{"id":114,"date":"2022-02-13T05:06:38","date_gmt":"2022-02-13T05:06:38","guid":{"rendered":"http:\/\/choosebiz.me\/?p=114"},"modified":"2022-05-27T03:21:01","modified_gmt":"2022-05-27T03:21:01","slug":"%e8%a1%b0%e8%80%81%e5%8f%af%e8%83%bd%e6%98%af%e5%8f%af%e9%80%86%e7%9a%84-%e7%94%a8-nad-%e4%bf%ae%e5%a4%8d%e7%bb%86%e8%83%9e%e4%b8%ad%e7%9a%84%e9%94%99%e8%af%af%e4%ba%a4%e6%b5%81","status":"publish","type":"post","link":"http:\/\/johnhealth.blog\/ch\/?p=114","title":{"rendered":"\u8870\u8001\u53ef\u80fd\u662f\u53ef\u9006\u7684\u2014\u7528 NAD+ \u4fee\u590d\u7ec6\u80de\u4e2d\u7684\u9519\u8bef\u4ea4\u6d41"},"content":{"rendered":"

\u7c92\u7ebf\u4f53\u548c\u7ec6\u80de\u6838\u4e4b\u95f4\u7684\u6c9f\u901a\u4e0d\u826f\u4f1a\u52a0\u901f\u8870\u8001\uff0c\u4f46\u8865\u5145 NAD+ \u6709\u52a9\u65bc\u6062\u590d\u5bf9\u8bdd\u5e76\u9006\u8f6c\u8870\u8001\u8ff9\u8c61\u3002<\/p>\n

\"\"<\/p>\n

\u6211\u4eec\u7684\u7ec6\u80de\u5c31\u50cf\u590d\u6742\u7684\u673a\u5668\uff0c\u4f9d\u8d56\u65bc\u4e0d\u540c\u7ec4\u4ef6\u7684\u5408\u4f5c\u548c\u4ea4\u6d41\uff0c\u5c24\u5176\u662f\u5728\u4e2d\u592e\u6307\u6325\u4e2d\u5fc3\u548c\u53d1\u7535\u5382\u2014\u2014\u7ec6\u80de\u6838\u548c\u7c92\u7ebf\u4f53\u4e4b\u95f4\u3002 \u54c8\u4f5b\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u8001\u9f20\u4f53\u5185\u4e24\u79cd\u7ec6\u80de\u5668\u4e4b\u95f4\u7684\u901a\u8baf\u4e2d\u65ad\u4f1a\u5bfc\u81f4\u52a0\u901f\u8870\u8001\u3002 \u4e0d\u8fc7\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u8eab\u4f53\u4ea7\u751f\u7684\u4e00\u79cd\u5929\u7136\u5316\u5408\u7269\u2014\u2014\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u6765\u9006\u8f6c\u3002<\/p>\n

\u8be5\u7814\u7a76\u7684\u8d44\u6df1\u5b66\u8005\u4e36\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7ec8\u751f\u6559\u6388\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14 (Prof. David Sinclair)\u8bf4\uff1a\u201c\u6211\u4eec\u53d1\u73b0\u8870\u8001\u7684\u8fc7\u7a0b\u5c31\u50cf\u4e00\u5bf9\u5df2\u5a5a\u592b\u5987\u2014\u2014\u4ed6\u4eec\u5e74\u8f7b\u7684\u65f6\u5019\u4ea4\u6d41\u5f97\u5f88\u597d\uff0c\u4f46\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u5728\u8fd1\u8ddd\u79bb\u751f\u6d3b\u591a\u5e74\uff0c\u4ea4\u6d41\u5c31\u4f1a\u4e2d\u65ad\u3002\u201d \u5b66\u6821\u53d1\u8868\u516c\u544a\u3002 \u201c\u5c31\u50cf\u4e00\u5bf9\u592b\u5987\u4e00\u6837\uff0c\u6062\u590d\u6c9f\u901a\u89e3\u51b3\u4e86\u95ee\u9898\u3002\u201d<\/p>\n

\u7c92\u7ebf\u4f53\u662f\u590d\u6742\u7ec6\u80de\u4e2d\u7684\u5fae\u5c0f\u7ed3\u6784\uff0c\u53ef\u4ea7\u751f\u4e09\u78f7\u9178\u817a\u82f7 (ATP)\uff0c\u8fd9\u662f\u65b0\u9648\u4ee3\u8c22\u7684\u751f\u7269\u71c3\u6599\u3002 \u5927\u7ea6 20 \u4ebf\u5e74\u524d\uff0c\u7c92\u7ebf\u4f53\u7684\u7ec6\u83cc\u7956\u5148\u5c06\u81ea\u8eab\u6574\u5408\u5230\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u5e76\u4e13\u95e8\u4ece\u4e8b\u80fd\u91cf\u751f\u4ea7\u3002 \u4eca\u5929\uff0c\u7c92\u7ebf\u4f53\u4ecd\u7136\u643a\u5e26\u5c11\u91cf\u81ea\u8eab\u7684 DNA\uff0c\u5e76\u5728\u4fc3\u8fdb\u7ec6\u80de\u4ee3\u8c22\u65b9\u9762\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002 \u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u8ba4\u8bc6\u5230\u7c92\u7ebf\u4f53\u529f\u80fd\u969c\u788d\u662f\u8870\u8001\u7684\u6807\u5fd7\u4e4b\u4e00\uff0c\u8870\u8001\u4f1a\u5bfc\u81f4\u764c\u75c7\u4e36\u7cd6\u5c3f\u75c5\u548c\u963f\u8328\u6d77\u9ed8\u75c7\u7b49\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\u3002<\/p>\n

\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u77e5\u9053\uff0c\u8870\u8001\u4e0e\u7c92\u7ebf\u4f53\u529f\u80fd\u7684\u9010\u6e10\u4e0b\u964d\u6709\u5173\u3002\u7136\u800c\uff0c\u4ee4\u7814\u7a76\u5c0f\u7ec4\u60ca\u8bb6\u7684\u662f\uff0c\u867d\u7136\u6765\u81ea\u7ec6\u80de\u6838\u7684\u7c92\u7ebf\u4f53\u86cb\u767d\u6c34\u5e73\u5728\u8001\u5e74\u5c0f\u9f20\u4e2d\u4fdd\u6301\u6b63\u5e38\uff0c\u4f46\u7c92\u7ebf\u4f53 DNA \u7f16\u7801\u7684\u86cb\u767d\u6c34\u5e73\u663e\u7740\u964d\u4f4e\u3002<\/p>\n

\u8fdb\u4e00\u6b65\u7684\u8c03\u67e5\u8868\u660e\uff0c\u6839\u672c\u539f\u56e0\u4e4b\u4e00\u53ef\u80fd\u662f NAD+ \u5206\u5b50\u6c34\u5e73\u7684\u4e0b\u964d\u3002\u8fd9\u4e2a\u57fa\u672c\u5206\u5b50\u5145\u5f53\u7a7f\u68ad\u5df4\u58eb\uff0c\u5728\u7ec6\u80de\u6838\u548c\u7c92\u7ebf\u4f53\u4e4b\u95f4\u4f20\u9012\u4fe1\u606f\uff0c\u534f\u8c03\u901a\u4fe1\u3002\u4f46\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\uff0cNAD+ \u6c34\u5e73\u4e0b\u964d\u7684\u539f\u56e0\u79d1\u5b66\u5bb6\u4eec\u4ecd\u7136\u4e0d\u660e\u767d\u3002<\/p>\n

Sinclair \u7684\u56e2\u961f\u6240\u77e5\u9053\u7684\u662f\uff0cNAD+ \u5bf9\u65bc\u652f\u6301 SIRT1 \u7684\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0cSIRT1 \u662f\u4e00\u79cd\u86cb\u767d\u8d28\uff0c\u53ef\u4fdd\u62a4\u7ec6\u80de\u6838\u548c\u7c92\u7ebf\u4f53\u57fa\u56e0\u7ec4\u4e4b\u95f4\u514d\u53d7\u5e72\u6270\u5206\u5b50 HIF-1 \u7684\u5f71\u54cd\u3002\u5982\u679c\u6ca1\u6709\u4f9d\u8d56 NAD+ \u7684 SIRT1 \u6765\u76d1\u89c6 HIF-1\uff0c\u5b83\u5c31\u4f1a\u81ea\u7531\u6f2b\u6e38\uff0c\u6270\u4e71\u5bf9\u8bdd\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8fd9\u79cd\u7834\u574f\u4f1a\u51cf\u5c11\u7ec6\u80de\u4e2d\u7684\u80fd\u91cf\u4ea7\u751f\u5e76\u52a0\u901f\u8870\u8001\u8fc7\u7a0b\u3002\u8fd9\u4e0d\u4ec5\u662f\u9996\u6b21\u63cf\u8ff0\u8870\u8001\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u6838-\u7c92\u7ebf\u4f53\u901a\u8baf\uff0c\u800c\u4e14\u8be5\u7814\u7a76\u8fd8\u8868\u660e\u8fd9\u79cd\u73b0\u50cf\u662f\u201c\u53ef\u9006\u7684\u201d\u3002<\/p>\n

\"\"<\/p>\n

\"\" \"\"<\/p>\n

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(Gomes et al., 2013) \u7528\u8f7d\u4f53 (PBS) \u6216 NMN \u6cbb\u7597\u7684 6 \u4e2a\u6708\u548c 22 \u4e2a\u6708\u5927\u7684\u5c0f\u9f20\u7684 NAD+ \u6c34\u5e73\uff08\u56fe E\uff09\u3002 \u540c\u4e00\u961f\u5217\u4e2d\u7ebf\u7c92\u4f53\u7f16\u7801\u57fa\u56e0\u7684\u8868\u8fbe\uff08\u56fe F\uff09\u3002 \u540c\u4e00\u961f\u5217\u7684 ATP \u542b\u91cf\uff08\u56fe G\uff09<\/p>\n

\u4ed6\u4eec\u53d1\u73b0\u901a\u8fc7\u5411 2 \u5c81\u5c0f\u9f20\u6ce8\u5c04 NAD+ \u8865\u5145\u5242\uff0c\u4ed6\u4eec\u53ef\u4ee5\u4fee\u590d\u8de8\u57fa\u56e0\u7ec4\u901a\u8baf\u7f51\u7edc\u5e76\u6062\u590d\u7c92\u7ebf\u4f53\u529f\u80fd\u3002 \u4e00\u5468\u7684\u6cbb\u7597\u8db3\u4ee5\u4f7f\u808c\u8089\u5065\u5eb7\u7684\u751f\u5316\u6307\u6807\u8fbe\u5230\u4e0e 6 \u4e2a\u6708\u5927\u7684\u5c0f\u9f20\u76f8\u4f3c\u7684\u6c34\u5e73\u3002 \u8fd9\u5c31\u50cf\u5728\u7279\u5b9a\u9886\u57df\u5c06\u4e00\u4e2a 60 \u5c81\u7684\u4eba\u8f6c\u53d8\u4e3a\u4e00\u4e2a 20 \u5c81\u7684\u4eba<\/span><\/strong>\u3002<\/p>\n

\u6ce8\u5c04\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178 (NMN)\uff0c\u589e\u52a0\u4e86\u5e74\u8f7b\u548c\u5e74\u8001\u5c0f\u9f20\u7684 NAD+ \u542b\u91cf\u3002 \u5728\u63a5\u53d7\u4ecb\u5165\u7684\u8001\u5e74\u5c0f\u9f20\u4e2d\uff0cNAD+ \u6c34\u5e73\u5927\u7ea6\u662f\u672a\u4ecb\u5165\u5c0f\u9f20\u7684\u4e24\u500d\u3002 \u7814\u7a76\u4eba\u5458\u8fd8\u89c2\u5bdf\u5230\u7528 NMN \u4ecb\u5165\u7684\u52a8\u7269\u5177\u6709\u66f4\u9ad8\u7684 ATP \u6c34\u5e73\uff0c\u8868\u660e\u7c92\u7ebf\u4f53\u6d3b\u52a8\u589e\u52a0\uff0c\u7ec6\u80de\u4ea7\u751f\u66f4\u591a\u80fd\u91cf\u3002<\/p>\n

\u201c\u8fd9\u91cc\u663e\u7136\u8fd8\u6709\u5f88\u591a\u5de5\u4f5c\u8981\u505a\uff0c\u4f46\u5982\u679c\u8fd9\u4e9b\u7ed3\u679c\u6210\u7acb\uff0c\u90a3\u9ebd\u5982\u679c\u53ca\u65e9\u53d1\u73b0\u8870\u8001\u7684\u8bb8\u591a\u65b9\u9762\u53ef\u80fd\u662f\u53ef\u9006\u7684\uff0c\u201dSinclair\u8bf4\u3002 \u8be5\u56e2\u961f\u5efa\u8bae\uff0c\u5f00\u53d1\u963b\u6b62 HIF-1 \u5e72\u9884\u7ec6\u80de\u901a\u8baf\u6216\u589e\u52a0 NAD+ \u6c34\u5e73\u7684\u5c0f\u5316\u5408\u7269\u53ef\u80fd\u662f\u672a\u6765\u6cbb\u7597\u8870\u8001\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n

\u53c2\u8003\u6587\u732e:<\/p>\n

Gomes AP, Price NL, Ling AJ, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-1638. doi:10.1016\/j.cell.2013.11.037<\/p>\n

\u6587\u7ae0\u6765\u6e90:<\/p>\n

https:\/\/www.nmn.com\/news\/aging-might-be-reversible-fixing-the-miscommunications-in-cells<\/p>\n

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\u7c92\u7ebf\u4f53\u548c\u7ec6\u80de\u6838\u4e4b\u95f4\u7684\u6c9f\u901a\u4e0d\u826f\u4f1a\u52a0\u901f\u8870\u8001\uff0c\u4f46\u8865\u5145 NAD+ \u6709\u52a9\u65bc\u6062\u590d\u5bf9\u8bdd\u5e76\u9006\u8f6c\u8870\u8001\u8ff9\u8c61\u3002 \u6211\u4eec\u7684\u7ec6\u80de\u5c31\u50cf\u590d\u6742\u7684\u673a\u5668\uff0c\u4f9d\u8d56\u65bc\u4e0d\u540c\u7ec4\u4ef6\u7684\u5408\u4f5c\u548c\u4ea4\u6d41\uff0c\u5c24\u5176\u662f\u5728\u4e2d\u592e\u6307\u6325\u4e2d\u5fc3\u548c\u53d1\u7535\u5382\u2014\u2014\u7ec6\u80de\u6838\u548c\u7c92\u7ebf\u4f53\u4e4b\u95f4\u3002 \u54c8\u4f5b\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u8001\u9f20\u4f53\u5185\u4e24\u79cd\u7ec6\u80de\u5668\u4e4b\u95f4\u7684\u901a\u8baf\u4e2d\u65ad\u4f1a\u5bfc\u81f4\u52a0\u901f\u8870\u8001\u3002 \u4e0d\u8fc7\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u8eab\u4f53\u4ea7\u751f\u7684\u4e00\u79cd\u5929\u7136\u5316\u5408\u7269\u2014\u2014\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u6765\u9006\u8f6c\u3002 \u8be5\u7814\u7a76\u7684\u8d44\u6df1\u5b66\u8005\u4e36\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u7684\u7ec8\u751f\u6559\u6388\u5927\u536b\u00b7\u8f9b\u514b\u83b1\u5c14 (Prof. David Sinclair)\u8bf4\uff1a\u201c\u6211\u4eec\u53d1\u73b0\u8870\u8001\u7684\u8fc7\u7a0b\u5c31\u50cf\u4e00\u5bf9\u5df2\u5a5a\u592b\u5987\u2014\u2014\u4ed6\u4eec\u5e74\u8f7b\u7684\u65f6\u5019\u4ea4\u6d41\u5f97\u5f88\u597d\uff0c\u4f46\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u5728\u8fd1\u8ddd\u79bb\u751f\u6d3b\u591a\u5e74\uff0c\u4ea4\u6d41\u5c31\u4f1a\u4e2d\u65ad\u3002\u201d \u5b66\u6821\u53d1\u8868\u516c\u544a\u3002 \u201c\u5c31\u50cf\u4e00\u5bf9\u592b\u5987\u4e00\u6837\uff0c\u6062\u590d\u6c9f\u901a\u89e3\u51b3\u4e86\u95ee\u9898\u3002\u201d<\/p>\n

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