{"id":17799,"date":"2022-05-29T17:06:06","date_gmt":"2022-05-29T17:06:06","guid":{"rendered":"http:\/\/johnhealth.blog\/ch\/?p=17799"},"modified":"2022-05-30T02:39:22","modified_gmt":"2022-05-30T02:39:22","slug":"nmn%e7%9a%84%e7%a0%94%e5%8f%91%e8%80%85","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=17799","title":{"rendered":"NMN\u7684\u7814\u53d1\u8005"},"content":{"rendered":"<h4>\u5927\u536b\u8f9b\u514b\u83b1\u4ecb\u7ecd<\/h4>\n<p>Wiki\u7ef4\u57fa\u767e\u79d1:<br \/>\n\u5927\u536b\u30fb\u5b89\u5fb7\u9c81\u30fb\u8f9b\u514b\u83b1\uff08David Andrew Sinclair\uff0c1969\u5e746\u670826\u65e5\u5728\u96ea\u68a8\u51fa\u751f\uff09\u662f\u4e00\u540d\u6fb3\u5927\u5229\u4e9a\u751f\u7269\u5b66\u5bb6\uff0c\u4e3b\u8981\u7814\u7a76\u9057\u4f20\u5b66\u4e2d\u5982\u4f55\u6709\u6548\u4ee4\u4eba\u7c7b\u751f\u547d\u5ef6\u957f\u548c\u6cbb\u7597\u8001\u5e74\u75be\u75c5\u3002[1] \u81ea1999\u5e74\u8d77\uff0c\u4ed6\u6210\u4e3a\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9057\u4f20\u7cfb\u7684\u7ec8\u751f\u6559\u6388\u3002<!--more--><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17800\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/21944632985991_188.jpg\" alt=\"\" width=\"635\" height=\"787\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/21944632985991_188.jpg 635w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/21944632985991_188-242x300.jpg 242w\" sizes=\"auto, (max-width: 635px) 100vw, 635px\" \/><\/p>\n<p>NMN\u7814\u53d1\u8005\u4ecb\u7ecd&#8211;\u5927\u536b\u30fb\u8f9b\u514b\u83b1(David Sinclair)<\/p>\n<p>\u5927\u536b\u30fb\u8f9b\u514b\u83b1(David Sinclair)\u662f\u6fb3\u5927\u5229\u4e9a\u7c4d\u9057\u4f20\u5b66\u5bb6\u548c\u751f\u7269\u5b66\u5bb6\uff0c\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7ec8\u8eab\u6559\u6388\uff0c\u7f8e\u56fd\u4fdd\u7f57\u30fb\u845b\u7c63\uff08Paul Glenn\uff09\u8870\u8001\u751f\u7269\u5b66\u4e2d\u5fc3\u4e3b\u4efb\u3002\u4ed6\u4ee5\u6297\u8870\u8001\u9886\u57df\u7684\u5353\u8d8a\u8868\u73b0\u548c\u5f00\u521b\u6027\u7684\u79d1\u5b66\u6210\u5c31\u800c\u4eab\u8a89\u5168\u7403\uff0c\u6210\u4e3a\u5927\u540d\u9f0e\u9f0e\u3001\u7099\u624b\u53ef\u70ed\u7684\u79d1\u5b66\u5bb6\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17801\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298.jpg\" alt=\"\" width=\"1050\" height=\"787\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298.jpg 1050w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298-300x225.jpg 300w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298-1024x768.jpg 1024w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298-768x576.jpg 768w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/7166118e380f7186e787f220e847d298-400x300.jpg 400w\" sizes=\"auto, (max-width: 1050px) 100vw, 1050px\" \/><\/p>\n<p>\u5927\u536b\u30fb\u8f9b\u514b\u83b1(David Sinclair)1999\u5e74\u8fdb\u5165\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u5de5\u4f5c\uff0c\u4ed6\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728sirtuins\uff08\u957f\u5bff\u86cb\u767d\u5bb6\u65cf\uff09\u3001NAD +\uff08\u8f85\u9176\u2160\uff09\u7b49\u751f\u547d\u957f\u5bff\u548c\u6297\u8870\u76f8\u5173\u9886\u57df\uff1b\u00a0Sinclair\u5b9e\u9a8c\u5ba4\u662f\u7b2c\u4e00\u4e2a\u9274\u5b9aNAD +\u751f\u7269\u5408\u6210\u5728\u5bff\u547d\u8c03\u8282\u4e2d\u4f5c\u7528\u7684\u5b9e\u9a8c\u5ba4\uff0c\u5e76\u4e14\u9996\u5148\u53d1\u73b0 #<span style=\"color: #0000ff;\"><strong>\u767d\u85dc\u82a6\u9187<\/strong><\/span>\uff08\u5e7f\u6cdb\u5b58\u5728\u65bc\u8461\u8404\u3001\u864e\u6756\u7b49\u690d\u7269\u4e2d\u7684\u5929\u7136\u7269\u8d28\uff09\u53ef\u4ee5\u6709\u6548\u542f\u52a8SIRT1\uff0cNAD+\u7684\u524d\u4f53NMN\uff08\u4e00\u79cd\u5e7f\u5b58\u5728\u65bc\u6bdb\u8c46\u3001\u897f\u5170\u82b1\u3001\u725b\u6cb9\u679c\u7b49\u690d\u7269\u4e2d\u7684\u5929\u7136\u7269\u8d28\uff09\u53ef\u4ee5\u6709\u6548\u542f\u52a8SIRT1~ SIRT7\u6574\u4e2asirtuins\u86cb\u767d\u5bb6\u65cf\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17802\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/161890180_2569467680025049_1404254545859152486_n.jpg\" alt=\"\" width=\"722\" height=\"960\" srcset=\"http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/161890180_2569467680025049_1404254545859152486_n.jpg 722w, http:\/\/johnhealth.blog\/ch\/wp-content\/uploads\/2022\/05\/161890180_2569467680025049_1404254545859152486_n-226x300.jpg 226w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><\/p>\n<p>\u8fd9\u4e9b\u91cd\u5927\u53d1\u73b0\u548c\u79d1\u7814\u6210\u679c\u5728\u4e16\u754c\u6700\u6743\u5a01\u7684\u300a\u81ea\u7136\u300b\u3001\u300a\u79d1\u5b66\u300b\u3001\u300a\u7ec6\u80de\u300b\u7b49\u6742\u5fd7\u76f8\u7ee7\u53d1\u8868\uff0c\u9707\u52a8\u5168\u7403\u3002\u6700\u524d\u6cbf\u7684\u63a2\u7d22\u548c\u79d1\u5b66\u7814\u7a76\u8ba9Sinclair\u6210\u4e3a35\u9879\u4e13\u5229\u7684\u53d1\u660e\u8005\uff0c\u5e76\u83b7\u5f97\u4e86\u591a\u8fbe25\u4e2a\u4e13\u4e1a\u5956\u9879\u548c\u653f\u5e9c\u8363\u8a89\uff1b\u4ed6\u8fd8\u662f\u300a\u8870\u8001\u300b\uff08AGING\uff09\u6742\u5fd7\u7684\u521b\u59cb\u4eba\u53ca\u4e3b\u7f16\u3002\u4ed6\u7684\u6297\u8870\u7406\u8bba\u548c\u4e3b\u5f20\u5728\u4ed6\u7684\u4e94\u90e8\u4e13\u8457\u3001\u4e24\u90e8\u7eaa\u5f55\u7247\u300160\u5206\u949f\u6469\u6839\u30fb\u5f17\u91cc\u66fc\uff08Morgan Freeman\uff09\u7684\u300a\u7a7f\u8d8a\u866b\u6d1e\u300b\uff08Through the Wormhole\uff09\u7b49\u4f5c\u54c1\u4e2d\u5f97\u4ee5\u5145\u5206\u4f53\u73b0\u3002<\/p>\n<p>\u957f\u8fbe20\u5e74\u7684\u6297\u8870\u8001\u7814\u7a76\u548c\u53d6\u5f97\u7684\u5de8\u5927\u6210\u5c31\u5f15\u8d77\u4e86\u4e16\u4eba\u7684\u5e7f\u6cdb\u5173\u6ce8\u548c\u8d5e\u8a89\uff1b\u66f4\u4e3a\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u548c\u5176\u4ed6\u79d1\u5b66\u5bb6\u4e00\u9053\uff0c\u79ef\u6781\u63a8\u52a8\u4e86\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u57282018\u5e74\u5c06\u8870\u8001\u5217\u4e3a\u4eba\u7c7b\u7684\u75be\u75c5\u4e4b\u4e00\uff0c\u4ece\u800c\u4e3a\u79d1\u5b66\u5730\u6291\u5236\u751a\u81f3\u6d88\u706d\u8870\u8001\u5efa\u7acb\u4e86\u89c4\u8303\u3002\u4ed6\u88ab\u6388\u4e88\u6fb3\u5927\u5229\u4e9a\u52cb\u7ae0\uff0c\u5e76\u88ab\u7f8e\u56fd\u65f6\u4ee3\u6742\u5fd7\u8bc4\u9009\u4e3a100\u4f4d\u6700\u5177\u5f71\u54cd\u529b\u7684\u4eba\u7269\u4e4b\u4e00\u3002<\/p>\n<div style=\"width: 640px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-17799-1\" width=\"640\" height=\"360\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"http:\/\/johnhealth.blog\/nmn\/sinclair-antiaging.mp4?_=1\" \/><a href=\"http:\/\/johnhealth.blog\/nmn\/sinclair-antiaging.mp4\">http:\/\/johnhealth.blog\/nmn\/sinclair-antiaging.mp4<\/a><\/video><\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_17799\" class=\"pvc_stats all  \" data-element-id=\"17799\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5927\u536b\u8f9b\u514b\u83b1\u4ecb\u7ecd Wiki\u7ef4\u57fa\u767e\u79d1: \u5927\u536b\u30fb\u5b89\u5fb7\u9c81\u30fb\u8f9b\u514b\u83b1\uff08David Andrew Sinclair\uff0c1969\u5e746\u670826\u65e5\u5728\u96ea\u68a8\u51fa\u751f\uff09\u662f\u4e00\u540d\u6fb3\u5927\u5229\u4e9a\u751f\u7269\u5b66\u5bb6\uff0c\u4e3b\u8981\u7814\u7a76\u9057\u4f20\u5b66\u4e2d\u5982\u4f55\u6709\u6548\u4ee4\u4eba\u7c7b\u751f\u547d\u5ef6\u957f\u548c\u6cbb\u7597\u8001\u5e74\u75be\u75c5\u3002[1] \u81ea1999\u5e74\u8d77\uff0c\u4ed6\u6210\u4e3a\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9057\u4f20\u7cfb\u7684\u7ec8\u751f\u6559\u6388\u3002<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_17799\" class=\"pvc_stats all  \" data-element-id=\"17799\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":1,"featured_media":17800,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172],"tags":[368,170,171,367,373],"class_list":{"0":"post-17799","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-nmn-","8":"tag-david-sinclair","9":"tag-dr-david-sinclair","10":"tag-nmn","12":"tag-373"},"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17799"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17799\/revisions"}],"predecessor-version":[{"id":17803,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17799\/revisions\/17803"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17800"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17799"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}