\u5e02\u573a\u4e0a\u6700\u77e5\u540d\u7684NAD+\u524d\u4f53\u8865\u5145\u5242\uff0c\u5176\u6b21\u662f\u70df\u9178\uff08NA\uff09\uff0c\u70df\u9170\u80fa\uff08Nam\uff09\u548c\u8272\u6c28\u9178\uff08Trp)\u3002\u00a0<sup>[1]\u00a0<\/sup>\u9664\u8272\u6c28\u9178\u5916\uff0c\u6240\u6709\u8fd9\u4e9b\u524d\u4f53\u5747\u4e3a\u7ef4\u751f\u7d20B3\u884d\u751f\u7269\u3002<\/p>\n<p>\u8272\u6c28\u9178\u662f\u5e7f\u6cdb\u51fa\u73b0\u5728\u5404\u79cd\u98df\u54c1\u4e2d\u7684\u4e00\u79cd\u6c28\u57fa\u9178\uff0c 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style=\"color: #ff0000;\">NMN\u6709\u5176\u72ec\u7279\u7684\u8f6c\u8fd0\u86cb\u767d\uff0cNR\u5374\u6ca1\u6709<\/span><\/p><\/blockquote>\n<p>NMN\u662f\u76f4\u63a5\u7684NAD+\u524d\u4f53\uff0c\u53ef\u4ee5\u5728\u7ec6\u80de\u4e2d\u6709\u6548\u5229\u7528\u3002<\/p>\n<p>\u65b0\u53d1\u73b0\u7684NMN\u8f6c\u8fd0\u86cb\u767d\u57fa\u56e0SLC12A8\u663e\u793a\uff0cNMN\u76f4\u63a5\u8fdb\u5165\u7ec6\u80de\uff0c\u800c\u8fdb\u5165\u7ec6\u80de\u4e4b\u524d\u6ca1\u6709\u53d8\u6210NR\u3002<sup>[5]<\/sup>\u5b9e\u9645\u4e0a\uff0cNMN\u62e5\u6709\u72ec\u7279\u7684\u5373\u65f6\u8fd0\u8f93\u7cfb\u7edf\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5f53\u7ec6\u80de\u4e2dNAD+\u542b\u91cf\u8f83\u4f4e\u65f6\uff0c\u5b83\u4eec\u4f1a\u901a\u8fc7\u8868\u8fbe\u66f4\u591aSLC12A8\u8f6c\u8fd0\u86cb\u767d\u6765\u505a\u51fa\u53cd\u5e94\uff0c\u4ece\u800c\u80fd\u591f\u6709\u6548\u5438\u6536\u8840\u6db2\u4e2d\u7684NMN\u3002 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#ff0000;\">NMN\u6bd4NR\u66f4\u7a33\u5b9a<\/span><\/strong><\/p><\/blockquote>\n<p>\u5728\u5c0f\u9f20\u548c\u4eba\u4f53\u7814\u7a76\u4e2d\uff0c\u5df2\u8bc1\u5b9eNR\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff0c\u5e76\u8fc5\u901f\u964d\u89e3\u4e3a\u5e38\u89c4\u7ef4\u751f\u7d20B3\u3002\u964d\u7ea7\u4e3aB3\u7684NR\u53ea\u80fd\u901a\u8fc7\u9176\u4fc3\u901f\u7387\u53d7\u9650\u7684\u4ece\u5934\u9014\u5f84\u8fdb\u884c\uff0c\u65e0\u6cd5\u5c06\u60a8\u7684NAD+\u6c34\u5e73\u63d0\u9ad8\u5230\u57fa\u7ebf\u4ee5\u4e0a\u3002<sup>[6]<\/sup><\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0cNMN\u5728\u4f53\u5185\u9ad8\u5ea6\u7a33\u5b9a\uff0c\u56e0\u6b64\u53ef\u4ee5\u66f4\u597d\u5730\u5229\u7528\u4e0d\u53d7\u9650\u5236\u7684\u633d\u6551\u9014\u5f84\uff0c\u5e76\u4f7fNAD+\u6c34\u5e73\u663e\u7740\u9ad8\u4e8e\u57fa\u7ebf\u3002<\/p>\n<p>\u6b64\u5916\uff0cNMN\u5728\u5316\u5b66\u548c\u7269\u7406\u7279\u6027\u65b9\u9762\u6bd4NR\u66f4\u7a33\u5b9a\u3002\u5ba4\u6e29\u4e0b\u7684NMN\u7c89\u672b\u7a33\u5b9a\uff0c\u53ef\u957f\u65f6\u95f4\u8fd0\u8f93\u548c\u50a8\u5b58\u3002<\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u7a33\u5b9a\u6027\u610f\u5473\u7740\u4eba\u4f53\u53ef\u4ee5\u5438\u6536\u66f4\u591a\u7684NAD\u3002<\/p>\n<blockquote><p><strong><span style=\"color: #ff0000;\">NMN\u6bd4NR\u5177\u6709\u66f4\u9ad8\u7684\u751f\u7269\u5229\u7528\u5ea6\uff08\u5438\u6536\uff09<\/span><\/strong><\/p><\/blockquote>\n<p>\u5728\u4e00\u9879\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0cNMN\u901a\u8fc7\u80a0\u9053\u5438\u6536\uff0c\u5e76\u57282-3\u5206\u949f\u5185\u5c31\u5728\u8840\u6db2\u4e2d\u68c0\u6d4b\u5230\u3002\u572815\u5206\u949f\u5185\uff0cNMN\u88ab\u5b8c\u5168\u5438\u6536\u5230\u7ec6\u80de\u7ec4\u7ec7\u4e2d\uff0c\u968f\u540e\u8f6c\u5316\u4e3aNAD+\u4ee5\u5907\u8fdb\u4e00\u6b65\u4f7f\u7528\u3002<sup>[7]<\/sup><\/p>\n<p>\u670d\u7528NR\u7684\u5c0f\u9f20\u809d\u810f\u4e2d\u7684NMN\u5728\u7ea63-4\u5c0f\u65f6\u540e\u53ef\u68c0\u6d4b\u5230\u589e\u52a0\u3002\u57287.7\u5c0f\u65f6\u65f6\uff0c\u8840\u6db2\u4e2d\u7684NAD+\u6bd4\u57fa\u7ebf\u6d53\u5ea6\u589e\u52a0\u4e862.7\u500d\u3002<sup>[3]<\/sup><\/p>\n<p>\u540c\u6837\uff0c\u4e00\u9879\u4eba\u7c7b\u7814\u7a76\u8868\u660e\uff0c\u57281000\u6beb\u514b\u5242\u91cf\u7684NR\u540e\uff0c\u5168\u8840\u4e2d\u7684NR\u6c34\u5e73\u57283\u5c0f\u65f6\u5de6\u53f3\u8fbe\u5230\u5cf0\u503c\u3002<sup>[8]<\/sup>\u56e0\u6b64\uff0cNR\u53ef\u80fd\u9700\u89812\u52303\u4e2a\u5c0f\u65f6\u624d\u80fd\u901a\u8fc7\u80a0\u9053\u5438\u6536\uff0c\u6216\u8005\u67d0\u4e9bNR\u5728\u8f6c\u5316\u4e3aNMN\u4e4b\u524d\u88ab\u964d\u89e3\u4e3a\u70df\u9170\u80fa\u3002<\/p>\n<p>\u7531\u6b64\u770b\u6765\uff0cNMN\u5728\u51e0\u5206\u949f\u5185\u5c31\u53ef\u4ee5\u901a\u8fc7\u80a0\u9053\u5438\u6536\uff0c\u800cNR\u53ef\u80fd\u9700\u89813\u4e2a\u5c0f\u65f6\u5de6\u53f3\u3002<\/p>\n<blockquote><p><strong><span style=\"color: #ff0000;\">NMN\u53ef\u4ee5\u589e\u5f3a\u8010\u529b\uff0c\u800c200mg\u5242\u91cf\u5185\uff0cNR\u5374\u8fbe\u4e0d\u5230<\/span><\/strong><\/p><\/blockquote>\n<p>\u6717\u8fbe\u5e15\u2022\u7279\u91cc\u514b\u535a\u58eb\u5bf9\u6234\u7ef4\u2022\u8f9b\u514b\u83b1\u8fdb\u884c\u4e86\u9762\u5bf9\u9762\u7684\u91c7\u8bbf\u3002\u5728\u6b64YouTube\u89c6\u9891\u4e2d\uff0c\u6234\u7ef4\u2022\u8f9b\u514b\u83b1\u535a\u58eb\u8c08\u5230\u4e86NMN\u548cNMN\u76f8\u5bf9\u4e8eNR\u7684\u4f18\u52bf\u3002\u4ed6\u8bf4\uff0c\u5728\u76f8\u540c\u7684200mg\u5242\u91cf\u4e0b\uff0cNR\u4e0d\u4f1a\u589e\u52a0\u8010\u529b\uff0c\u4f46\u662fNMN\u5374\u53ef\u4ee5\u3002<\/p>\n<p>\u4ed6\u5728\u8fd9\u6b21\u91c7\u8bbf\u4e2d\u63d0\u5230\u7684\u9a6c\u7279\u00b7\u51ef\u4f2f\u83b1\u56e0\uff08Matt Kaeberlein\uff09\u5728\u5ef6\u957fSIR2\u4f7f\u7528\u5bff\u547d\u540e\uff0c\u73b0\u5728\u5c31\u81f4\u529b\u4e8e\u7814\u7a76\u72d7\u7684\u8870\u8001\u3002 \u9a6c\u7279\u8fd8\u53d1\u8868\u4e86\u4e00\u7bc7\u6587\u7ae0\uff0c\u5c06NR\u548cNMN\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u53ea\u6709NMN\u5728\u4ed6\u7684\u75be\u75c5\u6a21\u578b\u4e2d\u8d77\u4f5c\u7528\uff0c\u8fd9\u662f\u4e00\u79cd\u7ebf\u7c92\u4f53\u75be\u75c5\uff0c\u5176\u4e2d\u90a3\u4e9b\u52a8\u7269\u786e\u5b9e\u9700\u8981\u63d0\u9ad8NAD+\u6c34\u5e73\u3002<\/p>\n<p>\u6240\u4ee5\uff0c\u5728\u8fd9\u65b9\u9762 NMN\u662f\u66f4\u597d\u7684\u9009\u62e9\u3002<\/p>\n<p>\u4e00\u9879\u5c0f\u9f20\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670dNR\u8865\u5145\u5242\uff08\u6bcf\u5343\u514b\u4f53\u91cd200\u6beb\u514b\uff09\u53ea\u4f1a\u63d0\u9ad8\u809d\u810f\u4e2dNAD+\u7684\u6c34\u5e73\uff0c\u65e0\u6cd5\u63d0\u9ad8\u808c\u8089\u4e2d\u7684NAD+\u6c34\u5e73\u3002<sup>\u00a0[9]<\/sup><\/p>\n<p>\u300a\u56fd\u9645\u8fd0\u52a8\u8425\u517b\u5b66\u4f1a\u6742\u5fd7\u300b 2016\u5e74\u53d1\u8868\u7684\u4e00\u9879\u9488\u5bf9\u5c0f\u9f20\u7684\u70df\u9170\u80fa\u6838\u7cd6\u82f7\u7814\u7a76\u8868\u660e\uff0c\u70df\u9170\u80fa\u6838\u7cd6\u82f7\u4f1a\u4f7f\u5927\u9f20\u7684\u8fd0\u52a8\u8868\u73b0\u964d\u4f4e35\uff05\u3002<sup>[10]<\/sup><\/p>\n<p>\u4e0eNR\u4e0d\u540c\uff0c\u901a\u8fc7\u8dd1\u6b65\u673a\u8fd0\u884c\u65f6\u95f4\u6d4b\u91cf\uff0cNMN\u53ef\u4ee5\u63d0\u9ad860\uff05\u7684\u8eab\u4f53\u673a\u80fd\uff0c\u5e76\u4e14\u4f7f\u8fd0\u52a8\u8010\u529b\u63d0\u9ad8\u4e24\u500d\uff0c\u8fbe\u5230\u751a\u81f3\u8d85\u8fc7\u5e74\u8f7b\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u00a0<sup>[6]<\/sup><\/p>\n<blockquote><p><strong><span style=\"color: #ff0000;\">NMN\u6bd4NR\u5177\u6709\u66f4\u591a\u4f18\u52bf<\/span><\/strong><\/p><\/blockquote>\n<p>NMN\u62e5\u6709\u8bb8\u591a\u5f3a\u5927\u7684\u4f18\u52bf\u3002NMN\u53ef\u4ee5\u5728\u5c0f\u9f20\u7814\u7a76\u4e2d\u505a\u4e00\u4e9bNR\u4e0d\u80fd\u505a\u7684\u4e8b\u60c5\u3002<\/p>\n<p>\u5728\u8bc4\u4f30\u5f17\u96f7\u5fb7\u91cc\u5e0c\u5171\u6d4e\u5931\u8c03\uff08FRDA\uff09\uff08\u4e00\u79cd\u7f55\u89c1\u7684\u513f\u7ae5\u9057\u4f20\u6027\u5fc3\u810f\u75c5\uff09\u7684\u7597\u6548\u65f6\uff0c\u53d1\u73b0NMN\u5728NR\u6cbb\u7597\u5931\u8d25\u7684\u5730\u65b9\u662f\u6210\u529f\u7684<sup>[7]<\/sup><\/p>\n<p>\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u76ae\u4e0b\u6ce8\u5c04NMN\u53ef\u51cf\u5c11-\u6dc0\u7c89\u6837\u6591\u5757\u7684\u4ea7\u751f\u3002\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u88ab\u5e7f\u6cdb\u8ba4\u4e3a\u662f\u7531-\u6dc0\u7c89\u6837\u80bd\u7684\u4ea7\u751f\u548c\u6c89\u79ef\u5f15\u8d77\u7684\u3002NMN\u80fd\u51cf\u5c11-\u6dc0\u7c89\u6837\u80bd\u7684\u79ef\u7d2f\uff0c\u800cNR\u5219\u4e0d\u80fd\u3002\u5c3d\u7ba1NR\u51cf\u5c11\u795e\u7ecf\u708e\u75c7\u3001\u51cf\u5c11\u6d77\u9a6c\u7ec6\u80de\u6b7b\u4ea1\u3001\u6539\u5584\u8ba4\u77e5\u529f\u80fd\uff0c\u4f46\u5b83\u6ca1\u6709\u51cf\u5c11\u6dc0\u7c89\u6837\u6591\u5757\u4ea7\u751f\u3002<\/p>\n<blockquote><p><strong><span style=\"color: #ff0000;\">NMN\u6bd4NR\u66f4\u6709\u524d\u9014<\/span><\/strong><\/p><\/blockquote>\n<p>\u76ee\u524d\uff0c\u5bf9NR\u7684\u7814\u7a76\u8981\u6bd4\u5bf9NN\u7684\u7814\u7a76\u66f4\u591a\u3002\u4f46\u662f\uff0c\u5168\u4e16\u754c\u6b63\u5728\u8fdb\u884c\u8bb8\u591aNMN\u4e34\u5e8a\u7814\u7a76\u3002\u6709\u5f85\u89e3\u51b3\u7684NMN\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u8d85\u8fc7\u4e86NR\uff0c\u5e76\u4e14\u57282020\u5e74\u5c06\u63ed\u793a\u51fa\u66f4\u5177\u8bf4\u670d\u529b\u7684\u7ed3\u679c\u3002<\/p>\n<p>\u5f53\u524d\uff0cNMN\u7684\u5236\u9020\u6210\u672c\u5f88\u9ad8\u3002\u4f46\u662f\uff0c\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684NMN\u6563\u88c5\u7c89\u5236\u9020\u5546\u52a0\u5165NMN\u4f9b\u5e94\u5e02\u573a\uff0c\u4ee5\u53ca\u6297\u8870\u8001\u8865\u5145\u5242\u548c\u5316\u5986\u54c1\u5e02\u573a\u4f20\u8fbe\u51fa\u66f4\u591a\u7684NMN\u9700\u6c42\uff0c\u5728\u672a\u6765\u51e0\u5e74\u7684\u5927\u89c4\u6a21\u751f\u4ea7\u548c\u6fc0\u70c8\u7684\u5e02\u573a\u7ade\u4e89\u4e0b\uff0c\u7ec8\u7aefNMN\u4ea7\u54c1\u7684\u4ef7\u683c\u5fc5\u5c06\u6025\u5267\u4e0b\u964d\u3002<\/p>\n<p>\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u901a\u7528\u5316\u5408\u7269\uff0c\u5e94\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c5\uff0c\u7cd6\u5c3f\u75c5\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\u65b9\u9762\u5bf9NMN\u8fdb\u884c\u66f4\u6709\u76ca\u7684\u7814\u7a76\u3002<\/p>\n<p>References:<\/p>\n<ol>\n<li>Lin, J., Pan, Y. &amp; Wang, J. Quant Biol. NAD+ and its precursors in human longevity. Quantitative Biology. December 2015,\u00a0Volume 3,\u00a0Issue\u00a04,\u00a0pp 193\u2013198 https:\/\/doi.org\/10.1007\/s40484-015-0055-9<\/li>\n<li>Verdin E. NAD\u207ain aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-13. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26785480<\/li>\n<li>Trammell SA, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27721479<\/li>\n<li>Denu JM. Vitamins and aging: pathways to NAD+ synthesis. Cell. 2007;129(3):453-4. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17482537<\/li>\n<li>Grozio A, Mills KF, Yoshino J, et al. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019;1(1):47-57. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31131364<\/li>\n<li>Das A, Huang GX, Bonkowski MS, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173(1):74-89.e20. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29570999<\/li>\n<li>Airhart SE, Shireman LM, Risler LJ, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS ONE. 2017;12(12):e0186459. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29211728<\/li>\n<li>Airhart SE, Shireman LM, Risler LJ, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS ONE. 2017;12(12):e0186459. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29211728<\/li>\n<li>Liu L, Su X, Quinn WJ, et al. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018;27(5):1067-1080.e5. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29685734<\/li>\n<li>Kourtzidis IA, Stoupas AT, Gioris IS, et al. The NAD(+) precursor nicotinamide riboside decreases exercise performance in rats. J Int Soc Sports Nutr. 2016;13:32. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27489522<\/li>\n<\/ol>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18155\" class=\"pvc_stats all  \" data-element-id=\"18155\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 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