{"id":1443,"date":"2016-03-14T10:25:47","date_gmt":"2016-03-14T14:25:47","guid":{"rendered":"http:\/\/www.deepthinkgohelper.com\/wp\/?p=1443"},"modified":"2022-05-23T13:25:43","modified_gmt":"2022-05-23T13:25:43","slug":"%e3%80%90%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%80%91-%e7%99%bd%e8%97%9c%e8%8a%a6%e9%86%87%e4%bf%9d%e6%8a%a4%e8%84%91%e8%a1%80%e7%ae%a1%e5%86%85%e7%9a%ae%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=1443","title":{"rendered":"\u3010\u7814\u7a76\u6210\u679c\u3011 \u767d\u85dc\u82a6\u9187\u4fdd\u62a4\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de"},"content":{"rendered":"<div class=\"post-header\"><span style=\"color: #82868b; font-size: 1rem;\">\u6458\u81ea<\/span><a style=\"background-color: #ffffff; font-size: 1rem;\" href=\"http:\/\/cetd.tmu.edu.tw\/etdservice\/view_metadata?etdun=U0007-1704200714562517&amp;query_field1=keyword&amp;&amp;query_word1=\u767d\u85dc\u8606\u9187&amp;\" target=\"_blank\" rel=\"noopener\">\u53f0\u5317\u533b\u5b66\u5927\u5b66.\u533b\u5b66\u7814\u7a76\u6240\u8bba\u6587<\/a><\/div>\n<div id=\"post-body-6773310099190785314\" class=\"post-body entry-content\">\n<p>\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de(cerebrovascular endothelial cells ; CECs)\u662f\u8840\u8111\u5c4f\u969c(blood brain barrier)\u7684\u7ec4\u6210\u4e4b\u4e00\uff0c\u8840\u8111\u5c4f\u969c\u80fd\u907f\u514d\u6709\u5bb3\u7269\u8d28\u4fb5\u5165\u8111\u90e8\u5f15\u8d77\u4f24\u5bb3\u3002\u6c27\u5316\u6001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(oxidized low density lipoprotein\uff1boxLDL)\u5df2\u88ab\u8bc1\u5b9e\u4f1a\u4f24\u5bb3\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff0c\u8fdb\u800c\u9020\u6210\u7ca5\u72b6\u52a8\u8109\u786c\u5316(atherosclerotic)\uff0c\u4f46\u5bf9\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u5f71\u54cd\u5219\u5c1a\u672a\u88ab\u8bc1\u5b9e\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187(resveratrol)\u662f\u4e00\u79cd\u5b58\u5728\u8461\u8404\u4e2d\u7684\u591a\u915a\u7c7b\u7269\u8d28\uff0c\u5177\u6297\u6c27\u5316\u529f\u80fd\u5e76\u5bf9\u9884\u9632\u6216\u6539\u5584\u5fc3\u8840\u7ba1\u76f8\u5173\u75be\u75c5\u6709\u4f5c\u7528\uff0c\u4f46\u662f\u80fd\u5426\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\u514d\u4e8eoxLDL\u7684\u4f24\u5bb3\u5219\u5c1a\u65e0\u76f8\u5173\u7814\u7a76\u3002\u672c\u7814\u7a76\u5c06\u4ee5\u5c0f\u9f20CECs\u4e3a\u7814\u7a76\u6a21\u5f0f\u63a2\u8ba8\u767d\u85dc\u82a6\u9187\u5982\u4f55\u4fdd\u62a4CECs\u514d\u4e8eoxLDL\u7684\u4f24\u5bb3\uff0c\u53ca\u5176\u53ef\u80fd\u673a\u5236\u3002<\/p>\n<p>\u9996\u5148\u4ee5\u4eba\u7684LDL (Low density lipoprotein\uff1bLDL)\u7528\u4e0d\u540c\u6d53\u5ea6\u7684\u786b\u9178\u94dc\u4e8e\u4e0d\u540c\u65f6\u95f4\u70b9\u4e0b\u57f9\u517b\uff0c\u4fa6\u6d4b\u6c27\u5316\u7a0b\u5ea6\u7684\u5dee\u5f02\uff0c\u7ed3\u679c\u53d1\u73b0\u786b\u9178\u94dc\u6d53\u5ea6\u8d8a\u9ad8\uff0c\u5904\u7406\u65f6\u95f4\u8d8a\u957f\uff0c\u5219\u4f1a\u4f7fLDL\u6c27\u5316\u8d8a\u4e25\u91cd\u3002\u5229\u75283-(4,5-dimethylthiazol-2-yl)-2,5\u2013diphenyltetra -zolium bromide (MTT)\u8272\u5ea6\u5206\u6790\u6cd5\u6765\u68c0\u9a8c\u7ec6\u80de\u7c92\u817a\u4f53\u5185\u819c\u7425\u73c0\u9178\u53bb\u6c22?(succinate dehydrogenase)\u7684\u6d3b\u6027\uff0c\u53d1\u73b0200 \u03bcg\/ml\u7684oxLDL\u5904\u7406CECs 48\u5c0f\u65f6\u4f1a\u4f7f\u5176\u5b58\u6d3b\u7387\u964d\u4f4e\u81f358.7 %\uff0c\u540c\u65f6\u89c2\u5bdf\u5230CECs\u578b\u6001\u7531\u539f\u5148\u7684\u7eba\u9524\u72b6\u76b1\u7f29\u4e3a\u5706\u5f62\u3001\u4ee5trypan blue\u67d3\u8272\u4e5f\u53d1\u73b0\u6d3b\u6027\u4e0b\u964d45.9 %\uff0c\u5e76\u6709DNA\u7247\u6bb5\u5316\u73b0\u8c61\u7684\u51fa\u73b0\uff0c\u8bc1\u5b9eoxLDL\u5177\u6709\u5f15\u53d1CECs\u7ec6\u80de\u51cb\u4ea1(apoptosis)\u7684\u80fd\u529b\u3002\u518d\u4ee5\u53cd\u8f6c\u5f55\u805a\u5408?\u8fde\u9501\u53cd\u5e94(reverse transcriptase-polymerase chain reaction)\u65b9\u6cd5\u5206\u6790CECs\u5185oxLDL\u7684\u53d7\u4f53(lectin-like oxLDL receptor-1\uff1bLOX-1) mRNA\uff0c\u53d1\u73b0CECs\u4e0eoxLDL\u5171\u540c\u57f9\u517b\u540e\uff0cLOX-1 mRNA\u7684\u8868\u73b0\u91cf\u4e0a\u5347\u3002\u6b64\u5916\u75312\u2019,7\u2019- dichlorofluorescin diacetate (DCFHDA)\u4fa6\u6d4b\u7ec6\u80de\u4e2d\u53cd\u5e94\u6027\u6c27\u5206\u5b50(reactive oxygen species\uff1bROS)\u7684\u542b\u91cf\uff0c\u5229\u7528\u897f\u65b9\u70b9\u58a8\u6cd5(western blotting)\u4ee5\u53cacaspase\u9175\u7d20\u6d3b\u6027\u5206\u6790\u8fdb\u4e00\u6b65\u8bc1\u660e\u7ec6\u80de\u51cb\u4ea1\u7684\u673a\u5236\u662f\u900f\u8fc7\u51cf\u5c11bcl-2\u4f7f\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u4e0a\u5347\uff0c\u589e\u52a0bax\u4e0ecytochrome c\u86cb\u767d\u8868\u73b0\u4e0e\u6d3b\u5316caspase 9\u3001caspase 3\u3001caspase 8\u3002<\/p>\n<p>\u767d\u85dc\u82a6\u9187\u5728\u975e\u7ec6\u80de\u5b9e\u9a8c\u4e2d\u663e\u793a\u5177\u6709\u6291\u5236LDL\u6c27\u5316\u7684\u6548\u679c\uff0c10 \u03bcM\u7684\u767d\u68a8\u82a6\u9187\u5e76\u4e0d\u5f71\u54cdCECs\u7684\u578b\u6001\u548c\u5b58\u6d3b\u7387\u3002\u5c06CECs\u540c\u65f6\u5904\u7406200 \u03bcg\/ml\u7684oxLDL\u4e0e10 \u03bcM\u7684\u767d\u85dc\u82a6\u9187\u540e\u53d1\u73b0\uff0c\u7ec6\u80de\u578b\u6001\u4ecd\u5448\u73b0\u7eba\u9524\u72b6\u3001\u7ec6\u80de\u5b58\u6d3b\u7387\u753154.1 % \u56de\u5347\u4e3a83.6 %\uff0c\u53e6\u5916DNA\u88c2\u89e3\u7a0b\u5ea6\u51cf\u4f4e\uff0c\u8bc1\u660e\u767d\u85dc\u82a6\u9187\u5bf9oxLDL\u9020\u6210\u7684\u7ec6\u80de\u51cb\u4ea1\u6709\u4fdd\u62a4\u7684\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4fdd\u62a4\u4f5c\u7528\u7684\u673a\u5236\uff0c\u53d1\u73b0LOX-1 mRNA\u7684\u8868\u73b0\u4e0d\u53d7\u767d\u85dc\u82a6\u9187\u5f71\u54cd\uff0c\u767d\u85dc\u82a6\u9187\u5bf9\u6291\u5236ROS\u7684\u4ea7\u751f\u3001\u964d\u4f4e\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u3001\u51cf\u5c11cytochrome c\u86cb\u767d\u91cf\u7684\u8868\u73b0\u4e0e\u6291\u5236caspase 9\u3001caspase 3\u53cacaspase 8\u7684\u6d3b\u6027\u5747\u6709\u4f5c\u7528\u3002<\/p>\n<p>\u7531\u672c\u7814\u7a76\u6210\u679c\u53ef\u77e5\uff0c\u767d\u85dc\u82a6\u9187\u4fdd\u62a4CECs\u7684\u673a\u5236\u5e76\u975e\u900f\u8fc7\u5f71\u54cdoxLDL\u8fdb\u5165\u7ec6\u80de\u7684\u8fc7\u7a0b\uff0c\u800c\u662f\u5728LDL\u7684\u6c27\u5316\u8fc7\u7a0b\u4e2d\u85c9\u7531\u672c\u8eab\u6297\u6c27\u5316\u80fd\u529b\u51cf\u8f7b\u8102\u8d28\u6c27\u5316\u7a0b\u5ea6\uff0c\u5e76\u964d\u4f4e\u56e0\u4e3aoxLDL\u7684\u8fdb\u5165\u5bfc\u81f4\u4e0a\u5347\u7684ROS\uff0c\u51cf\u8f7b\u5176\u5bf9\u7ec6\u80de\u4ea7\u751f\u7684\u7834\u574f\u3002\u4e0d\u4f46\u4f1a\u8c03\u63a7\u5916\u751f\u6027\u7684\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u51cf\u5c11caspase 8\u4ea7\u751f\uff1b\u4e5f\u5f71\u54cd\u5185\u751f\u6027\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\uff0c\u51cf\u5c11bax\u7684\u4ea7\u751f\uff0c\u589e\u52a0bcl-2\u4f7f\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u4e0a\u5347\u3001cytochrome c\u91ca\u51fa\u91cf\u51cf\u5c11\u3001caspase 9\u53cacaspase 3\u6d3b\u6027\u964d\u4f4e\uff0c\u6765\u5bf9CECs\u8fbe\u5230\u4fdd\u62a4\u7684\u4f5c\u7528\u3002<\/p>\n<\/div>\n<div class=\"pvc_clear\"><\/div>\n<p id=\"pvc_stats_1443\" class=\"pvc_stats all  \" data-element-id=\"1443\" style=\"\"><i class=\"pvc-stats-icon medium\" aria-hidden=\"true\"><svg aria-hidden=\"true\" focusable=\"false\" data-prefix=\"far\" data-icon=\"chart-bar\" role=\"img\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" class=\"svg-inline--fa fa-chart-bar fa-w-16 fa-2x\"><path fill=\"currentColor\" d=\"M396.8 352h22.4c6.4 0 12.8-6.4 12.8-12.8V108.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v230.4c0 6.4 6.4 12.8 12.8 12.8zm-192 0h22.4c6.4 0 12.8-6.4 12.8-12.8V140.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v198.4c0 6.4 6.4 12.8 12.8 12.8zm96 0h22.4c6.4 0 12.8-6.4 12.8-12.8V204.8c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v134.4c0 6.4 6.4 12.8 12.8 12.8zM496 400H48V80c0-8.84-7.16-16-16-16H16C7.16 64 0 71.16 0 80v336c0 17.67 14.33 32 32 32h464c8.84 0 16-7.16 16-16v-16c0-8.84-7.16-16-16-16zm-387.2-48h22.4c6.4 0 12.8-6.4 12.8-12.8v-70.4c0-6.4-6.4-12.8-12.8-12.8h-22.4c-6.4 0-12.8 6.4-12.8 12.8v70.4c0 6.4 6.4 12.8 12.8 12.8z\" class=\"\"><\/path><\/svg><\/i> <img loading=\"lazy\" decoding=\"async\" width=\"16\" height=\"16\" alt=\"Loading\" src=\"http:\/\/johnhealth.blog\/ch\/wp-content\/plugins\/page-views-count\/ajax-loader-2x.gif\" border=0 \/><\/p>\n<div class=\"pvc_clear\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u81ea\u53f0\u5317\u533b\u5b66\u5927\u5b66.\u533b\u5b66\u7814\u7a76\u6240\u8bba\u6587 \u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de(cerebrovascular endothelial cells ; CECs)\u662f\u8840\u8111\u5c4f\u969c(blood brain barrier)\u7684\u7ec4\u6210\u4e4b\u4e00\uff0c\u8840\u8111\u5c4f\u969c\u80fd\u907f\u514d\u6709\u5bb3\u7269\u8d28\u4fb5\u5165\u8111\u90e8\u5f15\u8d77\u4f24\u5bb3\u3002\u6c27\u5316\u6001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(oxidized low density lipoprotein\uff1boxLDL)\u5df2\u88ab\u8bc1\u5b9e\u4f1a\u4f24\u5bb3\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff0c\u8fdb\u800c\u9020\u6210\u7ca5\u72b6\u52a8\u8109\u786c\u5316(atherosclerotic)\uff0c\u4f46\u5bf9\u8111\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u5f71\u54cd\u5219\u5c1a\u672a\u88ab\u8bc1\u5b9e\u3002 \u767d\u85dc\u82a6\u9187(resveratrol)\u662f\u4e00\u79cd\u5b58\u5728\u8461\u8404\u4e2d\u7684\u591a\u915a\u7c7b\u7269\u8d28\uff0c\u5177\u6297\u6c27\u5316\u529f\u80fd\u5e76\u5bf9\u9884\u9632\u6216\u6539\u5584\u5fc3\u8840\u7ba1\u76f8\u5173\u75be\u75c5\u6709\u4f5c\u7528\uff0c\u4f46\u662f\u80fd\u5426\u4fdd\u62a4\u8840\u8111\u5c4f\u969c\u514d\u4e8eoxLDL\u7684\u4f24\u5bb3\u5219\u5c1a\u65e0\u76f8\u5173\u7814\u7a76\u3002\u672c\u7814\u7a76\u5c06\u4ee5\u5c0f\u9f20CECs\u4e3a\u7814\u7a76\u6a21\u5f0f\u63a2\u8ba8\u767d\u85dc\u82a6\u9187\u5982\u4f55\u4fdd\u62a4CECs\u514d\u4e8eoxLDL\u7684\u4f24\u5bb3\uff0c\u53ca\u5176\u53ef\u80fd\u673a\u5236\u3002 \u9996\u5148\u4ee5\u4eba\u7684LDL (Low density lipoprotein\uff1bLDL)\u7528\u4e0d\u540c\u6d53\u5ea6\u7684\u786b\u9178\u94dc\u4e8e\u4e0d\u540c\u65f6\u95f4\u70b9\u4e0b\u57f9\u517b\uff0c\u4fa6\u6d4b\u6c27\u5316\u7a0b\u5ea6\u7684\u5dee\u5f02\uff0c\u7ed3\u679c\u53d1\u73b0\u786b\u9178\u94dc\u6d53\u5ea6\u8d8a\u9ad8\uff0c\u5904\u7406\u65f6\u95f4\u8d8a\u957f\uff0c\u5219\u4f1a\u4f7fLDL\u6c27\u5316\u8d8a\u4e25\u91cd\u3002\u5229\u75283-(4,5-dimethylthiazol-2-yl)-2,5\u2013diphenyltetra -zolium bromide (MTT)\u8272\u5ea6\u5206\u6790\u6cd5\u6765\u68c0\u9a8c\u7ec6\u80de\u7c92\u817a\u4f53\u5185\u819c\u7425\u73c0\u9178\u53bb\u6c22?(succinate dehydrogenase)\u7684\u6d3b\u6027\uff0c\u53d1\u73b0200 \u03bcg\/ml\u7684oxLDL\u5904\u7406CECs 48\u5c0f\u65f6\u4f1a\u4f7f\u5176\u5b58\u6d3b\u7387\u964d\u4f4e\u81f358.7 %\uff0c\u540c\u65f6\u89c2\u5bdf\u5230CECs\u578b\u6001\u7531\u539f\u5148\u7684\u7eba\u9524\u72b6\u76b1\u7f29\u4e3a\u5706\u5f62\u3001\u4ee5trypan blue\u67d3\u8272\u4e5f\u53d1\u73b0\u6d3b\u6027\u4e0b\u964d45.9 %\uff0c\u5e76\u6709DNA\u7247\u6bb5\u5316\u73b0\u8c61\u7684\u51fa\u73b0\uff0c\u8bc1\u5b9eoxLDL\u5177\u6709\u5f15\u53d1CECs\u7ec6\u80de\u51cb\u4ea1(apoptosis)\u7684\u80fd\u529b\u3002\u518d\u4ee5\u53cd\u8f6c\u5f55\u805a\u5408?\u8fde\u9501\u53cd\u5e94(reverse transcriptase-polymerase chain reaction)\u65b9\u6cd5\u5206\u6790CECs\u5185oxLDL\u7684\u53d7\u4f53(lectin-like oxLDL receptor-1\uff1bLOX-1) mRNA\uff0c\u53d1\u73b0CECs\u4e0eoxLDL\u5171\u540c\u57f9\u517b\u540e\uff0cLOX-1 mRNA\u7684\u8868\u73b0\u91cf\u4e0a\u5347\u3002\u6b64\u5916\u75312\u2019,7\u2019- dichlorofluorescin diacetate (DCFHDA)\u4fa6\u6d4b\u7ec6\u80de\u4e2d\u53cd\u5e94\u6027\u6c27\u5206\u5b50(reactive oxygen species\uff1bROS)\u7684\u542b\u91cf\uff0c\u5229\u7528\u897f\u65b9\u70b9\u58a8\u6cd5(western blotting)\u4ee5\u53cacaspase\u9175\u7d20\u6d3b\u6027\u5206\u6790\u8fdb\u4e00\u6b65\u8bc1\u660e\u7ec6\u80de\u51cb\u4ea1\u7684\u673a\u5236\u662f\u900f\u8fc7\u51cf\u5c11bcl-2\u4f7f\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u4e0a\u5347\uff0c\u589e\u52a0bax\u4e0ecytochrome c\u86cb\u767d\u8868\u73b0\u4e0e\u6d3b\u5316caspase 9\u3001caspase 3\u3001caspase 8\u3002 \u767d\u85dc\u82a6\u9187\u5728\u975e\u7ec6\u80de\u5b9e\u9a8c\u4e2d\u663e\u793a\u5177\u6709\u6291\u5236LDL\u6c27\u5316\u7684\u6548\u679c\uff0c10 \u03bcM\u7684\u767d\u68a8\u82a6\u9187\u5e76\u4e0d\u5f71\u54cdCECs\u7684\u578b\u6001\u548c\u5b58\u6d3b\u7387\u3002\u5c06CECs\u540c\u65f6\u5904\u7406200 \u03bcg\/ml\u7684oxLDL\u4e0e10 \u03bcM\u7684\u767d\u85dc\u82a6\u9187\u540e\u53d1\u73b0\uff0c\u7ec6\u80de\u578b\u6001\u4ecd\u5448\u73b0\u7eba\u9524\u72b6\u3001\u7ec6\u80de\u5b58\u6d3b\u7387\u753154.1 % \u56de\u5347\u4e3a83.6 %\uff0c\u53e6\u5916DNA\u88c2\u89e3\u7a0b\u5ea6\u51cf\u4f4e\uff0c\u8bc1\u660e\u767d\u85dc\u82a6\u9187\u5bf9oxLDL\u9020\u6210\u7684\u7ec6\u80de\u51cb\u4ea1\u6709\u4fdd\u62a4\u7684\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u63a2\u8ba8\u4fdd\u62a4\u4f5c\u7528\u7684\u673a\u5236\uff0c\u53d1\u73b0LOX-1 mRNA\u7684\u8868\u73b0\u4e0d\u53d7\u767d\u85dc\u82a6\u9187\u5f71\u54cd\uff0c\u767d\u85dc\u82a6\u9187\u5bf9\u6291\u5236ROS\u7684\u4ea7\u751f\u3001\u964d\u4f4e\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u3001\u51cf\u5c11cytochrome c\u86cb\u767d\u91cf\u7684\u8868\u73b0\u4e0e\u6291\u5236caspase 9\u3001caspase 3\u53cacaspase 8\u7684\u6d3b\u6027\u5747\u6709\u4f5c\u7528\u3002 \u7531\u672c\u7814\u7a76\u6210\u679c\u53ef\u77e5\uff0c\u767d\u85dc\u82a6\u9187\u4fdd\u62a4CECs\u7684\u673a\u5236\u5e76\u975e\u900f\u8fc7\u5f71\u54cdoxLDL\u8fdb\u5165\u7ec6\u80de\u7684\u8fc7\u7a0b\uff0c\u800c\u662f\u5728LDL\u7684\u6c27\u5316\u8fc7\u7a0b\u4e2d\u85c9\u7531\u672c\u8eab\u6297\u6c27\u5316\u80fd\u529b\u51cf\u8f7b\u8102\u8d28\u6c27\u5316\u7a0b\u5ea6\uff0c\u5e76\u964d\u4f4e\u56e0\u4e3aoxLDL\u7684\u8fdb\u5165\u5bfc\u81f4\u4e0a\u5347\u7684ROS\uff0c\u51cf\u8f7b\u5176\u5bf9\u7ec6\u80de\u4ea7\u751f\u7684\u7834\u574f\u3002\u4e0d\u4f46\u4f1a\u8c03\u63a7\u5916\u751f\u6027\u7684\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\u51cf\u5c11caspase 8\u4ea7\u751f\uff1b\u4e5f\u5f71\u54cd\u5185\u751f\u6027\u7ec6\u80de\u51cb\u4ea1\u8def\u5f84\uff0c\u51cf\u5c11bax\u7684\u4ea7\u751f\uff0c\u589e\u52a0bcl-2\u4f7f\u7c92\u817a\u4f53\u819c\u901a\u900f\u6027\u4e0a\u5347\u3001cytochrome c\u91ca\u51fa\u91cf\u51cf\u5c11\u3001caspase 9\u53cacaspase 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