{"id":18128,"date":"2022-06-09T03:54:20","date_gmt":"2022-06-09T03:54:20","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18128"},"modified":"2022-06-09T03:55:43","modified_gmt":"2022-06-09T03:55:43","slug":"nmn%e7%a0%94%e7%a9%b6-%e6%97%b6%e9%92%9f%e5%80%92%e8%bd%ac","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18128","title":{"rendered":"NMN\u7814\u7a76 &#8211; \u65f6\u949f\u5012\u8f6c"},"content":{"rendered":"<p><iframe loading=\"lazy\" src=\"https:\/\/player.vimeo.com\/video\/261202564?h=582a3513a7&amp;color=456d86&amp;title=0&amp;byline=0&amp;portrait=0\" width=\"640\" height=\"360\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<h2 class=\"intro-subtitle\">\u6cbb\u7597\u53ef\u6062\u590d\u8840\u7ba1\u751f\u957f\u3001\u808c\u8089\u6d3b\u529b\u3001\u589e\u5f3a\u8870\u8001\u52a8\u7269\u7684\u8fd0\u52a8\u8010\u529b<\/h2>\n<div class=\"article-meta-wrapper\"><span class=\"article-author field__item\">\u4f5c\u8005\uff1a\u53f6\u5361\u6377\u7433\u5a1c\u00b7\u4f69\u8c22\u5a03<\/span><span class=\"article-date field__item\"><time datetime=\"2018-03-22T12:00:00Z\">2018 \u5e74 3 \u6708 22 \u65e5<\/time><\/span><\/div>\n<h4>\u7f57\u6770\u00b7\u79d1\u6069\u4f2f\u683c\u535a\u58eb<\/h4>\n<p>\u4fd7\u8bdd\u8bf4\uff0c\u4eba\u5982\u52a8\u8109\u4e00\u6837\u8001\uff0c\u90a3\u4e48\u9006\u8f6c\u8840\u7ba1\u8001\u5316\u80fd\u5426\u6210\u4e3a\u6062\u590d\u9752\u6625\u6d3b\u529b\u7684\u5173\u952e\uff1f<\/p>\n<p>\u6839\u636e\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u9886\u5bfc\u7684\u4e00\u9879\u65b0\u7814\u7a76\uff0c\u81f3\u5c11\u5728\u8001\u9f20\u8eab\u4e0a\uff0c<span style=\"color: #ff0000;\">\u7b54\u6848\u4f3c\u4e4e\u662f\u80af\u5b9a\u7684<\/span>\u3002<!--more--><\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u4e8e 3 \u6708 22 \u65e5\u53d1\u8868\u5728\u00a0<em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867418301521\" target=\"_blank\" rel=\"noopener noreferrer\">\u7ec6\u80de<\/a>\u3001<\/em>\u00a0\u786e\u5b9a\u4e86\u8840\u7ba1\u8870\u8001\u80cc\u540e\u7684\u5173\u952e\u7ec6\u80de\u673a\u5236\u53ca\u5176\u5bf9\u808c\u8089\u5065\u5eb7\u7684\u5f71\u54cd\uff0c\u5e76\u5df2\u6210\u529f\u9006\u8f6c\u52a8\u7269\u7684\u8fd9\u4e00\u8fc7\u7a0b\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u6307\u51fa\u4e86\u808c\u8089\u548c\u8840\u7ba1\u4e4b\u95f4\u53d1\u751f\u7684\u6b63\u5e38\u4e32\u6270\u4e2d\u7684\u4e00\u4e2a\u6545\u969c\uff0c\u5e76\u4fdd\u6301\u4e86\u4e24\u4e2a\u7ec4\u7ec7\u7684\u5065\u5eb7\u3002<\/p>\n<p>\u5229\u7528\u4f53\u5185\u5929\u7136\u5b58\u5728\u7684\u4e24\u79cd\u5206\u5b50\u7684\u5408\u6210\u524d\u4f53\uff0c\u79d1\u5b66\u5bb6\u4eec\u8fd8\u6210\u529f\u5730\u9006\u8f6c\u4e86\u8870\u8001\u5c0f\u9f20\u7684\u8840\u7ba1\u6b7b\u4ea1\u548c\u808c\u8089\u840e\u7f29\uff0c\u5728\u6b64\u8fc7\u7a0b\u4e2d\u63d0\u9ad8\u4e86\u5b83\u4eec\u7684\u8fd0\u52a8\u8010\u529b\u3002<\/p>\n<p>\u7814\u7a76\u5c0f\u7ec4\u8868\u793a\uff0c\u8fd9\u9879\u6210\u5c31\u4e3a\u786e\u5b9a\u4eba\u7c7b\u76f8\u5173\u7597\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/p>\n<p>\u201c\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u901a\u8fc7\u589e\u52a0\u5929\u7136\u5b58\u5728\u7684\u5206\u5b50\u5728\u8840\u7ba1\u4e2d\u7684\u5b58\u5728\u6765\u9006\u8f6c\u8840\u7ba1\u8870\u8001\u3002\u589e\u5f3a\u5bf9\u8fd0\u52a8\u7684\u751f\u7406\u53cd\u5e94\u7684\u8eab\u4f53\uff0c\u201d\u7814\u7a76\u9ad8\u7ea7\u7814\u7a76\u5458\u00a0<a href=\"http:\/\/genetics.med.harvard.edu\/sinclair\/people\/sinclair.php\">\u5927\u536b<\/a><a href=\"http:\/\/genetics.med.harvard.edu\/sinclair\/people\/sinclair.php\">\u00a0\u8f9b\u514b\u83b1<\/a>\u00a0\u8bf4\uff0c\u4ed6\u662f\u54c8\u4f5b\u533b\u5b66\u9662\u9057\u4f20\u5b66\u7cfb\u6559\u6388\u548c\u8054\u5408\u4e3b\u4efb\u3002\u54c8\u4f5b\u533b\u5b66\u9662\u7684 Paul F. Glenn \u8870\u8001\u751f\u7269\u5b66\u4e2d\u5fc3\u3002<\/p>\n<p>\u201c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u523a\u6fc0\u8840\u7ba1\u751f\u957f\uff0c\u589e\u5f3a\u5c0f\u9f20\u7684\u8010\u529b\u548c\u8010\u529b\uff0c\u5e76\u4e3a\u4eba\u7c7b\u6cbb\u7597\u4ee5\u89e3\u51b3\u8840\u7ba1\u8001\u5316\u5f15\u8d77\u7684\u4e00\u7cfb\u5217\u75be\u75c5\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u201d\u8f9b\u514b\u83b1\u5c14\u8865\u5145\u9053\uff0c\u4ed6\u4e5f\u662f\u7f8e\u56fd\u5927\u5b66\u7684\u6559\u6388\u6fb3\u5927\u5229\u4e9a\u6089\u5c3c\u7684\u65b0\u5357\u5a01\u5c14\u58eb\u533b\u5b66\u9662\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8b66\u544a\u8bf4\uff0c\u7531\u4e8e\u751f\u7269\u5b66\u5b58\u5728\u91cd\u5927\u5dee\u5f02\uff0c\u8bb8\u591a\u6709\u5e0c\u671b\u7684\u5c0f\u9f20\u6cbb\u7597\u65b9\u6cd5\u5bf9\u4eba\u7c7b\u7684\u6548\u679c\u5e76\u4e0d\u76f8\u540c\u3002\u7136\u800c\uff0c\u5b9e\u9a8c\u7ed3\u679c\u975e\u5e38\u5f15\u4eba\u6ce8\u76ee\uff0c\u8db3\u4ee5\u4fc3\u4f7f\u7814\u7a76\u56e2\u961f\u5728\u4eba\u7c7b\u8eab\u4e0a\u8fdb\u884c\u5b9e\u9a8c\u3002\u8f9b\u514b\u83b1\u8bf4\uff0c\u5b89\u5168\u6027\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<p><strong>\u548c\u6211\u4eec\u7684\u8840\u7ba1\u4e00\u6837\u53e4\u8001<\/strong><\/p>\n<p>Sinclair \u548c\u4ed6\u7684\u56e2\u961f\u7740\u624b\u89e3\u5f00\u751f\u7269\u5b66\u5fc5\u7136\u6027\u4e4b\u4e00\u80cc\u540e\u7684\u673a\u5236\uff1a<strong><span style=\"color: #ff0000;\">\u8870\u8001<\/span><\/strong>\u3002<\/p>\n<p>\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u6211\u4eec\u53d8\u5f97\u865a\u5f31\u65e0\u529b\u3002\u4e00\u7cfb\u5217\u751f\u7406\u53d8\u5316\u2014\u2014\u4e00\u4e9b\u5fae\u5999\u7684\uff0c\u4e00\u4e9b\u620f\u5267\u6027\u7684\u2014\u2014\u4fc3\u6210\u4e86\u8fd9\u79cd\u4e0d\u53ef\u907f\u514d\u7684\u8870\u9000\u3002\u6211\u4eec\u7ec6\u80de\u5185\u90e8\u7a76\u7adf\u53d1\u751f\u4e86\u4ec0\u4e48\u5bfc\u81f4\u5bfc\u81f4\u8870\u8001\u7684\u751f\u7269\u53d8\u5316\uff1f\u8fd9\u662f\u4e00\u4e2a\u56f0\u6270\u8f9b\u514b\u83b1\u548c\u56e2\u961f\u591a\u5e74\u7684\u95ee\u9898\u3002<\/p>\n<p>\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f<strong><span style=\"color: #ff0000;\">\uff0c\u6211\u4eec\u6700\u5c0f\u7684\u8840\u7ba1\u4f1a\u67af\u840e\u548c\u6b7b\u4ea1\uff0c\u5bfc\u81f4\u8840\u6d41\u51cf\u5c11\uff0c\u5668\u5b98\u548c\u7ec4\u7ec7\u7684\u6c27\u5408\u53d7\u635f<\/span><\/strong>\u3002\u8840\u7ba1\u8001\u5316\u662f\u9020\u6210\u4e00\u7cfb\u5217\u75be\u75c5\u7684\u539f\u56e0\uff0c\u4f8b\u5982\u5fc3\u810f\u548c\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3001\u808c\u8089\u635f\u5931\u3001\u4f24\u53e3\u6108\u5408\u53d7\u635f\u548c\u6574\u4f53\u865a\u5f31\u7b49\u3002\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u77e5\u9053\uff0c\u6d41\u5411\u5668\u5b98\u548c\u7ec4\u7ec7\u7684\u8840\u6d41\u51cf\u5c11\u4f1a\u5bfc\u81f4\u6bd2\u7d20\u79ef\u805a\u548c\u4f4e\u6c27\u6c34\u5e73\u3002\u6392\u5217\u8840\u7ba1\u7684\u6240\u8c13\u5185\u76ae\u7ec6\u80de\u5bf9\u8840\u7ba1\u7684\u5065\u5eb7\u548c\u751f\u957f\u81f3\u5173\u91cd\u8981\uff0c\u8fd9\u4e9b\u8840\u7ba1\u4e3a\u5668\u5b98\u548c\u7ec4\u7ec7\u63d0\u4f9b\u5bcc\u542b\u6c27\u6c14\u548c\u8425\u517b\u4e30\u5bcc\u7684\u8840\u6db2\u3002\u4f46\u968f\u7740\u8fd9\u4e9b\u5185\u76ae\u7ec6\u80de\u8001\u5316\uff0c\u8840\u7ba1\u840e\u7f29\uff0c\u65b0\u8840\u7ba1\u65e0\u6cd5\u5f62\u6210\uff0c\u6d41\u5411\u8eab\u4f53\u5927\u90e8\u5206\u90e8\u4f4d\u7684\u8840\u6d41\u91cf\u9010\u6e10\u51cf\u5c11\u3002\u8fd9\u79cd\u52a8\u6001\u5728\u808c\u8089\u4e2d\u5c24\u4e3a\u663e\u7740\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u808c\u8089\u6709\u5927\u91cf\u8840\u7ba1\u5316\u5e76\u4f9d\u8d56\u4e8e\u5f3a\u5927\u7684\u8840\u6db2\u4f9b\u5e94\u6765\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<p>\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0c\u808c\u8089\u5f00\u59cb\u840e\u7f29\u548c\u53d8\u5f31\uff0c\u8fd9\u79cd\u60c5\u51b5\u88ab\u79f0\u4e3a\u808c\u8089\u51cf\u5c11\u75c7\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u53ef\u4ee5\u901a\u8fc7\u5b9a\u671f\u953b\u70bc\u6765\u51cf\u6162\uff0c\u4f46\u9010\u6e10\u5730\uff0c\u5373\u4f7f\u662f\u953b\u70bc\u4e5f\u65e0\u6cd5\u6709\u6548\u5ef6\u7f13\u8fd9\u79cd\u51cf\u5f31<\/p>\n<p>Sinclair \u548c\u56e2\u961f\u60f3\u77e5\u9053\uff1a<strong><span style=\"color: #0000ff;\">\u7a76\u7adf\u662f\u4ec0\u4e48\u51cf\u5c11\u4e86\u8840\u6db2\u6d41\u52a8\u5e76\u4fc3\u6210\u4e86\u8fd9\u79cd\u4e0d\u53ef\u907f\u514d\u7684\u8870\u9000<\/span><\/strong>\uff1f<strong>\u4e3a\u4ec0\u4e48\u8fde\u8fd0\u52a8\u90fd\u5931\u53bb\u4e86\u7ef4\u6301\u808c\u8089\u6d3b\u529b\u7684\u4fdd\u62a4\u529b\uff1f\u8fd9\u4e2a\u8fc7\u7a0b\u662f\u53ef\u9006\u7684\u5417\uff1f<\/strong><\/p>\n<p>\u5728\u4e00\u7cfb\u5217\u5b9e\u9a8c\u4e2d\uff0c\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c<strong><span style=\"color: #800080;\">\u968f\u7740\u5185\u76ae\u7ec6\u80de\u5f00\u59cb\u5931\u53bb\u4e00\u79cd\u79f0\u4e3a sirtuin1 \u6216 SIRT1 \u7684\u5173\u952e\u86cb\u767d\u8d28\uff0c\u8840\u6d41\u51cf\u5c11<\/span><\/strong>\u3002\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0cSIRT1 \u53ef\u4ee5\u5ef6\u7f13\u9175\u6bcd\u548c\u5c0f\u9f20\u7684\u8870\u8001\u5e76\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n<p><strong><span style=\"color: #800080;\">SIRT1 \u7684\u4e22\u5931\u53cd\u8fc7\u6765\u53c8\u662f\u7531 NAD+ \u7684\u4e22\u5931\u5f15\u8d77\u7684<\/span><\/strong>\uff0cNAD+ \u662f\u4e00\u4e2a\u591a\u4e16\u7eaa\u524d\u53d1\u73b0\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u548c DNA \u4fee\u590d\u7684\u5173\u952e\u8c03\u8282\u56e0\u5b50\u3002 Sinclair \u548c\u5176\u4ed6\u4eba\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u4e5f\u4f1a\u4e0b\u964d\u7684 NAD+ \u4f1a\u589e\u5f3a SIRT1 \u7684\u6d3b\u6027\u3002<\/p>\n<p><strong>\u6fc0\u52a8\u4eba\u5fc3\u7684\u8c08\u8bdd<\/strong><\/p>\n<p>\u7814\u7a76\u8868\u660e\uff0cNAD+ \u548c SIRT1 \u63d0\u4f9b\u4e86\u4e00\u4e2a\u5173\u952e\u754c\u9762\uff0c\u4f7f\u8840\u7ba1\u58c1\u4e2d\u7684\u5185\u76ae\u7ec6\u80de\u548c\u808c\u8089\u7ec6\u80de\u4e4b\u95f4\u80fd\u591f\u8fdb\u884c\u5bf9\u8bdd\u3002<\/p>\n<p>\u5177\u4f53\u6765\u8bf4\uff0c\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u5e74\u8f7b\u7684\u5c0f\u9f20\u808c\u8089\u4e2d\uff0cSIRT1 \u4fe1\u53f7\u88ab\u6fc0\u6d3b\u5e76\u4ea7\u751f\u65b0\u7684\u6bdb\u7ec6\u8840\u7ba1\uff0c\u8fd9\u662f\u4f53\u5185\u6700\u5c0f\u7684\u8840\u7ba1\uff0c\u4e3a\u7ec4\u7ec7\u548c\u5668\u5b98\u63d0\u4f9b\u6c27\u6c14\u548c\u8425\u517b\u3002\u7136\u800c\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u968f\u7740 NAD+\/SIRT1 \u6d3b\u6027\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u51cf\u5c11\uff0c\u8840\u6db2\u6d41\u52a8\u4e5f\u4f1a\u51cf\u5c11\uff0c\u4ece\u800c\u5bfc\u81f4\u808c\u8089\u7ec4\u7ec7\u7f3a\u4e4f\u8425\u517b\u548c\u7f3a\u6c27\u3002<\/p>\n<p>\u786e\u5b9e\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u5728\u5e74\u8f7b\u5c0f\u9f20\u7684\u5185\u76ae\u7ec6\u80de\u4e2d\u5220\u9664 SIRT1 \u65f6\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u4e0e\u5177\u6709\u5b8c\u6574 SIRT1 \u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u6bdb\u7ec6\u8840\u7ba1\u5bc6\u5ea6\u548c\u6bdb\u7ec6\u8840\u7ba1\u6570\u91cf\u663e\u7740\u51cf\u5c11\u3002\u5185\u76ae\u7ec6\u80de\u7f3a\u4e4f SIRT1 \u7684\u5c0f\u9f20\u8fd0\u52a8\u8010\u91cf\u5dee\uff0c\u53ea\u80fd\u8dd1\u5230 SIRT1 \u5b8c\u597d\u7684\u5c0f\u9f20\u8dd1\u8fc7\u7684\u8ddd\u79bb\u7684\u4e00\u534a\u3002<\/p>\n<p>\u4e3a\u4e86\u786e\u5b9a SIRT1 \u5728\u8fd0\u52a8\u8bf1\u5bfc\u7684\u8840\u7ba1\u751f\u957f\u4e2d\u7684\u4f5c\u7528\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u4e86 SIRT1 \u7f3a\u9677\u5c0f\u9f20\u5bf9\u8fd0\u52a8\u7684\u53cd\u5e94\u3002\u7ecf\u8fc7\u4e00\u4e2a\u6708\u7684\u8bad\u7ec3\u540e\uff0c\u4e0e\u5185\u76ae\u7ec6\u80de\u4e2d\u5177\u6709\u5b8c\u6574 SIRT1 \u7684\u540c\u9f84\u5c0f\u9f20\u76f8\u6bd4\uff0cSIRT1 \u7f3a\u9677\u5c0f\u9f20\u7684\u540e\u817f\u808c\u8089\u5728\u8fd0\u52a8\u4e2d\u5f62\u6210\u65b0\u8840\u7ba1\u7684\u80fd\u529b\u663e\u7740\u964d\u4f4e\u3002<\/p>\n<p>\u5df2\u77e5\u8fd0\u52a8\u8bf1\u5bfc\u7684\u8840\u7ba1\u5f62\u6210\u662f\u54cd\u5e94\u808c\u8089\u5728\u7d27\u5f20\u72b6\u6001\u4e0b\u91ca\u653e\u7684\u523a\u6fc0\u751f\u957f\u7684\u86cb\u767d\u8d28\u800c\u53d1\u751f\u7684\u3002\u7136\u800c\uff0c\u7814\u7a76\u53d1\u73b0\uff0cSIRT1 \u4f3c\u4e4e\u662f\u5c06\u751f\u957f\u56e0\u5b50\u4fe1\u53f7\u4ece\u808c\u8089\u4f20\u9012\u5230\u8840\u7ba1\u7684\u5173\u952e\u4fe1\u4f7f\u3002<\/p>\n<p>\u5b9e\u9a8c\u8868\u660e\uff0c<strong><span style=\"color: #800080;\">\u7f3a\u4e4f SIRT1 \u7684\u5185\u76ae\u7ec6\u80de\u5bf9\u8fd0\u52a8\u808c\u8089\u91ca\u653e\u7684\u523a\u6fc0\u751f\u957f\u7684\u86cb\u767d\u8d28\u4e0d\u654f\u611f<\/span><\/strong>\u3002<\/p>\n<p>\u201c\u5c31\u597d\u50cf\u8fd9\u4e9b\u7ec6\u80de\u5bf9\u808c\u8089\u53d1\u51fa\u7684\u4fe1\u53f7\u5145\u8033\u4e0d\u95fb\uff0c \u201d\u8f9b\u514b\u83b1\u8bf4\u3002<\/p>\n<p>\u4ed6\u8865\u5145\u8bf4\uff0c\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u4e0e\u5e74\u9f84\u76f8\u5173\u7684 SIRT1 \u7f3a\u5931\u4f1a\u5bfc\u81f4\u808c\u8089\u840e\u7f29\u548c\u8840\u7ba1\u6b7b\u4ea1\u3002<\/p>\n<p>\u56e0\u4e3a\u5b9e\u9a8c\u63ed\u793a\u4e86 SIRT1 \u5728\u8fd0\u52a8\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u8bf1\u5bfc\u8840\u7ba1\u5f62\u6210\uff0c\u7814\u7a76\u4eba\u5458\u60f3\u77e5\u9053\u63d0\u9ad8 SIRT1 \u6c34\u5e73\u662f\u5426\u4f1a\u523a\u6fc0\u8840\u7ba1\u751f\u957f\u5e76\u907f\u514d\u808c\u8089\u840e\u7f29\u3002<\/p>\n<p><strong>\u5403\u836f\u5417\uff1f<\/strong><\/p>\n<p>\u79d1\u5b66\u5bb6\u4eec\u5c06\u76ee\u5149\u6295\u5411\u4e86 NAD<sup>+<\/sup>\uff0c\u8fd9\u662f\u4e00\u79cd\u5728\u8bb8\u591a\u751f\u547d\u5f62\u5f0f\u4e2d\u90fd\u4fdd\u5b58\u4e0b\u6765\u7684\u5206\u5b50\uff0c\u5df2\u77e5\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u8870\u9000\uff0c\u6b64\u524d\u5df2\u8bc1\u660e\u53ef\u523a\u6fc0 SIRT1 \u7684\u6d3b\u6027\u3002<\/p>\n<p>\u201c\u6211\u4eec\u63a8\u65ad NAD<sup>+<\/sup>\u00a0\u6c34\u5e73\u4e0b\u964d\u4f1a\u964d\u4f4e SIRT1 \u6d3b\u6027\uff0c\u4ece\u800c\u5e72\u6270\u8870\u8001\u5c0f\u9f20\u751f\u957f\u65b0\u8840\u7ba1\u7684\u80fd\u529b\uff0c\u201d\u7814\u7a76\u7b2c\u4e00\u4f5c\u8005\u00a0<a href=\"https:\/\/medicalsciences.med.unsw.edu.au\/people\/dr-abhirup-das\">\u963f\u6bd4\u9c81\u666e\u8fbe\u65af<\/a>\u00a0\u8bf4\uff0c\u4ed6\u8fdb\u884c\u4e86\u5728\u8f9b\u514b\u83b1\u5b9e\u9a8c\u5ba4\u62c5\u4efb\u535a\u58eb\u540e\u7814\u7a76\u5458\uff0c\u76ee\u524d\u662f\u54c8\u4f5b\u533b\u5b66\u9662\u9057\u4f20\u5b66\u8bbf\u95ee\u5b66\u8005\u548c\u5357\u65b0\u5a01\u5c14\u58eb\u5927\u5b66\u533b\u5b66\u9662\u535a\u58eb\u540e\u7814\u7a76\u5458\u3002<\/p>\n<p>\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u524d\u63d0\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f7f\u7528\u4e86\u4e00\u79cd\u540d\u4e3a NMN \u7684\u5316\u5408\u7269\uff0c\u5b83\u662f\u4e00\u79cd NAD<sup>+<\/sup>\u00a0\u524d\u4f53\uff0c<a href=\"https:\/\/hms.harvard.edu\/news\/unraveling-mysteries-aging\">\u5148\u524d\u5df2\u663e\u793a<\/a>\u5728\u4fee\u590d\u7ec6\u80de DNA \u548c\u7ef4\u6301\u7ec6\u80de\u6d3b\u529b\u65b9\u9762\u53d1\u6325\u4f5c\u7528<\/p>\n<p>\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u76bf\u5b9e\u9a8c\u4e2d\uff0c\u6765\u81ea\u7528 NMN \u6cbb\u7597\u7684\u4eba\u548c\u5c0f\u9f20\u7684\u5185\u76ae\u7ec6\u80de\u663e\u793a\u51fa\u589e\u5f3a\u7684\u751f\u957f\u80fd\u529b\u5e76\u51cf\u5c11\u4e86\u7ec6\u80de\u6b7b\u4ea1\u3002<\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u5c0f\u7ec4\u5c06 NMN \u7ed9\u4e88\u4e00\u7ec4 20 \u4e2a\u6708\u5927\u7684\u5c0f\u9f20\u8d85\u8fc7\u4e24\u4e2a\u6708\u8001\u2014\u2014\u5927\u7ea6\u76f8\u5f53\u4e8e\u4eba\u7c7b\u7684 70 \u5c81\u3002 NMN \u6cbb\u7597\u4f7f\u6bdb\u7ec6\u8840\u7ba1\u7684\u6570\u91cf\u548c\u6bdb\u7ec6\u8840\u7ba1\u5bc6\u5ea6\u6062\u590d\u5230\u5e74\u8f7b\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u808c\u8089\u7684\u8840\u6d41\u91cf\u4e5f\u589e\u52a0\uff0c\u660e\u663e\u9ad8\u4e8e\u672a\u63a5\u53d7 NMN \u7684\u540c\u9f84\u5c0f\u9f20\u7684\u808c\u8089\u8840\u6d41\u91cf\u3002<\/p>\n<p>\u7136\u800c\uff0c\u6700\u663e\u7740\u7684\u6548\u679c\u51fa\u73b0\u5728\u8870\u8001\u5c0f\u9f20\u7684\u8fd0\u52a8\u80fd\u529b\u4e0a\u3002\u7814\u7a76\u663e\u793a\uff0c\u4e0e\u672a\u7ecf\u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u52a8\u7269\u7684\u8fd0\u52a8\u80fd\u529b\u63d0\u9ad8\u4e86 56% \u5230 80%\u3002\u63a5\u53d7 NMN \u6cbb\u7597\u7684\u52a8\u7269\u5e73\u5747\u80fd\u8dd1 430 \u7c73\u6216\u7ea6 1,400 \u82f1\u5c3a\uff0c\u800c\u672a\u7ecf\u6cbb\u7597\u7684\u540c\u7c7b\u52a8\u7269\u5e73\u5747\u80fd\u8dd1 240 \u7c73\u6216 780 \u82f1\u5c3a\u3002<\/p>\n<p>\u4e3a\u4e86\u4e86\u89e3 NMN \u7684\u6548\u679c\u662f\u5426\u53ef\u4ee5\u8fdb\u4e00\u6b65\u589e\u5f3a\uff0c\u7814\u7a76\u4eba\u5458\u5728\u6cbb\u7597\u65b9\u6848\u4e2d\u6dfb\u52a0\u4e86\u7b2c\u4e8c\u79cd\u5316\u5408\u7269\u3002\u8be5\u5316\u5408\u7269\u6c22\u786b\u5316\u94a0 (NaHS) \u662f\u786b\u5316\u6c22\u7684\u524d\u4f53\uff0c\u5b83\u8fd8\u53ef\u4ee5\u63d0\u9ad8 SIRT1 \u7684\u6d3b\u6027\u3002<\/p>\n<p>\u4e00\u7ec4 32 \u4e2a\u6708\u5927\u7684\u5c0f\u9f20\uff08\u5927\u81f4\u76f8\u5f53\u4e8e\u4eba\u7c7b 90 \u5c81\uff09\u63a5\u53d7\u8054\u5408\u6cbb\u7597 4 \u5468\u540e\uff0c\u5e73\u5747\u80fd\u591f\u8dd1\u7684\u65f6\u95f4\u662f\u672a\u6cbb\u7597\u5c0f\u9f20\u7684\u4e24\u500d\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4ec5\u7528 NMN \u6cbb\u7597\u7684\u5c0f\u9f20\u6bd4\u672a\u6cbb\u7597\u7684\u52a8\u7269\u5e73\u5747\u8dd1\u5f97\u66f4\u8fdc 1.6 \u500d\u3002<\/p>\n<p>\u201c\u8fd9\u4e9b\u8001\u9f20\u771f\u7684\u5f88\u8001\uff0c\u6240\u4ee5\u6211\u4eec\u53d1\u73b0\u8054\u5408\u6cbb\u7597\u4f7f\u5b83\u4eec\u7684\u8dd1\u6b65\u80fd\u529b\u7ffb\u4e86\u4e00\u756a\uff0c\u8fd9\u7b80\u76f4\u662f\u4ee4\u4eba\u7740\u8ff7\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u3001\u54c8\u4f5b\u5927\u5b66\u9648\u66fe\u7199\u516c\u5171\u5b66\u9662\u9057\u4f20\u5b66\u548c\u590d\u6742\u75be\u75c5\u526f\u6559\u6388 James Mitchell \u8bf4\u5065\u5eb7\u3002\u7531 Mitchell \u9886\u5bfc\u5e76\u53d1\u8868\u5728\u540c\u4e00\u671f<em>Cell\u00a0<\/em>\u4e0a\u7684\u7814\u7a76\u8fd8\u53d1\u73b0\u786b\u6c22\u5316\u94a0\u53ef\u4ee5\u589e\u52a0\u5c0f\u9f20\u808c\u8089\u4e2d\u7684\u8840\u7ba1\u5f62\u6210\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0cNMN \u6cbb\u7597\u5e76\u6ca1\u6709\u6539\u5584\u8840\u7ba1\u5bc6\u5ea6\u548c\u4e45\u5750\u4e0d\u52a8\u7684\u5e74\u8f7b\u5c0f\u9f20\u7684\u8fd0\u52a8\u80fd\u529b\u3002\u7136\u800c\uff0c\u5b83\u786e\u5b9e\u4fc3\u8fdb\u4e86\u5df2\u7ecf\u5b9a\u671f\u953b\u70bc\u4e00\u4e2a\u6708\u7684\u5e74\u8f7b\u5c0f\u9f20\u7684\u8840\u7ba1\u5f62\u6210\u548c\u8fd0\u52a8\u80fd\u529b\u3002<\/p>\n<p>\u201c\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u5f3a\u8c03\u4e86\u8fd9\u6837\u4e00\u79cd\u89c2\u70b9\uff0c\u5373\u5e74\u9f84\u5728\u8840\u7ba1\u548c\u808c\u8089\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5e76\u4e14\u6307\u51fa NAD<sup>+<\/sup>\u00a0\u548c SIRT1 \u7684\u635f\u5931\u662f\u4e2d\u5e74\u4e4b\u540e\u5931\u53bb\u8fd0\u52a8\u6548\u679c\u7684\u539f\u56e0\uff0c\u201dDas \u8bf4\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u53ef\u80fd\u4e3a\u6cbb\u7597\u8fdb\u6b65\u94fa\u5e73\u9053\u8def\uff0c\u8fd9\u4e9b\u8fdb\u6b65\u4e3a\u6570\u767e\u4e07\u65e0\u6cd5\u5b9a\u671f\u8fdb\u884c\u4f53\u80b2\u953b\u70bc\u7684\u8001\u5e74\u4eba\u5e26\u6765\u5e0c\u671b\u3002<\/p>\n<p>\u201c\u5373\u4f7f\u4f60\u662f\u4e00\u540d\u8fd0\u52a8\u5458\uff0c\u4f60\u6700\u7ec8\u4e5f\u4f1a\u62d2\u7edd\uff0c\u201d\u8f9b\u514b\u83b1\u8bf4\u3002 \u201c\u4f46\u8fd8\u6709\u53e6\u4e00\u7c7b\u4eba\u2014\u2014\u90a3\u4e9b\u5750\u5728\u8f6e\u6905\u4e0a\u6216\u884c\u52a8\u4e0d\u4fbf\u7684\u4eba\u5462\uff1f\u201d<\/p>\n<p>\u8be5\u56e2\u961f\u7684\u6700\u7ec8\u76ee\u6807\u662f\u590d\u5236\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5e76\u6700\u7ec8\u8f6c\u5411\u5f00\u53d1\u57fa\u4e8e NMN \u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u4ee5\u6a21\u62df\u8fd0\u52a8\u7684\u6548\u679c\u2014\u2014\u589e\u5f3a\u808c\u8089\u548c\u5176\u4ed6\u7ec4\u7ec7\u7684\u8840\u6db2\u6d41\u52a8\u548c\u6c27\u5408\u3002\u7814\u7a76\u5c0f\u7ec4\u8868\u793a\uff0c\u6b64\u7c7b\u7597\u6cd5\u751a\u81f3\u53ef\u80fd\u6709\u52a9\u4e8e\u7ec4\u7ec7\u53d7\u635f\u7684\u8840\u6db2\u4f9b\u5e94\u548c\u6c27\u6c14\u635f\u5931\u5668\u5b98\u7684\u65b0\u8840\u7ba1\u751f\u957f\uff0c\u8fd9\u662f\u5fc3\u810f\u75c5\u53d1\u4f5c\u548c\u7f3a\u8840\u6027\u4e2d\u98ce\u7684\u5e38\u89c1\u60c5\u51b5\u3002<\/p>\n<p>\u65b0\u8840\u7ba1\u5f62\u6210\u2014\u2014\u5f62\u6210\u65b0\u8840\u7ba1\u2014\u2014\u7814\u7a76\u4eba\u5458\u8868\u793a\uff0c\u5e94\u8c28\u614e\u6cbb\u7597\uff0c\u56e0\u4e3a\u8840\u6db2\u4f9b\u5e94\u589e\u52a0\u53ef\u80fd\u4f1a\u65e0\u610f\u4e2d\u52a9\u957f\u80bf\u7624\u751f\u957f\u3002<\/p>\n<p>\u201c\u5982\u679c\u60a8\u5df2\u7ecf\u60a3\u6709\u80bf\u7624\uff0c\u60a8\u6700\u4e0d\u60f3\u505a\u7684\u4e8b\u60c5\u5c31\u662f\u4e3a\u80bf\u7624\u63d0\u4f9b\u989d\u5916\u7684\u8840\u6db2\u548c\u8425\u517b\uff0c\u201d\u8be5\u7814\u7a76\u7684\u5408\u8457\u8005\u3001\u65b0\u5357\u5a01\u5c14\u58eb\u5927\u5b66\u533b\u5b66\u9662\u7684\u00a0<a href=\"https:\/\/medicalsciences.med.unsw.edu.au\/people\/dr-lindsay-wu\">\u6797\u8d5b\u5434<\/a>\u00a0\u8bf4\u533b\u5b66\u79d1\u5b66\u3002<\/p>\n<p>Sinclair \u548c Wu \u6307\u51fa\uff0c\u4f5c\u4e3a\u5f53\u524d\u7814\u7a76\u7684\u4e00\u90e8\u5206\u8fdb\u884c\u7684\u5b9e\u9a8c\u6ca1\u6709\u63d0\u4f9b\u8bc1\u636e\u8868\u660e\u7528 NMN \u6cbb\u7597\u4f1a\u523a\u6fc0\u7528\u5316\u5408\u7269\u6cbb\u7597\u7684\u52a8\u7269\u7684\u80bf\u7624\u53d1\u5c55<\/p>\n<p>\u5171\u540c\u7814\u7a76\u4eba\u5458\u5305\u62ec George Huang\u3001Michael Bonkowski\u3001Alban Longchamp\u3001Catherine Li\u3001Michael Schultz\u3001Lynn-Jee Kim\u3001Brenna Osborne\u3001Sanket Joshi\u3001Yuancheng Lu\u3001Jose Humberto\u3001Trevine-Villareal\u3001Myung-Jin Kang\u3001Tzong- tyng Hung\u3001Brendan Lee\u3001Eric Williams\u3001Masaki Igarashi\u3001James Mitchell\u3001Nigel Turner\u3001Zolt Arany \u548c Leonard Guarente\u3002<\/p>\n<p>\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u683c\u4f26\u533b\u5b66\u7814\u7a76\u57fa\u91d1\u4f1a\u7684\u652f\u6301\uff08\u8d60\u6b3e RO1 AG028730 \u548c RO1 DK100263\uff09\uff0c\u548c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\/\u56fd\u5bb6\u5fc3\u80ba\u8840\u6db2\u7814\u7a76\u6240\uff08\u6388\u4e88 RO1 HL094499\uff09\u3002<\/p>\n<p>\u76f8\u5173\u62ab\u9732\uff1a<\/p>\n<p>Sinclair \u548c Wu \u662f\u6388\u6743\u7ed9 Metro International Biotech\u3001JumpStart Fertility\u3001Vium\u3001Life Biosciences \u548c Liberty Biosecurity \u7684\u4e13\u5229\u7684\u987e\u95ee\u548c\u53d1\u660e\u4eba\u3002 Sinclair \u662f EdenRoc Sciences\u3001Arc Bio\u3001Segterra\u3001Animal Biosciences\u3001Senolytic Therapeutics\u3001Spotlight Biosciences \u548c Continuum Biosciences \u7684\u987e\u95ee\u3002 Wu \u662f Intravital \u548c JumpStart Fertility \u7684\u987e\u95ee\u3002 Bonkowski \u662f Metro International Biotech \u7684\u987e\u95ee\u3002 Sinclair \u662f\u4fe1\u6258\u59d4\u5458\u4f1a\u7684\u6210\u5458\uff0c\u5e76\u62e5\u6709 EdenRoc Sciences\u3001Arc Bio\u3001Segterra\u3001Metro International Biotech\u3001Liberty Biosecurity\u3001Animal Biosciences\u3001Life Biosciences\u3001Senolytic Therapeutics\u3001Spotlight Biosciences \u548c Continuum Biosciences \u7684\u80a1\u6743\u3002\u4ed6\u662f EdenRoc Sciences\u3001Arc Bio\u3001Metro International Biotech\u3001Liberty Biosecurity\u3001Life Biosciences \u548c Spotlight Biosciences \u7684\u8054\u5408\u521b\u59cb\u4eba\u3002 Guarente \u662f Segterra\u3001Sebelius \u548c Elysium Health \u7684\u987e\u95ee\u3002 Das\u3001Wu \u548c Sinclair \u4f5c\u4e3a\u53d1\u660e\u4eba\u5df2\u63d0\u4ea4\u4e34\u65f6\u4e13\u5229\u7533\u8bf7<\/p>\n<p>\u53c2\u8003\uff1ahttps:\/\/hms.harvard.edu\/news\/rewinding-clock<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_18128\" class=\"pvc_stats all  \" data-element-id=\"18128\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg 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