{"id":1445,"date":"2016-03-14T10:27:24","date_gmt":"2016-03-14T14:27:24","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=1445"},"modified":"2022-05-23T13:44:18","modified_gmt":"2022-05-23T13:44:18","slug":"%e3%80%90%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%80%91-%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e6%8a%91%e5%88%b6%e8%a1%80%e5%b0%8f%e6%9d%bf%e5%87%9d%e9%9b%86%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=1445","title":{"rendered":"\u3010\u7814\u7a76\u6210\u679c\u3011 \u767d\u85dc\u82a6\u9187\u6291\u5236\u8840\u5c0f\u677f\u51dd\u96c6\u4f5c\u7528"},"content":{"rendered":"<h3 class=\"post-title entry-title\"><\/h3>\n<div id=\"post-body-5943177889197436805\" class=\"post-body entry-content\">\n<p>\u6458\u81ea<a href=\"http:\/\/cetd.tmu.edu.tw\/etdservice\/view_metadata?etdun=U0007-1704200714542076&amp;query_field1=keyword&amp;&amp;query_word1=\u767d\u85dc\u8606\u9187&amp;\" target=\"_blank\" rel=\"noopener\">\u53f0\u5317\u533b\u5b66\u5927\u5b66.\u533b\u5b66\u7814\u7a76\u6240\u8bba\u6587<\/a><\/p>\n<p>\u767d\u85dc\u82a6\u9187 (resveratrol) \u662f\u4e00\u79cd\u690d\u7269\u884d\u751f\u7684\u975e\u751f\u7269\u9ec4\u916e\u591a\u915a\u7c7b\u4e8c\u82ef\u4e59\u70ef (nonflavonoid polyphenol stilbene)\uff0c\u901a\u5e38\u5b58\u5728\u4e8e\u852c\u83dc\u548c\u6c34\u679c\u91cc\uff0c\u7279\u522b\u662f\u8461\u8404\u7684\u7c7d\u8ddf\u8461\u8404\u76ae\u3002<\/p>\n<p>\u6b64\u4e00\u7269\u8d28\u5df2\u88ab\u8bc1\u5b9e\u5177\u6709\u6297\u764c\u75c7\uff0c\u6297\u53d1\u708e\uff0c\u6e05\u9664\u81ea\u7531\u57fa\u4ee5\u53ca\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u529f\u80fd\u3002\u672c\u7814\u7a76\u5728\u4e8e\u66f4\u6df1\u5165\u8ba8\u8bba resveratrol \u5728\u8840\u5c0f\u677f\u6d3b\u5316\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5bf9\u4e8e\u8baf\u606f\u4f20\u9012\u7684\u6291\u5236\u673a\u8f6c\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a resveratrol \u968f\u8005\u6d53\u5ea6\u589e\u52a0 (0.02-45 ?M)\uff0c\u80fd\u6709\u6548\u6291\u5236 collagen (1 ?g\/ml)\u3001 U46619 (1 ?M) \u4ee5\u53ca arachidonic acid (AA) (60 ?M) \u6240\u5f15\u8d77\u7684\u4eba\u7c7b\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5e94\u4ee5\u53ca ATP \u91ca\u653e\u53cd\u5e94\u3002<\/p>\n<p>Resveratrol (0.15\u4e0e0.25 ?M) \u4ea6\u53ef\u6291\u5236 collagen (1 ?g\/ml) \u6240\u5f15\u8d77\u7684\u7ec6\u80de\u5185\u9499\u79bb\u5b50\u79fb\u52a8\u3001 phosphoinositide \u51cf\u5c11\u4ee5\u53ca thromboxane A2 (TxA2) \u7684\u5408\u6210\u3002\u6b64\u5916\uff0cresveratrol (0.15\u4e0e0.25 ?M) \u53ef\u4ee5\u589e\u52a0\u4eba\u7c7b\u8840\u5c0f\u677f\u5185 nitrite \u4e0e cyclic GMP \u7684\u542b\u91cf\uff0c\u4f46\u5bf9\u4e8e cyclic AMP \u7684\u542b\u91cf\u5e76\u6ca1\u6709\u663e\u8457\u589e\u52a0\uff1b\u53e6\u4e00\u65b9\u9762 resveratrol (0.15\u4e0e0.25 ?M) \u53ef\u4ee5\u6709\u6548\u6e05\u9664 collagen (1 ?g\/ml) \u523a\u6fc0\u4ea7\u751f\u7684 hydroxyl radicals\u3002\u6b64\u5929\u7136\u6210\u5206\u4e5f\u6291\u5236\u7531collagen (10 ?g\/ml) \u6240\u523a\u6fc0\u7684 p38 MAPK \u78f7\u9178\u5316\uff0c\u4f46\u662f\u5bf9\u4e8e extracellular signal regulated kinases (ERKs) \u548cc-Jun-NH2-terminal kinases (JNKs) \u4ee5\u53ca Akt \u7684\u78f7\u9178\u5316\u4e0d\u5177\u5f71\u54cd\u3002Resveratrol (0.15 \u4e0e 0.25 ?M) \u53ef\u6709\u6548\u6291\u5236 PDBu (150 nM) \u548c collagen (1 ?g\/ml) \u6240\u523a\u6fc0 47 kDa protein \u78f7\u9178\u5316\u3002<\/p>\n<p>\u7531\u7ed3\u679c\u8bc1\u5b9e\uff0cresveratrol \u6291\u5236\u8840\u5c0f\u677f\u6d3b\u6027\u7684\u4f5c\u7528\u53ef\u80fd\u7275\u6d89\u4e0b\u5217\u8def\u5f84\uff1a<\/p>\n<ul>\n<li>(\u4e00) Resveratrol \u4f1a\u523a\u6fc0 NO\u7684\u751f\u6210\uff0c\u63a5\u7740\u589e\u52a0\u8840\u5c0f\u677f\u7ec6\u80de\u5185cyclic GMP\u7684\u542b\u91cf\uff0c\u5e76\u4e14\u8bf1\u53d1 VASP \u78f7\u9178\u5316\u3001\u6291\u5236 phospholipase C \u7684\u6d3b\u6027\u3002<\/li>\n<li>(\u4e8c) Resveratrol \u5229\u7528\u5176\u6e05\u9664 hydroxyl radicals\u7684\u4f5c\u7528\u4ee5\u53ca\u6291\u5236 p38 MAPK \u78f7\u9178\u5316\uff0c\u5f71\u54cd phospholipase A2-cyclooxygenase \u8def\u5f84\u7684\u53cd\u5e94\uff0c\u8fdb\u4e00\u6b65\u6291\u5236 TxA2 \u7684\u751f\u5408\u6210\u3002<\/li>\n<\/ul>\n<p>\u7efc\u5408\u4ee5\u4e0a\u7ed3\u679c\uff0c\u5bfc\u81f4 resveratrol\u6291\u5236\u8840\u5c0f\u677f\u7ec6\u80de\u5185\u9499\u79bb\u5b50\u7684\u79fb\u52a8\u4ee5\u53ca\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u6700\u540e\u56e0\u800c\u6291\u5236\u8840\u5c0f\u677f\u7684\u51dd\u96c6\u53cd\u5e94\u3002\u6b64\u9879\u4f5c\u7528\u610f\u5473\u7740 resveratrol \u53ef\u6709\u6548\u5730\u5e94\u7528\u5728\u6cbb\u7597\u4e0e\u8840\u5c0f\u677f\u8fc7\u5ea6\u6d3b\u5316\u76f8\u5173\u4e4b\u75be\u75c5\u3002<\/p>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_1445\" class=\"pvc_stats all  \" data-element-id=\"1445\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u81ea\u53f0\u5317\u533b\u5b66\u5927\u5b66.\u533b\u5b66\u7814\u7a76\u6240\u8bba\u6587 \u767d\u85dc\u82a6\u9187 (resveratrol) \u662f\u4e00\u79cd\u690d\u7269\u884d\u751f\u7684\u975e\u751f\u7269\u9ec4\u916e\u591a\u915a\u7c7b\u4e8c\u82ef\u4e59\u70ef (nonflavonoid polyphenol stilbene)\uff0c\u901a\u5e38\u5b58\u5728\u4e8e\u852c\u83dc\u548c\u6c34\u679c\u91cc\uff0c\u7279\u522b\u662f\u8461\u8404\u7684\u7c7d\u8ddf\u8461\u8404\u76ae\u3002 \u6b64\u4e00\u7269\u8d28\u5df2\u88ab\u8bc1\u5b9e\u5177\u6709\u6297\u764c\u75c7\uff0c\u6297\u53d1\u708e\uff0c\u6e05\u9664\u81ea\u7531\u57fa\u4ee5\u53ca\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u529f\u80fd\u3002\u672c\u7814\u7a76\u5728\u4e8e\u66f4\u6df1\u5165\u8ba8\u8bba resveratrol \u5728\u8840\u5c0f\u677f\u6d3b\u5316\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5bf9\u4e8e\u8baf\u606f\u4f20\u9012\u7684\u6291\u5236\u673a\u8f6c\u3002 \u7814\u7a76\u7ed3\u679c\u663e\u793a resveratrol \u968f\u8005\u6d53\u5ea6\u589e\u52a0 (0.02-45 ?M)\uff0c\u80fd\u6709\u6548\u6291\u5236 collagen (1 ?g\/ml)\u3001 U46619 (1 ?M) \u4ee5\u53ca arachidonic acid (AA) (60 ?M) \u6240\u5f15\u8d77\u7684\u4eba\u7c7b\u8840\u5c0f\u677f\u51dd\u96c6\u53cd\u5e94\u4ee5\u53ca ATP \u91ca\u653e\u53cd\u5e94\u3002 Resveratrol (0.15\u4e0e0.25 ?M) \u4ea6\u53ef\u6291\u5236 collagen (1 ?g\/ml) \u6240\u5f15\u8d77\u7684\u7ec6\u80de\u5185\u9499\u79bb\u5b50\u79fb\u52a8\u3001 phosphoinositide \u51cf\u5c11\u4ee5\u53ca thromboxane A2 (TxA2) \u7684\u5408\u6210\u3002\u6b64\u5916\uff0cresveratrol (0.15\u4e0e0.25 ?M) \u53ef\u4ee5\u589e\u52a0\u4eba\u7c7b\u8840\u5c0f\u677f\u5185 nitrite \u4e0e cyclic GMP \u7684\u542b\u91cf\uff0c\u4f46\u5bf9\u4e8e cyclic AMP \u7684\u542b\u91cf\u5e76\u6ca1\u6709\u663e\u8457\u589e\u52a0\uff1b\u53e6\u4e00\u65b9\u9762 resveratrol (0.15\u4e0e0.25 ?M) \u53ef\u4ee5\u6709\u6548\u6e05\u9664 collagen [&hellip;]<\/p>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_1445\" class=\"pvc_stats all  \" data-element-id=\"1445\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[2],"tags":[218,5,48],"class_list":["post-1445","post","type-post","status-publish","format-standard","hentry","category-2","tag-218","tag-5","tag-48"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/1445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1445"}],"version-history":[{"count":1,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/1445\/revisions"}],"predecessor-version":[{"id":16883,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=\/wp\/v2\/posts\/1445\/revisions\/16883"}],"wp:attachment":[{"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1445"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/johnhealth.blog\/ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}