{"id":18085,"date":"2022-06-05T14:02:38","date_gmt":"2022-06-05T14:02:38","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=18085"},"modified":"2022-06-05T15:13:11","modified_gmt":"2022-06-05T15:13:11","slug":"%e3%80%90%e7%a7%91%e6%8a%80%e6%96%87%e7%8c%ae%e3%80%91nmn%e9%80%9a%e8%bf%87nad-sirt3%e9%80%9a%e8%b7%af%e6%94%b9%e5%96%84%e7%ba%bf%e7%b2%92%e4%bd%93%e5%8a%9f%e8%83%bd%e6%8a%91%e5%88%b6%e9%97%b4","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=18085","title":{"rendered":"\u3010\u79d1\u6280\u6587\u732e\u3011NMN\u901a\u8fc7NAD~+\/Sirt3\u901a\u8def\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u6291\u5236\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8870\u8001\u7684\u4f5c\u7528\u7814\u7a76"},"content":{"rendered":"<div class=\"c-card__title2\">NMN\u901a\u8fc7NAD~+\/Sirt3\u901a\u8def\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u6291\u5236\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u8870\u8001\u7684\u4f5c\u7528\u7814\u7a76<\/div>\n<div class=\"c-card__subline\">\n<div class=\"c-card__author\"><a href=\"https:\/\/wap.cnki.net\/touch\/web\/Organization\/List\/1046463.html\">\u5409\u6797\u5927\u5b66<\/a>\u00a0<a class=\"author-icon\">|<\/a>\u00a0<a href=\"https:\/\/wap.cnki.net\/touch\/web\/Scholar\/Index\/?code=07670462&amp;name=%E7%8E%8B%E6%AC%A2\">\u738b\u6b22<\/a><\/div>\n<\/div>\n<p>\u6210\u4f53\u5e72\u7ec6\u80de\u8870\u8001\u662f\u5bfc\u81f4\u7ec4\u7ec7\u5668\u5b98\u8870\u8001\u3001\u4e2a\u4f53\u8870\u8001\u4ee5\u53ca\u8001\u5e74\u6027\u75be\u75c5\u7684\u91cd\u8981\u539f\u56e0\u3002\u5176\u4e2d,\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de(mesenchymal stem cells,MSCs)\u662f\u7814\u7a76\u8f83\u65e9\u4e14\u8f83\u4e3a\u6df1\u5165\u7684\u4e00\u79cd\u6210\u4f53\u5e72\u7ec6\u80de,\u5177\u6709\u5e7f\u6cdb\u7684\u57fa\u7840\u7814\u7a76\u548c\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002\u7136\u800c,\u5728\u4f53\u5916\u57f9\u517b\u4f20\u4ee3\u6269\u589e\u8fc7\u7a0b\u4e2d,MSCs\u51fa\u73b0\u7684\u590d\u5236\u6027\u8870\u8001\u4e25\u91cd\u9650\u5236\u4e86\u5176\u5728\u7ec4\u7ec7\u635f\u4f24\u4fee\u590d\u53ca\u4e34\u5e8a\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u56e0\u6b64,\u5f00\u53d1\u6709\u6548\u7684\u6297\u8870\u8001\u836f\u7269\u4ee5\u5ef6\u7f13\u5e72\u7ec6\u80de\u8870\u8001\u662f\u6211\u4eec\u4e9f\u5f85\u89e3\u51b3\u7684\u5173\u952e\u95ee\u9898\u3002<!--more--><\/p>\n<div class=\"c-card__aritcle\">\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178(nicotinamide adenine dinucleotide,NAD~+)\u662f\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22\u548c\u6c27\u5316\u5e94\u6fc0\u9002\u5e94\u6027\u53cd\u5e94\u7684\u4e00\u4e2a<strong><span style=\"color: #ff0000;\">\u5173\u952e\u8f85\u9176<\/span><\/strong>,\u53c2\u4e0e<strong><span style=\"color: #ff0000;\">\u591a\u79cd\u4ee3\u8c22\u9014\u5f84\u5e76\u5f71\u54cd\u7ebf\u7c92\u4f53\u529f\u80fd<\/span><\/strong>\u3002<strong><span style=\"color: #ff6600;\">\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u662f\u8870\u8001\u7684\u7279\u5f81\u4e4b\u4e00<\/span><\/strong>,NAD~+\u8017\u7aed\u4e0e\u7ec6\u80de\u8870\u8001\u53ca\u80fd\u91cf\u4ee3\u8c22\u5931\u8c03\u5bc6\u5207\u76f8\u5173\u3002<\/div>\n<p>Sirt3\u662f\u7ebf\u7c92\u4f53\u5185NAD~+\u4f9d\u8d56\u6027\u53bb\u4e59\u9170\u5316\u9176,\u5bf9\u7ebf\u7c92\u4f53\u529f\u80fd\u53ca\u7ec6\u80de\u8870\u8001\u8d77\u91cd\u8981\u7684\u8c03\u8282\u4f5c\u7528\u3002\u6709\u7814\u7a76\u8868\u660e,NAD~+\u7684\u524d\u4f53\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178(nicotinamide mononucleotide,NMN)\u53ef\u4ee5\u63d0\u9ad8\u7ebf\u7c92\u4f53NAD~+\u6c34\u5e73,\u4f7fNAD~+\/NADH\u6bd4\u503c\u6b63\u5e38\u5316,\u8fdb\u800c\u6291\u5236\u8001\u9f84\u5c0f\u9f20\u808c\u8089\u5e72\u7ec6\u80de\u7684\u8870\u8001\u5e76\u6539\u5584\u5176\u7ebf\u7c92\u4f53\u7a33\u6001\u8c03\u8282\u529f\u80fd\u3002\u7ed3\u5408\u6211\u4eec\u524d\u671f\u5b9e\u9a8c,\u968f\u7740MSCs\u8870\u8001,\u7ec6\u80de\u5185NAD~+\u542b\u91cf\u51cf\u5c11,\u540c\u65f6\u4f34\u6709Sirt3\u8868\u8fbe\u964d\u4f4e,NMN\u80fd\u591f\u6291\u5236Nampt\u6291\u5236\u5242FK866\u8bf1\u5bfc\u7684MSCs\u8870\u8001\u3002<\/p>\n<div class=\"c-card__aritcle\">\u6211\u4eec\u63d0\u51fa\u672c\u7814\u7a76\u5047\u8bf4:\u5728MSCs\u8870\u8001\u8fc7\u7a0b\u4e2d,NMN\u53ef\u80fd\u901a\u8fc7NAD~+\/Sirt3\u901a\u8def\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u5e76\u8fdb\u4e00\u6b65\u6291\u5236MSCs\u8870\u8001\u3002\u7136\u800c,\u8870\u8001MSCs\u4e2d\u7ebf\u7c92\u4f53\u529f\u80fd\u662f\u5426\u53d1\u751f\u5f02\u5e38?NMN\u80fd\u5426\u6539\u5584\u8870\u8001MSCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd?NMN\u53c8\u662f\u5982\u4f55\u5f71\u54cd\u7ebf\u7c92\u4f53\u529f\u80fd\u53c2\u4e0e\u8c03\u63a7MSCs\u8870\u8001?\u4e0a\u8ff0\u95ee\u9898\u5747\u4e0d\u6e05\u695a\u3002<\/div>\n<div><\/div>\n<h3 class=\"c-card__aritcle\"><span style=\"color: #008000;\">\u76ee\u7684:<\/span><\/h3>\n<div><\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">\u7814\u7a76NMN\u5bf9\u8870\u8001MSCs\u7ebf\u7c92\u4f53\u529f\u80fd\u53ca\u7ec6\u80de\u8870\u8001\u7684\u5f71\u54cd,\u63a2\u8ba8NMN\u8c03\u63a7\u5e72\u7ec6\u80de\u8870\u8001\u7684\u673a\u5236,\u4e3a\u6709\u6548\u6297\u8870\u8001\u836f\u7269\u7684\u5f00\u53d1,\u89e3\u51b3\u5e94\u7528\u57fa\u7840\u6cbb\u7597\u4e2d\u5e72\u7ec6\u80de\u4e0d\u8db3\u95ee\u9898\u63d0\u4f9b\u5b9e\u9a8c\u4f9d\u636e\u3002<\/div>\n<div><\/div>\n<h3 class=\"c-card__aritcle\"><span style=\"color: #008000;\">\u65b9\u6cd5:<\/span><\/h3>\n<div><\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">1.\u4ee51-2\u6708\u9f84\u96c4\u6027Wistar\u5927\u9f20\u4e3a\u5b9e\u9a8c\u52a8\u7269\u5bf9\u8c61,\u901a\u8fc7\u5168\u9aa8\u9ad3\u8d34\u58c1\u6cd5\u548c\u4f53\u5916\u4f20\u4ee3\u57f9\u517b\u6cd5\u83b7\u5f97P3MSCs(early passage,EP)\u548cP10MSCs(late passage,LP),\u901a\u8fc7\u7ec6\u80de\u5f62\u6001\u5b66\u89c2\u5bdf\u3001\u8870\u8001\u76f8\u5173\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176(SA-\u03b2-gal)\u6d3b\u6027\u53ca\u8870\u8001\u76f8\u5173\u56e0\u5b50p16~(INK4a) mRNA\u7684\u8868\u8fbe\u8bc4\u4f30\u7ec6\u80de\u8870\u8001,\u5efa\u7acb\u4f53\u5916MSCs\u590d\u5236\u6027\u8870\u8001\u6a21\u578b(\u4ee5EPMSCs\u4e3a\u5e74\u8f7b\u7ec6\u80de,LPMSCs\u4e3a\u8870\u8001\u7ec6\u80de)\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">2.\u901a\u8fc7\u7ebf\u7c92\u4f53\u5f62\u6001\u7ed3\u6784\u89c2\u5bdf,ATP\u542b\u91cf\u3001\u6d3b\u6027\u6c27(ROS)\u6c34\u5e73\u3001\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u53ca\u8017\u6c27\u7387\u7684\u6d4b\u5b9a,\u660e\u786e\u8870\u8001MSCs\u4e2d\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u53d8\u5316\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">3.\u5229\u7528NAD~+\/NADH\u5b9a\u91cf\u8bd5\u5242\u76d2\u6d4b\u5b9a\u7ec6\u80de\u5185NAD~+\u542b\u91cf\u548cNAD~+\/NADH\u6bd4\u503c,\u5e94\u7528RT-qPCR\u548cWestern Blot\u68c0\u6d4b\u7ec6\u80de\u5185Sirt3\u7684\u8868\u8fbe\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">4.\u5229\u7528NAD~+\u7684\u524d\u4f53\u5c0f\u5206\u5b50NMN\u5904\u7406\u8870\u8001MSCs,\u63a2\u8ba8\u5176\u5bf9\u7ebf\u7c92\u4f53\u529f\u80fd\u53caMSCs\u8870\u8001\u7684\u5f71\u54cd\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">5.\u5229\u7528Sirt3\u6162\u75c5\u6bd2\u8fc7\u8868\u8fbe\u6216Sirt3\u6291\u5236\u52423-TYP,\u63a2\u8ba8Sirt3\u5bf9\u7ebf\u7c92\u4f53\u529f\u80fd\u53caMSCs\u8870\u8001\u7684\u5f71\u54cd,\u8fdb\u4e00\u6b65\u63a2\u8ba8NMN\u6539\u5584\u7ebf\u7c92\u4f53\u529f\u80fd\u6291\u5236MSCs\u8870\u8001\u7684\u5206\u5b50\u673a\u5236\u3002<\/div>\n<div><\/div>\n<h3 class=\"c-card__aritcle\"><span style=\"color: #008000;\">\u7ed3\u679c:<\/span><\/h3>\n<div><\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">1.\u4e0e\u5e74\u8f7bMSCs\u76f8\u6bd4,\u8870\u8001MSCs\u5f62\u6001\u53d1\u751f\u660e\u663e\u53d8\u5316,\u7ec6\u80de\u5448\u73b0\u94fa\u5c55\u72b6\u3001\u8fb9\u754c\u53d8\u5f97\u6a21\u7cca,\u5931\u53bb\u7acb\u4f53\u611f,\u8868\u9762\u79ef\u589e\u52a0\u800c\u957f\u5bbd\u6bd4\u964d\u4f4e;SA-\u03b2-gal\u9633\u6027\u7ec6\u80de\u660e\u663e\u589e\u591a,\u8870\u8001\u76f8\u5173\u56e0\u5b50p16~(INK4a) mRNA\u7684\u8868\u8fbe\u663e\u8457\u4e0a\u8c03\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">2.\u8870\u8001MSCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d,\u8868\u73b0\u4e3a:\u7ebf\u7c92\u4f53\u5206\u5e03\u5206\u6563,\u7247\u6bb5\u5316\u660e\u663e;\u7ebf\u7c92\u4f53\u4f53\u79ef\u589e\u5927,\u51fa\u73b0\u7a7a\u6ce1,\u53cc\u5c42\u819c\u7ed3\u6784\u6d88\u5931,\u5185\u90e8\u5d74\u65ad\u88c2;\u8870\u8001MSCs\u5185ATP\u542b\u91cf\u51cf\u5c11\u800cROS\u4ea7\u751f\u589e\u52a0,\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u53ca\u8017\u6c27\u7387(OCR)\u5747\u964d\u4f4e\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">3.NMN\u4f7f\u8870\u8001MSCs\u7684\u7ec6\u80de\u5f62\u6001\u53d1\u751f\u6539\u53d8,\u8868\u9762\u79ef\u51cf\u5c0f\u800c\u957f\u5bbd\u6bd4\u5347\u9ad8,\u8870\u8001\u7ec6\u80de\u6570\u76ee\u53cap16~(INK4a) mRNA\u7684\u8868\u8fbe\u5747\u663e\u8457\u4e0b\u8c03\u3002NMN\u80fd\u591f\u6539\u5584\u8870\u8001MSCs\u7ebf\u7c92\u4f53\u529f\u80fd,\u7ebf\u7c92\u4f53\u5206\u5e03\u53d8\u5f97\u96c6\u4e2d,\u8870\u8001\u7ec6\u80de\u5185ATP\u542b\u91cf\u548c\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u5747\u5347\u9ad8,\u800cROS\u6c34\u5e73\u964d\u4f4e\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">4.\u4e0e\u5e74\u8f7bMSCs\u76f8\u6bd4,\u8870\u8001MSCs\u4e2dNAD~+\u542b\u91cf\u3001NAD~+\/NADH\u6bd4\u503c\u53caSirt3\u8868\u8fbe\u5747\u964d\u4f4e;NMN\u5904\u7406\u540e\u8870\u8001MSCs\u4e2dNAD~+\u542b\u91cf\u589e\u52a0,NAD~+\/NADH\u6bd4\u503c\u5347\u9ad8,Sirt3\u8868\u8fbe\u4e5f\u4e0a\u8c03\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">5.\u8fc7\u8868\u8fbeSirt3\u80fd\u591f\u6709\u6548\u6539\u5584\u8870\u8001MSCs\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d,\u4f7f\u8870\u8001\u7ec6\u80de\u7684\u7ebf\u7c92\u4f53\u5f62\u6001\u8d8b\u5411\u6b63\u5e38,\u7ec6\u80de\u5185ATP\u542b\u91cf\u3001\u7ebf\u7c92\u4f53\u8017\u6c27\u7387(OCR)\u663e\u8457\u5347\u9ad8,\u800cROS\u6c34\u5e73\u660e\u663e\u964d\u4f4e;\u8fc7\u8868\u8fbeSirt3\u4f7f\u8870\u8001MSCs\u4e2d\u8870\u8001\u7ec6\u80de\u6570\u76ee\u51cf\u5c11,\u8870\u8001\u76f8\u5173\u56e0\u5b50p16~(INK4a) mRNA\u7684\u8868\u8fbe\u660e\u663e\u4e0b\u8c03,\u5177\u6709\u6291\u5236MSCs\u8870\u8001\u7684\u4f5c\u7528\u3002\u5728\u5e74\u8f7bMSCs\u4e2d,Sirt3\u6291\u5236\u52423-TYP\u80fd\u591f\u5bfc\u81f4\u7ec6\u80de\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d,\u4fc3\u8fdbMSCs\u8870\u8001\u3002<\/div>\n<div class=\"c-card__aritcle\" style=\"padding-left: 40px;\">6.\u5728\u8870\u8001MSCs\u4e2d,3-TYP\u53ef\u4ee5\u4f7fNMN\u5f15\u8d77\u7684\u8d8b\u4e8e\u6b63\u5e38\u7684\u7ebf\u7c92\u4f53\u5f62\u6001\u53d1\u751f\u5f02\u5e38,\u4e0b\u8c03NMN\u6240\u81f4\u7684\u7ec6\u80de\u5185ATP\u542b\u91cf\u53ca\u7ebf\u7c92\u4f53\u819c\u7535\u4f4d\u7684\u5347\u9ad8,\u5e76\u4e14\u9006\u8f6cROS\u6c34\u5e73\u7684\u964d\u4f4e;3-TYP\u80fd\u591f\u9006\u8f6c\u8870\u8001MSCs\u4e2dNMN\u6240\u81f4\u7684\u8870\u8001\u7ec6\u80de\u9633\u6027\u7387\u53caP16~(INK4a) mRNA\u8868\u8fbe\u7684\u4e0b\u964d\u3002\u5728\u5e74\u8f7bMSCs\u4e2d,NMN\u4e5f\u80fd\u591f\u6539\u5584\u6216\u6291\u52363-TYP\u5f15\u8d77\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u548c\u7ec6\u80de\u8870\u8001\u3002<\/div>\n<div><\/div>\n<h3 class=\"c-card__aritcle\"><span style=\"color: #008000;\">\u7ed3\u8bba:<\/span><\/h3>\n<div><\/div>\n<ul>\n<li class=\"c-card__aritcle\">1.\u8870\u8001MSCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d,NAD~+\u542b\u91cf\u53caSirt3\u8868\u8fbe\u663e\u8457\u964d\u4f4e\u3002<\/li>\n<li class=\"c-card__aritcle\">2.\u8fc7\u8868\u8fbe<span style=\"color: #ff0000;\">Sirt3\u80fd\u591f\u6539\u5584\u8870\u8001MSCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd<\/span>,<span style=\"color: #ff0000;\">\u6291\u5236MSCs\u8870\u8001<\/span>;Sirt3\u6291\u5236\u52423-TYP\u53d1\u6325\u4e86\u76f8\u53cd\u4f5c\u7528\u3002<\/li>\n<li class=\"c-card__aritcle\">3.N<span style=\"color: #ff0000;\">MN\u80fd\u591f\u6539\u5584\u8870\u8001MSCs\u7684\u7ebf\u7c92\u4f53\u529f\u80fd<\/span>,\u6291\u5236MSCs\u8870\u8001,\u8be5\u8c03\u63a7\u4f5c\u7528\u662f\u901a\u8fc7\u4e0a\u8c03\u7ec6\u80de\u5185NAD~+\u542b\u91cf\u53caSirt3\u8868\u8fbe\u5b9e\u73b0\u7684\u3002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<div><span style=\"font-size: 1rem;\">\u673a\u3000\u6784:\u00a0 <\/span><a style=\"background-color: #ffffff; font-size: 1rem;\" 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