{"id":15154,"date":"2021-07-29T04:04:13","date_gmt":"2021-07-29T04:04:13","guid":{"rendered":"http:\/\/health-anything.com\/?p=15154"},"modified":"2022-05-23T16:18:34","modified_gmt":"2022-05-23T16:18:34","slug":"%e5%b7%b2%e7%9f%a5%e7%9a%84-%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87-%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=15154","title":{"rendered":"\u5df2\u77e5\u7684 \u767d\u85dc\u82a6\u9187 \u529f\u80fd"},"content":{"rendered":"

\u767d\u85dc\u82a6\u9187 \u8fd9\u79cd\u5168\u8eab\u529f\u6548\u662f\u56e0\u4e3a\u5168\u8eab\u7ec6\u80de\u7684\u57fa\u56e0\u76f8\u540c\uff1a \u90fd\u6709SIRT1\u57fa\u56e0\u3002 \u901a\u8fc7\u8840\u6db2\u5faa\u73af\u5230\u8fbe\u5168\u8eab\u5404\u7ec6\u80de\uff0c\u4e0e\u57fa\u56e0SIRT1\u7ed3\u5408\u4ea7\u751f\u6297\u8870\u8001\u86cb\u767d, \u8fbe\u5230\u4fdd\u5065\u7684\u76ee\u7684\uff0c\u662f\u771f\u6b63\u7684\u57fa\u56e0\u8425\u517b\u54c1\u3002 \u4f3c\u4e4e\u6ca1\u6709\u4e9a\u5065\u5eb7\u72b6\u6001\uff0c \u6ca1\u6709\u5f62\u6210\u75be\u75c5\uff0c \u8ba9\u52a8\u7269\u591a\u6d3b30%\uff0c \u65e0\u75be\u800c\u7ec8! \u767d\u85dc\u82a6\u9187\u53d1\u6325\u4e86\u751f\u547d\u7684\u6f5c\u529b!<\/p>\n

\"\"<\/p>\n

\u767d\u85dc\u82a6\u9187\u7684\u7814\u7a76\u51e0\u4e4e\u5f15\u8d77\u4e86\u6240\u6709\u751f\u547d\u79d1\u5b66\u5bb6\u7684\u5174\u8da3! \u767d\u85dc\u82a6\u9187\u76ca\u5904\u6709\u8bb8\u591a\uff0c\u5728\u73b0\u4ee3\u79d1\u5b66\u7814\u7a76\u57fa\u7840\u4e0a\u5df2\u77e5\u7684\u767d\u85dc\u82a6\u9187\u529f\u80fd\u6709\uff1a<\/p>\n

    \n
  1. \n
      \n
    1. \u5ef6\u957f\u5bff\u547d (12\uff0c13)<\/li>\n
    2. \u589e\u5f3a\u514d\u75ab\u7cfb\u7edf (25)<\/li>\n
    3. \u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5 (15),(16)<\/li>\n
    4. \u9632\u6cbb\u7cd6\u5c3f\u75c5 (13, 34)<\/li>\n
    5. \u7ef4\u62a4\u809d\u529f\u80fd (13, 34)\uff0c<\/li>\n
    6. \u7537\u6027\u5929\u80fd\u5a01\u800c\u521a, \u6539\u5584\u524d\u4f8b\u817a\u95ee\u9898(21)<\/li>\n
    7. \u8212\u7f13\u66f4\u5e74\u671f\u969c\u788d (12\uff0c22)<\/li>\n
    8. \u63d0\u9ad8\u751f\u6b96\u80fd\u529b(12\uff0c22, 35)<\/li>\n
    9. \u51cf\u80a5\u7626\u8eab(13)<\/li>\n
    10. \u9632\u6b62\u7ec6\u80de\u764c\u53d8\uff0c \u6291\u5236\u80bf\u7624 (13\uff0c23, 24)<\/li>\n
    11. \u6297\u8fc7\u654f\uff0c \u6c14\u5598 (27\uff0c 28)<\/li>\n
    12. \u89e3\u6bd2\u6392\u6bd2\uff0c\u4fdd\u62a4\u80be\u810f(28)<\/li>\n
    13. \u9632\u6cbb\u5fe7\u90c1\u75c7, \u9547\u5b9a\u5b89\u7720(17, 18, 19, 20)<\/li>\n
    14. \u9884\u9632\u9aa8\u8d28\u758f\u677e\u75c7 (13\uff0c 29\uff0c 31)<\/li>\n
    15. \u9632\u6cbb\u76ae\u80a4\u8870\u8001, \u523a\u6fc0\u80f6\u539f\u86cb\u767d\u7684\u4ea7\u751f, (32)<\/li>\n
    16. \u9632\u6cbb\u6d41\u611f\u75c5\u6bd2\u548c\u5176\u5b83\u75c5\u6bd2(33)<\/li>\n
    17. \u51cf\u8f7b\u5173\u8282\u708e\u75bc\u75db, \u6709\u6548\u6d88\u9664\u9888\u690e\u8170\u690e\u75bc\u75db (26, 36\uff0c 37)<\/li>\n
    18. \u6291\u5236\u773c\u775b\u5185\u6bdb\u7ec6\u8840\u7ba1\u7834\u88c2\uff0c\u9884\u9632\u5931\u660e(38)<\/li>\n
    19. \u6291\u5236\u542c\u529b\u4e0b\u964d(39)<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

      \u60a8\u9047\u5230\u8fc7\u8fd9\u4e9b\u75be\u75c5\u7684\u75c5\u4eba\u5417? \u4e86\u89e3\u75c5\u4eba\u7684\u75db\u82e6\u5417? \u60a8\u5e0c\u671b\u60a8\u7684\u5bb6\u4eba\uff0c\u670b\u53cb\uff0c\u540c\u4e8b\u8fdc\u79bb\u75be\u75c5\u7684\u75db\u82e6\u5417? \u88ab\u75be\u75c5\u593a\u53bb\u4eb2\u4eba\u7684\u60b2\u4f24\uff0c\u53c8\u6709\u8c01\u6ca1\u6709\u7ecf\u5386\u8fc7? \u6d41\u611f\u9020\u6210\u7684\u75db\u82e6\uff0c \u60a8\u8fd8\u8bb0\u5f97\u5417? \u522b\u7684\u75be\u75c5\u6bd4\u6d41\u611f\u4e25\u91cd\u5341\u500d\uff0c \u767e\u500d\u3002<\/p>\n

      \u6240\u5217\u529f\u6548\u540e\u5728\u62ec\u53f7\u4e2d\u7684\u6587\u732e\u5747\u6765\u81ea\u79d1\u5b66\u6742\u5fd7\u3002 \u767d\u85dc\u82a6\u9187\u80fd\u9632\u4e73\u817a\u764c\u548c\u7f29\u5c0f\u4e73\u817a\u80bf\u7624\uff0c \u662f\u56e0\u4e3a\u767d\u85dc\u82a6\u9187\u80fd\u51cf\u5c11\u4e73\u817a\u80bf\u7624\u7ec6\u80de\u751f\u957f\u6240\u9700\u7684\u86cb\u767d\u8d28-\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff0c \u4ece\u800c\u5f15\u5bfc\u4e73\u817a\u764c\u7ec6\u80de\u6b7b\u4ea1(39A)\u3002 \u5176\u5b9e\uff0c \u764c\u75c7\u751f\u6210\u7684\u539f\u7406\u662f\u4e00\u6837\u7684\uff0c \u6240\u4ee5\uff0c\u767d\u85dc\u82a6\u9187\u5bf9\u80c3\u764c\uff0c \u524d\u5217\u817a\u764c\uff0c \u8840\u764c\uff0c \u6dcb\u5df4\u764c\uff0c\u7532\u72b6\u817a\u764c\u7b49\u7b49\u5747\u6709\u7597\u6548(\u89c1\u8bc1\u5f55)\u3002 \u6211\u4eec\u8eab\u4f53\u91cc\u7684\u764c\u7ec6\u80de\u662f\u7ec6\u80de\u8870\u8001\u9020\u6210\u7684\uff0c \u65f6\u523b\u90fd\u5728\u3002\u4e00\u65e6\u4e0d\u80fd\u6e05\u9664\uff0c \u4fbf\u5f62\u6210\u764c\u75c7\u3002 \u73b0\u5728\u5df2\u7ecf\u5341\u5206\u660e\u4e86\uff1a \u6211\u4eec\u5927\u5bb6\u4e3a\u4ec0\u4e48\u9700\u8981\u7528\u767d\u85dc\u82a6\u9187!<\/p>\n

      \u53c2\u8003\u6587\u732e:<\/h3>\n

      (1). Hills, B. The island of the Ancients. TheSecrets of Sardina’s Centenarians. Murdoch Books, 2008<\/p>\n

      (2). We will be able to live to 1,000’\u3002 By Dr Aubrey de Grey University of Cambridge\u3002 BBC on line news 3 December, 2004<\/p>\n

      (2A). Atul Gawande, Being Mortal. Published October 7th 2014 by Metropolitan Books<\/p>\n

      (2B). Jared Mason Diamond. The Rise and Fall of the Third Chimpanzee: Evolution and Human Life. Hutchinson Radius, 2004<\/p>\n

      (3). “Live to 150, Can you do it?”, ABC Special TV program, August 24, 2012<\/p>\n

      (4). National Geographic, May 2013<\/p>\n

      (5) Klatz, R. and Goldman, R. The New Anti-Aging Revolution. Basic Health Publications, Inc. 2003<\/p>\n

      (6). The Healing Power of Vitamins and Minerals & Herbs. Readers Digest. 2000<\/p>\n

      (7). \u909d\u5b89\u5764. \u8001\u5e74\u533b\u5b66\u5728\u4e2d\u56fd\u3002 \u6e56\u5357\u79d1\u5b66\u6280\u672f\u51fa\u7248\u793e CHINA 1989.<\/p>\n

      (8). Can Meditation really slow aging? Australia Readers digest. February 2015<\/p>\n

      (9). Strand, R.\uff0c \u522b\u8ba9\u4e0d\u61c2\u8425\u517b\u5b66\u7684\u533b\u751f\u5bb3\u4e86\u4f60 What Your Doctor Doesn’t Know about Nutritional Medicine May Killing You. \u4e2d\u56fd\u9752\u5e74\u51fa\u7248\u793e 2009<\/p>\n

      (10).Stableford, B. Future Man. Crown Publishers, Inc, USA 1984<\/p>\n

      (10A). Sears,B. (2000). The Age-Free Zone. ReganBooks, A Imprint of HarperCollinsPublishers<\/p>\n

      (10B). Grimm Brothers; Margarate Hunt (Translator) (1944). Death’s Messengers (Die Boten des Todes) The Complete Grimm’s Fairy Tales. New York: Pantheon Books<\/p>\n

      (11).\u6b66\u632f\u5a1f\uff0c \u674e\u8389\u3002 \u845b\u6d2a\u7684\u517b\u751f\u4e4b\u9053\u7814\u7a76\u3002 \u5170\u53f0\u4e16\u754c\uff0c 2012\uff0c 12<\/p>\n

      (12).Valenzano, D., Terzibasi, E., Genade, T., Cattaneo, A., Domenici, L. And Cellerino, A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Current Biology 16, 2960300, Febuary 7, 2006.<\/p>\n

      (13).Baur, J. A., Pearson, K, J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., Pistell, P. J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K. W., Spencer, R. G., Lakatta, E. G., Couteur, D. L., Shaw, R. J., Navas, P., Puigserver, P., Ingram, D, K., de Cabo, R., & Sinclair, D. A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342 (16 November 2006)<\/p>\n

      (14).60 minutes. CBS Nov 17, 1991<\/p>\n

      (15).Kaga, S., Zhan L., Matsumoto, MMaulik N., Resveratrol enhance neovascularisationin the infracted rat myocardium through the induction of thioredoxin-1,heme oxygenase-1 and vascular endothelial growth factor. J. Molecular and Cellular Cardiology. Vol. 39, Issue 5. Nov. 2005<\/p>\n

      (16).Paolo Gresele\uff0c Pasquale Pignatelli\uff0c Giuseppe Guglielmini\uff0c Roberto Carnevale\uff0c Anna Maria Mezzasoma\uff0c Andrea Ghiselli\uff0c Stefania Momi, and Francesco Violi\u3002 Resveratrol, at Concentrations Attainable with Moderate Wine Consumption, Stimulates Human Platelet Nitric Oxide Production\u3002 J. Nutr. September 2008 vol. 138 no. 9 1602-1608<\/p>\n

      (17).McCrone, J. Going Inside. Published by Faber and Faber, 1999<\/p>\n

      (18).Capiralla H, Vingtdeux V, Zhao H, Sankowski R, Al-Abed Y, Davies P, Marambaud P. Resveratrol mitigates lipopolysaccharide- and A\u25a1mediated microglial inflammation by inhibiting the TLR4\/NF-kB\/STAT signaling cascade. J Neurochem. 2011 November<\/p>\n

      (19).X. J. Meng,* F. Wang, and C. K. Li\u3002 Resveratrol is Neuroprotective and Improves Cognition in Pentylenetetrazole-kindling Model of Epilepsy in Rats\u3002 Indian J Pharm Sci. 2014 Mar-Apr; 76(2): 125\u01d4131<\/p>\n

      (20).Hurley LL1, Akinfiresoye L1, Kalejaiye O1, Tizabi Y\u3002Antidepressant effects of resveratrol in an animal model of depression. Behav Brain Res. 2014 Jul 15;268:1-7. doi: 10.1016\/j.bbr.2014.03.052. Epub 2014 Apr 6.<\/p>\n

      (21).Ourique GM1, Finamor IA, Saccol EM, Riffel AP, Pes TS, Gutierrez K, Goncalves PB, Baldisserotto B, Pavanato MA, Barreto KP. Resveratrol improves sperm motility, prevents lipid peroxidation and enhances antioxidant defencesin the testes of hyperthyroid rats\u3002 Reproductive Toxicology\u3002 Volume 37,June 2013, Pages 31-39<\/p>\n

      (22).Juan ME1, Gonzaez-Pons E, Munuera T, Ballester J, Rodriuez-Gil JE, PlanasJM. trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats\u3002 J Nutr. 2005 Apr;135(4):757-60<\/p>\n

      (23).Minutolo, F., Sala, G., Bagnacani, A., Bertini, S., Carboni, S., Placanica, G, Prota, G, Rapposelli, S, Sacchi, N. And Ghidoni, R. Synthesis of a resveratrol analogue with high ceramide-madiated proappoptotic activity on human breast cancer cells. J. Medicinal Chemistry 48: 6783-86, 2005.<\/p>\n

      (24).Zhang, Q., Tang, X., Lu, Q., Zhang, Z., Brown, J., and Le, A. Reseveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamouse cell carcinoma and hepatoma cells. Mol Cancer Ther. Oct;4(10):1465-74, 2005.<\/p>\n

      (25).Wong YT, Gruber J, Jenner AM, Tay FE, Ruan R. Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice. Age (Dordr). 2011 Sep;33(3):229-46.<\/p>\n

      (26).Gao Xuzhu\uff0c Mousa Komai-Koma, Bernard P Leung\uff0c Hwee Siew Howe, Charles McSharry, Iain B McInnes, Damo Xu\u3002 Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function\u3002 Ann Rheum Dis 2012;71:129-135<\/p>\n

      (27).Jing Chen,Sang-Myeong Lee, Deyu Fang, and Ulus Atasoy\u3002The therapeutic role of resveratrol in allergic lung inflammation\u3002 The Journal of Immunology, 2010, 184, 97.2<\/p>\n

      (28).Meltem Kolgazi, , Gsel Sener, , Sule Gtinel, , Nursal Gedik, M.D.\u25a1 Inci Alican, M.D. Resveratrol Reduces Renal and Lung Injury Caused by Sepsis in Rats\u3002J. Surgical research. August 2006Volume 134, Issue 2, Pages 315-321<\/p>\n

      (29).Jian Zhang, Oxana P. Lazarenko, Michael L. Blackburn, Thomas M. Badger, Martin J. J. Ronis, Jin-Ran Chen\u3002 Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells\u3002AGE\u3002 June 2013, Volume 35, Issue 3, pp 807-820<\/p>\n

      (30).Uysal T, Gorgulu S, Yagci A, Karslioglu Y, Gunhan O, Sagdic D: Effect of resveratrol on bone formation in the expanded inter-premaxillary suture:early bone changes Orthod Craniofac Res 2011;14:80-87<\/p>\n

      (31).Stephanie M. Durbin, Janna R. Jackson, Michael J. Ryan, Joseph C. Gigliotti,Stephan E. Alway, Janet C. Tou\u3002 Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats\u3002 Journal of Bone and Mineral Metabolism\u3002 May 2013<\/p>\n

      (32).Mary Ndiaye,a Carol Philippe,a Hasan Mukhtar,a,b and Nihal Ahmada,b,*Author information _ Copyright and License information _he Grape Antioxidant Resveratrol for Skin Disorders: Promise, Prospects, and Challenges\u3002 Arch Biochem Biophys. 2011 Apr 15; 508(2): 164\u01d4170.Published online 2011 Jan 4. doi: 10.1016\/j.abb.2010.12.030<\/p>\n

      (33).Palamara AT1, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E\u3002 Inhibition of influenza A virus replication by resveratrol.J Infect Dis. 2005 May 15;191(10):1719-29<\/p>\n

      (34).Jennifer L. Fiori1, Yu-Kyong Shin1,2, Wook Kim1,3, Susan M. Krzysik-Walker1, Isabel Gonz lez-Mariscal1, Olga D. Carlson1, Mitesh Sanghvi1, Ruin Moaddel1, Kathleen Farhang1, Shekhar K. Gadkaree1, Maire E. Doyle4, Kevin J. Pearson5,6, Julie A. Mattison5, Rafael de Cabo5 and Josephine M. Egan1_Resveratrol Prevents \u25a1Cell Dedifferentiation in Nonhuman Primates Given a High-Fat\/High-Sugar Diet\u3002Diabetes October 2013 vol. 62 no. 10 3500-3513<\/p>\n

      (35).Balestrieri, M., Schiano, C., Felice, F. Casamassimi, A., Balestrieri, A.,Milone, L., Servillo, L. Ad Napoli, C. Effect of lo doses of red wine and pure resveratrol on the circulating endothelial progenitor cells. J.Biochem.143, 179-0186,2008.<\/p>\n

      (36).Young-Joon Kwon\u3002 Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model\u3002 J Korean Med Sci. 2013 Jun; 28(6): 939-945.<\/p>\n

      (37).Wuertz K1, Quero L, Sekiguchi M, Klawitter M, Nerlich A, Konno S, Kikuchi S, Boos N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo.Spine (Phila Pa 1976). 2011 Oct 1;36(21):E1373-84.<\/p>\n

      (38).Khan AA1, Dace DS, Ryazanov AG, Kelly J, Apte RS. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol. 2010 Jul;177(1):481-92. doi: 10.2353\/ajpath.2010.090836. Epub 2010 May 14.<\/p>\n

      (39).M. D. Seidman, W. Tang, V. U. Bai, N. Ahmad, H. Jiang, J. Media, N. Patel,C. J. Rubin, R. T. Standring. Resveratrol Decreases Noise-Induced Cyclooxygenase-2 Expression in the Rat Cochlea. Otolaryngology — Head and Neck Surgery,2013<\/p>\n

      (39A)Garvin S., Ollinger K and Dabrosin C. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer letters, Vol. 231, Issue No. 1 113-122 (2006).<\/p>\n

      (40).Fremont, Lucie. “Biological Effects of Resveratrol”. Life Sciences. Elservier, France. Retrieved 6 June 2014.<\/p>\n

      (41).Filippo Minutolo, Giusy Sala, Annalisa Bagnacani, Simone Bertini, Isabella Carboni, Giorgio Placanica, Giovanni Prota, Simona Rapposelli, Nicoletta Sacchi, Marco Macchia, and Riccardo Ghidoni\u3002 Synthesis of a Resveratrol Analogue with High Ceramide-Mediated Proapoptotic Activity on Human Breast Cancer Cells\u3002 Journal Medicinal Chemistry 48, 6783-6786, 2005. pp 6783\u01d46786 Publication Date (Web): October 04, 2005 (Letter)DOI: 10.1021\/jm050528k<\/p>\n

      (42).Liu Y, Ma W, Zhang P, He S, Huang D; Ma; Zhang; He; Huang (March 2014). “Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials”. Clinical Nutrition 34 (1): 27\u01d434. doi:10.1016\/j.clnu.2014.03.009. PMID 24731650.<\/p>\n

      Nagnun, D., Canadian Studies in Population. 1986, 13(1):83-102<\/p>\n

      (43).Timmers S,\u00e1Konings E,\u00e1Bilet L,\u00e1Houtkooper RH,\u00e1van de Weijer T,\u00e1Goossens GH,\u00e1Hoeks J,\u00e1van der Krieken S,\u00e1Ryu D,\u00e1Kersten S,\u00e1Moonen-Kornips E,\u00e1Hesselink MK,\u00e1Kunz I,\u00e1Schrauwen-Hinderling VB,\u00e1Blaak EE,\u00e1Auwerx J,\u00e1Schrauwen P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011 Nov 2;14(5):612-22. doi: 10.1016\/j.cmet.2011.10.002.<\/p>\n

      (44).Garvin S1, Ollinger K, Dabrosin C.\uff0c Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett. 2006 Jan 8;231(1):113-22<\/p>\n

      (45).Sangeeta Shrotriya, Rajesh Agarwal, Robert A. Sclafani. A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma. Advances in Experimental Medicine and Biology, December 2014 DOI: 10.1007\/978-3-319-09614-8_19<\/p>\n

      (46).Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. Oatis, Jr. and U. Kristina Walle\u3002 HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS\u3002 DRUG METABOLISM AND DISPOSITION\uff0c 32:1377-1382, 2004<\/p>\n

      (47).A Q&A Audience With Bill Gates\uff0c ABC\uff0c Australia, May 28, 2013<\/p>\n

      (48).Xu Y., Live healthier, Live longer and Liver forever\u3002 (2006).<\/p>\n

      (49).Angela Epstein\u3002 Old before your time: When your body really starts going downhill. Read more:ttp:\/\/www.dailymail.co.uk\/health\/article-1035037\/Old-time-When-body-really-starts-going-downhill.html#ixzz3TqhXrvNE<\/p>\n

      (50).Kirsty L. Spalding, Ratan D. Bhardwaj, Bruce A. Buchholz, Henrik Druid, and Jonas Fris\u00e9n. Retrospective Birth Dating of Cells in Humans. Cell, Vol 122, 133-143, 15 July 2005.<\/p>\n

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      \u767d\u85dc\u82a6\u9187 \u8fd9\u79cd\u5168\u8eab\u529f\u6548\u662f\u56e0\u4e3a\u5168\u8eab\u7ec6\u80de\u7684\u57fa\u56e0\u76f8\u540c\uff1a \u90fd\u6709SIRT1\u57fa\u56e0\u3002 \u901a\u8fc7\u8840\u6db2\u5faa\u73af\u5230\u8fbe\u5168\u8eab\u5404\u7ec6\u80de\uff0c\u4e0e\u57fa\u56e0SIRT1\u7ed3\u5408\u4ea7\u751f\u6297\u8870\u8001\u86cb\u767d, \u8fbe\u5230\u4fdd\u5065\u7684\u76ee\u7684\uff0c\u662f\u771f\u6b63\u7684\u57fa\u56e0\u8425\u517b\u54c1\u3002 \u4f3c\u4e4e\u6ca1\u6709\u4e9a\u5065\u5eb7\u72b6\u6001\uff0c \u6ca1\u6709\u5f62\u6210\u75be\u75c5\uff0c \u8ba9\u52a8\u7269\u591a\u6d3b30%\uff0c \u65e0\u75be\u800c\u7ec8! \u767d\u85dc\u82a6\u9187\u53d1\u6325\u4e86\u751f\u547d\u7684\u6f5c\u529b! \u767d\u85dc\u82a6\u9187\u7684\u7814\u7a76\u51e0\u4e4e\u5f15\u8d77\u4e86\u6240\u6709\u751f\u547d\u79d1\u5b66\u5bb6\u7684\u5174\u8da3! \u767d\u85dc\u82a6\u9187\u76ca\u5904\u6709\u8bb8\u591a\uff0c\u5728\u73b0\u4ee3\u79d1\u5b66\u7814\u7a76\u57fa\u7840\u4e0a\u5df2\u77e5\u7684\u767d\u85dc\u82a6\u9187\u529f\u80fd\u6709\uff1a \u5ef6\u957f\u5bff\u547d (12\uff0c13) \u589e\u5f3a\u514d\u75ab\u7cfb\u7edf (25) \u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5 (15),(16) \u9632\u6cbb\u7cd6\u5c3f\u75c5 (13, 34) \u7ef4\u62a4\u809d\u529f\u80fd (13, 34)\uff0c \u7537\u6027\u5929\u80fd\u5a01\u800c\u521a, \u6539\u5584\u524d\u4f8b\u817a\u95ee\u9898(21) \u8212\u7f13\u66f4\u5e74\u671f\u969c\u788d (12\uff0c22) \u63d0\u9ad8\u751f\u6b96\u80fd\u529b(12\uff0c22, 35) \u51cf\u80a5\u7626\u8eab(13) \u9632\u6b62\u7ec6\u80de\u764c\u53d8\uff0c \u6291\u5236\u80bf\u7624 (13\uff0c23, 24) \u6297\u8fc7\u654f\uff0c \u6c14\u5598 (27\uff0c 28) \u89e3\u6bd2\u6392\u6bd2\uff0c\u4fdd\u62a4\u80be\u810f(28) \u9632\u6cbb\u5fe7\u90c1\u75c7, \u9547\u5b9a\u5b89\u7720(17, 18, 19, 20) \u9884\u9632\u9aa8\u8d28\u758f\u677e\u75c7 (13\uff0c 29\uff0c 31) \u9632\u6cbb\u76ae\u80a4\u8870\u8001, \u523a\u6fc0\u80f6\u539f\u86cb\u767d\u7684\u4ea7\u751f, (32) \u9632\u6cbb\u6d41\u611f\u75c5\u6bd2\u548c\u5176\u5b83\u75c5\u6bd2(33) \u51cf\u8f7b\u5173\u8282\u708e\u75bc\u75db, \u6709\u6548\u6d88\u9664\u9888\u690e\u8170\u690e\u75bc\u75db (26, 36\uff0c 37) \u6291\u5236\u773c\u775b\u5185\u6bdb\u7ec6\u8840\u7ba1\u7834\u88c2\uff0c\u9884\u9632\u5931\u660e(38) \u6291\u5236\u542c\u529b\u4e0b\u964d(39) […]<\/p>\n

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