{"id":18149,"date":"2022-06-11T13:36:15","date_gmt":"2022-06-11T13:36:15","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18149"},"modified":"2022-06-11T13:41:51","modified_gmt":"2022-06-11T13:41:51","slug":"%e5%88%9d%e6%ad%a5%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e6%95%b0%e6%8d%ae%e6%98%be%e7%a4%ba%e5%8d%87%e9%ab%98%e7%9a%84-nad-%e5%8f%af%e6%94%b9%e5%96%84%e4%ba%ba%e7%b1%bb%e6%82%a3%e8%80%85%e5%bf%83","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18149","title":{"rendered":"\u521d\u6b65\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\u5347\u9ad8\u7684 NAD+ \u53ef\u6539\u5584\u4eba\u7c7b\u60a3\u8005\u5fc3\u529b\u8870\u7aed\u7684\u708e\u75c7\u53cd\u5e94"},"content":{"rendered":"

NR \u8865\u5145\u5242\u53ef\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u5f71\u54cd\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u708e\u75c7\u53cd\u5e94<\/span><\/p>\n

\u5c3d\u7ba1\u708e\u75c7\u662f\u514d\u75ab\u7cfb\u7edf\u8bd5\u56fe\u6cbb\u6108\u8eab\u4f53\u7684\u4e00\u79cd\u65b9\u5f0f\uff0c\u4f46\u5b83\u53ef\u80fd\u4e0e\u5fc3\u529b\u8870\u7aed\u7684\u8fdb\u5c55\u6709\u5173\u3002\u4ecb\u5bfc\u8fd9\u4e00\u8fc7\u7a0b\u7684\u7ec6\u80de\uff0c\u5373\u514d\u75ab\u7ec6\u80de\uff0c\u9ad8\u5ea6\u4f9d\u8d56\u7ebf\u7c92\u4f53\uff0c\u5373\u5b83\u4eec\u7684\u80fd\u91cf\u53d1\u751f\u5668\u3002\u7136\u800c\uff0c\u67d0\u4e9b\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u662f\u5426\u4f1a\u52a0\u5267\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u708e\u75c7\u72b6\u6001\u5347\u9ad8\u5c1a\u4e0d\u6e05\u695a\u3002\"\"<\/p>\n

Zhou \u53ca\u5176\u540c\u4e8b\u5728 Journal of Clinical Investigation \u4e0a\u53d1\u8868\u4e86\u4e34\u5e8a\u8bd5\u9a8c (NCT03727646) \u7ed3\u679c\uff0c\u7814\u7a76\u4e86\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u3001\u708e\u75c7\u548c\u5fc3\u529b\u8870\u7aed\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\u5c0f\u7ec4\u5728\u4ed6\u4eec\u7684\u6587\u7ae0\u4e2d\u8868\u660e\uff0c\u60a3\u8005\u5fc3\u810f\u7684\u708e\u75c7\u4e0e\u79f0\u4e3a\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de (PBMC) \u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u7ebf\u7c92\u4f53\u529f\u80fd\u5dee\u6709\u5173\u3002\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u53e3\u670d\u70df\u9170\u80fa\u6838\u82f7\uff08NR\uff09\uff08\u6bcf\u5929\u4e24\u6b21\uff0c\u6bcf\u6b21 1000 \u6beb\u514b\uff09\uff0c\u8fd9\u662f\u5fc5\u9700\u7684\u7ebf\u7c92\u4f53\u5206\u5b50\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u524d\u4f53\uff0c\u53ef\u589e\u5f3a PBMC \u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u51cf\u5c11\u708e\u75c7\u53cd\u5e94\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0cNAD+ \u589e\u5f3a\u53ef\u80fd\u5bf9\u4eba\u7c7b\u5fc3\u810f\u75c5\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n

NAD+ \u5e2e\u52a9\u5c0f\u9f20\u5fc3\u810f\u6108\u5408<\/strong><\/span><\/p>\n

\u63d0\u9ad8\u5bf9\u7ebf\u7c92\u4f53\u529f\u80fd\u81f3\u5173\u91cd\u8981\u7684 NAD+ \u6c34\u5e73\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u51cf\u5c11\u708e\u75c7\u5e76\u4fdd\u62a4\u5c0f\u9f20\u7684\u5fc3\u810f\u3002\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u63d0\u51fa\u4e86\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u80fd\u901a\u8fc7\u8c03\u8282\u4e0e\u8fd9\u79cd\u53ef\u6015\u7684\u533b\u7597\u72b6\u51b5\u76f8\u5173\u7684\u708e\u75c7\u800c\u4f7f\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u53d7\u76ca\u7684\u53ef\u80fd\u6027\u3002\u4f46\u662f\uff0c\u63d0\u9ad8 NAD+ \u662f\u5426\u53ef\u4ee5\u5e2e\u52a9\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u6291\u5236\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u708e\u75c7\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n

NAD+ \u80fd\u4fdd\u62a4\u4eba\u7c7b\u5fc3\u810f\u75c5\u60a3\u8005\u5417\uff1f<\/strong><\/span><\/p>\n

Zhou \u53ca\u5176\u540c\u4e8b\u6bd4\u8f83\u4e86 19 \u540d\u4f4f\u9662\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u548c 19 \u540d\u5065\u5eb7\u53c2\u4e0e\u8005\u7684 PBMC \u7ebf\u7c92\u4f53\u529f\u80fd\u3002\u6765\u81ea\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684 PBMC \u663e\u793a\u7ebf\u7c92\u4f53\u529f\u80fd\u964d\u4f4e\u3002\u8fd9\u4e9b\u7ec6\u80de\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u4e5f\u6709\u6240\u5347\u9ad8\uff0c\u8fd9\u4e9b\u5c0f\u86cb\u767d\u5bf9\u63a7\u5236\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u548c\u8840\u7ec6\u80de\u7684\u751f\u957f\u548c\u6d3b\u6027\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

Zhou \u53ca\u5176\u540c\u4e8b\u8fd8\u68c0\u67e5\u4e86\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u5728\u53e3\u670d NAD+ \u524d\u4f53\u70df\u9170\u80fa\u6838\u82f7 (NR) 5 \u81f3 9 \u5929\u524d\u540e\u7684\u8840\u6db2\u3002\u5bf9\u4e8e\u4e0e\u53e3\u670d NR \u7ed9\u836f\u76f8\u5173\u7684\u5b9e\u9a8c\uff0c5 \u540d\u5fc3\u529b\u8870\u7aed\u4f4f\u9662\u60a3\u8005\u7684 NR \u5242\u91cf\u9010\u6e10\u589e\u52a0\uff08\u7b2c 1 \u5929 250 mg\uff0c\u6bcf\u5929 2 \u6b21\uff0c\u7b2c 2 \u5929 500 mg\uff0c\u6bcf\u5929 2 \u6b21\uff0c\u4ece\u7b2c 3 \u5929\u5f00\u59cb\uff0c\u6bcf\u5929 2 \u6b21 1,000 mg ) 5 \u5230 9 \u5929\u3002<\/p>\n

<\/p>\n

\u7528 NR \u589e\u52a0 NAD+ \u6c34\u5e73\u53ef\u589e\u5f3a\u4eba\u7c7b\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u3002\u5b83\u8fd8\u51cf\u5c11\u4e86\u8fd9\u4e9b\u60a3\u8005\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u7ed3\u679c\u8868\u660e\uff0cNR \u7684\u4f5c\u7528\u662f\u5728\u708e\u75c7\u89e6\u53d1\u7684\u60c5\u51b5\u4e0b\u4fdd\u7559\u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u51cf\u5c11\u5bf9\u79f0\u4e3a\u6d3b\u6027\u6c27\u7684\u7ec6\u80de\u6709\u5bb3\u5206\u5b50\u7684\u4ea7\u751f\u3002<\/p>\n

\u8fd9\u9879\u7814\u7a76\u8bc1\u660e\u4e86\u7ebf\u7c92\u4f53\u529f\u80fd\u5728\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u5916\u5468\u514d\u75ab\u7ec6\u80de\u708e\u75c7\u6fc0\u6d3b\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u5b83\u8fd8\u8868\u660e\uff0c\u589e\u52a0 NAD+ \u6c34\u5e73\u53ef\u80fd\u6709\u53ef\u80fd\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u51cf\u8f7b\u5fc3\u529b\u8870\u7aed\u4e2d PBMC \u5f15\u8d77\u7684\u708e\u75c7\u3002\u901a\u8fc7\u963b\u65ad\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u7684\u4fc3\u708e\u6fc0\u6d3b\u6765\u505c\u6b62\u5168\u8eab\u708e\u75c7\uff0c\u53ef\u4ee5\u4f7f\u7cfb\u7edf\u6446\u8131\u4f7f\u75be\u75c5\u957f\u671f\u5b58\u5728\u7684\u6076\u6027\u5faa\u73af\u3002<\/p>\n

<\/p>\n

\u9700\u8981\u66f4\u591a\u5173\u4e8e NAD+ \u548c\u5fc3\u529b\u8870\u7aed\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/span><\/p>\n

\u7136\u800c\uff0c\u8fd9\u9879\u7814\u7a76\u5728\u51e0\u4e2a\u65b9\u9762\u53d7\u5230\u9650\u5236\u3002\u4f8b\u5982\uff0c\u6d89\u53ca\u5411\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u65bd\u7528 NR \u7684\u5b9e\u9a8c\u6570\u91cf\u5c11\u4e14\u6cbb\u7597\u671f\u77ed\uff085 \u81f3 9 \u5929\uff09\uff0c\u8fd9\u9650\u5236\u4e86\u5bf9 NR \u7684\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u5f97\u51fa\u7ed3\u8bba\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e3a\u672a\u6765\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76 NR \u6f5c\u5728\u7684\u6297\u708e\u4f5c\u7528\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u673a\u4f1a\u3002<\/p>\n

\u201c\u636e\u6211\u4eec\u6240\u77e5\uff0c\u8fd9\u9879\u7814\u7a76\u662f\u7b2c\u4e00\u4e2a\u68c0\u9a8c NAD+ \u589e\u5f3a\u662f\u5426\u5728\u4eba\u7c7b\u5fc3\u529b\u8870\u7aed\u7684\u60c5\u51b5\u4e0b\u5177\u6709\u6297\u708e\u4f5c\u7528\u7684\u7814\u7a76\uff0c\u201d\u7814\u7a76\u4eba\u5458\u5728\u6587\u7ae0\u4e2d\u8bf4\u3002\u201c\u867d\u7136\u76ee\u524d\u7f3a\u4e4f\u4eba\u7c7b\u7597\u6548\u6570\u636e\uff0c\u4f46 NAD+ \u8865\u5145\u5bf9\u4fdd\u62a4\u5fc3\u810f\u529f\u80fd\u548c\u51cf\u5c11\u5168\u8eab\u708e\u75c7\u7684\u96c6\u4f53\u4f5c\u7528\u53ef\u80fd\u4e3a\u65b0\u578b\u5fc3\u529b\u8870\u7aed\u6cbb\u7597\u63d0\u4f9b\u5206\u5b50\u57fa\u7840\u3002\u201d<\/p>\n

 <\/p>\n

\u5168\u6587\u6765\u6e90<\/strong><\/p>\n

NMN.com<\/a><\/p>\n

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NR \u8865\u5145\u5242\u53ef\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u5f71\u54cd\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u708e\u75c7\u53cd\u5e94 \u5c3d\u7ba1\u708e\u75c7\u662f\u514d\u75ab\u7cfb\u7edf\u8bd5\u56fe\u6cbb\u6108\u8eab\u4f53\u7684\u4e00\u79cd\u65b9\u5f0f\uff0c\u4f46\u5b83\u53ef\u80fd\u4e0e\u5fc3\u529b\u8870\u7aed\u7684\u8fdb\u5c55\u6709\u5173\u3002\u4ecb\u5bfc\u8fd9\u4e00\u8fc7\u7a0b\u7684\u7ec6\u80de\uff0c\u5373\u514d\u75ab\u7ec6\u80de\uff0c\u9ad8\u5ea6\u4f9d\u8d56\u7ebf\u7c92\u4f53\uff0c\u5373\u5b83\u4eec\u7684\u80fd\u91cf\u53d1\u751f\u5668\u3002\u7136\u800c\uff0c\u67d0\u4e9b\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u662f\u5426\u4f1a\u52a0\u5267\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u7684\u708e\u75c7\u72b6\u6001\u5347\u9ad8\u5c1a\u4e0d\u6e05\u695a\u3002 Zhou \u53ca\u5176\u540c\u4e8b\u5728 Journal of Clinical Investigation \u4e0a\u53d1\u8868\u4e86\u4e34\u5e8a\u8bd5\u9a8c (NCT03727646) \u7ed3\u679c\uff0c\u7814\u7a76\u4e86\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u3001\u708e\u75c7\u548c\u5fc3\u529b\u8870\u7aed\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u534e\u76db\u987f\u5927\u5b66\u7684\u7814\u7a76\u5c0f\u7ec4\u5728\u4ed6\u4eec\u7684\u6587\u7ae0\u4e2d\u8868\u660e\uff0c\u60a3\u8005\u5fc3\u810f\u7684\u708e\u75c7\u4e0e\u79f0\u4e3a\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de (PBMC) \u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u7ebf\u7c92\u4f53\u529f\u80fd\u5dee\u6709\u5173\u3002\u5fc3\u529b\u8870\u7aed\u60a3\u8005\u53e3\u670d\u70df\u9170\u80fa\u6838\u82f7\uff08NR\uff09\uff08\u6bcf\u5929\u4e24\u6b21\uff0c\u6bcf\u6b21 1000 \u6beb\u514b\uff09\uff0c\u8fd9\u662f\u5fc5\u9700\u7684\u7ebf\u7c92\u4f53\u5206\u5b50\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u524d\u4f53\uff0c\u53ef\u589e\u5f3a PBMC \u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u51cf\u5c11\u708e\u75c7\u53cd\u5e94\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0cNAD+ \u589e\u5f3a\u53ef\u80fd\u5bf9\u4eba\u7c7b\u5fc3\u810f\u75c5\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n

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