{"id":17592,"date":"2022-02-28T03:37:27","date_gmt":"2022-02-28T03:37:27","guid":{"rendered":"http:\/\/choosebiz.me\/?p=255"},"modified":"2022-05-28T14:50:01","modified_gmt":"2022-05-28T14:50:01","slug":"%e4%bb%80%e4%b9%88%e6%98%afnmn%ef%bc%9f-3","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=17592","title":{"rendered":"\u4ec0\u4e48\u662fNMN\uff1f"},"content":{"rendered":"

NMN \u7684\u53d1\u73b0\u53ca\u7814\u7a76<\/p>\n

NMN \u88ab\u79d1\u5b66\u5bb6\u79f0\u4e3a 21 \u4e16\u7eaa\u7684\u300c\u957f\u751f\u4e0d\u8001\u836f\u300d\uff0c\u662f\u4e16\u754c\u4e0a\u9996\u4e2a\u7ecf\u4e25\u8c28\u79d1\u5b66\u9a8c\u8bc1\u53ef\u4ee5\u663e\u7740\u9006\u8f6c\u8870\u8001\u4e36\u5ef6\u957f\u5bff\u547d\u7684\u79d1\u5b66\u7814\u7a76\u6210\u679c\uff0c\u65bc 2013 \u5e74\u7531\u54c8\u4f5b\u5927\u5b66\u7684 Prof. David Sinclair ( \u5927\u536b\u2022\u8f9b\u514b\u83b1\u5c14\u6559\u6388 ) \u5b9e\u9a8c\u5ba4\u521d\u6b65\u53d1\u73b0\u5728\u6297\u8870\u8001\u9886\u57df\u7684\u6210\u679c\u3002<\/p>\n

\"\"<\/p>\n

Prof. David Sinclair \u5927\u536b\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u662f\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u7ec8\u751f\u6559\u6388\uff0c\u4ed6\u662f\u767d\u85dc\u82a6\u9187<\/a>\u7684\u53d1\u73b0\u8005\uff0c\u8fd1\u5e74\u66f4\u56e0\u4e3a\u5bf9 NMN \u548c NAD+ \u7684\u53d1\u73b0\u548c\u7a81\u7834\uff0c\u83b7\u9009\u4e3a 2014 \u5e74\u65f6\u4ee3\u6742\u5fd7\u7684\u767e\u5927\u6700\u6709\u5f71\u54cd\u529b\u4eba\u7269\u548c 2018 \u5e74\u7684\u5065\u5eb7\u98ce\u4e91\u4eba\u7269 50\u4eba\u3002 \u5927\u536b\u8f9b\u514b\u83b1\u6559\u6388\u7531\u65bc NMN \u53ef\u4ee5\u6297\u8f90\u5c04\u548c\u589e\u52a0\u9aa8\u9abc\u808c\uff0c\u800c\u5206\u522b\u5728 2016 \u5e74\u548c 2018 \u5e74\u83b7\u9881 NASA \u7684 iTech \u5956\u3002<\/p>\n

\"\"<\/p>\n

\n

\u6709\u6548\u6297\u8870\u8001 NMN<\/span><\/h3>\n

2015 \u5e74\uff0c\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u7ec8\u751f\u6559\u6388 \u5927\u536b\u8f9b\u514b\u83b1\u5c14 \u6210\u529f\u8ba9\u8001\u9f20\u4ece 60 \u5c81\u9006\u8f6c\u5230 20 \u5c81\uff0c\u8865\u5145 NAD+ \u524d\u9a71\u7269 NMN\uff0c\u8ba9\u5c0f\u9f20\u8870\u8001\u901f\u5ea6\u964d\u4f4e 2\/3\uff0c\u4f7f\u5bff\u547d\u88ab\u5ef6\u957f\u4e86 30% ~ 50%<\/p>\n

\"\"<\/p>\n

NMN \u662f NAD+ \u7684\u524d\u9a71\u7269<\/span><\/strong><\/p>\n

NAD+ \uff08 Nicotinamide adenine dinucleotide \uff09\u83f8\u7877\u91af\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08\u7b80\u79f0\uff1a\u8f85\u9176 \u2160 \uff09
\nNAD+ \u5b58\u5728\u65bc\u4eba\u4f53\u6bcf\u4e2a\u7ec6\u80de\u4e2d\uff0c\u53c2\u4e0e\u8bb8\u591a\u91cd\u8981\u7684\u7ec6\u80de\u6d3b\u52a8\uff0c\u5305\u542b\u80fd\u91cf\u4ee3\u8c22\u4e36\u7cd6\u9175\u89e3\u4e36DNA \u590d\u5236\u7b49…\u4e3b\u5bfc\u4e86\u5404\u6837\u7684\u751f\u547d\u6d3b\u52a8\u3002<\/p>\n

NAD+ \u5206\u5b50\u592a\u5927\uff0c\u56e0\u6b64\u8865\u5145 NAD+ \u7684\u524d\u4f53\u7269\u8d28 NMN \uff08\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u6765\u63d0\u5347 NAD+ \u7684\u6c34\u5e73\u662f\u6700\u6709\u6548\u7684\u65b9\u6cd5\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\n

\u8870\u8001\u4e0eNMN\u7684\u5173\u7cfb<\/span><\/h3>\n

NAD+ \u5206\u5b50\u592a\u5927\uff0c\u56e0\u6b64\u8865\u5145 NAD+ \u7684\u524d\u4f53\u7269\u8d28 NMN \u6765\u63d0\u5347 NAD+ \u7684\u6c34\u5e73\u662f\u6700\u6709\u6548\u7684\u65b9\u6cd5\u3002<\/p>\n

NMN \uff08\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u5206\u5b50\u91cf 334.2192\uff0c\u53e3\u670d\u5f8c 10 \u5206\u949f\u53ef\u8fdb\u5165\u8840\u6db2\uff0c\u7531\u65bc\u5206\u5b50\u5c0f\u5f88\u5bb9\u6613\u7a7f\u8fc7\u7ec6\u80de\u819c\uff0c\u8fdb\u5165\u7ec6\u80de\u5185\u90e8\uff0c15 \u5206\u949f\u5373\u53ef\u63d0\u5347NAD+ \u7684\u6c34\u5e73\u3002<\/p>\n

\"\"<\/p>\n

NAD\uff0b\u968f\u7740\u5e74\u9f84\u5448\u6307\u6570\u6027\u4e0b\u964d\uff0c\u3000\uff14\uff10\u5c81\u65f6\u53ea\u6709\uff12\uff10\u5c81\u65f6\u4e0d\u5230\u4e00\u534a\u7684\u542b\u91cf\u3002<\/p>\n

\n

NMN\u7684\u4f5c\u7528\u673a\u8f6c<\/span><\/h3>\n

NMN \u662f\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 Nicotinamide mononucleotide \u7684\u7b80\u79f0\uff0c\u5206\u5b50\u91cf 334.2192\uff0c\u5b83\u662f\u4eba\u4f53\u5185\u56fa\u6709\u7684\u7269\u8d28\uff0c\u5b89\u5168\u4e14\u65e0\u526f\u4f5c\u7528\uff0c\u4e5f\u5bcc\u542b\u5728\u4e00\u4e9b\u6c34\u679c\u548c\u852c\u83dc\u4e2d\uff0c\u7eaf\u5929\u7136\u65e0\u5bb3\u3002 \u5728\u4eba\u4f53\u4e2d\uff0cNMN \u662f NAD+ \u7684\u524d\u4f53\uff0c\u5176\u529f\u80fd\u7686\u901a\u8fc7 NAD+ \u4f53\u73b0\u3002<\/p>\n

\"\"<\/p>\n

NMN \u7684\u5f3a\u5927\u7684\u529f\u6548\u6765\u81ea\u5176\u8f6c\u53d8\u4e3a NAD+ \u5f8c\u7684\u4e09\u9879\u6838\u5fc3\u673a\u5236\uff1a\u542f\u52a8\u957f\u5bff\u86cb\u767d Sirtuins1~7<\/span>\u00a0\uff0f\u542f\u52a8 DNA \u4fee\u590d\u9176 PARP\uff0f<\/span><\/strong> \u542f\u52a8\u514d\u75ab\u8c03\u8282\u73af ADP \u6838\u7cd6\u5408\u6210\u9176<\/strong><\/span>\u3002<\/p>\n

    \n
  • NMN \u8f6c\u53d8\u4e3a NAD+ \u5f8c\uff0c\u53ef\u4ee5\u5e2e\u52a9\u67d3\u8272\u4f53\u7684\u7aef\u7c92\u4e0d\u7f29\u77ed<\/li>\n
  • NMN \u8f6c\u53d8\u4e3a NAD+ \u5f8c\uff0c\u53ef\u4ee5\u8ba9 DNA \u4fee\u590d\u9176 ( PARP ) \u4fee\u590d\u65ad\u88c2\u7684DNA<\/li>\n
  • NMN \u8f6c\u53d8\u4e3a NAD+ \u5f8c\uff0c\u53ef\u4ee5\u8ba9\u957f\u5bff\u86cb\u767d ( Sirtuins ) \u53bb\u5f53\u5de1\u903b\u961f\uff0c\u8c03\u8282\u5404\u5668\u5b98\u7684\u57fa\u56e0\u8868\u8fbe<\/li>\n<\/ul>\n

    \"\"<\/p>\n

    \u6709\u5145\u8db3\u7684 NAD+\uff0c\u624d\u80fd\u8ba9\u4ee5\u4e0a\u8fd9\u4e9b\u6297\u8870\u8001\u7684\u6838\u5fc3\u529f\u80fd\u6b63\u5e38\u8fd0\u4f5c<\/p>\n

    \n

    NMN\u79d1\u7814\u7ed3\u679c<\/span><\/h3>\n

    NMN \u662f\u552f\u4e00\u7ecf\u8fc7\u56fd\u9645\u4e09\u5927\u9876\u7ea7\u5b66\u672f\u671f\u520a\u300aScience\u300b\u4e36\u300aNature\u300b\u4e36\u300aCell\u300b\u520a\u8f7d\u7684\u6570\u5341\u7bc7\u5b66\u672f\u8bba\u6587\u7684\u7814\u7a76\u5b9e\u8bc1\uff0c\u5177\u6709\u663e\u7740\u9006\u8f6c\u8870\u8001\u529f\u80fd\u7684\u7ec6\u80de\u56e0\u6570\uff0c\u53ef\u4ee5\u542f\u52a8\u4eba\u4f53\u5df2\u77e5\u7684\u5168\u90e8 7 \u4e2a\u957f\u5bff\u86cb\u767d ( Sitruins ) \u548c DNA \u4fee\u590d\u9176 ( PARP )\uff0c\u8fbe\u5230\u5168\u9762\u6297\u8870\u7684\u673a\u8f6c\uff0c\u662f\u76ee\u524d\u79d1\u5b66\u5df2\u77e5\u7684\u6700\u5168\u9762\u4e36\u529f\u80fd\u6700\u5f3a\u5927\u4e14\u4e0d\u542b\u526f\u4f5c\u7528\u7684\u7ec6\u80de\u6297\u8870\u56e0\u6570\uff0c\u88ab\u8ba4\u4e3a\u662f\u73b0\u9636\u6bb5\u6700\u6709\u53ef\u80fd\u63a7\u5236\u4eba\u7c7b\u8001\u5316\u7684\u7269\u8d28\u3002<\/p>\n

    \"\"
    \n\u53e6\u5916 ~ \u54c8\u4f5b\u5927\u5b66\u4e36\u534e\u76db\u987f\u5927\u5b66\u4e36\u65e5\u672c\u5e86\u5e94\u5927\u5b66\u7b49\u9876\u7ea7\u79d1\u7814\u673a\u6784\u7684\u591a\u4e2a\u5b9e\u9a8c\u5ba4\u5148\u5f8c\u5f00\u5c55\u9488\u5bf9 NMN \u7684\u6297\u8870\u8001\u6548\u679c\u8be6\u7ec6\u8bc4\u4f30\u3002 \u76ee\u524d\u80fd\u67e5\u5230\u516c\u5f00\u4fe1\u606f\u7684\uff0c\u5c31\u6709\u516b\u4f4d\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u4e36\u533b\u5b66\u4e36\u5316\u5b66\u5956\u5f97\u4e3b\uff0c\u90fd\u5bf9 NAD+ \u6297\u8870\u8001\u7406\u8bba\u8868\u793a\u516c\u5f00\u7684\u652f\u6301\u3002<\/p>\n

    \n

    <\/div>\n

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    <\/div>\n","protected":false},"excerpt":{"rendered":"

    NMN \u7684\u53d1\u73b0\u53ca\u7814\u7a76 NMN \u88ab\u79d1\u5b66\u5bb6\u79f0\u4e3a 21 \u4e16\u7eaa\u7684\u300c\u957f\u751f\u4e0d\u8001\u836f\u300d\uff0c\u662f\u4e16\u754c\u4e0a\u9996\u4e2a\u7ecf\u4e25\u8c28\u79d1\u5b66\u9a8c\u8bc1\u53ef\u4ee5\u663e\u7740\u9006\u8f6c\u8870\u8001\u4e36\u5ef6\u957f\u5bff\u547d\u7684\u79d1\u5b66\u7814\u7a76\u6210\u679c\uff0c\u65bc 2013 \u5e74\u7531\u54c8\u4f5b\u5927\u5b66\u7684 Prof. David Sinclair ( \u5927\u536b\u2022\u8f9b\u514b\u83b1\u5c14\u6559\u6388 ) \u5b9e\u9a8c\u5ba4\u521d\u6b65\u53d1\u73b0\u5728\u6297\u8870\u8001\u9886\u57df\u7684\u6210\u679c\u3002 Prof. David Sinclair \u5927\u536b\u8f9b\u514b\u83b1\u5c14\u6559\u6388\u662f\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u7ec8\u751f\u6559\u6388\uff0c\u4ed6\u662f\u767d\u85dc\u82a6\u9187\u7684\u53d1\u73b0\u8005\uff0c\u8fd1\u5e74\u66f4\u56e0\u4e3a\u5bf9 NMN \u548c NAD+ \u7684\u53d1\u73b0\u548c\u7a81\u7834\uff0c\u83b7\u9009\u4e3a 2014 \u5e74\u65f6\u4ee3\u6742\u5fd7\u7684\u767e\u5927\u6700\u6709\u5f71\u54cd\u529b\u4eba\u7269\u548c 2018 \u5e74\u7684\u5065\u5eb7\u98ce\u4e91\u4eba\u7269 50\u4eba\u3002 \u5927\u536b\u8f9b\u514b\u83b1\u6559\u6388\u7531\u65bc NMN \u53ef\u4ee5\u6297\u8f90\u5c04\u548c\u589e\u52a0\u9aa8\u9abc\u808c\uff0c\u800c\u5206\u522b\u5728 2016 \u5e74\u548c 2018 \u5e74\u83b7\u9881 NASA \u7684 iTech \u5956\u3002 \u6709\u6548\u6297\u8870\u8001 NMN 2015 \u5e74\uff0c\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u9057\u4f20\u5b66\u7ec8\u751f\u6559\u6388 \u5927\u536b\u8f9b\u514b\u83b1\u5c14 \u6210\u529f\u8ba9\u8001\u9f20\u4ece 60 \u5c81\u9006\u8f6c\u5230 20 \u5c81\uff0c\u8865\u5145 NAD+ \u524d\u9a71\u7269 NMN\uff0c\u8ba9\u5c0f\u9f20\u8870\u8001\u901f\u5ea6\u964d\u4f4e 2\/3\uff0c\u4f7f\u5bff\u547d\u88ab\u5ef6\u957f\u4e86 30% ~ 50% NMN \u662f NAD+ \u7684\u524d\u9a71\u7269 […]<\/p>\n

    <\/div>\n

    <\/path><\/svg><\/i> \"Loading\"<\/p>\n

    <\/div>\n","protected":false},"author":1,"featured_media":17582,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[172],"tags":[274,171],"class_list":["post-17592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nmn-","tag-nad","tag-nmn"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17592"}],"version-history":[{"count":2,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17592\/revisions"}],"predecessor-version":[{"id":17602,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/17592\/revisions\/17602"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/media\/17582"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17592"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}